85 results about "Mucosal tissue" patented technology

A method of treating a soft palate in a patient may involve advancing a tissue treatment portion of a soft palate treatment device through the patient's mouth, contacting a treatment surface of the tissue treatment portion with mucosal tissue of the soft palate, and delivering energy from the tissue treatment portion through the mucosal tissue to a target tissue in the soft palate beneath to the mucosal tissue, to change at least one property of the target tissue. The method may further involve cooling the mucosal tissue with a cooling member on the treatment surface of the tissue treatment portion and removing the tissue treatment portion from the mouth.

The invention relates to the technical field of life science, in particular to a method for constructing an atrophic gastritis-based SPEM lesion model, which comprises the following steps: S1, constructing an Slc7a11 conditional knockout mouse strain: carrying out cage hybridization on an Slc7a11 flox / flox mouse and an ATP4b-Cre transgenic mouse, and knocking out a gastric wall cell specific Slc7a11 gene; s2, carrying out genotyping identification; the identification method based on the atrophic gastritis SPEM lesion model and the construction method based on the atrophic gastritis SPEM lesion model comprise the following steps: S1, pathological model verification: taking a mouse gastric mucosa tissue slice, quantitatively analyzing the proportion of an SPEM region by adopting an immunofluorescence double-standard technology, and confirming Slc7a11 knockout induced SPEM pathological characteristics in combination with the existence of SPEM in the gastric mucosa; and S2, long-term pathology evolution monitoring. Through gastric wall cell specific Slc7a11 gene knockout and multiple PCR identification technologies, the initial response SPEM state after gastric mucosa damage is successfully simulated, and the kit is used for researching atrophic gastritis pathological mechanisms and evaluating drug intervention.

Systems and methods for treating a patient's mucus hypersecretion condition are disclosed herein. Certain implementations may involve a method for reducing mucus secretion in an upper airway of a patient to treat at least one of post nasal drip or chronic cough. The method may include advancing a treatment delivery portion of an energy-based treatment device into a nostril of the patient. The treatment delivery portion may contact mucosal tissue of the upper airway without piercing the mucosal tissue. The treatment delivery portion may deliver treatment to at least one tissue selected from the group of the mucosal tissue and another tissue underlying the mucosal tissue to modify a property of the at least one tissue and thus treat at least one of post nasal drip or chronic cough in the patient.

Modular mucosal tissue bioreactors combined with bioartificial mucus provide a high-fidelity, medium-throughput platform for evaluating CF treatments and modeling host-pathogen biology, a stepping stone towards better options for HEMT-nonresponsive patients. Whole lung ex vivo Cystic Fibrosis model system allows for investigation of candidate CF therapies.

The invention relates to polysaccharide-based composite hydrogel as well as a preparation method and application thereof. The composite hydrogel is prepared from the following raw materials: hydroformylated modified ortho-hydroxyl-containing polysaccharide, an extracellular matrix enzyme digestive juice, tannic acid, cannabidiol, neomycin sulfate and borneol, by compounding multiple components, the use performance of the hydrogel can be remarkably improved, and the hydrogel is particularly suitable for a harsh environment. The composite hydrogel disclosed by the invention has excellent mechanical properties, good biological safety, certain self-repairing performance and relatively high anti-inflammatory, antibacterial and antioxidant properties, and can be applied to skin or mucous membrane tissue wound repairing.

The invention discloses Kluyveromyces marxianus KUST3801 and application thereof in relieving constipation, and the preservation number of the Kluyveromyces marxianus KUST3801 is CGMCC (China General Microbiological Culture Collection Center) NO.32767. The Kluyveromyces marxianus strain is classified and named as Kluyveromyces marxianus, and the Kluyveromyces marxianus strain is named as Kluyveromyces marxianus. The sequence of the 16SrRNA is as shown in SEQ ID NO. 1; the composition is used for improving constipation symptoms. After the kluyveromyces marxianus KUST3801 is applied, the excrement water content and the small intestine propulsion rate of a mouse with ICR constipation induced by loperamide hydrochloride are remarkably improved, and the defecation frequency and the defecation number within the same time are remarkably increased; intestinal mucosa tissues of constipation mice can be protected, and intestinal mucosa injury is relieved; the concentration of SP and MTL is obviously improved, and the concentration of VIP is reduced; iL-6 concentration is reversed, and inflammatory response is relieved; the concentrations of acetic acid, butyric acid, isobutyric acid and isovaleric acid in the short-chain fatty acid are obviously higher than those of mice with constipation, and the composition has a relatively strong effect of relieving constipation symptoms.

