753 results about "Uretero-ureteral" patented technology

The negative pressure flexible ureteroscope sheath with the front end actively bent and telescopic comprises a sheath tube body, an operation channel is formed in the sheath tube body, an operation channel connector is fixed to the rear end of the sheath tube body, and a negative pressure suction connector communicated with the operation channel is fixed to one side of the rear end of the sheath tube body; the sheathing canal body is integrally formed by a telescopic bending section and a straight pipe section, pneumatic telescopic bending adjusting mechanisms are arranged on the upper side, the lower side, the left side and the right side of the telescopic bending section, and a pneumatic telescopic bending control mechanism is arranged at the rear end of the sheathing canal body. The front end of the flexible ureteroscope sheath can be telescopically adjusted and can be bent in multiple directions, the sheath tube can be telescopically adjusted at the rear end and is extremely easy and convenient to operate and adjust, and the sheath tube can increase the trafficability of calculi at the upper section of the ureter and prevent the ureter from being damaged.

The invention discloses a preparation method of a dual-pH intelligent response drug-loaded ureteral stent, which belongs to the technical field of medical instruments, and is characterized in that the dual-pH intelligent response drug-loaded ureteral stent comprises a dual-pH intelligent response drug-loaded coating and a bare stent; wherein the dual pH intelligent response drug-loading coating contains polymer-modified porous silicon dioxide drug-loading particles, and the main effect of the drug-loading coating is that after the pH of the internal environment of the ureteral stent is changed due to bacterial infection, the antibacterial agent is controllably released through the structural change of the drug-loading particles or the property of the surface polymer is changed, so that the bactericidal ability is improved; and a complex infection environment can be accurately dealt with.

The invention relates to a negative pressure suction ureter guiding sheath which comprises a sheath tube, a bending adjusting handle and a multifunctional connector which are connected in sequence. The sheathing canal is communicated with the multifunctional joint through the bending adjusting handle; the bending adjusting handle comprises an upper shell, a lower shell, a traction scroll and a locking assembly. The upper shell and the lower shell are connected to form a handle body, the traction wire disc is rotationally installed in a cavity defined by the lower shell and the upper shell, the traction wire disc is connected with the sheathing canal through a traction wire, and the traction wire disc rotates to drive the traction wire to pull the head end of the sheathing canal to be bent. The locking assembly is installed on the traction scroll and can be switched between a locking state and an unlocking state, and when the locking assembly is in the locking state, the traction scroll and the upper shell are relatively fixed; when the locking assembly is in the unlocking state, the traction wire disc can rotate relative to the upper shell, and the operation is convenient and fast, the handle does not need to be continuously operated, the operation burden of a doctor is effectively relieved, and the operation effect is improved.

The invention relates to the technical field of medical instruments, in particular to a flexible ureteroscope used in cooperation with a diameter-variable ureteroscope sheath, which comprises a ureteroscope sheath body and a flexible ureteroscope body, the ureteroscope sheath body comprises a deformation section and a support section, the deformation section has a first form and a second form, and the flexible ureteroscope body comprises a handle section and a ureteroscope tube section. The endoscope tube section comprises a first tube body part and a second tube body part, a fixing groove is formed in the first tube body part, and the outer diameter of the deformation section in the first form is smaller than or equal to the outer diameter of the first tube body part; the inner diameter of the deformation section in the second form is greater than the outer diameter of the first pipe body part; a first liquid injection channel is further arranged in the endoscope tube section, and a first liquid outlet hole is formed in the fixing groove. Compared with the prior art, in the operation of expanding the human body ureterostenosis section by the deformation section, a stenosis ring in the human body ureterostenosis section does not need to be broken by supporting, so that the injury to the human body ureter in the ureteroscope lithotripsy is effectively reduced, and the postoperative pain of a patient is reduced.

