110 results about "Perfusion fluid" patented technology

The utility model discloses a filling system. The filling system comprises a first material barrel used for containing liquid materials and a second material barrel used for containing granular materials, the first material barrel is connected with a first pipeline, the second material barrel is connected with a second pipeline, the first pipeline is provided with a first pump body used for pumping liquid materials, the second pipeline is provided with a second pump body used for pumping granular materials, and the first pipeline and the second pipeline are separately arranged. According to the filling system provided by the embodiment of the utility model, the first pipeline for filling the liquid material and the second pipeline for filling the granular material are separately arranged, so that the filling amount is accurate when a product with particulate matters is filled, and the liquid material and the granular material are provided with independent conveying pipelines, so that the production efficiency is improved. The interference of hydrodynamic factors can be reduced, and the situation of pipeline blockage is reduced.

The invention relates to a system for storing or cultivating organ or tissue models and its use. The system is designed for verifying the functionality of the harvested organ or tissue models and allowing them to be processed. The system can be used for cultivating organ and / or tissue models harvested from donors and / or prepared using other techniques, such as using 3D and / or 4D bioprinting or electrospinning techniques, and comprises a chamber (2) for the organ or tissue models, which is equipped with means for measuring and adjusting the temperature of the perfusion liquid in the chamber, a perfusion liquid container (1), which is equipped with means for measuring and adjusting the temperature of the perfusion liquid therein, means (4) for measuring the glucose concentration in the perfusion liquid and adding glucose to the perfusion liquid in a metered amount, means (3) for measuring the pH of the perfusion liquid and adding a substance for adjusting the pH of the perfusion liquid in a metered amount, means for non-contact mixing of the perfusion liquid, and means for measuring and controlling the flow parameters of the perfusion liquid.

An intravascular device and methods of using the same are provided. An expandable portion includes struts movable between a collapsed position and an expanded position, and tissue modification element(s), each having a lower portion residing within or attached to one of the struts, an upper portion which extends outwardly from an outer surface of the strut and physically interacts with tissue during use. Irrigation and / or suction device(s) are provided for providing at least one of irrigation fluid and suction force at the expandable portion when operated.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

This invention relates to a method and application for enriching circulating tumor cells (CTCs) based on ambient temperature mechanical perfusion technology, belonging to the field of biomedical technology. The method comprises the following steps: flushing the liver resected during liver transplantation via the portal vein and hepatic artery, connecting it to an ambient temperature mechanical perfusion loop, and performing in vitro perfusion using simulated blood perfusion fluid; when perfusion exceeds 2 hours and the lactate content drops to <5 mmol / L, collecting the simulated blood perfusion fluid; and sequentially subjecting the simulated blood perfusion fluid to centrifugation, red blood cell removal, and white blood cell removal to obtain enriched circulating tumor cells (CTCs) for liver cancer. A human liver cancer ex vivo organ perfusion model is constructed using NMP technology to fully recreate the tumor microenvironment and CTC generation process, and the large volume of perfusion fluid is processed to achieve efficient enrichment of CTCs.

The subject matter of the present invention is a perfusion fluid in the form of an oil-in-water PFC nanoemulsion, methods of producing this perfusion fluid, and its use in particular for organ perfusion and as a blood substitute preparation.

The application provides a safe and effective water seal bottle for closed drainage of thoracic cavity, a liquid storage cavity is connected with the right top end of a U-shaped negative pressure display, the middle part of a right tube is connected with a water seal cavity, the top end of a left tube is communicated with atmosphere, and a thoracic cavity effusion and gas drainage tube is arranged on the top of the liquid storage cavity; the top of the water seal cavity is sequentially connected with a drainage flow control valve, a negative pressure adjusting valve and a negative pressure generator; a first floating ball float rod in the liquid storage cavity penetrates through a first connecting tube upward and is fixed to an outer shell; a second floating ball is arranged on the upper end of the left tube, and a third floating ball is arranged on the top end of the right tube. The first connecting tube is provided with a one-way valve; the negative pressure display and the water seal cavity are filled with liquid, the liquid surface is higher than the right side of the negative pressure display when there is no negative pressure, the liquid is connected with the water seal cavity, and a slanting tube is arranged below the liquid surface of the water seal cavity; the application is injected with standard water when leaving the factory, liquid does not need to be injected into the water seal cavity and the negative pressure observation cavity when being used, and the application is provided with an over-negative pressure automatic protection function, a slanting tube observer and a flow adjusting valve, is convenient to move and carry, and prevents the liquid in the liquid storage cavity from flowing back.

