22results about How to "Speed up progress" patented technology

The invention provides a 6061 aluminum alloy rheological behavior constitutive relation prediction method based on physical information machine learning, and the method comprises the steps: carrying out the interception of a yield point of experimental stress-strain curve data, retaining a plastic segment, and combining with a corresponding experimental condition, thereby obtaining a data set for the training of a physical information machine learning model; performing ANN model training on the data set to obtain a data driving loss item between an ANN model prediction stress value and an experimental stress value; secondly, a physical constitutive model is embedded into a loss function of an ANN model, a physical law serves as a constraint condition to be introduced into neural network learning, and an additional physical driving loss item is formed by calculating the difference between neural network prediction and physical results described by the constitutive model; and establishing a loss function by combining the physical driving loss item and the data driving loss item according to different weights, training a physical information machine learning model according to the loss function, and outputting a final prediction stress-strain curve.

The invention provides a heart point cloud reconstruction method and system for echocardiography, and the method comprises the following steps: obtaining three-dimensional heart structure data, and carrying out the preprocessing of the data; reading voxel data of the three-dimensional heart structure data, and performing point clouding to form voxel reconstruction point cloud data; performing standardization processing on the voxel reconstruction point cloud data to obtain all-center point cloud data, and performing segmentation acquisition to obtain standard section point cloud data; establishing a scanning guide network based on the heart structure data to be processed and the standard section point cloud data; and obtaining a test sample, inputting the test section point cloud data in the test sample into the scanning guide network, and outputting the three-dimensional heart structure data of the test sample and the heart point cloud data of the section where the test section point cloud data is located. After the scheme is adopted, an echocardiogram scanning guide network based on the point cloud is provided, a complete three-dimensional heart model is constructed, and meanwhile, the tangent plane where the two-dimensional echocardiogram is located is determined in the three-dimensional heart model.

The invention relates to the technical field of nano-drugs, in particular to an acoustic / chemical power synergistic anti-tumor nano-drug as well as a preparation method and application thereof. The invention provides an acoustic / chemical power synergistic anti-tumor nano-drug, which takes hollow mesoporous MnO2 nano-particles as a carrier, and is loaded with vitamin C and a sound-sensitive agent chlorin e6. Vc can generate abundant H2O2 to provide a raw material for CDT, and MnO2 is used as a peroxidase-like enzyme to catalyze H2O2 to generate O2, so that tumor hypoxia is effectively relieved, and the effect of sonodynamic therapy is enhanced. Besides, GSH induces MnO2 degradation, GSH consumption is caused to enhance CDT, GSH depletion can cause glutathione peroxidase 4 (GPX4) activity reduction, ROS generation and GPX4 activity reduction have a synergistic effect, lipid peroxides (LPOs) are increased, and finally ferroptosis of tumor cells is caused.

The invention discloses application of ZMYM1 as a biomarker in liver cancer diagnosis and / or treatment. The expression of ZMYM1 in liver cancer patients is up-regulated. Database analysis, cell experiments and animal model experiments prove that ZMYM1 is a cancer promoting gene of liver cancer, ZMYM1 interacts with METTL3 to promote migration of tumor cells and improve the inflammation level in a tumor microenvironment, and finally the effect of promoting the progress of liver cancer is achieved. Based on TCGA, GEO, ICGC and NGDC databases, the application of the ZMYM1 as a biomarker in liver cancer diagnosis, liver cancer prognosis risk assessment, liver cancer immunotherapy effect prediction and targeted drug therapy effect prediction is provided according to a bioinformatics analysis result, so that a prevention scheme or a treatment scheme is clinically provided for a subject, and the clinical application of the ZMYM1 in liver cancer diagnosis, liver cancer prognosis risk assessment, liver cancer immunotherapy effect prediction and targeted drug therapy effect prediction is promoted. The precise molecular treatment of the liver cancer is realized.

The invention provides an application of chimeric SFT2D2-TBX19 in diagnosis and treatment of prostatic cancer, and particularly relates to an application of the chimeric SFT2D2-TBX19 as a marker in diagnosis and treatment of prostatic cancer. The nucleotide sequence of the chimeric SFT2D2-TBX19 disclosed by the invention is as shown in SEQ ID NO.1. The overexpression of the chimeric SFT2D2-TBX19 promotes the proliferation, migration and invasion of prostate cancer cells; the chimeric SFT2D2-TBX19 is used for encoding the TBX19-202 protein, the TBX19-202 protein encoded by the chimeric SFT2D2-TBX19 has a carcinogenic effect similar to that of a parent TBX19 in the aspect of promoting the progress of prostatic cancer, and the amino acid sequence of the TBX19-202 protein is shown as SEQ ID NO. 4. Specific high expression of the chimeric SFT2D2-TBX19 in a neuroendocrine prostate cancer (NEPC) cell line is found for the first time, and a new target spot is provided for diagnosis and treatment of related diseases, so that a clinician is guided to provide a prevention method or a treatment scheme for a subject.

