525 results about "Uretero-ureteral" patented technology

The negative pressure flexible ureteroscope sheath with the front end actively bent and telescopic comprises a sheath tube body, an operation channel is formed in the sheath tube body, an operation channel connector is fixed to the rear end of the sheath tube body, and a negative pressure suction connector communicated with the operation channel is fixed to one side of the rear end of the sheath tube body; the sheathing canal body is integrally formed by a telescopic bending section and a straight pipe section, pneumatic telescopic bending adjusting mechanisms are arranged on the upper side, the lower side, the left side and the right side of the telescopic bending section, and a pneumatic telescopic bending control mechanism is arranged at the rear end of the sheathing canal body. The front end of the flexible ureteroscope sheath can be telescopically adjusted and can be bent in multiple directions, the sheath tube can be telescopically adjusted at the rear end and is extremely easy and convenient to operate and adjust, and the sheath tube can increase the trafficability of calculi at the upper section of the ureter and prevent the ureter from being damaged.

The invention relates to a negative pressure suction ureter guiding sheath which comprises a sheath tube, a bending adjusting handle and a multifunctional connector which are connected in sequence. The sheathing canal is communicated with the multifunctional joint through the bending adjusting handle; the bending adjusting handle comprises an upper shell, a lower shell, a traction scroll and a locking assembly. The upper shell and the lower shell are connected to form a handle body, the traction wire disc is rotationally installed in a cavity defined by the lower shell and the upper shell, the traction wire disc is connected with the sheathing canal through a traction wire, and the traction wire disc rotates to drive the traction wire to pull the head end of the sheathing canal to be bent. The locking assembly is installed on the traction scroll and can be switched between a locking state and an unlocking state, and when the locking assembly is in the locking state, the traction scroll and the upper shell are relatively fixed; when the locking assembly is in the unlocking state, the traction wire disc can rotate relative to the upper shell, and the operation is convenient and fast, the handle does not need to be continuously operated, the operation burden of a doctor is effectively relieved, and the operation effect is improved.

The invention belongs to the technical field of biological medicine, and particularly relates to application of chlorbuconazole or salt thereof in preventing, relieving or treating diseases related to HIF-2alpha. In-vitro experiments prove that the chlorbuconazole enhances the transcriptional activity of HIF-2alpha so as to promote the expression of downstream genes regulated and controlled by the HIF-2alpha; it is proved that chlorburazol has the effects of increasing erythropoiesis and relieving renal injury on an aristolochic acid-induced zebra fish chronic kidney disease model, a cisplatin-caused acute kidney injury and renal anemia model and a unilateral ureteral obstruction model. Meanwhile, the traditional Chinese medicine composition belongs to new use of old medicines, so that the medicine research and development cost and the treatment cost are saved, and the traditional Chinese medicine composition has obvious economic benefits and clinical application values.

The invention relates to the technical field of medical apparatus and instruments, in particular to a pressure sensing ureter guiding sheath which comprises a flexible sheath tube body provided with a near-end operation section and a far-end intervention section. The annular pressure sensing array is formed by equidistantly arranging a plurality of piezoresistive sensors along the circumferential direction of the far-end intervention section, and is used for monitoring the ureter wall contact pressure in real time; the signal processing module is integrated on the near-end operation section and is used for carrying out dynamic noise filtering and baseline calibration on the pressure signals from the annular pressure sensing array; and the display screen is connected to the signal processing module and is used for displaying the pressure distribution of the annular pressure sensing array in real time. The scheme is used for solving the problem of mechanical trauma caused by inappropriate size selection, pathological or physiological stenosis and the like in the sheathing canal implantation process in the prior art, and real-time monitoring and dynamic adjustment of the ureter wall contact pressure are realized, so that the surgical risk is reduced, and the surgical success rate is improved.