The present application relates to a kind of arthroscopic approach water leakage prevention device, including the elastic cover with dome structure, the sealing valve being arranged in the center position of cover and negative pressure suction mechanism, sealing valve has the conical hollow structure extending to base direction and gradually reducing outer diameter, reverse compensation sealing is realized using joint cavity infusion liquid pressure, cover base edge is equipped with flexible sealing skirt, by the negative pressure interface connection external negative pressure source, so that cover and skin form negative pressure sealing space, the device can be connected in series by negative pressure interface multiple occluder, and equipped with detachable guide rod auxiliary coaxial positioning.The present application uses non-insertion type surface adsorption occlusion, effectively solve the space interference and tissue damage problem in multiple tunnel operation, realize the dynamic water stop of pressure self-adaption, with the advantages of simple operation, sealing stable, strong dissection adaptability, can significantly improve the operation visual clarity and maintain joint cavity pressure stability.

An endoscope includes a handle including a handle housing, an irrigation inlet port adapted to receive irrigation fluid, and an irrigation channel; and an insertion cord extending distally from the handle. The insertion cord includes an insertion tube; a bending section extending from the insertion tube; a distal tip extending from the bending section and including a tip housing; a camera at least partially enclosed in the tip housing; interstitial space within the insertion tube in fluid communication with the irrigation channel; and at least one interstitial flow opening in fluid communication with the interstitial space and adapted to discharge the irrigation fluid.

Serum albumin is an important molecule in human and animal blood. It provides oncotic pressure and acts as a transportation agent, delivering nutrients from the blood to the tissue and removing waste products from the tissue to the blood. This invention describes an organ preservation and / or perfusion solution which comprises acetylated serum albumin, as well as method of making and using such a solution, and uses of acetylated serum albumin itself. The acetylated serum albumin utilised in the present invention can protect the vascular endothelium during perfusion of an isolated organ or tissue.

The application discloses an ultrasonic emulsification perfusion assembly, which comprises a metal connector, a plastic needle tube arranged in the metal connector, a metal perfusion sleeve provided with a water inlet and a perfusion port, and a plastic clamping perfusion sleeve which is sleeved outside the metal perfusion sleeve and forms a liquid storage space, wherein the water inlet is arranged in the liquid storage space. The application has the following beneficial effects: the slender needle head of the plastic needle tube can improve the stability of the anterior chamber and reduce the probability of surge occurrence; the relatively soft plastic needle head tip can also reduce the probability of puncturing the lens capsule; the metal perfusion sleeve effectively separates the ultrasonic emulsification needle tube body from the extrusion of the incision, greatly reduces or even eliminates the incision burn caused by ultrasonic friction; the relatively hard metal perfusion sleeve effectively prevents the perfusion liquid from being reduced or blocked due to the extrusion or distortion of the incision, thereby improving the stability of the anterior chamber and reducing the probability of surge occurrence.

The present disclosure describes techniques for providing directed instillation or irrigation of fluid during wound therapy to deliver cleansing fluid precisely onto a wound to improve wound cleansing. Directed instillation or irrigation of fluid onto wounds using techniques of the present disclosure can accelerate wound healing and provide improved patient outcomes. One example of the present disclosure is a device for providing directed fluid irrigation to a wound. The device can include an irrigation tube extending between a first end and a second end, with the second end having a perforated section or a non-perforated closed section. The device can further include a foam structure arranged around the perforated section, with the foam structure being configured to dispense fluid received from the perforated section uniformly into a wound for cleansing. The perforated section can include a plurality of perforations or a plurality of perforated irrigation tubes in examples.

A composition and method for perfusing tissue. A perfusate is composed of an endothelial cell stabilizer. thrombocyte concentrate (TC). The perfusate may further comprise a protein solution that may be an albumin-based solution or fresh frozen plasma (FFP). The perfusate composition may further comprise red blood cells. The perfusate composition may be perfused through an organ that has been removed from an organ donor and is being prepared for transport and transplant into a recipient. The perfusate composition may be perfused through an organ using a machine perfusion device.

Systems and methods are provided herein for preparing a non-naturally-occurring preparation of DNA from perfusion fluid or flush, the preparation being useful for assessing transplantation outcomes of a donor organ or donor tissue which was perfused with the perfusion fluid or prepared for transplantation with flush. The preparation may also be useful for evaluating quality of the organ or tissue. Analysis of the DNA may be used to make clinical decisions. Analysis of the DNA may also be used for adaptive control of a mechanical perfusion system used for preserving the organ or tissue, by generating and executing appropriate parameter adjustments based on characteristics of the sampled DNA.

