5results about How to "Speed up progress" patented technology

The invention discloses application of a palmitoylation inhibitor in prevention and treatment of gastric cancer. The chromatin remodeling protein SNF2 derived from S.anginosus EVs can be combined with a transcription factor TEAD1, so that the transcription of the palmitoyl transferase ZDHHC11 is promoted together. Then, the stability of the ZDHHC11 is enhanced by catalyzing palmitoylation of PD-L1, and finally immune escape is induced. In addition, SNF2 also can activate AXL, CTGF, CYR61 and other carcinogenic targets at the downstream of TEAD1, thereby further accelerating the malignant progression of gastric cancer. In an in-vivo experiment, the intragastric administration of the S.anginosus EVs not only promotes the tumor growth of mice, but also significantly inhibits the infiltration of CD8 + T cells. Blocking of ZDHHC11 can effectively reverse immune escape, and has a synergistic effect with an anti-PD-1 therapy, so that the treatment effect is remarkably improved.

The application discloses a single-exposure compressed ultrafast coherent modulation imaging device. By combining coherent modulation imaging and compressed ultrafast imaging technology, a sample to be measured is illuminated by coherent light, after the sample diffracts the light wave, the phase modulation of a random phase modulation plate is carried out, the integral intensity distribution of the modulated wave front is recorded by deflection on a detection plane by using a slit fully opened stripe camera, a single compressed diffraction pattern is obtained, a spatial two-dimensional to space-time three-dimensional image reconstruction algorithm based on a plug-and-play framework and a depth image priori is developed, and data recovery is carried out on the collected image by using the algorithm. Compared with traditional ultrafast optical imaging and phase imaging technology, the application can quantitatively obtain complete intensity and phase information of a transient scene in a single measurement process, has the characteristics of picosecond time resolution and real-time quantitative intensity-phase imaging capacity in single-exposure phase imaging, and can be widely applied to various ultrafast phenomena requiring phase observation.

This invention relates to the field of blasting construction technology for highway hard rock tunnels, specifically a method for blasting construction of highway hard rock tunnels. The method employs a blasting construction device for highway hard rock tunnels, including a movable base. A material storage base is fixedly installed on the left rear end of the movable base, and a support frame is fixedly installed on the upper surface of the movable base. The support frame is equipped with an adjustment mechanism for automatically installing blasting detonators on different hard rock tunnel construction faces. The device automatically installs blasting detonators according to the borehole location, accelerating the construction efficiency of highway hard rock tunnels. Before installation, the depth of the borehole is pre-positioned according to the fixed installation position of the borehole using a sliding cylinder frame, ensuring that the detonator is correctly placed at the appropriate depth in each borehole. This improves the accuracy of blasting and increases the efficiency of construction operations. Furthermore, it ensures the consistency of the installation process for each borehole, making the blasting effect of each borehole more reliable and predictable.

The application provides a case information exchange method and device, electronic equipment and storage medium. The case information exchange method comprises the following steps: generating N patient identification numbers based on obtained patient identity information; obtaining a patient identification number corresponding to a first institution identification number from the N patient identification numbers, the institution identification number being an identification number of an obtained medical institution; sending a query request to a second institution by the first institution based on the patient identification number corresponding to the first institution identification number; in response to the query request, the second institution judges whether the patient identification number corresponding to the first institution identification number has been used to query the first institution; and if not, exchanging case information. Under the premise of protecting patient privacy data, information can be quickly exchanged, the purpose of reducing the high cost of clinical trials and accelerating the progress of clinical trials is achieved.