The present application relates to a kind of anticoagulation, anti-
oxidative stress hemodialysis apparatus and preparation method, belong to biomedical
polymer and
hemodialysis field.
Oxygen-containing functional group carbon dots, anticoagulation
monomer, initiator and crosslinking agent are added into water, to obtain modified liquid of anticoagulation and anti-oxidation;Protective gas is introduced into
hemodialysis apparatus to remove
oxygen, then modified liquid is introduced into
dialysis apparatus, then sealing heating is carried out to initiate anticoagulation
monomer in situ polymerization on the surface of
dialysis membrane, and the
oxygen-containing functional group carbon dots form gel microspheres under the wrapping of
polymer, i.e., anticoagulation, anti-
oxidative stress hemodialysis apparatus is obtained.The APTT of modified
dialysis apparatus can reach 600s, and the removal rate of
DPPH and
ABTS free radicals is 71.25% and 97.47% respectively.The present application only needs to carry out one-step
surface modification to dialysis apparatus finished product, which can give hemodialysis apparatus the dual functions of anticoagulation and anti-
oxidative stress, is simple and convenient, and has good application prospect.