The invention relates to an organ perfusion device (1), which in one embodiment comprises: a perfusion fluid container (2); an oxygenator (4) in fluid communication with the perfusion fluid container (2) by means of a deoxygenated perfusion fluid supply line (LI) comprising a pump (5); an organ container (3) in fluid communication with the oxygenator (4) by means of a primary oxygenated perfusion fluid supply line (L2) and in fluid communication with the perfusion fluid container (2) by means of a deoxygenated perfusion fluid discharge line (L7) and a seeping perfusion fluid discharge line (L8); and a set (17) of syringe pumps in fluid communication with the perfusion fluid container (2). The primary oxygenated perfusion fluid supply line (L2) comprises an arterial filter (51) in fluid communication with the perfusion fluid container (2), a perfusion fluid heat exchanger (6) with a perfusion fluid temperature sensor, a pH sensor (8), a dissolved oxygen sensor (9), a flow sensor (10) and a pressure transducer (11). The deoxygenated perfusion fluid discharge line (L7) comprises a pressure transducer (21), a throttle valve (22), a dissolved oxygen sensor (23) and a sampling unit (24). The invention also relates to an organ perfusion container (3).

A parathyroid gland perfusion preservation device is provided, which relates to the field of human organ preservation technologies. The device includes a parathyroid gland preservation box, a perfusion liquid circulation system and a control system. The parathyroid gland preservation box defines a space for placing parathyroid glands. The perfusion liquid circulation system is connected to the parathyroid glands stored in the parathyroid gland preservation box through inlet pipes, indwelling needles and a reflux pipe to supply perfusion liquid to the parathyroid glands. The control system is electrically connected to components of the perfusion liquid circulation system, and configured to receive a working state signal of the components of the perfusion liquid circulation system, and send a control instruction to the components of the perfusion liquid circulation system according to the working state signal. The device can achieve in vitro preservation of parathyroid glands, and can effectively protect the parathyroid glands.

A device for transporting an organ or tissue. The device comprises a container for containing the organ or tissue and a pneumatic pump for pumping a perfusion fluid in order circulating the perfusion fluid through the organ or tissue. The device comprises a holder for holding at least one gas vessel comprising pressurised gas. The pressurised gas is used to create a pulsating gas flow to the pump for pumping the perfusion fluid.

A three-dimensional (3D) lymphoid tissue model is provided, the model including a cellularized stromal compartment and a plurality of cellularized compartments including lymphocytes disposed within the stromal compartment; and a controlled fluid perfusion system configured to perfuse the model with a perfusion fluid. Methods of fabricating a 3D lymphoid tissue model and producing antibodies with the 3D lymphoid tissue model are also provided.

The utility model discloses a pasting film for otology operation, which belongs to the technical field of medical consumables and comprises a film body, a liquid collecting hopper connected with the film body for forming, a connecting film, a second opening arranged on the surface of the connecting film and corresponding to the first opening, and the liquid collecting hopper is connected with the film body for forming. And a strip-shaped side opening communicated with the second opening is formed in the surface of the connecting film. The ear protection film has the beneficial effects that the connecting film, the second opening and the strip-shaped side opening are arranged, so that the second opening of the connecting film corresponds to the first opening in the film body, and the film body is firstly adhered to the ear of a patient, so that the ear penetrates out of the first opening; the connecting film is attached to the film body after being sleeved on the ear through the strip-shaped side opening, the design is tightly attached to the outline of the ear, flushing or perfusate permeation is effectively blocked, pollution of an operation area and discomfort of the ear of a patient are avoided, cleanliness and comfort of the ear operation are improved, and the postoperative infection risk is reduced.

The utility model provides an infusion pump assembly and an intrusive pump flow catheter, an infusion pump comprises an impeller, a supporting tube body and a transmission mechanism, a liquid drainage flow channel is arranged in the supporting tube body, and the liquid drainage flow channel extends from the far end part of the supporting tube body to the near end part of the supporting tube body; the impeller is arranged outside the far end of the supporting tube body; the transmission mechanism comprises a transmission shaft and a bearing, the bearing is located in the supporting pipe body, the transmission shaft is in transmission connection with the impeller, and the transmission shaft is rotatably arranged in the supporting pipe body through the bearing; the bearing is located on the path of the liquid discharging flow channel and provided with a through hole or a through groove penetrating in the axial direction, and the through hole or the through groove is communicated with the liquid discharging flow channel. Due to the fact that the bearing is located on the path of the liquid discharging flow channel and the bearing is provided with the through hole or the through groove which is through in the axial direction and communicated with the liquid discharging flow channel, perfusate can penetrate through the bearing through the through hole or the through groove when being discharged along the liquid discharging flow channel, the area of an overflowing section when the perfusate flows through the bearing is increased, and resistance borne when the perfusate is discharged is reduced.