The invention relates to a ureteral access sheath (10) for insertion in the ureter (56) of a human or animal patient, wherein the access sheath (10) has, at a proximal end, an introduction portion (16) for a medical instrument and has an elongate portion (18) which extends from the proximal introduction portion (16) to a distal end (12) of the access sheath (10), wherein the elongate portion (18) comprises, over at least substantially the length of the elongate portion (18), at least one lumen (20) for guiding through the medical instrument. According to the invention, at least in some regions along the elongate portion (18), an elastically deformable cover element (22) is arranged on an outer wall of the lumen (20), wherein the cover element (22) can be deformed between a basic position, in which the cover element (22) rests against the outer wall of the lumen (20), and a guide-wire position, in which the cover element (22) is moved away from the outer wall of the lumen (20) by a guide wire (24) and forms a guide channel (26) for the guide wire (24).

An improved ureteral sheath, includes: an introducer sheath including a sheath tube and a sheath base arranged at a proximal end of the sheath tube, the sheath base is provided with a tube segment in communication with the sheath tube and a connecting part arranged at a distal end of the tube segment; the sheath tube is provided, from a proximal end to a distal end thereof, with a main body segment and a head segment arranged at a distal end of the main body segment, the main body segment is composed of a hard tube segment, and the head segment is composed of a deformable tube segment; and the tube segment extends outwards relative to a central axis thereof in a communication manner to form a negative pressure connecting tube, a tube wall of the negative pressure connecting tube is provided with vent groove.

The invention relates to the technical field of medical instruments, and discloses a flexible ureteroscope sheath device and a pressure control method thereof.The flexible ureteroscope sheath device is characterized in that one end of a connector tube seat is connected with a sheath tube, the other end of the connector tube seat is provided with three connectors, the first connector is connected with a pressure relief device and a control device, the second connector is used for a flexible ureteroscope and perfusion, and the third connector is used for negative pressure suction; a central channel is arranged in the sheathing canal, and passage type pressure measuring sensors are axially and uniformly arranged around the channel; the control device comprises an adjusting key, a digital display, an indicating lamp and a buzzer, and is electrically connected with the pressure measuring sensor and the pressure relief device; the control device comprises an automatic pressure relief module which is used for collecting analog voltage signals and converting the analog voltage signals into pressure data values, and when a detection value reaches a set threshold value, the electric control pressure relief device automatically relieves pressure. According to the invention, real-time and continuous detection and control of the pressure in the cavity are realized.

The invention discloses an anti-fibrosis drug coating degradable woven stent for treating urethrostenosis, the stent is a hollow cylinder formed by spirally weaving wires, the wires are made of biodegradable polymer materials, the surface of the stent is coated with a drug coating, anti-fibrosis drugs are selected as the drugs, and the anti-fibrosis drug coating is made of biodegradable polymer materials. The drug coating is prepared by using an ultrasonic atomization spraying method; the biodegradable polymer material comprises one or a compound of more than one of poly L-lactic acid, poly D, L-lactic acid, poly (L-lactic acid / D, L-lactic acid), poly (glycolide / lactide), poly (glycolide-lactide), poly (L-lactic acid / caprolactone), poly (glycolide / caprolactone), poly (D, L-lactic acid / caprolactone), polydioxanone and the like. The stent body is made into a self-expanding stent by adopting a weaving method; the biodegradable ureteral stent with the drug coating has good biocompatibility, degradability and mechanical property, and has a wide market application prospect.

The invention discloses a safe ureter dilatation guide wire system and a progressive pressure control method, and relates to the technical field of medical instruments.The safe ureter dilatation guide wire system comprises a guide wire body and a pressure sensor, the guide wire body comprises a water bag structure and a double-cavity structure which are communicated, the water bag structure is made of an elastic structure, and the double-cavity structure is made of an elastic material; the interior of the water bag structure is used for being filled with expansion liquid and expanding according to the target volume so as to expand the narrow position of the ureter. A guide wire cavity and a liquid injection cavity which are independently arranged are formed in the double-cavity structure, the guide wire cavity and the liquid injection cavity are both communicated with the water bag structure, the guide wire cavity is used for allowing the identification light source to penetrate through, and the liquid injection cavity is used for providing expansion liquid for the water bag structure; the pressure sensor is installed outside the water bag structure so as to detect the pressure of the inner wall tissue of the ureter in real time. According to the technical scheme, the problem that an existing ureter guide wire cannot monitor the deformation state of narrow tissue in real time is solved.