The present invention provides a nutritional composition comprising one or more of vitamin D, polydextrose and galacto-oligosaccharides in combination with a calcium source. The composition has the effect of improving the intestinal mucosal barrier including improving intestinal mucosal permeability, modulating expression of intercellular tight junction proteins, improving intestinal mucosal tissue structure and improving levels of markers of the intestinal mucosal barrier.

The invention provides an intelligent prediction and early warning method and system for oral implantation risks, and the method comprises the steps: obtaining the mechanical response data of oral mucosa tissues under an occlusion load and the three-dimensional strain gradient tensor of a target contact surface, and combining a preset stress-strain analysis model, establishing a target dynamic attenuation curve of the elastic modulus of the oral mucosa tissue in the whole healing period; performing coupling analysis on the target dynamic attenuation curve of the three-dimensional strain gradient tensor and the elastic modulus to generate a multi-level relaxation correlation parameter, and analyzing the stress conduction path offset of the target contact surface by combining a lightweight network with the multi-level relaxation correlation parameter; and generating a hierarchical early warning instruction according to the space-time correlation between the stress conduction path offset and a preset healing stage biomechanical threshold. According to the application, the capability of predicting and early warning abnormal conditions possibly occurring at the contact surface of the implant and the oral mucosa tissue is improved.

The utility model discloses an annular cervical canal curettage device, which comprises a curettage handle and a sleeve, the sleeve is sleeved on the curettage handle and can axially move relative to the curettage handle, the curettage handle comprises an operating end and a leading-in end, and the leading-in end of the curettage handle is provided with a leading-in head; one end of the sleeve is provided with a non-closed elastic annular curettage head, and the elastic annular curettage head is arranged on the curettage handle in a sleeving manner and is attached to the guide-in head; the operating end of the curettage handle drives the leading-in head to abut against the elastic annular curettage head under the action of external tension, so that the elastic annular curettage head is stressed and expanded; and an adjustable locking mechanism is also arranged between the curettage handle and the sleeve. The elastic annular curettage head of the annular cervical canal curettage device can be stretched under stress, can be fully attached to the cervical canal and can gently scrape mucosa tissue cells from the mucosa of the cervical canal, pain and discomfort of a patient are avoided, meanwhile, standardized and normalized operation is facilitated, and operation technicians are easy to train.

The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.

To provide an assisting tool for rectal mucosal biopsy that enables convenient and accurate collection of mucosal tissue from a predetermined region.SOLUTION: A rectal biopsy assisting tool 1 includes a cylindrical main body portion 11 that is inserted into a patient's rectum and has a distal end portion 111 that is closed and a proximal end portion 112 that is open, a through-hole 12 formed in a wall of the main body portion 11, and a projection amount indicating portion 13 provided so as to protrude near the insertion side of the through-hole 12 on an inner wall of the main body portion 11, the projection amount indicating portion 13 indicating an appropriate projection amount of a biopsy site, which is rectal mucosa, from the through-hole 12.SELECTED DRAWING: Figure 1

The invention relates to the technical field of surgical instruments, in particular to an anorectal anastomat with a function of selectively excising mucosal tissues on hemorrhoids, which comprises a handle and a hard tube, the hard tube is fixedly mounted at the front end of the handle, and an air tube joint connected with a negative pressure vacuum pump is arranged at the rear end of the handle. The air pipe connector is connected with the hard pipe through a connecting pipe penetrating through the interior of the handle, and an air channel opening and closing button for controlling opening and closing of a valve on the connecting pipe is arranged on the right side wall of the handle. A knotting rope ring is arranged at the position of a pipe opening of the hard pipe, the two ends of the knotting rope ring are connected to the pipe opening of the hard pipe and the kneading handle respectively, and the kneading handle is rotationally connected to the handle. A pipe head is rotationally connected to a pipe opening of the hard pipe through a steering mechanism, the steering mechanism is sleeved with a corrugated hose, the two ends of the corrugated hose are in sealed connection with the pipe head and the hard pipe respectively, and a control button of the steering mechanism is arranged on the left side wall of the handle. Through steering positioning, negative pressure adsorption and selective ligation anastomosis mechanisms, the anorectal minimally invasive surgery is safer, more accurate and more economical.