This invention belongs to the field of biomedical technology and provides a high-throughput drug screening system and its usage method for enriching circulating tumor cells (CTCs) in liver cancer. It includes an information processing and control unit; a diseased liver perfusion device comprising an organ chamber containing injection fluid at the bottom, an arterial supply line, an arterial end sensor, an arterial end clamp valve, at least two membrane lungs, a portal vein supply line, a portal vein end clamp valve, and a portal vein end sensor; a CTC enrichment device, which uses erythrocyte lysis to remove erythrocytes and immunomagnetic bead labeling to remove leukocytes, enabling the processing of large volumes of perfusion fluid in a single step to obtain enriched circulating tumor cells; a high-throughput drug screen; and phototubes, arterial end sensors, and portal vein end sensors, each electrically connected to the information processing and control unit. Compared with existing technologies, the high-throughput drug screening system and its usage method of this invention have the advantages of establishing a room-temperature mechanically perfused ex vivo liver cancer model, realizing the processing of large volumes of liquid specimens, and providing automated high-throughput drug screening functionality.

This utility model belongs to the field of living organism preservation technology, and in particular relates to a limb perfusion and transport device. The limb perfusion and transport device includes an insulated outer shell, a limb box, a solution container, and a perfusion system. The insulated outer shell contains a cold zone chamber and a waste liquid chamber for containing a waste liquid bag; the limb box contains a limb chamber for containing the severed limb, and is at least partially located within the cold zone chamber; the solution container contains a solution chamber for containing the perfusion fluid, located within the cold zone chamber, and is spaced apart from the limb box in the X direction. A filling port for adding a cold-storing substance to the cold zone chamber is located between the solution container and the limb box; the perfusion system is located within the insulated outer shell and connects the solution container, the limb box, and the waste liquid bag, so that the perfusion fluid in the solution chamber is infused into the severed limb in the limb chamber and then into the waste liquid bag. In this device, the perfusion fluid in the solution container is only infused once, ensuring the viability of the severed limb, and the miniaturized design facilitates transport.

An apparatus suitable for clamping at least one microfluidic device, which includes (i) a fluid-tight chamber having a fluid inlet, the chamber being configured to receive a microfluidic device to be clamped by compression of at least one deformable part of the microfluidic device under the action of a pressure of a clamping fluid in the chamber, and (ii) a perfusion fluid management system configured to adjust the pressure of a perfusion fluid in the microfluidic device in such a way that, during a clamping operation, the pressure of the clamping fluid in the chamber is strictly higher than the pressure of the perfusion fluid in the microfluidic device.

A system for ex vivo normothermic organ preservation may include a pump configured to circulate a perfusate through a perfusion circuit, an oxygenator coupled configured to oxygenate the perfusate, a heat exchanger configured to regulate a temperature of the perfusate and an organ chamber having an internal volume configured to receive an organ. The perfusion circuit may be configured to be coupled in fluid communication with an arterial inlet into the organ. The system may also include a processor and memory having instructions that when executed by the processor cause the system to carry out a method. The method may include changing a temperature of the perfusate from an initial temperature to a normothermic temperature within a normothermic temperature range, maintaining the perfusate within the normothermic temperature range for at least one hour, receiving sensor data for perfusate parameters, and displaying the sensor data.

An apparatus for perfusing an eye or portions thereof, includes: an enclosure configured to provide physical protection to an eye or portions thereof; and a fluid flow loop extending from an outlet connection of the enclosure to an inlet connection of the enclosure, the fluid flow loop including a pump, an oxygenator, and a waveform generator; and at least one sensor operable to sense a parameter of a perfusate flowing within the fluid flow loop and generate a signal representative thereof; and a control and monitoring unit configured to receive.