The present application belongs to the technical field of medical instruments. Provided are a negative pressure regulation and control structure and a ureteral access sheath. The negative pressure regulation and control structure comprises a negative pressure tube and a suction valve. The negative pressure tube is provided with a suction channel and a hole which are communicated with each other, wherein the suction valve is in a sliding fit with the negative pressure tube, and the flow area of the hole can be adjusted by sliding the suction valve. The suction valve comprises a valve main body and a connecting protrusion which are connected to each other, the valve main body being arranged outside the negative pressure tube; the connecting protrusion passes through the hole and partially protrudes out of the inner wall of the negative pressure tube, and is snap-fastened to the inner wall of the negative pressure tube, the face of the connecting protrusion snap-fastened to and abutting against the inner wall of the negative pressure tube is a limiting face; and in the direction from the side of the limiting face close to the hole towards the side away from the hole, the limiting face inclines in a direction away from the valve main body. By means of setting the limiting face to be inclined in the direction away from the valve main body so as to expand a mounting space between the limiting face and the valve main body, the present application reduces the amount of deformation of the valve main body required by the connecting protrusion entering the suction channel, thereby improving the convenience in mounting the suction valve.

Provided is a ureteral lithotripsy catheter, comprising a sheath (1). One end of the sheath (1) is fixedly connected to a vortex cavity (3), and the other end of the sheath (1) is connected to a bending section (9). The sheath (1) is provided with a pressure detection hole (8) and a pressure detection channel (10). The pressure detection hole (8) is in communication with the pressure detection channel (10). The other end of the pressure detection channel (10) is connected to a detachable pressure sensor. By means of arranging the detachable pressure sensor, the sensor body can be detached when not in use, facilitating storage. During use, the connection between the sensor body and the sensor chip is convenient, rapid, and reliable. The pressure sensor can monitor accurate and reliable data by means of the pressure detection channel, avoid high pressure in the minimally invasive cavity, and significantly improve the safety rate of surgery and the calculus removal efficiency.

A method of localizing a target anatomy involves advancing a ureteroscope to a target calyx of a kidney of a patient through at least a portion of a urinary tract of the patient, determining a positional offset between one or more position sensors associated with the ureteroscope and a target papilla of the kidney that is at least partially exposed within the target calyx, and determining a percutaneous access target based at least in part on one or more of a present position of the one or more position sensors or the positional offset.

Devices, systems, and methods for treating stones in anatomical structures are disclosed. A device may include an elongate member and a tubular member extending distally from the elongate member. The elongate member may define one or more lumens with an opening at a distal end of the elongate member. The tubular member may be configured to collapse to a pre-determined shape when in a relaxed state and expand in response to receiving an object. The device may be used with a scope, such as a ureteroscope, lithotripsy devices, and / or other medical devices or systems.

The present invention seeks to protect a renal pelvic pressure monitoring device, which includes a ureteroscope, an operation channel is provided in the ureteroscope, the ureteroscope is used to enter the renal pelvis from the ureter, a pressure detection ring is arranged around the outer wall of the ureteroscope, a pressure measuring channel is provided on the pressure detection ring, a pressure measuring pipe is arranged in the pressure measuring channel, one end of the pressure measuring pipe is flush with the pressure measuring channel, and the other end extends outside the body and is connected to the pressure detector, and a fixing bag is arranged around the outer wall of the pressure detection ring, and the fixing bag is used to fix the position of the ureter. In summary, the above technical scheme has the following beneficial effects: the ureteroscope is consistent with the existing surgical soft mirror, and has functions such as lighting, lithotripsy and liquid injection. The pressure detection ring on the ureteroscope can detect the pressure after the liquid is injected into the renal pelvis, and then the pressure in the renal pelvis can be further adjusted by adjusting the injection speed and injection amount through the ureteroscope.

The invention discloses application of SAA1 as a target spot in preparation of a medicine for preventing and treating kidney diseases, and belongs to the field of gene functions, application and biological medicine. In-vivo and in-vitro experiments prove that in an ischemia / reperfusion or ureteral obstruction induced mouse kidney disease model, the knockout of the SAA1 gene can relieve renal interstitial vascular endothelial cell injury, recover a renal capillary network, improve vascular permeability, reduce collagen deposition, inhibit renal fibrosis and effectively delay the progress of kidney diseases; furthermore, by adopting the SAA1 recombinant protein vaccine to immunize mice, the organism can be induced to generate a protective neutralizing antibody, and the SAA1 recombinant protein vaccine has a remarkable protective effect on kidney diseases induced by ischemia / reperfusion and ureteral obstruction. Therefore, the SAA1 is an intervention target for preventing and treating the kidney diseases, the SAA1 recombinant protein vaccine is an effective means for preventing and treating the kidney diseases, and active immunization by adopting the vaccine is an effective strategy for preventing and treating the kidney diseases.