The invention relates to the technical field of medical instruments, and discloses a pedal control type urinary surgery ureteroscope perfusion pressure pulse adjusting device which is characterized in that the piston head in the middle of three groups of piston heads is inserted into a liquid injection cavity, and the piston heads on the two sides are inserted into a pressure cavity; the three sets of piston heads can inject liquid and high-pressure gas into the control valve cavity from the liquid injection cavity and the pressure cavity. A pedal control mechanism is innovatively introduced, a worker treads a pedal frame in a reciprocating mode, controls liquid to clean a lens and flushes broken stones in a matched mode, the rhythm of treading flushing can be better controlled through autonomous reciprocating treading of a doctor, the situation that an assistant needs to repeatedly use an injector and an extension tube for pushing injection in a traditional urinary surgery is avoided, and the working efficiency is improved. The problems that doctors need to be frequently matched with nurses, the examination concentration of the doctors is easily affected are solved, operation is more efficient, and the problem that the injectors are repeatedly replaced is solved.

The invention belongs to the technical field of biological medicine, and particularly relates to application of chlorbuconazole or salt thereof in preventing, relieving or treating diseases related to HIF-2alpha. In-vitro experiments prove that the chlorbuconazole enhances the transcriptional activity of HIF-2alpha so as to promote the expression of downstream genes regulated and controlled by the HIF-2alpha; it is proved that chlorburazol has the effects of increasing erythropoiesis and relieving renal injury on an aristolochic acid-induced zebra fish chronic kidney disease model, a cisplatin-caused acute kidney injury and renal anemia model and a unilateral ureteral obstruction model. Meanwhile, the traditional Chinese medicine composition belongs to new use of old medicines, so that the medicine research and development cost and the treatment cost are saved, and the traditional Chinese medicine composition has obvious economic benefits and clinical application values.

The utility model provides a negative pressure regulation and control structure and a ureter sheath, and belongs to the technical field of medical instruments. The negative pressure regulation and control structure comprises a negative pressure pipe and a suction valve; the negative pressure pipe is provided with a suction channel and an opening which are communicated with each other, the suction valve is in sliding fit with the negative pressure pipe, and the circulation area of the opening can be adjusted by sliding the suction valve; the suction valve comprises a valve body and a connecting protrusion which are connected with each other, the valve body is located outside the negative pressure pipe, the connecting protrusion penetrates through the open hole, partially protrudes out of the inner wall of the negative pressure pipe and is connected with the inner wall of the negative pressure pipe in a buckled mode, and the face, connected with the inner wall of the negative pressure pipe in a buckled and abutting mode, of the connecting protrusion is a limiting face. The limiting face inclines in the direction away from the valve body from the side, close to the open hole, of the limiting face to the side, away from the open hole, of the limiting face. According to the suction valve, the limiting face is obliquely arranged in the direction away from the valve body, so that the installation space between the limiting face and the valve body is enlarged, the deformation amount of the valve body needed by the connecting protrusion entering the suction channel is reduced, and the convenience of assembly of the suction valve is improved.

The invention relates to the technical field of medical apparatus and instruments, in particular to a pressure sensing ureter guiding sheath which comprises a flexible sheath tube body provided with a near-end operation section and a far-end intervention section. The annular pressure sensing array is formed by equidistantly arranging a plurality of piezoresistive sensors along the circumferential direction of the far-end intervention section, and is used for monitoring the ureter wall contact pressure in real time; the signal processing module is integrated on the near-end operation section and is used for carrying out dynamic noise filtering and baseline calibration on the pressure signals from the annular pressure sensing array; and the display screen is connected to the signal processing module and is used for displaying the pressure distribution of the annular pressure sensing array in real time. The scheme is used for solving the problem of mechanical trauma caused by inappropriate size selection, pathological or physiological stenosis and the like in the sheathing canal implantation process in the prior art, and real-time monitoring and dynamic adjustment of the ureter wall contact pressure are realized, so that the surgical risk is reduced, and the surgical success rate is improved.

The invention relates to a ureteral access sheath (10) for insertion in the ureter (56) of a human or animal patient, wherein the access sheath (10) has, at a proximal end, an introduction portion (16) for a medical instrument and has an elongate portion (18) which extends from the proximal introduction portion (16) to a distal end (12) of the access sheath (10), wherein the elongate portion (18) comprises, over at least substantially the length of the elongate portion (18), at least one lumen (20) for guiding through the medical instrument. According to the invention, at least in some regions along the elongate portion (18), an elastically deformable cover element (22) is arranged on an outer wall of the lumen (20), wherein the cover element (22) can be deformed between a basic position, in which the cover element (22) rests against the outer wall of the lumen (20), and a guide-wire position, in which the cover element (22) is moved away from the outer wall of the lumen (20) by a guide wire (24) and forms a guide channel (26) for the guide wire (24).

