The invention relates to drug for the treatment of migraine. The drug is made with, by weight, capillary wormwood herb, tree peony bark, leaf of paniculate microcos, rhizome of broadleaf common valeriana, Lapis Chloriti, common coltsfoot flower, pummelo peel, Chinese thorowax root, Divaricate Saposhnikovia root, sea-ear shell, Turpinia leaf, rhizome of oriental water plantain, Chinese starjasmine stem, eucommia bark, Zaocys dhumnades, Szechwan chinaberry fruit, gordon euryale seed, chingma abutilon seed, rhizome of paniculate Bolbostemma, small centipeda herb, indigoplant leaf, Philippine violet herb, Szechuan lovage rhizome, pine nodular branch, scorpion, Japanese ampelopsis root, stalactite, fruit of Polygonum Orientale, dried black soybean sprout, wild buckwheat rhizome, Chinese honey locust, Chinese honeylocust spine, Chinese Torreya seed, common lophatherum herb, tabasheer, long pepper, Psammosilene Tunicoides root, dried longan pulp, common Jasminorange leaf and twig, fruit of Rangoon creeper, humifuse euphorbia herb, Chinese wax gourd peel, manyinflorescenced sweetvetch root, longtube ground ivy herb, ophicslcite, Entadae stem, cockscomb flower, dried ginger, lotus leaf and common dayflower herb. A prescription of the drug is simple; the drug is cheap, has specific curative effect, highly suitable for patients, and applicable to large-scale clinical popularization.