The utility model relates to a ureter stone removal catheter in the technical field of medical instruments, which comprises a sheathing canal, one end of the sheathing canal is fixedly connected with a swirling cavity, the other end of the sheathing canal is connected with a bending part, the sheathing canal is provided with a pressure detection hole and a pressure detection channel, and the pressure detection hole is communicated with the pressure detection channel. The other end of the pressure detection channel is connected with a detachable pressure sensor. The pressure sensor is reasonable in structure, the detachable pressure sensor is arranged, when the pressure sensor is not used, the sensor body can be detached to be stored conveniently, and when the pressure sensor is used, the sensor body and the sensor chip are connected conveniently, rapidly and reliably; the pressure sensor can monitor accurate and reliable data through the pressure detection channel, high pressure in a minimally invasive cavity is avoided, and the safety rate of an operation and the calculus removing efficiency are remarkably improved.

The utility model provides an improved ureter sheath, which comprises an expanded sheath seat and a slender sheath tube, the size and shape of the sheath tube are suitable for entering a target area in a body through a body lumen, the sheath tube longitudinally extends from a near end to a far end, and the sheath tube defines a central channel longitudinally extending from the near end to the far end. The sheath base is coaxially connected to the near end of the sheath tube, a cavity communicated with the central channel is defined by the sheath base, the near end of the cavity is provided with an inlet allowing an instrument to enter, a sealing valve is arranged at the inlet, and the sealing valve comprises a passage penetrating through the sealing valve to allow the instrument to enter in a sealed mode; a connector communicated with the cavity is arranged on the sheath base, and the connector is suitable for being connected with external suction equipment so as to generate negative pressure in the central channel; a pressure regulating valve used for regulating the pressure in the cavity is arranged on the sheath seat, and the pressure regulating valve is arranged by avoiding a negative pressure suction path.

The invention discloses a prediction method for kidney stone prognosis based on CT imaging omics, and relates to the field of medicine. Comprising the following steps that CT images and clinical data are collected, retrieval is conducted through a hospital medical record system, clinical information is collected, and the CT images are scanned through a scanner; cT image processing and feature extraction are carried out, calculus areas are sketched layer by layer on all cross sections of the CT image, information is recorded, and then feature extraction is carried out; and image omics feature screening and model construction: extracting image omics features from each original CT image. According to the method, CT image features and clinical prediction factors are combined, a clinical-image omics model is developed and verified, a repeatable, non-invasive, non-invasive and safe preoperative prediction method is provided, the calculus removal success rate of a kidney stone patient after flexible ureteroscope lithotripsy can be accurately evaluated, and the calculus removal success rate of the kidney stone patient after flexible ureteroscope lithotripsy is improved. And a clinician can be assisted to make a clinical decision and implement precise medical treatment.

The invention belongs to the technical field of biological medicine, and particularly relates to an in-vitro fusion technology for multi-lineage human kidney organs and application thereof. The invention provides a method for realizing culture of multilineage kidney organs by fusing kidney units and ureteral bud organs in vitro. According to the in-vitro fusion technology of the kidney organoid reported by the invention, two organoid with different pedigree sources, namely the kidney unit and the ureteral bud, can be efficiently fused, a UB tubular structure is integrated into the kidney unit organoid, and the UB tubular structure starts from a single ureteral bud and is wrapped by kidney unit precursor cells in a similar in-vivo development process, and finally develops into a kidney with glomerulus and a plurality of kidney cells. The multi-lineage renal organ comprises a catheter, a proximal tube, a marrow tab thin section, a distal tube, a connecting tube and a ureteral bud with a single outlet. A framework is provided for an engineered renal unit and a smooth collection system, and the method is an important step for generating the functional renal tissue from the beginning.