The present application provides an intelligent prediction and early warning method and system for oral implant risks, wherein the mechanical response data of oral mucosal tissue under occlusal load and the three-dimensional strain gradient tensor of the target contact surface are obtained, and combined with a preset stress-strain analysis model, a target dynamic attenuation curve of the elastic modulus of the oral mucosal tissue during the entire healing cycle is established; the three-dimensional strain gradient tensor and the target dynamic attenuation curve of the elastic modulus are coupled and analyzed to generate multi-level relaxation correlation parameters, and the stress conduction path offset of the target contact surface is analyzed through a lightweight network combined with the multi-level relaxation correlation parameters; hierarchical early warning instructions are generated based on the spatiotemporal correlation between the stress conduction path offset and the preset healing stage biomechanical threshold. The present application improves the ability to predict and warn of abnormal conditions that may occur at the contact surface between the implant and the oral mucosal tissue.

The present invention relates to a light irradiation device for strengthening urethral muscles and a method for using same. The light irradiation device according to the present invention minimizes damage to urethral mucosal tissue and transmits light to a target surrounding muscle layer by using a balloon structure and a movable and rotatable light-emitting unit, thereby increasing lost muscle density and strengthening the urethral muscles.

This utility model relates to an orthodontic anchorage screw, which, from bottom to top, comprises a threaded section, a smooth section, a middle cap, a connecting rod section, and a top cap. The width of the connecting rod section is smaller than the width of the middle cap and the top cap at both ends. The middle cap, the connecting rod section, and the top cap form a groove for binding with a strap. The top cap is circular, with its top surface being an arched spherical surface with a smooth transition at the periphery, and its bottom surface also having a smooth transition at the periphery. The middle cap has a hexagonal prism-shaped portion. It is an orthodontic anchorage screw with a reasonable structure that reduces postoperative discomfort caused by friction between the intraoral anchorage screw and the mucosal tissue.

In some aspects, the disclosure relates to compositions and methods for skin repair and regeneration. In some embodiments, compositions described by the disclosure comprise natural products (e.g., extracts) combined with biotechnological excipient systems, such as bio surfactants, suitable for the repair of compromised skin, such as mucosal tissue (e.g., oral mucosal tissue).

The invention relates to the field of intelligent medical treatment, in particular to an oral mucosa canceration prediction method and device based on a pathological image and a program product. Comprising the following steps: S1, acquiring a pathological image of oral mucosa tissue of a to-be-detected person; s2, phenotypes of microvessels are obtained based on the pathological image, the phenotypes comprise an elliptic type and a non-elliptic type, when the phenotype is the non-elliptic type, ANGPTL2 gene detection is carried out to obtain a gene expression quantity, and when the gene expression quantity of ANGPTL2 is larger than a first preset threshold value, it is judged that a prediction result of oral mucosa canceration occurs, and if the prediction result of oral mucosa canceration occurs, the prediction result of oral mucosa canceration does not occur. The method can be used for oral mucosa canceration prediction and progress prediction, and has a very good clinical value.

The utility model relates to an intermaxillary traction screw which is provided with a threaded section, a polished rod section, a middle cap part, a connecting rod section and a top cap part from bottom to top, the width of the connecting rod section is smaller than the width of the middle cap part and the width of the top cap part at the two ends, and the middle cap part, the connecting rod section and the top cap part define a groove part for binding a rubber band; the top cap is characterized in that the top cap part is circular, the periphery of the top surface of the top cap part is in smooth transition, the peripheral wall of the middle cap part is formed by alternately connecting a plurality of plane sections and cambered surface sections, and one cambered surface section is arranged between every two adjacent plane sections. The polygonal part for screwing the traction nail is arranged on the middle cap part, so that the traction nail can be screwed by a hand tool; the top cap portion is designed to be round, the periphery of the top face of the top cap portion is in smooth transition, and the top cap portion is located at the outermost end during operation, so that the discomfort of friction between the traction nail in the mouth of a patient and oral mucosa tissue is effectively reduced, and the minimum oral mucosa friction irritation is achieved.