Methods for visualizing a ureter, including fluorescent visualization of a ureter, as well as other target tissues, during a surgical procedure, comprising administering to a subject a fluorescent conjugate comprising a peptide and a fluorescent moiety.

An improved ureteral sheath, includes: an introducer sheath including a sheath tube and a sheath base arranged at a proximal end of the sheath tube, the sheath base is provided with a tube segment in communication with the sheath tube and a connecting part arranged at a distal end of the tube segment; the sheath tube is provided, from a proximal end to a distal end thereof, with a main body segment and a head segment arranged at a distal end of the main body segment, the main body segment is composed of a hard tube segment, and the head segment is composed of a deformable tube segment; and the tube segment extends outwards relative to a central axis thereof in a communication manner to form a negative pressure connecting tube, a tube wall of the negative pressure connecting tube is provided with vent groove.

The invention provides a reducing ureter guiding sheath which comprises an operation portion and an intubation tube suitable for being inserted into a ureter, the operation portion is connected to the near end of the intubation tube, and a center channel extending from the near end to the far end is defined in the intubation tube. An inlet communicated with a central channel of the cannula is defined by the operating portion, a sealing valve is arranged at the position of the inlet so that an instrument can penetrate through the inlet in a sealed mode and then enter the central channel, a negative pressure connector communicated with the central channel is arranged on the operating portion, the cannula comprises a large-diameter section and a small-diameter section, the large-diameter section is connected with the small-diameter section, and the large-diameter section is connected with the small-diameter section. The large-diameter section is connected to the near end of the small-diameter section, a large channel is defined in the large-diameter section, a small channel is defined in the small-diameter section, and the diameter of the large channel is larger than that of the small channel so as to accelerate fluid passing.

The invention relates to the technical field of medical instruments, and discloses a flexible ureteroscope sheath device and a pressure control method thereof.The flexible ureteroscope sheath device is characterized in that one end of a connector tube seat is connected with a sheath tube, the other end of the connector tube seat is provided with three connectors, the first connector is connected with a pressure relief device and a control device, the second connector is used for a flexible ureteroscope and perfusion, and the third connector is used for negative pressure suction; a central channel is arranged in the sheathing canal, and passage type pressure measuring sensors are axially and uniformly arranged around the channel; the control device comprises an adjusting key, a digital display, an indicating lamp and a buzzer, and is electrically connected with the pressure measuring sensor and the pressure relief device; the control device comprises an automatic pressure relief module which is used for collecting analog voltage signals and converting the analog voltage signals into pressure data values, and when a detection value reaches a set threshold value, the electric control pressure relief device automatically relieves pressure. According to the invention, real-time and continuous detection and control of the pressure in the cavity are realized.

The invention discloses an anti-fibrosis drug coating degradable woven stent for treating urethrostenosis, the stent is a hollow cylinder formed by spirally weaving wires, the wires are made of biodegradable polymer materials, the surface of the stent is coated with a drug coating, anti-fibrosis drugs are selected as the drugs, and the anti-fibrosis drug coating is made of biodegradable polymer materials. The drug coating is prepared by using an ultrasonic atomization spraying method; the biodegradable polymer material comprises one or a compound of more than one of poly L-lactic acid, poly D, L-lactic acid, poly (L-lactic acid / D, L-lactic acid), poly (glycolide / lactide), poly (glycolide-lactide), poly (L-lactic acid / caprolactone), poly (glycolide / caprolactone), poly (D, L-lactic acid / caprolactone), polydioxanone and the like. The stent body is made into a self-expanding stent by adopting a weaving method; the biodegradable ureteral stent with the drug coating has good biocompatibility, degradability and mechanical property, and has a wide market application prospect.

