87 results about "Kidney stone" patented technology

The invention belongs to the field of biomedicine, and particularly relates to application of CRYL1 protein in preparation of a product for evaluation, diagnosis or auxiliary diagnosis of postoperative recurrence risk of calcium oxalate kidney stone combined with renal nipple calcium spot, and the sequence of the CRYL1 protein is shown as SEQ ID NO.1. The invention discovers that the expression of the CRYL1 protein in renal tubules and collecting tube cells of renal papillary calcium spot tissues is reduced for the first time, and tests prove that the urine CRYL1 protein is a predictive factor and a predictive marker for postoperative recurrence of a patient with CaOx kidney stone combined with renal papillary calcium spot. The CRYL1 protein detection kit is further researched and developed to be used for detecting or evaluating the postoperative recurrence risk of patients suffering from CaOx kidney stone combined with renal nipple calcium spots, personalized follow-up visit and prevention schemes of the patients are promoted, and the CRYL1 protein detection kit has huge clinical application prospects.

Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and / or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.

The invention relates to the technical field of microorganisms, in particular to compound probiotics capable of degrading indole and preventing or relieving nephropathy and application of the compound probiotics. The compound probiotics comprise bifidobacterium animalis subsp. Lactis YYS-J9 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.28185 and bifidobacterium longum subsp. Longum YYS-BSM8 with the preservation number of CGMCC NO.28611. The invention further discloses a preparation method of the compound probiotics. Compared with the use of a single YYS-J9 strain or YYS-BSM8 strain, the two strains have synergistic effects after being compounded, the viable count is remarkably increased after mixed culture, the inhibition effect on pathogenic enterobacteria and the adhesion to intestinal cells are remarkably enhanced, the degradation capacity on indole and oxalic acid is higher, the proliferation and phagocytic activity of macrophages is remarkably improved, and the application range of the YYS-J9 strain and the YYS-BSM8 strain is widened. And when being applied to food, health-care products or medicines, the exopolysaccharide can be used for effectively preventing or improving nephropathy and kidney stone, regulating intestinal health and improving intestinal immunity.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

Disclosed in the present invention is an siRNA for inhibiting the expression of a urate transporter 1 (URAT1) gene in human cells. In the present invention, a plurality of siRNAs capable of inhibiting URAT1 expression are obtained by screening, and on this basis, appropriate modifications are performed to obtain sequences with improved target silencing ability. Drugs with the siRNAs as active ingredients are expected to be clinically applicable in the prevention and treatment of diseases related to the URAT1 target, such as gout, hyperuricemia, gouty arthritis and renal calculi.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

The present application provides a system for guided removal of particulate matter from a body of a subject, in particular a system for removing a plurality of small stone fragments from a kidney of a subject. The system comprises a ureter kidney access sheath, a kidney perfusion catheter, an imaging device and a double-acting pumping device. The ureteral kidney access sheath includes a fluid discharge port connected to a double-acting pumping device. The kidney perfusion catheter includes a fluid inlet port connected to the double-acting pumping device. Also disclosed is a method for removing particulate matter from a kidney of a subject, the method comprising using the system.

Kidney stone removal system is disclosed having components including a handle mechanism, a nozzle tip, and a guiding device. The handle mechanism employs a trigger that enables control of irrigation and vacuum / suction. Depression of a trigger in the trigger mechanism conveys status of vacuum / suction and irrigation to a user by providing increased resistance at different points of depression. When the trigger is in a home (undepressed) position, irrigation and vacuum / suction are turned off. When the trigger is in a fully depressed position, irrigation and vacuum / suction are turned on. When the trigger is in an intermediate position, irrigation may be turned on, while vacuum / suction remains turned off. The nozzle includes one or more irrigation ports positioned at a distal end of the nozzle and having an irrigation port departure angle of 30 to 60 degrees for directing irrigation fluid forward and laterally from the distal end of the nozzle. The guiding device is configured to be removably positioned in the nozzle for receiving a debris fragmentizing device, such as a laser device. The guiding device is configured to prevent an unintended movement of the fragmentizing device when the fragmentizing device is positioned in the nozzle while allowing fluid and debris to flow past the fragmentizing device and through a vacuum tube.

The invention discloses a kidney stone removal system. Assembly of the kidney stone removal system comprises a handle mechanism, a nozzle tip and a guiding device. The handle mechanism employs a trigger capable of controlling perfusion and vacuum / suction. A trigger in a pressing trigger mechanism may communicate the state of vacuum / suction and infusion to a user by providing increased resistance at different pressing points. The infusion and vacuum / suction are closed when the trigger is in an initial position (undepressed). When the trigger is in a fully depressed position, perfusion and vacuum / suction are open. When the trigger is in an intermediate position, infusion may be opened while vacuum / aspiration remains closed. The nozzle includes one or more perfusion ports at a distal end of the nozzle, each having a perfusion port departure angle of 30 to 60 degrees for directing perfusion fluid forward and laterally from the distal end of the nozzle. The guide device is configured to be removably positioned in the nozzle for receiving a debris crushing device, such as a laser device. The guiding device is configured to prevent unexpected movement of the fragment breaking device when the fragment breaking device is positioned in the nozzle while flowing fluid and fragments through the fragment breaking device and through the vacuum tube.

