2166 results about "Powder injection" patented technology

The invention discloses a manufacturing method of a multilayer shell-core composite structural part, which comprises the following steps of: (1) respectively preparing feed for injection forming of a core layer, a transition layer and a shell layer, wherein powder in the feed of the core layer and the powder in the feed of the shell layer are selected from one or a mixture of some of metal powder, ceramic powder, or toughened ceramic powder and are different from each other, and the powder in the feed of the transition layer is gradient composite powder; (2) respectively manufacturing blanks of the multilayer shell-core composite structural part layer by layer with a powder injection forming method; (3) degreasing the blanks; and (4) sintering the blanks to obtain the multilayer shell-core composite structural part. The multilayer shell-core composite structural part is manufactured with the powder injection forming method, and has the advantages of high surface hardness, abrasion resistance, uniform thickness of the shell layer, stable and persistent performance, strong binding force between the shell layer and the core layer due to the transition layer, good integral bending strength and good impact toughness and is difficult to crack.

The invention provides a method for preparing a nickel-base ODS (oxide dispersion strengthened) alloy by injection molding, belonging to the technical field of injection molding of powder. The method comprises the following steps: carrying out high-energy ball milling on the raw material powder so that Y2O3 particles are uniformly dispersed in a nickel substrate, refining mechanical alloy powder by jet milling, and carrying out plasma nodularization on the powder which is refined by jet milling; evenly mixing and smelting the powder, which is refined by jet milling and plasma nodularization, and adhesive to obtain a uniform feed material; and carrying out injection molding, two-step degreasing and sintering on the feed material to obtain a sintered blank of which the density is 93-96%, carrying out hot isostatic compaction on the sintered blank so that the sintered blank is completely compact, and finally, carrying solution heat treatment and aging heat treatment to obtain the injection-molding nickel-base ODS alloy. The nickel-base ODS alloy can be prepared into high-precision parts in complex shapes, thereby solving the problem of difficulty in molding of nickel-base ODS alloy. The gamma' phase and the oxide strengthening mechanism are combined to greatly enhance the high-temperature mechanical properties of the nickel-base ODS alloy.

The invention relates to a freeze-dried powder injection of L-oxiracetam and a process for preparing the freeze-dried powder injection. The freeze-dried powder injection comprises, by weight, 1 part of the L-oxiracetam, 0.1 to 10 parts of an excipient, 0.01 to 1 part of an antisticking agent and 0.01 to 0.5 part of a pH regulator, wherein polyethylene glycol (PEG) series of products serve as the antisticking agent preferably. The freeze-dried powder injection which is prepared on the basis of a prescription according to the process has the advantages of being short in freeze-drying time, attractive in appearance, short in redissolving time and high in stability.

The invention relates to the technical field of powder injection molding and particularly discloses a method for preparing a special-shaped complex part through a powder injection molding technology. The method includes the steps of mixing and pelleting, injection molding, and degreasing and sintering. In the injection molding step, a green body of the special-shaped complex part and a green body of a profile-followed supporting part corresponding to the special-shaped complex part are prepared; in the degreasing and sintering step, the special-shaped complex part is placed on the profile-followed supporting part corresponding to the special-shaped complex part for degreasing and sintering. According to the method, the problems of deformation, collapse and even breakage in the degreasing and sintering process of the special-shaped complex part can be well solved, the problem that the special-shaped complex part cannot be sintered through a traditional method is effectively solved, and the complexity of the powder injection molding field is lowered.

The invention relates to a pemetrexed disodium lyophilized powder injection, which consists of pemetrexed disodium, mannitol and sodium sulfite in the following weight portions: 50 portions of the pemetrexed disodium, 10 to 50 portions of mannitol, and 0.1 to 1 portions of sodium sulfite; and the pH value of the pemetrexed disodium lyophilized powder injection is between 7.0 and 8.0. The process for preparing the pemetrexed disodium lyophilized powder injection comprises the following steps: placing the mannitol in a sterile chamber; adding 80 percent of water for injection into the sterile chamber to dissolve the mannitol; adding the sodium sulfite to the mixture after the water for injection is cooled to a temperature of between 15 and 25 DEG C, and evenly stirring the solution for dissolving the sodium sulfite; then, adding the pemetrexed disodium into the solution, and stirring the solution to completely dissolve the pemetrexed disodium and evenly mixing the pemetrexed disodium, and adjusting the pH value of the solution to between 7.0 and 8.0; decarbidizing; after an intermediate compound passes examination, carrying out volume fixing, filtering, filling, partially stopping, traying, lyophilizing, nitrogen aerating, stopping and unboxing, sealing by a plastic-aluminum combined cap, and packaging after passes quality inspection to obtain the pemetrexed disodium lyophilized powder injection. The invention has the advantages of simple preparation process, convenience and practicality, good repeatability and low production cost, and can realize industrial large-scale production easily.

