This application relates to the field of
cell type
identification technology and discloses a
cell type identification method based on multi-
omics decoupled representation and
graph embedding, including the following steps: Step 1, acquiring single-
cell multi-
omics data and preprocessing it; Step 2, obtaining cell spectrum embedding representation using a
graph embedding model, calculating single-cell sample similarity based on the spectrum embedding representation, and then constructing a sample similarity graph; Step 3, using a variational
autoencoder model to map different
omics data to the same dimensional space for
data integration, obtaining a single-cell shared latent representation; Step 4, clustering cells using a
Gaussian mixture model based on the shared latent representation to obtain
cell cluster assignments; Step 5, constructing an objective function based on maximum likelihood
estimation. Through a scalable
model architecture and high-quality
cell type identification, this method improves the
performance efficiency of single-cell multi-
omics data integration and analysis, providing new directions and possibilities for single-cell multi-
omics data integration.