The invention discloses application of a palmitoylation inhibitor in prevention and treatment of gastric cancer. The chromatin remodeling protein SNF2 derived from S.anginosus EVs can be combined with a transcription factor TEAD1, so that the transcription of the palmitoyl transferase ZDHHC11 is promoted together. Then, the stability of the ZDHHC11 is enhanced by catalyzing palmitoylation of PD-L1, and finally immune escape is induced. In addition, SNF2 also can activate AXL, CTGF, CYR61 and other carcinogenic targets at the downstream of TEAD1, thereby further accelerating the malignant progression of gastric cancer. In an in-vivo experiment, the intragastric administration of the S.anginosus EVs not only promotes the tumor growth of mice, but also significantly inhibits the infiltration of CD8 + T cells. Blocking of ZDHHC11 can effectively reverse immune escape, and has a synergistic effect with an anti-PD-1 therapy, so that the treatment effect is remarkably improved.

The invention discloses a molecular mechanism research method regulated and controlled through metabolism reprogramming, and relates to the technical field of molecular biology. The method specifically comprises the following steps: S1, preparing an experimental cell material and an experimental reagent; the experimental cell material is melanoma cells, and the experimental reagent comprises a DMEM high glucose culture medium, PINK1 targeting lentivirus and the like. According to the application, cell infection, RNA (Ribonucleic Acid) extraction, RT-qPCR (Reverse Transcription-Quantitative Polymerase Chain Reaction) detection, Western blot experiment, cell activity detection and the like are carried out on lentivirus targeting PINK1, a molecular mechanism of melanoma caused by BRAF gene V600E mutation regulated by PINK1 through metabolic reprogramming is researched, and aerobic glycolysis caused by PINK1 down-regulation can be alleviated by inhibiting ENO2, so that PINK1 inhibits aerobic glycolysis of melanoma cells, and the application has the advantages that the application is simple, the application is convenient, and the application has a wide application prospect. The low-expression PINK1 promotes the growth of melanoma cells.

According to the radio frequency device behavior model parameter extraction method based on transfer learning, the polynomial model coefficient is extracted through the neural network model, the data size needed for building the neural network model is reduced, the portability and optimization efficiency of the model are improved, seamless integration of the neural network model and EDA software is achieved, and the performance of the neural network model is improved. The progress of the electronic design process is accelerated; the neural network model uses the test model in the old working state as the starting point of the new working state, so that the model coefficient is prevented from being re-extracted, and the test time and the instrument cost are saved.

The invention relates to the technical field of molecular biology, in particular to a pneumonia genome detection system and method based on a throat swab sample. The method comprises the following steps: obtaining a pharynx throat swab sample solution, and adding lysozyme for sample digestion to obtain a sterile throat swab sample; the method comprises the following steps: putting a sterile throat swab sample into a nucleic acid extraction kit, and carrying out nucleic acid quality screening treatment on the sterile throat swab sample to obtain a sterile throat swab nucleic acid high-quality sample; the method comprises the following steps: obtaining a pneumonia related pathogen historical genome sequence, and carrying out related pathogen primer design and PCR amplification library construction to obtain a throat swab nucleic acid PCR amplification sequence library; and performing high-throughput sequencing treatment and genomic sequence pathogen comparison detection on each group of throat swab nucleic acid pneumonia gene sequences in the throat swab nucleic acid PCR amplification sequence library to obtain a throat swab sample pneumonia pathogen genome detection result. According to the invention, accurate identification and quantitative analysis of pneumonia pathogens can be realized.

The present invention belongs to the technical field of obstetric care, and discloses a transfer device for obstetric care, comprising a support shell, a side surface of which is provided with a vertical through hole; a lower end surface of the support shell is fixedly connected to a support frame, and four corners of the lower end surface of the support frame are provided with universal wheels; a lifting mechanism and a detachable bed board are provided inside the support shell; baffles are connected to both sides of the vertical through hole, and one side surface of the baffle is connected to the inner side surface of the support shell; a pregnant woman can be automatically lifted up for work through the guidance of a guide track, and the force of the lifting work will not cause the pregnant woman herself to suffer, thereby preventing the pregnant woman from feeling uncomfortable, reducing the harm to the pregnant woman, improving safety, and improving versatility and usability.