To provide a ureteral stent removal tool and a ureteral stent removal method capable of easily and safely removing a placed ureteral stent.SOLUTION: Ureteral stent removal tools 1, 2 respectively comprise: hook-shaped hook parts 13, 23 which are formed of a rod-shaped member, and are formed on one end of the rod-shaped member, and to which a part of a stent placed in a body is hooked; grip parts 12, 22 which are formed on the other end of the rod-shaped member and are gripped by the fingers of an operator; and circular-column shaped or elliptic-column shaped body parts 11, 21 which connect the hook parts 13, 23 and the grip parts 12, 22. The hook parts 13, 23 are opened to the body parts 11, 21 side, and contours of the hook parts 13, 23 in view in an axial direction of the body parts 11, 21 are formed so as to be settled in contours of the body parts 11, 21.SELECTED DRAWING: Figure 1

The utility model belongs to the technical field of medical instruments, in particular to a ureter stent tube and a pulling device, which comprises a stent tube, a guide wire, a pushing tube, a catheter and a catcher, a plurality of tail wires are arranged on the stent tube, a plurality of suckers are arranged on the tail wires at equal intervals, one end of the pushing tube wraps the tail wires and is sleeved at the outer end of the stent tube, and the other end of the pushing tube is sleeved at the outer end of the catheter. A first operation cavity, a second operation cavity, an air inflation cavity and a water injection cavity are formed in the catheter, the first operation cavity and the second operation cavity facilitate penetrating of the guide wire and the capturing device, the air inflation cavity facilitates air inflation into the air bag, the water injection cavity injects water into the bladder, a traction base, a mounting plate and a reset spring are arranged in the capturing device, and the traction base is connected with the mounting plate and a pull ring through a traction rope. By means of the device, a stent tube can be directly pulled out conveniently, pain and inconvenience caused by pulling out of special instruments such as a cystoscope and a ureteroscope can be avoided, and meanwhile the economic burden of a patient is reduced.

The invention provides a flexible ureteroscope surgical robot and a supporting mechanism thereof. The supporting mechanism comprises a telescopic device which comprises a fixing part connected with a cantilever mechanism of the flexible ureteroscope surgical robot; the sliding piece is arranged on the fixed piece in a sliding and penetrating mode, and a plurality of positioning holes are formed in the sliding piece; the locking part is connected with the fixed part and arranged on the sliding part in a sleeving mode, the locking part comprises a locking column, and the locking column is inserted into the positioning hole through operation so that the sliding part can be prevented from sliding in the fixed part or the locking column can be separated from the positioning hole so that the sliding part can slide in the fixed part; one end of the clamping device is connected with the sliding part, and the other end of the clamping device is connected with a sheath of the flexible ureteroscope.

The flexible ureteroscope device comprises a flexible ureteroscope body and a sheathing canal body used for supporting the urethra to form a passage for the flexible ureteroscope body to enter, the flexible ureteroscope body comprises a miniature camera used for imaging and a holmium laser optical fiber used for cutting stones, a guide groove and a positioning groove are formed in the outer wall of the flexible ureteroscope body, and the guide groove and the positioning groove are communicated with each other. A balloon is connected into the sheath tube body and used for being matched with the flexible lens body to expand a narrow urethra area, a cross air pipe is fixedly connected to the outer side of the sheath tube body and used for injecting air into the balloon, a bearing seat is axially connected to the outer side of the sheath tube body in a sliding mode, and an adjusting assembly is connected into the bearing seat and used for driving the sheath tube body to move automatically. The adjusting assembly comprises a pressure sensor used for detecting the pressure in the ureter. According to the technical scheme, the operation cost is reduced, the operation period is shortened, and the stability of the operation process is improved.

Methods of identifying an enriched heterogeneous renal cell population having therapeutic potential, enriched heterogeneous renal cell populations having therapeutic potential and uses for same. In some embodiments, it includes a method of identifying an enriched heterogeneous renal cell population as having a therapeutic potential. In the method, it is determined whether cells of the enriched heterogeneous renal cell population express at least one: (i) ureteric bud and / or cap mesenchyme (UB / CM) marker; and / or (ii) podocyte marker.

