173 results about "Mucosal tissue" patented technology

A method of treating a soft palate in a patient may involve advancing a tissue treatment portion of a soft palate treatment device through the patient's mouth, contacting a treatment surface of the tissue treatment portion with mucosal tissue of the soft palate, and delivering energy from the tissue treatment portion through the mucosal tissue to a target tissue in the soft palate beneath to the mucosal tissue, to change at least one property of the target tissue. The method may further involve cooling the mucosal tissue with a cooling member on the treatment surface of the tissue treatment portion and removing the tissue treatment portion from the mouth.

The utility model discloses oral mucosa tissue biopsy sampling forceps which comprise a main body, the main body is of a rod-shaped structure, a groove is formed in one end of the main body, sampling forceps are hinged to the interior of the groove, the sampling forceps are arranged in the groove in a crossed mode, a movable block is movably arranged in the main body, and the movable block is arranged in the main body. A groove is formed in one end of the main body, the sampling clamp is movably arranged in the groove, the movable block is cylindrical, connecting plates are arranged on the surface of one end, close to the sampling clamp, of the movable block, the number of the connecting plates is two, the two connecting plates are symmetrically arranged, and a connecting rod is movably arranged between the connecting plates. The movable block is movably arranged in the main body and is connected with the sampling forceps through the connecting rod, and the sampling forceps are driven to open and close by controlling the movable block to move, so that the main body can be arranged into any shape so as to be convenient for medical personnel to operate, thereby improving the efficiency and reducing the sampling difficulty.

The invention relates to the technical field of life science, in particular to a method for constructing an atrophic gastritis-based SPEM lesion model, which comprises the following steps: S1, constructing an Slc7a11 conditional knockout mouse strain: carrying out cage hybridization on an Slc7a11 flox / flox mouse and an ATP4b-Cre transgenic mouse, and knocking out a gastric wall cell specific Slc7a11 gene; s2, carrying out genotyping identification; the identification method based on the atrophic gastritis SPEM lesion model and the construction method based on the atrophic gastritis SPEM lesion model comprise the following steps: S1, pathological model verification: taking a mouse gastric mucosa tissue slice, quantitatively analyzing the proportion of an SPEM region by adopting an immunofluorescence double-standard technology, and confirming Slc7a11 knockout induced SPEM pathological characteristics in combination with the existence of SPEM in the gastric mucosa; and S2, long-term pathology evolution monitoring. Through gastric wall cell specific Slc7a11 gene knockout and multiple PCR identification technologies, the initial response SPEM state after gastric mucosa damage is successfully simulated, and the kit is used for researching atrophic gastritis pathological mechanisms and evaluating drug intervention.

According to the double-end needle and thread suturing device, suturing needles can be alternately locked on two clamping bases, so that the suturing needles drive suturing threads to penetrate through human mucous membrane tissues, and the suturing needles penetrate through the human mucous membrane tissues for multiple times by repeating multiple operations, so that the purpose of suturing the human mucous membrane tissues is achieved. When the suture needle is used, only the two ends of the suture needle need to be fixed, a complex fixing structure and a complex driving structure are not needed, and therefore the complexity of a product is reduced, the error-tolerant rate of the suture needle in the suture process is increased, the operation difficulty of the product is reduced, and the product is easier to operate.

Systems and methods for treating a patient's mucus hypersecretion condition are disclosed herein. Certain implementations may involve a method for reducing mucus secretion in an upper airway of a patient to treat at least one of post nasal drip or chronic cough. The method may include advancing a treatment delivery portion of an energy-based treatment device into a nostril of the patient. The treatment delivery portion may contact mucosal tissue of the upper airway without piercing the mucosal tissue. The treatment delivery portion may deliver treatment to at least one tissue selected from the group of the mucosal tissue and another tissue underlying the mucosal tissue to modify a property of the at least one tissue and thus treat at least one of post nasal drip or chronic cough in the patient.

Modular mucosal tissue bioreactors combined with bioartificial mucus provide a high-fidelity, medium-throughput platform for evaluating CF treatments and modeling host-pathogen biology, a stepping stone towards better options for HEMT-nonresponsive patients. Whole lung ex vivo Cystic Fibrosis model system allows for investigation of candidate CF therapies.