The invention discloses a safe ureter dilatation guide wire system and a progressive pressure control method, and relates to the technical field of medical instruments.The safe ureter dilatation guide wire system comprises a guide wire body and a pressure sensor, the guide wire body comprises a water bag structure and a double-cavity structure which are communicated, the water bag structure is made of an elastic structure, and the double-cavity structure is made of an elastic material; the interior of the water bag structure is used for being filled with expansion liquid and expanding according to the target volume so as to expand the narrow position of the ureter. A guide wire cavity and a liquid injection cavity which are independently arranged are formed in the double-cavity structure, the guide wire cavity and the liquid injection cavity are both communicated with the water bag structure, the guide wire cavity is used for allowing the identification light source to penetrate through, and the liquid injection cavity is used for providing expansion liquid for the water bag structure; the pressure sensor is installed outside the water bag structure so as to detect the pressure of the inner wall tissue of the ureter in real time. According to the technical scheme, the problem that an existing ureter guide wire cannot monitor the deformation state of narrow tissue in real time is solved.

The present application belongs to the technical field of medical instruments. Provided are a negative pressure regulation and control structure and a ureteral access sheath. The negative pressure regulation and control structure comprises a negative pressure tube and a suction valve. The negative pressure tube is provided with a suction channel and a hole which are communicated with each other, wherein the suction valve is in a sliding fit with the negative pressure tube, and the flow area of the hole can be adjusted by sliding the suction valve. The suction valve comprises a valve main body and a connecting protrusion which are connected to each other, the valve main body being arranged outside the negative pressure tube; the connecting protrusion passes through the hole and partially protrudes out of the inner wall of the negative pressure tube, and is snap-fastened to the inner wall of the negative pressure tube, the face of the connecting protrusion snap-fastened to and abutting against the inner wall of the negative pressure tube is a limiting face; and in the direction from the side of the limiting face close to the hole towards the side away from the hole, the limiting face inclines in a direction away from the valve main body. By means of setting the limiting face to be inclined in the direction away from the valve main body so as to expand a mounting space between the limiting face and the valve main body, the present application reduces the amount of deformation of the valve main body required by the connecting protrusion entering the suction channel, thereby improving the convenience in mounting the suction valve.

The present application provides a ureteral stent, a traction mechanism, and a ureteral stent system. The ureteral stent system comprises the ureteral stent and the traction mechanism. A urine guide channel is formed in the ureteral stent; the ureteral stent comprises a middle part, and a renal pelvis part and a bladder part which are arranged on the two opposite sides of the middle part; the renal pelvis part and the bladder part are both in a curved shape; the traction mechanism comprises a traction member and a sliding member; an accommodating recess is formed in the peripheral side wall of the traction member; at least part of the bladder part can be arranged in the accommodating recess; the traction member is further provided with a slide channel communicated with the accommodating recess; part of the sliding member is arranged in the slide channel; and the sliding member can slide relative to the traction member such that an opening of the accommodating recess can be closed or open. When at least part of the bladder part is arranged in the accommodating recess and the opening of the accommodating recess is closed, the ureteral stent is fixed to the traction member. Therefore, the ureteral stent can be pulled out of the body of a user along with the traction mechanism, such that the user does not need to have a cystoscopy operation for pulling out the ureteral stent, thereby enhancing the user experience.

Provided is a ureteral lithotripsy catheter, comprising a sheath (1). One end of the sheath (1) is fixedly connected to a vortex cavity (3), and the other end of the sheath (1) is connected to a bending section (9). The sheath (1) is provided with a pressure detection hole (8) and a pressure detection channel (10). The pressure detection hole (8) is in communication with the pressure detection channel (10). The other end of the pressure detection channel (10) is connected to a detachable pressure sensor. By means of arranging the detachable pressure sensor, the sensor body can be detached when not in use, facilitating storage. During use, the connection between the sensor body and the sensor chip is convenient, rapid, and reliable. The pressure sensor can monitor accurate and reliable data by means of the pressure detection channel, avoid high pressure in the minimally invasive cavity, and significantly improve the safety rate of surgery and the calculus removal efficiency.

The utility model relates to the technical field of surgical medical instruments, in particular to an expansion tube and a ureter sheath, which comprise a tube body, a first channel, a second channel and a third channel are axially arranged in the tube body, the first channel is used for a guide wire to pass through, the second channel is used for fluid to pass through, and the third channel is used for an optical fiber assembly to pass through. A notch is formed in the peripheral wall of the far end of the tube body, the notch penetrates to the end face of the far end of the tube body in the axial direction of the tube body, the notch penetrates to be communicated with the first channel in the radial direction of the tube body, and the notch corresponds to the first channel. The notch corresponding to the first channel is formed in the peripheral wall of the tube body, so that the exposed area of the far-end port of the first channel is increased, the insertion difficulty of a guide wire into the guide wire channel is reduced, an operator can quickly and accurately find the first channel used for insertion of the guide wire from the multiple channels on the expansion tube, and the operation efficiency is improved. The accuracy and convenience of inserting the guide wire into the first channel are improved, and the use convenience of the expansion tube and the ureter sheath is effectively improved.