The utility model relates to the technical field of medical balloons, in particular to a balloon device which comprises a catheter seat, a flexible catheter, a fixing ring and a balloon. One end of the flexible catheter is communicated with the catheter seat, the other end of the flexible catheter is fixedly connected with the fixing ring, the balloon is arranged on the side, away from the flexible catheter, of the fixing ring, and the flexible catheter is communicated with the balloon through a through hole in the fixing ring. Part of the balloon is attached to the circumferential contour of the fixing ring to form a connecting part, the balloon is fixedly connected with the fixing ring through the connecting part, and the balloon forms an expanding structure extending in the axial direction of the fixing ring after being expanded. In order to solve the technical problem that an existing ESD operation has defects, according to the balloon device, a catheter base is communicated with an external gas-liquid source, gas or liquid can be injected into a balloon through the catheter base so that the balloon can be filled, the filled balloon can eject pathological upper-layer mucous membrane tissue open, the lower layer of the mucous membrane can be exposed, and therefore the balloon device can be used for protecting the upper layer of the mucous membrane. Therefore, a doctor can conveniently perform stripping.

A method of treating an inflammatory condition in mucosal tissue of the airways of a subject, the method comprising locally contacting mucosal airway tissue of the subject with a microemulsion comprising a cannabinoid compound, and wherein the microemulsion when in a diluted form has a viscosity of 15cP or less, a surface tension of 45 mN / m or less and a hydrodynamic radius of 100 nm or less. Also a kit for treating an inflammatory condition in mucosal tissue of the airways in a subject, comprising (a) the microemulsion comprising the cannabinoid; and (b) a device for delivering the microemulsion to the mucosal tissue of the airways of the subject, wherein the device delivers the microemulsion in a liquid, spray, or aerosolized form.

A drug delivery nozzle for a local site, comprising a drug delivery insert and a dispensing mechanism. The drug delivery insert includes a drug delivery olive shell, with a medicine squeezing water inlet at the bottom and a top opening at the top. The drug delivery insert is used to be inserted into the local site. The dispensing mechanism is arranged on the drug delivery insert and includes an elastic medicine sac and a dispensing valve orifice. The dispensing valve orifice is arranged at the top opening. The dispensing mechanism is used to squeeze the elastic medicine sac through water pressure to bulge forward through the dispensing valve orifice to push the contents forward and spray the liquid medicine to the local site. The drug delivery nozzle for the local site can be inserted into the local site without damaging the mucosal tissue, and accurately apply the medicine after pushing the contents forward.

The invention discloses a magnetic control intelligent traction system for endoscopic surgery. The magnetic control intelligent traction system comprises an in-vivo magnetic clamp assembly, an in-vitro magnetic control device, a navigation positioning subsystem and a central processing unit. The in-vivo magnetic clamp assembly firmly grabs mucous membrane tissues through the shape memory effect and the surface spinule structure of a nickel-titanium alloy clamp arm; the in-vivo magnetic clamp assembly is integrated with an MEMS force sensor, actual traction force is detected in real time, and data of the force sensor are transmitted to the central processing unit through the wireless communication module. The in-vitro magnetic force control device is used for pulling the in-vivo magnetic clamp to move, receiving target magnetic field parameters of the central processing unit and outputting a PWM signal to adjust current; the navigation positioning subsystem receives the position information of the in-vivo magnetic clamp, tracks the position of an in-vivo magnetic clamp assembly, and distributes an optimal traction vector through a particle swarm optimization algorithm; the central processing unit receives navigation positioning data, feedback of the force sensor and an operator operation instruction, generates a magnetic field control signal and distributes traction force vectors of all clamps through a PSO algorithm. Accurate and stable output of traction force in the ESD operation is achieved.