The invention relates to polysaccharide-based composite hydrogel as well as a preparation method and application thereof. The composite hydrogel is prepared from the following raw materials: hydroformylated modified ortho-hydroxyl-containing polysaccharide, an extracellular matrix enzyme digestive juice, tannic acid, cannabidiol, neomycin sulfate and borneol, by compounding multiple components, the use performance of the hydrogel can be remarkably improved, and the hydrogel is particularly suitable for a harsh environment. The composite hydrogel disclosed by the invention has excellent mechanical properties, good biological safety, certain self-repairing performance and relatively high anti-inflammatory, antibacterial and antioxidant properties, and can be applied to skin or mucous membrane tissue wound repairing.

The utility model discloses an anastomosis nail releasing device and a suturing device, and the anastomosis nail releasing device comprises a main body, a moving seat, a driving assembly, a needle pushing plate, a driving part and a control part. The mucous membrane tissue is fixed under the action of the extrusion seat and the moving seat, and then the mucous membrane tissue is sutured through the anastomosis nails, so that on one hand, the accuracy and safety of following anastomosis nail puncture can be effectively improved, and effective suturing of the anastomosis nails to the mucous membrane tissue is guaranteed; therefore, safe and effective treatment on mucous membrane tissues is ensured; and on the other hand, simple pushing and pulling actions are needed in the operation, other complicated operation modes are avoided, the operation difficulty of the product is reduced, and therefore the use comfort of the product is effectively improved.

The invention discloses Kluyveromyces marxianus KUST3801 and application thereof in relieving constipation, and the preservation number of the Kluyveromyces marxianus KUST3801 is CGMCC (China General Microbiological Culture Collection Center) NO.32767. The Kluyveromyces marxianus strain is classified and named as Kluyveromyces marxianus, and the Kluyveromyces marxianus strain is named as Kluyveromyces marxianus. The sequence of the 16SrRNA is as shown in SEQ ID NO. 1; the composition is used for improving constipation symptoms. After the kluyveromyces marxianus KUST3801 is applied, the excrement water content and the small intestine propulsion rate of a mouse with ICR constipation induced by loperamide hydrochloride are remarkably improved, and the defecation frequency and the defecation number within the same time are remarkably increased; intestinal mucosa tissues of constipation mice can be protected, and intestinal mucosa injury is relieved; the concentration of SP and MTL is obviously improved, and the concentration of VIP is reduced; iL-6 concentration is reversed, and inflammatory response is relieved; the concentrations of acetic acid, butyric acid, isobutyric acid and isovaleric acid in the short-chain fatty acid are obviously higher than those of mice with constipation, and the composition has a relatively strong effect of relieving constipation symptoms.

Disclosed herein are methods for inducing immunity against a virus such as a coronavirus in the mucosal tissue of a patient, include administering a vaccine composition to the patient by oral administration (e.g., nasal injection, nasal inhalation, oral inhalation, and / or oral ingestion). Also disclosed are compositions for assaying the presence of anti-viral antibodies induced by the administered vaccine or the presence of viral proteins in a saliva sample include a stabilizing solution and may also include the use of aragonite particle beads. Compositions and methods are presented for prevention and / or treatment of a coronavirus disease wherein the composition comprises a recombinant entity. The recombinant entity is bivalent, comprising a nucleic acid encoding a coronavirus 2 nucleocapsid protein CoV2 nucleocapsid protein fused to an endosomal targeting sequence, and a nucleic acid encoding a CoV2 spike protein sequence optimized for cell surface expression.

The present invention provides a nutritional composition comprising one or more of vitamin D, polydextrose and galacto-oligosaccharides in combination with a calcium source. The composition has the effect of improving the intestinal mucosal barrier including improving intestinal mucosal permeability, modulating expression of intercellular tight junction proteins, improving intestinal mucosal tissue structure and improving levels of markers of the intestinal mucosal barrier.

The invention provides an intelligent prediction and early warning method and system for oral implantation risks, and the method comprises the steps: obtaining the mechanical response data of oral mucosa tissues under an occlusion load and the three-dimensional strain gradient tensor of a target contact surface, and combining a preset stress-strain analysis model, establishing a target dynamic attenuation curve of the elastic modulus of the oral mucosa tissue in the whole healing period; performing coupling analysis on the target dynamic attenuation curve of the three-dimensional strain gradient tensor and the elastic modulus to generate a multi-level relaxation correlation parameter, and analyzing the stress conduction path offset of the target contact surface by combining a lightweight network with the multi-level relaxation correlation parameter; and generating a hierarchical early warning instruction according to the space-time correlation between the stress conduction path offset and a preset healing stage biomechanical threshold. According to the application, the capability of predicting and early warning abnormal conditions possibly occurring at the contact surface of the implant and the oral mucosa tissue is improved.