The invention provides an omeprazole sodium lyophilized powder for injection (pH of 10.8-11.2), comprising omeprazole sodium as the main active component, as well as excipient, metal ion complexing agent, stabilizer, antioxidant and pH regulator. The omeprazole sodium lyophilized powder for injection has higher active component content than that of the conventional omeprazole sodium injection, solves solution clarity problem, and effectively prevents loss of bone calcium due to complexation with calcium ion. The omeprazole sodium lyophilized powder for injection also has the advantages of stable color and properties, low side effects, good stability, good redissolution, and convenient application.

The invention belongs to the technical field of medication, and in particular relates to a pemetrexed disodium freeze-dried powder injection and a preparation method thereof. The pemetrexed disodium freeze-dried powder injection consists of pemetrexed disodium and mannitol, wherein the mass ratio of the mannitol to the pemetrexed disodium is (0.6-2.0):1. The preparation method comprises the following steps: adding injecting water into a liquid preparation tank; adding the pemetrexed disodium weighted according to the formula; stirring until the pemetrexed disodium completely dissolved; adding the mannitol; regulating the pH by utilizing a hydrochloric acid solution or a sodium hydroxide solution; adding activated carbon for decoloration; filtering to remove the carbon; finely filtering with a filter membrane; subpackaging; and freezing and drying. The pemetrexed disodium freeze-dried powder injection has excellent moldability; the appearance of the solution before freezing is clear; the frozen and dry product has good re-dissolubility; and the re-dissolved product has the advantages of good clarity, low impurity content, low moisture content, good stability and controllable quality.

A freeze dried minocycline hydrochloride powder as antibacterial injection is prepared from minocycline hydrochloride (0.05-10 wt.portions), freeze dried power supporting agent (10-100) and pH regulator. Its advantages are broad antibacterial sprectrum, high stability to light, heat, oxygen and water, and no pollution.

The invention discloses oxiracetam freeze-dried powder injection and a preparation method thereof; and the oxiracetam freeze-dried powder injection disclosed by the invention is prepared by comprising the following steps: dissolving oxiracetam in water for injection, adding ethanol which is 1.2-2.0% (V/V) of the total volume, preparing into a 200-500 mg/ml oxiracetam solution, and freeze-drying. The oxiracetam freeze-dried powder injection disclosed by the invention is prepared by adopting a proper amount of ethanol with the help of the special freeze-drying process, particularly a special pre-freezing manner; pre-freezing process parameters are established, therefore, the surface of the solution is crystallized at first; the solute on the surface is prevented from being accumulated; and the oxiracetam freeze-dried powder injection prepared by the invention is basically free from accessories, rapid to re-dissolve, good in quality and steady for storage.

The invention relates to a preparation method of linezolid and a preparation thereof, in particular to a preparation method of a linezolid raw material and a freeze-dried powder injection thereof. The preparation method mainly comprises the following steps: (1) synthesizing 2(S)-1-amino-3-chloro-2-propanol hydrochloride; (2) synthesizing (S)-N-[2-acetoxyl-3-chloropropyl] acetamide; (3) synthesizing 3-fluoro-4-morpholinyl nitrobenzene; (4) synthesizing N-carbobenzoxy-3-fluoro-4-morpholinyl aniline; (5) synthesizing the linezolid; and (6) preparing the linezolid preparation. The freeze-dried powder injection of the linezolid for injection, which is prepared by the invention, effectively improves the stability of medicines so that the medicines have longer shelf life, can be transported more conveniently and are more favorable for clinical applications. Moreover, the method of the invention for preparing the raw material linezolid and the freeze-dried powder injection thereof is simple and effective and is suitable for large-scale industrial production.

The invention discloses a fireproof electric meter box, and the box comprises a housing. The interior of the housing is provided with a temperature control device, an independent power supply, and a plurality of independent fire extinguishing devices. Each fire extinguishing device comprises a powder injection apparatus and a fire extinguishing agent pot, wherein the powder injection apparatus comprises a pressing device and a nozzle, and the nozzle is disposed at one end of the fire extinguishing agent pot. Each pressing device comprises a hydraulic rod and a sealing valve, wherein the sealing valve is disposed in the corresponding nozzle, and one end of the hydraulic rod is fixedly connected with one end of the sealing valve, and the sealing valve comprises a supporting rod. The beneficial effects are that the box is simple in structure, is convenient to use, and can timely find and extinguish fire through the temperature control device and the fire extinguishing devices when fire is mall.

The invention discloses a preparation method of a polyinosinic acid-polycytidylic acid lyophilized powder injection. The method comprises the preparation of a polyinosinic acid-polycytidylic acid solution and a preparation of a lyophilized powder injection thereof. According to the invention, proper amounts of polyinosinic acid and polycytidylic acid are respectively dissolved by using normal saline; the mixtures are mixed and stirred, such that the polyinosinic acid-polycytidylic acid solution is prepared; a lyophilization additive is added and well mixed; and filtering, sub-packaging, and lyophilization are carried out. The prepared injection is suitable for frost preservation under a temperature below 0 DEG C. Therefore, expiration date is postponed, oxidative degradation speed is reduced, toxic and side effect are reduced, and stability is improved.

