The invention discloses a special graph avoiding method for optimizing manufacturability of an integrated circuit. The back-end process of the integrated circuit comprises five basic steps of design data input, layout planning, layout, clock tree synthesis and wiring, after the steps are completed, a generated integrated circuit layout is analyzed, a graph with the manufacturing success rate of achip manufacturer lower than a preset threshold value is found out, and it is determined that associated standard units cannot be adjacent in the specific placement direction according to the graph; and then, according to a layout graphic result extracted after the wiring of the back-end process step is completed, the formed unit limiting file is supplemented into a file list provided by a processmanufacturer in the init stage of inputting the design data, the design data is read in again, and then, the whole back-end design process is carried out again. According to the method, files related to process manufacturing provided by process manufacturers and EDA tool manufacturers do not need to be modified, and new file formats of the EDA tool manufacturers do not need to be supplemented.