The utility model discloses an annular cervical canal curettage device, which comprises a curettage handle and a sleeve, the sleeve is sleeved on the curettage handle and can axially move relative to the curettage handle, the curettage handle comprises an operating end and a leading-in end, and the leading-in end of the curettage handle is provided with a leading-in head; one end of the sleeve is provided with a non-closed elastic annular curettage head, and the elastic annular curettage head is arranged on the curettage handle in a sleeving manner and is attached to the guide-in head; the operating end of the curettage handle drives the leading-in head to abut against the elastic annular curettage head under the action of external tension, so that the elastic annular curettage head is stressed and expanded; and an adjustable locking mechanism is also arranged between the curettage handle and the sleeve. The elastic annular curettage head of the annular cervical canal curettage device can be stretched under stress, can be fully attached to the cervical canal and can gently scrape mucosa tissue cells from the mucosa of the cervical canal, pain and discomfort of a patient are avoided, meanwhile, standardized and normalized operation is facilitated, and operation technicians are easy to train.

The present invention discloses a suture implantation device and suture, wherein the suture implantation device comprises a first body and a second body, the first body is rotatably mounted on the second body, a first push-pull member is arranged at the rear end of the first body, a sleeve portion is arranged at the rear end of the second body, the first push-pull member passes through the sleeve portion, an implantation needle is rotatably mounted at the front end of the first body, an implantation avoidance groove corresponding to the implantation needle is arranged at the front end of the second body, a thread withdrawal portion is arranged in the second body, a second push-pull member for moving the thread withdrawal portion is arranged in the second body, the second push-pull member passes through the sleeve portion, and the implantation needle is provided with a thread withdrawal groove, which is arranged along the length direction of the implantation needle. The suture implantation device in the present invention can effectively implement the implantation of sutures into target mucosal tissues under endoscopy, and the thread withdrawal portion can realize the function of pushing the sutures out of the implantation needle, and the present invention can be widely used in the field of medical device technology.

The invention is suitable for the technical field of cell separation and culture, and provides a pig nasal mucosa epithelial cell separation and culture method. A mixed enzyme overnight digestion method is adopted, mucous membrane tissue mucus is effectively removed, and more complete digestion is achieved. The pig nasal mucosa epithelial cells with relatively high purity are obtained through a differential attachment technology. And the culture medium is replaced by a complete culture medium containing EGF and vitamin A during first liquid replacement, so that a stable and excellent in-vitro growth environment is provided for epithelial cells. The method not only can rapidly and accurately separate the primary cells, but also ensures the stability and high quality of the culture state of the epithelial cells. According to the method, the blank of porcine nasal mucosa primary cell separation research is filled up, the primary porcine nasal mucosa epithelial cell in-vitro model which is simple and easy to implement and high in repeatability is constructed, and the model can simulate physiological and morphological characteristics of porcine nasal mucosa and can be used for preparing the porcine nasal mucosa epithelial cell in-vitro model. And a reliable in-vitro experimental basis is provided for researches on respiratory tract pathogen infection mechanisms, respiratory system disease drug screening, gene therapy and the like.

The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.

To provide an assisting tool for rectal mucosal biopsy that enables convenient and accurate collection of mucosal tissue from a predetermined region.SOLUTION: A rectal biopsy assisting tool 1 includes a cylindrical main body portion 11 that is inserted into a patient's rectum and has a distal end portion 111 that is closed and a proximal end portion 112 that is open, a through-hole 12 formed in a wall of the main body portion 11, and a projection amount indicating portion 13 provided so as to protrude near the insertion side of the through-hole 12 on an inner wall of the main body portion 11, the projection amount indicating portion 13 indicating an appropriate projection amount of a biopsy site, which is rectal mucosa, from the through-hole 12.SELECTED DRAWING: Figure 1

The invention relates to the technical field of surgical instruments, in particular to an anorectal anastomat with a function of selectively excising mucosal tissues on hemorrhoids, which comprises a handle and a hard tube, the hard tube is fixedly mounted at the front end of the handle, and an air tube joint connected with a negative pressure vacuum pump is arranged at the rear end of the handle. The air pipe connector is connected with the hard pipe through a connecting pipe penetrating through the interior of the handle, and an air channel opening and closing button for controlling opening and closing of a valve on the connecting pipe is arranged on the right side wall of the handle. A knotting rope ring is arranged at the position of a pipe opening of the hard pipe, the two ends of the knotting rope ring are connected to the pipe opening of the hard pipe and the kneading handle respectively, and the kneading handle is rotationally connected to the handle. A pipe head is rotationally connected to a pipe opening of the hard pipe through a steering mechanism, the steering mechanism is sleeved with a corrugated hose, the two ends of the corrugated hose are in sealed connection with the pipe head and the hard pipe respectively, and a control button of the steering mechanism is arranged on the left side wall of the handle. Through steering positioning, negative pressure adsorption and selective ligation anastomosis mechanisms, the anorectal minimally invasive surgery is safer, more accurate and more economical.