The application discloses a single-exposure compressed ultrafast coherent modulation imaging device. By combining coherent modulation imaging and compressed ultrafast imaging technology, a sample to be measured is illuminated by coherent light, after the sample diffracts the light wave, the phase modulation of a random phase modulation plate is carried out, the integral intensity distribution of the modulated wave front is recorded by deflection on a detection plane by using a slit fully opened stripe camera, a single compressed diffraction pattern is obtained, a spatial two-dimensional to space-time three-dimensional image reconstruction algorithm based on a plug-and-play framework and a depth image priori is developed, and data recovery is carried out on the collected image by using the algorithm. Compared with traditional ultrafast optical imaging and phase imaging technology, the application can quantitatively obtain complete intensity and phase information of a transient scene in a single measurement process, has the characteristics of picosecond time resolution and real-time quantitative intensity-phase imaging capacity in single-exposure phase imaging, and can be widely applied to various ultrafast phenomena requiring phase observation.

The utility model discloses a pouring guide pipe fixing device for self-compacting core filling column construction, which comprises a bottom plate, support frames are fixedly connected to the periphery of the top of the bottom plate, a driving motor is fixedly mounted at the top of each support frame, a threaded rod is fixedly connected to the output end of each driving motor, and a threaded sleeve is in threaded connection to the surface of each threaded rod. A ground insert is fixedly connected to one side of the threaded sleeve, supporting plates are fixedly connected to the two sides of the top of the bottom plate, first electric telescopic rods are fixedly installed at the top and the bottom of one side of each supporting plate, and a first fixing plate is fixedly connected to one side of each first electric telescopic rod. After the pouring guide pipe is fixed, the threaded rod is driven by the driving motor to rotate, and in the rotating process of the threaded rod, the threaded sleeve and the ground insert are driven to move downwards, so that the ground insert is inserted into soil, the fixing device does not have the possibility of displacement, and the phenomenon that the fixed pouring guide pipe is displaced and inclined is avoided; and the progress of pouring work is further improved.

The invention relates to a method for simulating a sodium ion battery to form a solid electrolyte interface, a medium and a program product, and the method comprises the following steps: generating an initial model: generating an initial sodium ion battery model by using Packmol software, defining the size and boundary conditions of a simulation system, and setting the number and distribution of molecules; setting force field parameters; performing simulation operation, namely operating the adjusted initial sodium ion battery model by using an LAMMPS command, and recording the locus and energy change of atoms in the simulation process; and data analysis: performing post-processing analysis on the recorded track and energy change data by using ReacNetGenerator software, and analyzing a chemical reaction path, energy change and product distribution in the SEI forming process. Compared with the prior art, the method can be used for more comprehensively understanding and predicting products and reactions in the sodium ion battery in the SEI forming process, so that theoretical support is provided for design and optimization of the sodium ion battery.

The utility model relates to a pregnant and lying-in woman forward leaning position auxiliary device which comprises a base, a lifting adjusting mechanism is arranged in the base, a fixing plate is arranged at the top of the lifting adjusting mechanism, a kneeling plate is movably installed at the top of the fixing plate, and an angle adjusting mechanism is arranged between the fixing plate and the kneeling plate. The angle adjusting mechanism comprises a driving motor, the driving motor is fixedly installed on the left side of the fixing plate, a lead screw rotationally connected with the right inner wall of the fixing plate is fixedly installed at the position of an output shaft of the driving motor, the outer surface of the lead screw is in threaded connection with a screw sleeve, and a sliding block is fixedly installed at the bottom of the screw sleeve. According to the forerake auxiliary device for the pregnant and lying-in woman, by arranging the angle adjusting mechanism, the kneeling plate can rotate on the supporting frame, the inclination angle of the kneeling plate can be adjusted, and therefore the angle of kneeling on the kneeling plate can be adjusted according to the physical condition and the comfort requirement of the lying-in woman, the body is in a proper forerake state, and the development of the birth process is promoted.

The present invention relates to the technical field of drugs related to neurotoxicity or neurological diseases, and specifically to the use of small molecule compounds in the preparation of drugs for antagonizing neurotoxicity or neurological diseases caused by impaired autophagic flow. The present technical solution studies and discovers the autophagic flow regulating molecule RAB7A, which is a key downstream molecule of SIRT5. Among them, the key site is Lys31, and inhibiting the desuccinylation of RAB7A Lys31 will inhibit the activity of RAB7A, thereby leading to the blockage of autophagic flow. Small molecule compounds were screened for the key site Lys31 of SIRT5 acting on RAB7A, which can antagonize the neurotoxicity induced by heavy metal cadmium exposure and the adverse consequences of the aggravation of neurological diseases including Alzheimer's disease. The present technical solution solves the technical problem of the lack of small molecule drugs for antagonizing neurotoxicity or neurological diseases caused by impaired autophagic flow in the prior art, and has an ideal prospect for application and promotion.