A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

The subject matter described herein includes a kidney stone suction tube device and related methods of use. According to one example, the disclosed subject matter includes a suction tube device comprising a flexible tubing element comprising a modified suction tube portion characterized as having U-shaped hollow lumen channel and an intra-renal portion characterized as having circular shaped lumen channel. The intra-renal portion of the suction tube device further includes a collection cylinder section configured for storing kidney stone fragments. In addition, the connection of the modified suction tube portion and the collection cylinder section includes a mesh filter element configured to prevent admittance of kidney stones into the modified suction tube portion of the flexible tubing element.

Kidney stone removal system is disclosed having components including a handle mechanism, a nozzle tip, and a guiding device. The handle mechanism employs a trigger that enables control of irrigation and vacuum / suction. Depression of a trigger in the trigger mechanism conveys status of vacuum / suction and irrigation to a user by providing increased resistance at different points of depression. When the trigger is in a home (undepressed) position, irrigation and vacuum / suction are turned off. When the trigger is in a fully depressed position, irrigation and vacuum / suction are turned on. When the trigger is in an intermediate position, irrigation may be turned on, while vacuum / suction remains turned off. The nozzle includes one or more irrigation ports positioned at a distal end of the nozzle and having an irrigation port departure angle of 30 to 60 degrees for directing irrigation fluid forward and laterally from the distal end of the nozzle. The guiding device is configured to be removably positioned in the nozzle for receiving a debris fragmentizing device, such as a laser device. The guiding device is configured to prevent an unintended movement of the fragmentizing device when the fragmentizing device is positioned in the nozzle while allowing fluid and debris to flow past the fragmentizing device and through a vacuum tube.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

Embodiments of the present disclosure generally relate to medical aspiration devices and methods of use thereof. In some cases, the devices are configured to generate a vacuum to capture and / or immobilize solid deposits at a location within a subject. Such configurations can be useful, for example, for removing intact kidney stones that are small enough to pass through a ureter. In some cases, the devices further include ablation instruments. Such devices can be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location within a subject (e.g., ablating a kidney stone that is too large to pass through a ureter). In some cases, the vacuum generated by the devices is used to remove the plurality of smaller particles from the location within the subject.

The invention provides a traditional Chinese medicine composition for improving kidney stone and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition for improving kidney stone comprises the following components in parts by weight: 25-35 parts of endothelium corneum gigeriae galli, 15-25 parts of semen coicis, 15-25 parts of herba lysimachiae, 15-25 parts of cacumen biotae, 5-15 parts of rhizoma alismatis, 10-20 parts of radix morindae officinalis, 10-20 parts of herba cistanche, 3-9 parts of radix angelicae pubescentis, 10-20 parts of fructus trichosanthis, 10-20 parts of semen boitae, 5-15 parts of radix angelicae sinensis, 5-15 parts of radix codonopsis, 5-15 parts of cassia twig and 15-25 parts of rhizoma dioscoreae. Through synergistic compatibility of the components, the kidney power can be effectively improved, calculi can be removed, the effect of stably improving kidney calculi is achieved, no damage is caused to the human body, the running capacity of other viscera can be synchronously improved, and the materials are safe, easy to obtain and free of toxic and side effects.

The invention relates to a triazole derivative and an application thereof in medicine, in particular to a compound shown in a general formula (I) or a stereoisomer, a tautomer, a deuterated compound, a solvate, a prodrug, a metabolite, pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate and a preparation method thereof, and an application of the triazole derivative in preparation of medicines for treating kidney stone, recurrent kidney stone, renal calculus and the like. The invention also relates to application of the pharmaceutical composition in drugs for treating type I primary hyperoxaluria (PH). # imgabs0 #

Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and / or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.

The invention discloses an application of a fibroblast growth factor 2 in preparation of a medicine for preventing and / or treating calcium oxalate kidney stone, and breaks through the technical prejudice that FGF-2 mainly promotes renal fibrosis in the prior art. It is found and proved for the first time that exogenous supplement FGF-2 can play a significant therapeutic effect in a calcium oxalate kidney stone model. Animal experiments prove that through intraperitoneal injection of FGF-2 (0.1 mg / kg / day), calcium salt crystal deposition in kidney tissue can be effectively reduced (Von Kossa dyeing verification), structural damage of renal tubular epithelial cells is relieved, inflammatory response is inhibited (HE dyeing verification), and meanwhile the serum creatinine and urea nitrogen level is remarkably improved. The invention provides a brand new molecular target and drug strategy for treatment of kidney stone, can be used as an effective auxiliary scheme of the existing physical lithotripsy technology, and reduces the risk of stone residue and recurrence.