The present application provides an intelligent prediction and early warning method and system for oral implant risks, wherein the mechanical response data of oral mucosal tissue under occlusal load and the three-dimensional strain gradient tensor of the target contact surface are obtained, and combined with a preset stress-strain analysis model, a target dynamic attenuation curve of the elastic modulus of the oral mucosal tissue during the entire healing cycle is established; the three-dimensional strain gradient tensor and the target dynamic attenuation curve of the elastic modulus are coupled and analyzed to generate multi-level relaxation correlation parameters, and the stress conduction path offset of the target contact surface is analyzed through a lightweight network combined with the multi-level relaxation correlation parameters; hierarchical early warning instructions are generated based on the spatiotemporal correlation between the stress conduction path offset and the preset healing stage biomechanical threshold. The present application improves the ability to predict and warn of abnormal conditions that may occur at the contact surface between the implant and the oral mucosal tissue.

The present invention relates to a light irradiation device for strengthening urethral muscles and a method for using same. The light irradiation device according to the present invention minimizes damage to urethral mucosal tissue and transmits light to a target surrounding muscle layer by using a balloon structure and a movable and rotatable light-emitting unit, thereby increasing lost muscle density and strengthening the urethral muscles.

This utility model relates to an orthodontic anchorage screw, which, from bottom to top, comprises a threaded section, a smooth section, a middle cap, a connecting rod section, and a top cap. The width of the connecting rod section is smaller than the width of the middle cap and the top cap at both ends. The middle cap, the connecting rod section, and the top cap form a groove for binding with a strap. The top cap is circular, with its top surface being an arched spherical surface with a smooth transition at the periphery, and its bottom surface also having a smooth transition at the periphery. The middle cap has a hexagonal prism-shaped portion. It is an orthodontic anchorage screw with a reasonable structure that reduces postoperative discomfort caused by friction between the intraoral anchorage screw and the mucosal tissue.

The invention relates to the technical field of medical machinery, and discloses a nephrology enema-type osmotic treatment device, comprising a material storage box, an enema gun, a processing cylinder and a lubricating liquid tank, wherein the upper left side of the material storage box is fixedly connected with a bracket, the enema gun is located at the upper part of the bracket and contacts the inner side of the bracket, the right side of the enema gun is fixedly connected with a connecting pipe, the right side of the connecting pipe is fixedly connected with a connecting head, and the inner side of the connecting head is threadedly connected with a rectal inlet tube; when the present invention is used, when the rectal inlet tube is replaced, the disassembly of the rectal inlet tube is more convenient and quick, and at the same time, by heating the rectal inlet tube and evenly applying lubricating liquid on the outer side thereof, the discomfort and pain of the patient during enema are greatly reduced, and the friction and stimulation of the enema tube on the intestinal mucosa can also be reduced, so as to avoid scratching or damaging the mucosal tissue, and the practicability of the device is greatly improved.

The invention discloses an oral mucosa blood vessel OCT image processing method and system. The method comprises the following steps: acquiring an OCT image of a target oral mucosa tissue; segmenting a plurality of blood vessel regions from the OCT image based on a trained image segmentation model; determining a disease probability corresponding to each blood vessel region; according to the disease probability, carrying out image enhancement on an image region of the OCT image nearby along each blood vessel region to obtain an enhanced OCT image result; the intensity and range of the image enhancement are in direct proportion to the disease probability. Therefore, more targeted and more efficient image enhancement can be realized, a data image basis with higher reference is provided for disease diagnosis or research of related tissues, and the image processing cost is reduced.