The invention provides a flexible ureteroscope surgical robot and a bending device thereof. The bending device comprises a supporting frame, one end of the supporting frame is connected with a cantilever mechanism of the flexible ureteroscope surgical robot, and the other end of the supporting frame is connected with the flexible ureteroscope; the deflection driving part comprises a driving assembly connected with the supporting frame; one end of the transition piece is connected with the driving assembly, the other end of the transition piece is connected with a bending knob of the flexible ureteroscope, and the driving assembly drives the transition piece to drive the bending knob to rotate, so that the tip end of the flexible ureteroscope is bent.

The invention provides a flexible ureteroscope surgical robot and an optical fiber delivery device thereof. The optical fiber delivery device comprises a delivery base connected with a cantilever mechanism of the flexible ureteroscope surgical robot; a driving wheel; a driven wheel; the optical fiber driving part penetrates through the delivery base to be connected with the driving wheel so as to drive the driving wheel to rotate; and the control assembly is connected with the driven wheel and is configured to enable the driven wheel to be far away from or close to the driving wheel by operating the control assembly, so that the optical fiber is allowed to freely penetrate through the flexible ureteroscope between the driving wheel and the driven wheel, or the optical fiber is driven to move in the flexible ureteroscope based on the friction force between the driven wheel and the driving wheel.

The present invention relates to the technical field of medical surgical instruments, and particularly relates to a flexible ureteroscope, which includes an operating handle. A toggling member for controlling the bending direction and angle of the flexible ureteroscope is provided on the operating handle. The toggling member is rotatably connected to the operating handle. An angle indicating device is provided on the operating handle, and the angle indicating device is located on one side of the toggling member. By providing an angle indicating device on the operating handle and adjusting the toggling member to make the pointer correspond to different values on the angle indicating device, the bending state of the flexible ureteroscope inside the body can be obtained based on the data of the flexible ureteroscope outside the body. This enables the operation and learning of the flexible ureteroscope to be based on data and have a quantifiable standard to execute, increases the convenience during the surgical process, reduces the surgical difficulty, and shortens the learning curve of the flexible ureteroscope surgery.

A medical device includes a sheath extending longitudinally from a proximal end to a distal end and a handle coupled to the proximal end of the sheath. The handle includes a deflection lever coupled thereto. The deflection lever is rotatable proximally and distally along the handle to deflect a distal end of the shaft to which it is operably coupled and a locking mechanism movable between an locked configuration in which the locking mechanism engages an engagement feature on the outer surface of the handle, preventing the deflection lever from rotating and locking the distal end of the shaft in a desired position, and an unlocked configuration in which the locking mechanism releases the engagement feature to allow rotation of the deflection lever and deflection of the distal end of the shaft.

To provide a pump configured to be deployed in a patient's body.SOLUTION: A pump assembly for increasing urine output from a patient includes at least one ureteral catheter 614 including a distal portion having a retention portion 624 configured to be positioned in a kidney, renal pelvis, and / or ureter of the patient and a proximal portion defining a drainage lumen. The retention portion includes at least one drainage port 626 that permits fluid flow into the drainage lumen. The pump assembly further includes a pump 612 configured to provide negative pressure to at least one of the renal pelvis or the kidney through the drainage lumen of the at least one ureteral catheter. The pump includes at least one fluid port in fluid communication with the drainage lumen of the proximal portion of the ureteral catheter for receiving fluid from the patient's kidney, and at least a portion of the pump is configured to be positioned within the patient's body.SELECTED DRAWING: Figure 15A

The utility model relates to technical field of ureteral stent solves the technical problem that ureteral stent still needs special operation to take out, especially to a kind of ureteral stent of operation-free convenient to take out, including as the support base ureteral stent body, the ureteral stent body outside is provided with the limiting component for increasing its limiting capacity, the ureteral stent body bottom end is provided with the convenient component for taking out from the patient's body, the convenient component includes the fixed seat fixedly connected in the bottom of ureteral stent body both sides, the utility model discloses because the setting of convenient component, the process of ureteral stent body can be taken out from human body inside more convenient, and will not hurt patient urethra, so that patient oneself can also take out, need not suffer the harm of secondary operation, can also alleviate the burden of doctor simultaneously.