The invention relates to Brinell hardness 450-level abrasion-resistant steel. The steel comprises, by weight, 0.17%-0.22% of C, 0.40%-0.60% of Si, 1.2%-1.45% of Mn, 0-0.01% of P, 0-0.005% of S, 0.6%-0.85% of Cr, 0-0.1% of Ni, 0-0.1% of Mo, 0.02%-0.05% of Als, 0-0.015% of Ti, 0-0.02% of V, 0-0.004% of B, and the balance Fe and inevitable impurities. The invention further provides a manufacturing method of the Brinell hardness 450-level abrasion-resistant steel. By the adoption of the manufacturing method, the abrasion-resistant steel has good abrasion resistance and high toughness, and meanwhile even pressure stress is achieved on the surface of the abrasion-resistant steel, so that the abrasion resistance and anti-fatigue performance are further enhanced. The abrasion-resistant steel is good in residual stress homogeneity, cracking and deformation cannot happen in the using process, abrasion resistance is achieved, and the service life is long.