Application of miR-193a-5p antagonist or medicine composition of miR-193a-5p antagonist

A mir-193a-5p, 1.mir-193a-5p technology, applied in the application of drugs for the treatment of prostate cancer, application field, can solve the problems of hidden disease, toxicity and drug resistance, adverse effects, etc.

Inactive Publication Date: 2018-03-16
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although surgery is an effective treatment for the radical cure of prostate cancer, most of the diagnosed prostate cancer patients with clinical symptoms are in the advanced stage due to the relatively hidden onset of the disease.
Androgen deprivation therapy (ADT) is a common method for the treatment of advanced prostate cancer, but most patients will develop hormone-independent prostate cancer in about 18 months, and the life expectancy of patients at this time is usually only about one year
Currently, chemotherapy based on doxtaxel (Doc) is considered to be an effective method for the treatment of metastatic hormone-independent prostate cancer. Unfortunately, many drug patients often encounter some adverse side effects, such as toxicity or drug resistance, Drug resistance is often the leading cause of treatment failure in hormone-independent prostate cancer

Method used

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  • Application of miR-193a-5p antagonist or medicine composition of miR-193a-5p antagonist
  • Application of miR-193a-5p antagonist or medicine composition of miR-193a-5p antagonist
  • Application of miR-193a-5p antagonist or medicine composition of miR-193a-5p antagonist

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Embodiment Construction

[0016] In order to make the present invention easier to understand, specific embodiments of the present invention will be further described below.

[0017] 1. Specific test process

[0018] 1. Experimental animals: 4-6 weeks old male BALB / c nude mice (18-22g).

[0019] 2. Prostate cancer PC3 cell grouping:

[0020] Group 1, 5×10 6 Prostate cancer PC3 cells infected with LV-Ctl (vehicle control), about two titers of LV-Ctl in each cell, were resuspended in 0.2mL PBS mixed with 50% Matrigel; the suspension was subcutaneously injected into Right dorsal side. When the average volume of prostate cancer PC3 cell xenograft tumor reached 180mm 3 At , mice were treated with PBS and injected intraperitoneally once a week for four weeks.

[0021] Second group, 5×10 6 Prostate cancer PC3 cells infected with LV-Ctl (vehicle control), about two titers of LV-Ctl in each cell, were resuspended in 0.2mL PBS mixed with 50% Matrigel; the suspension was subcutaneously injected into Right d...

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Abstract

The invention relates to application of a miR-193a-5p antagonist or a medicine composition of the miR-193a-5p antagonist to preparation of medicine for treating prostate cancer, and belongs to the technical field of medicine. The medicine composition is the miR-193a-5p antagonist and docetaxel. According to the application, the miR-193a-5p antagonist can enhance the curative effect of the docetaxel or can inhibit the drug tolerance of the tumor on the docetaxel, so that the cell apoptosis sensitization effect induced by prostate cancer cells on the docetaxel is greatly improved. The miR-193a-5p antagonist and the docetaxel are combined for medication, so that an effective path is provided for the prostate cancer treatment.

Description

technical field [0001] The invention relates to an application, in particular to an application of a miR-193a-5p antagonist or a pharmaceutical composition thereof in the preparation of a drug for treating prostate cancer, and belongs to the technical field of medicine. Background technique [0002] Prostate cancer, as an epithelial malignant tumor originating in male prostate, has always been one of the most common malignant tumors of male genitourinary system in European and American countries, with a high incidence rate. Survey data in recent years show that In the statistics of malignant tumor death rate in the United States, the death rate of prostate cancer has surpassed that of lung cancer, ranking first in the death rate of male cancer. In recent years, the incidence of prostate cancer in my country has been increasing year by year, and the increasing trend is very obvious. At present, the incidence of prostate cancer among Chinese men over 70 years old ranks first a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/337A61K31/7105A61P35/00
CPCA61K31/337A61K31/7105A61K45/06A61K2300/00
Inventor 杨展张勇王晓路
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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