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Oral solution containing ambroxol hydrochloride and salbutamol sulfate

A technology of albuterol sulfate and ambroxol hydrochloride, which is applied in the field of medicine and can solve problems such as complex prescriptions, slow disintegration of tablets and capsules, and many additives

Inactive Publication Date: 2015-05-20
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN103251577A and CN103239431A relate to tablet compositions and capsule compositions of ambroxol hydrochloride and salbutamol sulfate respectively, but the tablets and capsules disintegrate slowly, which affects absorption; CN102018694A relates to a capsule filled with ambroxol hydrochloride tablets and salbutamol sulfate The tablet capsule of tablet needs to be absorbed through double disintegration of capsule and tablet after it is taken, and effect is relatively poor; CN101204386B relates to a kind of liquid combination of ambroxol hydrochloride and salbutamol sulfate, but this method has added stabilizer, pH adjustment Agents, sodium chloride, fragrances, complex prescriptions and many additives

Method used

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  • Oral solution containing ambroxol hydrochloride and salbutamol sulfate
  • Oral solution containing ambroxol hydrochloride and salbutamol sulfate
  • Oral solution containing ambroxol hydrochloride and salbutamol sulfate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Ambroxol Hydrochloride 90.0g

[0012] Salbutamol Sulfate 28.8g

[0013] Sodium Benzoate 50.0g

[0014] Stevia 18.0g

[0015] Sodium saccharin 30.0

[0016] Purified water to 60L

[0017] Makes 1000 bottles

[0018] Preparation:

[0019] Take 4 / 5 of the prescribed amount of purified water (45-50°C), add the prescribed amount of ambroxol hydrochloride, and stir to completely dissolve the ambroxol hydrochloride. Add the prescribed amount of albuterol sulfate, sodium benzoate, stevia and sodium saccharin, and stir to dissolve completely. Adjust the pH value of the medicinal solution to 4.0 with hydrochloric acid solution, add purified water to the full amount; measure the pH value of the medicinal solution and the content of the main ingredient; filter with a 0.45 μm microporous membrane; fill, 60ml per bottle, seal, and pack after passing the inspection .

[0020] Stability experiments and results

[0021] 1. Influencing factor test

[0022] Ambroxolalbutamol ora...

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Abstract

The invention provides an oral solution containing ambroxol hydrochloride and salbutamol sulfate, and belongs to the technical field of medicines. An auxiliary material of the oral solution mainly comprises preservatives and corrigents. The oral solution is used for treating respiratory system diseases such as acute and chronic bronchitis, asthmatoid bronchitis and bronchial asthma, has a simple prescription, a good medication effect and a good taste, and is quick in response.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an oral solution containing ambroxol hydrochloride and salbutamol sulfate. The invention provides an oral solution agent for treating acute and chronic bronchitis, asthma and other respiratory diseases that is safe, effective, stable in quality, enhanced in patient compliance, and capable of acting rapidly. Background technique [0002] Ambroxol hydrochloride is a mucolytic agent, which can improve the function of the respiratory mucosal tissue, increase the fluid volume of the respiratory tract and reduce the viscosity of the mucus. In addition, it can increase the movement of cilia and promote the secretion of pulmonary surfactant. These effects make the mucus easy to move , in conjunction with the lubrication of the respiratory wall, makes sputum easy to cough up. Salbutamol sulfate is a bronchodilator that selectively activates beta- 2 adrenergic receptors, and play a broncho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61K9/08A61K47/26A61P11/00A61P11/06
Inventor 王明刚任莉陈阳生孙桂玉汪泓
Owner CP PHARMA QINGDAO CO LTD
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