This application discloses a biomarker for calcium oxalate kidney stones and its application, relating to the field of pharmaceutical technology. Specifically, it proposes a biomarker for calcium oxalate kidney stones, namely isolithocholic acid. It reveals that isolithocholic acid directly targets and activates the PARP1 protein, inducing parthanatos in renal tubular epithelial cells, leading to cell damage and a microenvironment conducive to crystal adhesion, ultimately driving kidney stone formation. Isolithocholic acid is specifically elevated in feces, serum, kidney, and urine in a calcium oxalate kidney stone model, and its spatial localization is associated with areas of renal tubular damage, indicating its high relevance as a diagnostic or risk warning biomarker.

This invention belongs to the field of biomedical technology, specifically disclosing the use of neuron-derived neurotrophic factors in the preparation of drugs for the prevention and treatment of kidney stones. Using a glyoxylate-induced mouse model of kidney calcium deposition, this invention demonstrates that neuron-derived neurotrophic factors can significantly reduce kidney calcium deposition, alleviate renal tubular structural damage, and improve renal function indicators. This achieves comprehensive intervention in the entire process of kidney stone disease, from crystal formation to tissue damage to functional abnormalities, exhibiting superior technical effects compared to single stone-dissolving or stone-expelling strategies, and possesses significant application value and clinical translational potential.

The invention belongs to the field of biomedicine, and relates to application of Herbacetin in prevention of renal nipple calcium spot related calcium oxalate kidney stone. The invention relates to an application of Herbacetin or pharmaceutically acceptable salt, ester, solvate, crystal form or prodrug thereof in preparation of a reagent for preventing renal papillary calcium spot related calcium oxalate kidney stone, the Herbacetin has the following structural formula: the Herbacetin is used for preventing and treating renal interstitial calcium salt deposition and Randall plaque progress for the first time, and experiments prove that the Herbacetin can be used for preventing and treating renal interstitial calcium salt deposition and Randall plaque progress. Herbacetin has the effect of inhibiting the inflammation induction of renal interstitial hydroxyapatite crystals on fibroblasts, and has the application prospect of improving the immune microenvironment of renal interstitial and the deposition of renal interstitial calcium salt.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

The application provides rhamnogalacturonan I, a pharmaceutical composition and a preparation method and application thereof, and belongs to the field of biotechnology and chemistry.A new rhamnogalacturonan I is separated from polygonum aviculare, and the structure and performance of the rhamnogalacturonan I are characterized.It is found that the new rhamnogalacturonan I can play an anti-kidney stone role.The new rhamnogalacturonan I has important clinical significance and application prospect in preparation of a medicine for preventing and / or treating kidney stones.

According to the invention, a human renal cortex proximal tubule epithelial cell HK2-CaOx model and a rat kidney stone animal model are adopted, differential modified proteins are analyzed and verified through a protein modification omics technology, and key factors and key sites of lactic acid modification participating in regulation and control of kidney stone generation are identified; single cell sequencing is combined with space transcriptome analysis, identification and subdivision of kidney cell subgroups, and differential expression ligand and receptor pairs and key signal channels of macrophages and renal tubular epithelial cells are analyzed through cell communication. On the basis, the key function of the LDHB protein lactic acid modification site K156 in the kidney stone progress process is identified, and a new molecular marker and a treatment target are provided for early diagnosis of kidney stone and intervention of kidney stone.

1. Name of the designed product: label (wolf kidney stone). 2. Use of the designed product: label for packaging container. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo that best shows the design points: main view of component 1. 5. The designed product is a thin product, and other views of component 1 and component 2 are omitted.

Devices for guiding an instrument into a body of a patient, at a targeted point of entry and along an insertion path at a targeted insertion angle, are described herein, such as a guide for an access needle in a PCNL procedure for accessing the kidney to remove kidney stones, the devices comprising a base component, a guide assembly, and optionally an insertion mechanism. The base component is aligned in use with the point of entry and the guide assembly cooperates with the base component to allow for the instrument to be aligned and fixed at any circumferential angle around an axis perpendicular to the point of entry and at any vertical angle ranging from 0 to 45 degrees away from the axis in a direction toward the body. The optional mechanism allows for mechanical insertion once the instrument is aligned and fixed. Devices and methods disclosed herein allow a medical professional to accurately and stably guide an instrument at a targeted point and angle and to a desired depth, while minimizing the exposure to radiation in the surgical field that is used to image the insertion path.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.

Implementations of the present disclosure generally relate to medical aspiration devices and their methods of use. In some cases, the devices are configured to create a vacuum to capture and / or immobilize a solid deposit at a location internal to a subject. Such configurations may be useful, for example, for removing intact kidney stones small enough to pass through the ureter. In some cases, the devices further include an ablation instrument. Such devices may be useful, for example, for ablating larger solid deposits into a plurality of smaller particles at a location internal to the subject (e.g., ablating kidney stones that are too large to pass through the ureter). In some cases, the vacuum created by the devices is used to remove the plurality of smaller particles from the location internal to the subject.