The utility model discloses a dilator, a ureter sheath and an endoscope assembly, and relates to the technical field of medical instruments. The dilator disclosed by the utility model is used for the ureter sheath. The dilator comprises a dilation tube and a clamp, the clamp comprises a base portion and at least two clamping arms distributed in the circumferential direction of the base portion, and the clamp can be connected with the near end of a sheath tube of the ureter sheath through the clamping arms; the base part is provided with a mounting hole, the near end of the dilation tube penetrates through the mounting hole, and the near end of the dilation tube and the base part are clamped, positioned and matched in the axial direction and the circumferential direction of the dilator. The scheme at least can be used for improving the smoothness of the insertion action of the ureter sheath.

The present invention discloses a capacitive ureteral sheath and a method for controlling the renal pelvic pressure thereof. The capacitive ureteral sheath comprises a soft endoscope outer sheath, the front end of which is provided with an annular pressure sensor; the rear end of which is provided with an elastic outer cavity. The capacitive ureteral sheath is applied to the dynamic control of the renal pelvic pressure. The present invention has the characteristics of alleviating accidental high-pressure injuries, strong adaptability, and high-frequency dynamic control, and can perform dynamic control of the renal pelvic pressure according to patients of different ages and genders.

Methods for visualizing a ureter, including fluorescent visualization of a ureter, as well as other target tissues, during a surgical procedure, comprising administering to a subject a fluorescent conjugate comprising a peptide and a fluorescent moiety.

A method of localizing a target anatomy involves advancing a ureteroscope to a target calyx of a kidney of a patient through at least a portion of a urinary tract of the patient, determining a positional offset between one or more position sensors associated with the ureteroscope and a target papilla of the kidney that is at least partially exposed within the target calyx, and determining a percutaneous access target based at least in part on one or more of a present position of the one or more position sensors or the positional offset.

The utility model relates to the technical field of tools for flexible ureteroscope operations, and provides a flexible ureteroscope perfusion negative pressure controller which comprises a flexible ureteroscope connecting part, a water inlet channel, a negative pressure channel and an adjusting valve, the flexible ureteroscope connecting part is used for being detachably connected with a flexible ureteroscope handle connector, and the water inlet channel and the negative pressure channel are communicated with the flexible ureteroscope handle connector. The water inlet channel is used for being connected with a filling pump, the negative pressure channel is used for being connected with a negative pressure aspirator, and the adjusting valve is connected with the water inlet channel and the negative pressure channel and used for adjusting the size of the water inlet channel and the size of the negative pressure channel. The water inlet channel, the negative pressure channel and the adjusting valve are arranged, the water inlet channel is connected with the filling pump, the negative pressure channel is connected with the negative pressure aspirator, part of water in the flexible ureteroscope is discharged while water is injected by adjusting the adjusting valve, water inlet and water outlet are dynamically controlled, and certain balance between water inlet and water outlet is kept. The operation view is kept clear; and the renal pelvis pressure is continuously reduced.

A visual ureteroscope includes a ureteroscope body and a ureteroscope tip. The ureteroscope tip includes a tip portion and an image capture device, wherein the tip portion is arranged at a front end of a ureteroscope tube of the ureteroscope body; the tip portion has a camera end face and an aspiration end face; the tip portion includes an aspiration hole, which is in communication with an aspiration channel of the ureteroscope body, and an operating hole for an operating component to pass therethrough, the aspiration hole axially extending forwards from the aspiration channel to the aspiration end face to form an aspiration opening, and the operating hole obliquely extending forwards such that the operating component that passes out from the operating hole, obliquely extends forwards to extend out of the tip portion; and the image capture device comprises a camera.