The invention provides a clindamycin phosphate freeze-dried powder injection, which is prepared by the steps that: clindamycin phosphate solution is added with NaOH and is freeze-dried, wherein, the weight ratio of clindamycin phosphate to the NaOH is between 12 and 18 to 1, and the preferred weight ratio is 16.5 to 1. The clindamycin phosphate freeze-dried powder injection has simple formula and less auxiliary materials, overcomes side effects due to the fact that the auxiliary materials are excessively added, and ensures that patients are safer for use.

The present invention relates to a lansoprazole freeze-dried powder injection and its preparation method. Said lansoprazole freeze-dried powder injection contains ethylene diamine tetraacetic acid (EDTA) and/or its salt, and is made up by using active component lansoprazole, ethylene diamine tetraacetic acid and/or its salt, stabilizing agent, excipient, pH regulator and injection water through a certain preparation process. Besides, said invention also provides the concrete steps of said preparation process.

The invention provides a method with effects of saving cost and improving efficiency for liquid pollination of pear tree, which belongs to the fruit trees production technical field. The method comprises the following steps: preparing a nutrient solution in full-bloom stage of pear flowers, adding 0.8g pure pollen in every liter of nutrient solution, spraying and pollinating by an electrostatic sprayer to achieve the purpose of artificial pollination. The pollination method has the advantages of simple operation, fast pollination speed, uniform powder injection, concentration, accuracy, pollen and manual work saving, low cost and the like, and solves the practical problems that pollen can not be uniformly dissolved in water in liquid pollination of fruit trees, pollen is easy to adhere with the wall of a container, pollen is obstructed a nozzle, uneven powder injection causes poor pollination effect and the real application of liquid pollination can not be realized for a long time. According to the invention, the new collected pure pollen (germination rate is 60%-80%) in current year required by per mu is 8-11g. In addition, the method of the invention is capable of increasing the moisture and nutrient of pistil stigma and prolonging the fecundation time of stigma pollination, and the fruit quality can not be affected by increasing the fruit setting rate.

In accordance with the invention, water extraction method is employed to extract the effective components of safflower and radix paeoniae rubrathe, big porous resin adsorption method is employed for purification and refining.

The present invention discloses a cefotiam hydrochloride medicament composition sterile powder injection, including 500 to 600 weight shares of cefotiam hydrochloride and 110 to 150 weight shares of anhydrous sodium carbonate. The cefotiam hydrochloride medicament composition sterile powder injection has advantages of a good stability and a high purity. The invention also discloses a method for preparing the cefotiam hydrochloride medicament composition sterile powder injection, including steps of weighing the cefotiam hydrochloride and the anhydrous sodium carbonate according to the formula amount separately and mixing them in a sterile container uniformly. The method is simple, and the cefotiam hydrochloride prepared by the above method has a good stability.

The invention discloses a powder-injection wax-injection integrated structure. The integrated structure comprises a wax-injection area and a powder flapping area, wherein the wax-injection area comprises a wax injection nozzle capable of injecting wax; the powder flapping area comprises a powder blowing nozzle capable of blowing powder; the integrated structure also comprises a fixture structure similar to a clamp die and a driving device; the driving device can be used for pushing and pulling the fixture structure to the wax-injection area or the powder flapping area. A manual powder flapping operation procedure is replaced by a mechanical operation mode of firstly flapping the powder and then injecting the wax, the time is saved, the efficiency is improved, and the cost is reduced.

The invention relates to a stable preparation for injection by taking S-oxiracetam as active ingredient. The preparation is a composition for injection, and is formed by the S-oxiracetam or salts thereof serving as active ingredient and pharmaceutically acceptable auxiliary material. To restrain the racemization of the S-oxiracetam, when the powder injection with the active ingredient is prepared, and only the pH value of the S-oxiracetam medicament solution ranges from 4.5 to 7.0, the pH value is between 5.4 to 6.6 preferably, so that the S-oxiracetam medicament solution can be produced, and the final freeze-dried product has acceptable long stability; and moreover, when injection is produced, a rotary steam sterilization method needs to be adopted, terminal rotating sterilization is performed for 15 to 45 minutes under the temperature of 121 DEG C, and the terminal rotating sterilization is performed for 15 to 20 minutes preferably, so that the S-oxiracetam injection with high purity can be obtained and has acceptable long stability.

The invention provides a method for preparing a lansoprazole lyophilized powder injection for injection. By pre-preparing high-purity lansoprazole sodium salts, the impurities introduced during the procedures for synthesizing and storing the lansoprazole material and the impurities in auxiliary materials, particularly in sodium hydroxide, can be removed, thereby preventing the impurities from entering the lansoprazole lyophilized powder injection for injection, reducing insoluble particles and improving the quality and the storage stability of the lansoprazole products for injection; furthermore, the safety is high for clinical use and fewer adverse reactions are caused.