The invention relates to a medicine for treating kidney calculus, and belongs to the technical field of medicinal preparations. The medicine comprises pills and decoction, namely pills and oral liquid, wherein the pills consist of the following components in part by weight: 3 to 5 of amber, 55 to 75 parts of chicken's gizzard-membrane, 5 to 15 parts of akebia stem, 10 to 20 parts of rhubarb and 4to 8 parts of Japanese climbing fern spore; and the decoction consists of the following components in part by weight: 1 to 5 parts of bupleurum, 3 to 8 parts of liquoric root, 3 to 6 parts of red paeony root, 3 to 6 parts of black morning glory, 20 to 40 parts of longhairy antenoron herb, 0.5 to 3 parts of juncus pith, 4 to 8 parts of knotgrass, 12 to 25 parts of Mongolian dandelion her, 5 to 12 parts of pyrrosia leaf, 10 to 15 parts of corn stigma and 5 to 10 parts of bupleurum. The medicine for treating the kidney calculus also can be used for treating ureteral calculus, vesical calculus, urethra calculus, cholecyst calculus, calculus of bile ducts and the like, and the absorption is facilitated by administrating the pills and the oral liquid simultaneously; and due to the adoption of Chinese medicinal herbs, the medicine is small in side effect, good in curative effect and short in treatment course and is praised unanimously, and the relapse rate is almost zero.