The invention relates to a negative pressure suction sheath kit for a ureter. The negative pressure suction sheath kit comprises an outer sheath, a first inner core and a second inner core, the outer sheath is provided with a sheath tube and a connector tube connected to the rear end of the sheath tube, the sheath tube comprises a base tube section and a flexible tube section connected to the front end of the base tube section, a joint part is formed at the rear end of the connector tube, a negative pressure tube communicated with the operation channel is formed on the side portion of the connector tube, and a negative pressure adjusting structure is arranged on the negative pressure tube. The first inner core is provided with a first core tube made of a hard material, a rotary buckle joint used for fixing the flexible ureteroscope and a first involution buckle joint used for being buckled and fixed with the joint part of the outer sheath, and when the first inner core is inserted and fixed in the outer sheath, the front end of the flat head of the first core tube is flush with the front end of the flexible tube section. And the second inner core is provided with a second core tube and a second involution buckle joint used for being buckled and fixed with the joint part of the outer sheath, and when the second inner core is inserted and fixed in the outer sheath, the conical front end of the second core tube extends out of the front end of the flexible tube section. The external member is more convenient to operate, and the outer sheath can be placed in place.

Devices, systems, and methods for treating stones in anatomical structures are disclosed. A device may include an elongate member and a tubular member extending distally from the elongate member. The elongate member may define one or more lumens with an opening at a distal end of the elongate member. The tubular member may be configured to collapse to a pre-determined shape when in a relaxed state and expand in response to receiving an object. The device may be used with a scope, such as a ureteroscope, lithotripsy devices, and / or other medical devices or systems.

The present invention seeks to protect a renal pelvic pressure monitoring device, which includes a ureteroscope, an operation channel is provided in the ureteroscope, the ureteroscope is used to enter the renal pelvis from the ureter, a pressure detection ring is arranged around the outer wall of the ureteroscope, a pressure measuring channel is provided on the pressure detection ring, a pressure measuring pipe is arranged in the pressure measuring channel, one end of the pressure measuring pipe is flush with the pressure measuring channel, and the other end extends outside the body and is connected to the pressure detector, and a fixing bag is arranged around the outer wall of the pressure detection ring, and the fixing bag is used to fix the position of the ureter. In summary, the above technical scheme has the following beneficial effects: the ureteroscope is consistent with the existing surgical soft mirror, and has functions such as lighting, lithotripsy and liquid injection. The pressure detection ring on the ureteroscope can detect the pressure after the liquid is injected into the renal pelvis, and then the pressure in the renal pelvis can be further adjusted by adjusting the injection speed and injection amount through the ureteroscope.

The invention discloses application of SAA1 as a target spot in preparation of a medicine for preventing and treating kidney diseases, and belongs to the field of gene functions, application and biological medicine. In-vivo and in-vitro experiments prove that in an ischemia / reperfusion or ureteral obstruction induced mouse kidney disease model, the knockout of the SAA1 gene can relieve renal interstitial vascular endothelial cell injury, recover a renal capillary network, improve vascular permeability, reduce collagen deposition, inhibit renal fibrosis and effectively delay the progress of kidney diseases; furthermore, by adopting the SAA1 recombinant protein vaccine to immunize mice, the organism can be induced to generate a protective neutralizing antibody, and the SAA1 recombinant protein vaccine has a remarkable protective effect on kidney diseases induced by ischemia / reperfusion and ureteral obstruction. Therefore, the SAA1 is an intervention target for preventing and treating the kidney diseases, the SAA1 recombinant protein vaccine is an effective means for preventing and treating the kidney diseases, and active immunization by adopting the vaccine is an effective strategy for preventing and treating the kidney diseases.

The utility model relates to a ureter stone removal catheter in the technical field of medical instruments, which comprises a sheathing canal, one end of the sheathing canal is fixedly connected with a swirling cavity, the other end of the sheathing canal is connected with a bending part, the sheathing canal is provided with a pressure detection hole and a pressure detection channel, and the pressure detection hole is communicated with the pressure detection channel. The other end of the pressure detection channel is connected with a detachable pressure sensor. The pressure sensor is reasonable in structure, the detachable pressure sensor is arranged, when the pressure sensor is not used, the sensor body can be detached to be stored conveniently, and when the pressure sensor is used, the sensor body and the sensor chip are connected conveniently, rapidly and reliably; the pressure sensor can monitor accurate and reliable data through the pressure detection channel, high pressure in a minimally invasive cavity is avoided, and the safety rate of an operation and the calculus removing efficiency are remarkably improved.