The present invention discloses the use of a Chimonanthus dahurica leaf extract in preparing a drug for treating allergic rhinitis, and relates to the field of traditional Chinese medicine. Based on an allergic rhinitis animal model, the present invention investigates the effects of Chimonanthus dahurica leaves on the behavior, nasal mucosal tissue morphology, and serum inflammatory factor levels of AR rats, and clarifies the pharmacodynamics of Chimonanthus dahurica leaves in treating AR. That is, Chimonanthus dahurica leaves can significantly reduce the levels of IgE, histamine, ICAM-1, and inflammatory factors in the serum of rats with allergic rhinitis, and can also significantly improve the nasal mucosal symptoms of rats with allergic rhinitis, among which the Chimonanthus dahurica leaf water extract has a better effect. At the same time, by preparing different active component groups of Chimonanthus dahurica leaves, the effective parts of Chimonanthus dahurica for treating allergic rhinitis are screened, among which the 70% ethanol elution group and the 50% ethanol elution group have the best effects. The present invention has prospects for developing and preparing drugs for treating allergic rhinitis.

An object of the present invention is to provide a cultured cell sheet that can solve problems accompanied by defects of mucosal tissue, such as inflammation in mucosal tissues covering bone tissues and granulation tissue formation. The present inventors have found that a cultured cell sheet obtained by culturing cells collected from a nasal mucosal tissue as a source under specific conditions, and reconstructing the cells into a sheet are engrafted onto mucosal tissue defective sites; promote the regeneration of mucosal tissues; efficiently reduce inflammation that occurs in a middle ear bone tissue; and prevent fibrosis and the like that are characteristic of bone tissue inflammation, thereby demonstrating that the cultured cell sheet can solve the problems. It is also found that the cultured cell sheet of the present invention is also useful for preventing inflammation of bone tissues in areas other than the middle ear.

The present disclosure relates to methods and compositions for local expression of IL-12 in mucosal tissues, preferably in combination with an IFN-1 activator / inducer, for use in cancer immunotherapy.SOLUTION: The present invention solves the unmet need in the art for effective local expression of IL-12 using derivatized chitosan polyplexes reversibly coated with polyanion-containing block copolymers for potent transfection of mucosal tissues present in or proximal to tumors.SELECTED DRAWING: Figure 6

The present invention relates to iota-carrageenan for use as a main or sole active ingredient in an aqueous pharmaceutical composition for the prevention or treatment of non-viral non-allergic clinically relevant eye conditions affecting at least one of mucosal tissues at or around an individual's eye, an eye surface, corneal tissue, and fluid inside the eye, said clinically relevant eye conditions selected from the group consisting of increased intraocular pressure, non- allergic and non-viral conjunctivitis, irritations caused by airborne particulate matter other than allergens, and late complications of non-viral and non-allergic conjunctivitis selected from the group consisting of corneal opacities, subepithelial infiltrates, and formation of ocular pseudomembranes.

The present invention relates to a non-human mammal model of HSV latent infection, which enables detection of HSV in mucosal tissue upon exposure to a stimulus that reactivates latent HSV within the body. The non-human mammal according to the present invention can contribute to elucidating the mechanism of HSV latent infection and reactivation in humans and to developing drugs and the like for HSV.

A method of treating a soft palate in a patient may involve advancing a tissue treatment portion of a soft palate treatment device through the patient's mouth, contacting a treatment surface of the tissue treatment portion with mucosal tissue of the soft palate, and delivering energy from the tissue treatment portion through the mucosal tissue to a target tissue in the soft palate beneath to the mucosal tissue, to change at least one property of the target tissue. The method may further involve cooling the mucosal tissue with a cooling member on the treatment surface of the tissue treatment portion and removing the tissue treatment portion from the mouth.

The invention relates to a nanoparticle for use as a drug carrier and the synthesis method of this nanoparticle. In the invention, magnesium / aluminium (Mg / AI) mucoadhesive thiolated layered double hydroxide (nLDHT) nanoparticles are thiolated with L-cysteine and / or thioglycolic acid and / or 2-iminothiolane hydrochloride and / or glutathione and / or N-acetyl cysteine and / or 3-mercaptopropionic acid and / or 6- mercaptohexanoic acid. Thus, nLDHT interacts with the mucin on the surface of the targeted mucosal tissue for a longer period of time and acts with fewer side effects in the target tissues.

In some aspects, the disclosure relates to compositions and methods for skin repair and regeneration. In some embodiments, compositions described by the disclosure comprise natural products (e.g., extracts) combined with biotechnological excipient systems, such as biosurfactants, suitable for the repair of compromised skin, such as mucosal tissue (e.g., oral mucosal tissue).