The utility model discloses a kind of automatic continuous filling's corpse antiseptic high-pressure perfusion device, including liquid storage tank, medicament box, automatic liquid preparation liquid filling device, medicament box is sequentially connected liquid storage tank by medicament branch pipe, first solenoid valve, first flowmeter, medicament main pipe, the upper portion of liquid storage tank is connected distilled water tank by water pipe, second flowmeter, second solenoid valve;Automatic liquid preparation liquid filling device includes liquid pump, controller and liquid level sensor, the import of liquid pump is connected liquid storage tank by liquid extraction pipe, the outlet of liquid pump is connected perfusion needle by gate valve, liquid guide pipe, hose;Liquid level sensor is arranged in liquid storage tank, and upper and lower limit switch of liquid level sensor is electrically connected with first solenoid valve, second solenoid valve, liquid pump switch and controller respectively.The utility model integrates automatic liquid preparation and high-pressure liquid filling function, can continuously, stably obtain sufficient perfusion fluid supply, realizes high pressure, automatic, continuous perfusion, improves perfusion efficiency and uniformity.

Disclosed herein are components, systems, and methods to maintain a stable pressure within a body cavity. A tubing set may deliver irrigation fluid to a body cavity or remove waste fluid from the body cavity. An irrigation system may include one or both of the tubing sets that deliver irrigation fluid to the body cavity and remove waste fluid from the body cavity. The tubing set includes a primary path from a fluid reservoir to the body cavity via a pump, and a secondary path that bypasses the pump. The secondary path may include a constriction with a reduced internal cross-sectional dimension that is smaller than the internal cross-sectional dimensions of other components of the tubing set.

Systems and methods for selectively perfusing cadaverous organ systems for surgical simulation are provided. A first fluid reservoir contains a first perfusion fluid and fluidically connects to conduit, which fluidically connects to a first body part associated with the organ system. A pump fluidically connects to the first reservoir and conduit and directs the first perfusion fluid into the first body part. A second fluid reservoir contains a second perfusion fluid and fluidically connects to conduit, which fluidically connects to a second body part associated with the organ system. In aspects, the second fluid reservoir is positioned at higher elevation than the organ system to create passive feed pressure of the second perfusion fluid to the second body part. The systems may include drainage mechanisms from the organ system. Aspects include selective perfusion of the liver, thorax, head and neck, and / or extremities of a cadaver.

The utility model provides an isolated organ perfusion preservation device which comprises an organ preservation assembly, a perfusion circulation assembly, a temperature adjusting assembly and a control assembly. The organ preservation assembly comprises a preservation tank body, an organ tray and a side plate supporting frame, the preservation tank body comprises an inner layer and an outer layer, the organ tray and the side plate supporting frame are both arranged in the inner layer of the preservation tank body, the side plate supporting frame is connected with the organ tray in the circumferential direction, and the organ tray is used for supporting an isolated organ; the perfusion circulation assembly comprises a perfusion liquid container, a gas separator and a filtering remover, the perfusion liquid container comprises an inner layer and an outer layer, and the inner layer of the perfusion liquid container is communicated with the inner layer of the storage tank body; the temperature adjusting assembly comprises a temperature adjusting liquid container, a temperature sensor and a temperature control unit, and the temperature adjusting liquid container, the outer layer of the storage tank body and the outer layer of the perfusate container are communicated with one another; the control assembly is connected with the temperature adjusting assembly and comprises a filtering unit and a PID adjusting unit. The utility model is beneficial to improving the organ preservation quality and improving the success rate of transplantation operation.

The invention discloses a multi-cavity ureter sheathing canal system integrating flushing and pressure monitoring functions, and relates to the technical field of medical instruments, the multi-cavity ureter sheathing canal system is characterized by comprising a sheathing canal main body and a micro-catheter channel, the micro-catheter channel is integrated in the wall of the sheathing canal main body, and the micro-catheter channel is communicated with the sheathing canal main body. The sheathing canal main body is provided with a main working channel penetrating through the sheathing canal main body, and the micro-catheter channel and the main working channel extend in parallel; a flexible ureteroscope is arranged in the main working channel in a penetrating mode, and a lateral suction connector is arranged at the near end of the main working channel and used for being connected with a negative pressure suction device. The near end of the sheath tube body is connected with a ureter sheath base, and a water sealing cap is connected to an opening in the near end of the ureter sheath base. The system can continuously supplement perfusate to the pelvis during negative pressure suction, maintain the shape of the pelvis, avoid mucosal injury and realize real-time and accurate pressure monitoring in an operation, so that the broken stone removal efficiency and the operation safety are remarkably improved.