The invention discloses an open source platform developer recommendation method and device based on knowledge decomposition, and the method comprises the steps: extracting a problem description text and related codes from an open source platform, and extracting a plurality of knowledge keywords in combination with a large language model, natural language processing and a multi-label classification technology to simplify problem representation. According to the method, question information and extracted knowledge keywords are stored through a knowledge graph, historical questions solved by developers are combined, and a knowledge graph recommendation technology in deep learning is applied, so that personalized accurate recommendation of the developers and question lists is realized. Compared with an existing recommendation technology, the method has the advantages that codes are not simply regarded as texts, knowledge keywords are subdivided and extracted from the texts and the codes by using proper technical stacks, and the knowledge graph is constructed for recommendation, so that the method has higher recommendation accuracy and interpretability.

The invention discloses a Modelica-based two-dimensional dynamic characteristic modeling and evaluation method for a cross-flow SOFC (Solid Oxide Fuel Cell). The method comprises the following steps: determining the physical field involved in a two-dimensional cross-flow SOFC dynamic simulation model; the two-dimensional cross flow SOFC is divided into four parts including an interconnection body, an anode flow channel, a PEN layer and a cathode flow channel in the height direction; aiming at a plurality of infinitesimal modules in the two-dimensional cross flow SOFC, respectively establishing corresponding dynamic mathematical models according to different physical and chemical processes of the infinitesimal modules; an overall two-dimensional cross flow SOFC dynamic model is constructed; establishing a two-dimensional cross flow SOFC performance comprehensive evaluation method; and carrying out two-dimensional cross flow SOFC dynamic simulation research. According to the method, the strong coupling system can be more effectively described and simulated, the maintainability and simulation efficiency of the model are improved, the progress of the engineering design and optimization process is promoted, and the method is suitable for the strong coupling solid oxide fuel cell system containing multiple physical domains.

The present invention discloses a bispecific probe-linker complex and a preparation method and use thereof, wherein the bispecific probe-linker complex comprises a linker, a first probe covalently connected to the linker, and a second probe covalently connected to the linker; the first probe can specifically bind to nucleolin protein, and the second probe can specifically bind to CTLA-4. The bispecific probe-linker complex can bind to tumor cells containing nucleolin protein on the surface through the first probe and simultaneously bind to immune cells with CTLA-4 through the second probe, thereby promoting immunotherapy, and has the characteristics of low immunogenicity, easy synthesis, low side toxicity and high efficiency.

This invention relates to the field of blasting construction technology for highway hard rock tunnels, specifically a method for blasting construction of highway hard rock tunnels. The method employs a blasting construction device for highway hard rock tunnels, including a movable base. A material storage base is fixedly installed on the left rear end of the movable base, and a support frame is fixedly installed on the upper surface of the movable base. The support frame is equipped with an adjustment mechanism for automatically installing blasting detonators on different hard rock tunnel construction faces. The device automatically installs blasting detonators according to the borehole location, accelerating the construction efficiency of highway hard rock tunnels. Before installation, the depth of the borehole is pre-positioned according to the fixed installation position of the borehole using a sliding cylinder frame, ensuring that the detonator is correctly placed at the appropriate depth in each borehole. This improves the accuracy of blasting and increases the efficiency of construction operations. Furthermore, it ensures the consistency of the installation process for each borehole, making the blasting effect of each borehole more reliable and predictable.

The application provides a case information exchange method and device, electronic equipment and storage medium. The case information exchange method comprises the following steps: generating N patient identification numbers based on obtained patient identity information; obtaining a patient identification number corresponding to a first institution identification number from the N patient identification numbers, the institution identification number being an identification number of an obtained medical institution; sending a query request to a second institution by the first institution based on the patient identification number corresponding to the first institution identification number; in response to the query request, the second institution judges whether the patient identification number corresponding to the first institution identification number has been used to query the first institution; and if not, exchanging case information. Under the premise of protecting patient privacy data, information can be quickly exchanged, the purpose of reducing the high cost of clinical trials and accelerating the progress of clinical trials is achieved.

The invention provides an application of a composition containing an mCCL6 / hCCL15-CCR1 signal channel blocking agent in preparation of a medicine for treating diseases related to inflammatory bowel diseases. According to the application, the mechanism that expression of mCCL6 / hCCL15 in intestinal fibrosis is increased, intestinal fibroblast activation and collagen generation are promoted, and then intestinal fibrosis progress can be promoted is found for the first time. In a mouse intestinal fibrosis model, the intestinal fibrosis can be effectively relieved by blocking a CCL6-CCR1 signal transduction pathway by using an mCCL6 neutralizing antibody and a CCR1 small molecule antagonist. According to the application, the specific target spot is found, the CCL6-CCR1 signal channel is inhibited, and the intestinal fibrosis is specifically treated, so that the application has breakthrough significance on health improvement of patients with the intestinal fibrosis and even intestinal stenosis, and a new idea is provided for treatment of the intestinal fibrosis.