Disclosed is a topical therapeutic product formulated for pain relief of wounded or damaged epidermis and mucosal tissue. The topical therapeutic product may comprise a pharma- ceutical effective amount of sodium pyruvate incorporated into various delivery vehicles, including sprays, soaks, emollient ointments, lotions, gels, roll-ons, and disposable products. In at least some embodiments, the topical therapeutic may be an admixture for existing skin care products. The topical therapeutic disclosed herein may alleviate symptoms of the body's inflammatory response to injury and side effects of various cancer treatments, providing patients with improved quality of life. Methods of using the topical therapeutic product to alleviate pain in affected areas are also disclosed.

In some aspects, the disclosure relates to compositions and methods for skin repair and regeneration. In some embodiments, compositions described by the disclosure comprise natural products (e.g., extracts) combined with biotechnological excipient systems, such as bio surfactants, suitable for the repair of compromised skin, such as mucosal tissue (e.g., oral mucosal tissue).

The present invention provides compositions and formulations comprising glutathione with or without thiocyanate and methods of use thereof to treat diseases and disorders in mucosal / epithelial tissue.

The invention relates to the field of intelligent medical treatment, in particular to an oral mucosa canceration prediction method and device based on a pathological image and a program product. Comprising the following steps: S1, acquiring a pathological image of oral mucosa tissue of a to-be-detected person; s2, phenotypes of microvessels are obtained based on the pathological image, the phenotypes comprise an elliptic type and a non-elliptic type, when the phenotype is the non-elliptic type, ANGPTL2 gene detection is carried out to obtain a gene expression quantity, and when the gene expression quantity of ANGPTL2 is larger than a first preset threshold value, it is judged that a prediction result of oral mucosa canceration occurs, and if the prediction result of oral mucosa canceration occurs, the prediction result of oral mucosa canceration does not occur. The method can be used for oral mucosa canceration prediction and progress prediction, and has a very good clinical value.

The utility model relates to an intermaxillary traction screw which is provided with a threaded section, a polished rod section, a middle cap part, a connecting rod section and a top cap part from bottom to top, the width of the connecting rod section is smaller than the width of the middle cap part and the width of the top cap part at the two ends, and the middle cap part, the connecting rod section and the top cap part define a groove part for binding a rubber band; the top cap is characterized in that the top cap part is circular, the periphery of the top surface of the top cap part is in smooth transition, the peripheral wall of the middle cap part is formed by alternately connecting a plurality of plane sections and cambered surface sections, and one cambered surface section is arranged between every two adjacent plane sections. The polygonal part for screwing the traction nail is arranged on the middle cap part, so that the traction nail can be screwed by a hand tool; the top cap portion is designed to be round, the periphery of the top face of the top cap portion is in smooth transition, and the top cap portion is located at the outermost end during operation, so that the discomfort of friction between the traction nail in the mouth of a patient and oral mucosa tissue is effectively reduced, and the minimum oral mucosa friction irritation is achieved.

The utility model relates to the technical field of medical balloons, in particular to a balloon device which comprises a catheter seat, a flexible catheter, a fixing ring and a balloon. One end of the flexible catheter is communicated with the catheter seat, the other end of the flexible catheter is fixedly connected with the fixing ring, the balloon is arranged on the side, away from the flexible catheter, of the fixing ring, and the flexible catheter is communicated with the balloon through a through hole in the fixing ring. Part of the balloon is attached to the circumferential contour of the fixing ring to form a connecting part, the balloon is fixedly connected with the fixing ring through the connecting part, and the balloon forms an expanding structure extending in the axial direction of the fixing ring after being expanded. In order to solve the technical problem that an existing ESD operation has defects, according to the balloon device, a catheter base is communicated with an external gas-liquid source, gas or liquid can be injected into a balloon through the catheter base so that the balloon can be filled, the filled balloon can eject pathological upper-layer mucous membrane tissue open, the lower layer of the mucous membrane can be exposed, and therefore the balloon device can be used for protecting the upper layer of the mucous membrane. Therefore, a doctor can conveniently perform stripping.

A method of treating an inflammatory condition in mucosal tissue of the airways of a subject, the method comprising locally contacting mucosal airway tissue of the subject with a microemulsion comprising a cannabinoid compound, and wherein the microemulsion when in a diluted form has a viscosity of 15cP or less, a surface tension of 45 mN / m or less and a hydrodynamic radius of 100 nm or less. Also a kit for treating an inflammatory condition in mucosal tissue of the airways in a subject, comprising (a) the microemulsion comprising the cannabinoid; and (b) a device for delivering the microemulsion to the mucosal tissue of the airways of the subject, wherein the device delivers the microemulsion in a liquid, spray, or aerosolized form.