176 results about "Perfusion fluid" patented technology

The invention relates to the technical field of medical instruments, and provides an organ low-temperature perfusion system and a perfusion device.The organ low-temperature perfusion system comprises an organ bin and a perfusion assembly; the perfusion assembly is used for providing perfusion power and perfusing perfusion liquid into the blood vessel of the biological organ through the perfusion channel; the perfusion assembly comprises an oscillation generator, and the oscillation generator is used for applying alternating oscillation to perfusate, so that the perfusate flows in the perfusion channel and the blood vessel of the biological organ in a periodic oscillation state; a boundary layer can be broken by oscillating fluid flow, so that perfusate is more tightly attached to the surface of an organ, and the heat transfer efficiency is improved; the ice crystal structure which is being formed can be damaged, and the icing process is slowed down; a dead zone of fluid in an organ can be reduced, the uniformity of perfusate is ensured, the local temperature gradient is reduced, and tissue damage is reduced; in addition, the oscillating flow of the perfusate can more accurately simulate the physiological conditions in a real living body, and an environment closer to the interior of the living body is provided.

Systems and methods of in situ unclogging a working channel in a medical device during a procedure are disclosed. An exemplary unclogging system comprises a flow sensor to sense a flow rate through a working channel, and a control module to detect a channel state indicating a presence or absence of clogging based on the flow rate. In the presence of channel clogging, the control module can control one or more of an irrigation source or a suction source to provide respectively irrigation fluid or suction pressure to unclog the obstructed channel. The control module can adjust one or more of an irrigation flow rate or a suction flow rate through the working channel to maintain a desired pressure of the anatomical environment at the anatomical site, or to maintain a desired flow condition in the working channel, during the procedure.

The invention discloses an organ mechanical perfusion system which comprises a liquid storage container used for storing perfusion liquid; the perfusion pump is used for extracting the perfusion liquid in the liquid storage container and perfusing the organ through the perfusion pipeline; the oxygenator is used for oxygenating perfusate and organs; the temperature control module is used for maintaining the temperature of the organ and the perfusate in a set range; the main control module is used for controlling the perfusion pump and the temperature control module according to the perfusion parameters, controlling the temperature control module to place the organ in a low-temperature state in a first time period, and controlling the perfusion pump to stop perfusion action or perform slow perfusion action in the low-temperature state so as to enter a maintenance stage; and in the second time period, the temperature control module is controlled to place the organ in a normal temperature or sub-normal temperature state, and the perfusion pump is controlled to execute normal perfusion action in the normal temperature or sub-normal temperature state, so that a normal perfusion stage is started. Wherein the maintenance stage of the first time period and the normal perfusion stage of the second time period can be alternately carried out.

The invention relates to the technical field of organ transplantation, and discloses organ preserving fluid, application and organ dynamic supercooling perfusion equipment. The organ preserving fluid is prepared from ribose, glucose, mannitol, lidocaine, adenosine, a high-molecular polymer, L-proline, trehalose, inorganic salt and organic salt. The high-molecular polymer comprises one of hydroxyethyl starch, polyethylene glycol and albumin. According to the organ preserving fluid disclosed by the invention, the freezing point of the perfusate is reduced through the micromolecular cryoprotectant, and meanwhile, the micromolecular cryoprotectant and the high-molecular polymer jointly inhibit formation and growth of ice crystals; the problem of liquid preservation at the temperature below zero is solved from the two dimensions of physics (reducing the freezing point and inhibiting ice crystals) and biology (maintaining cell viability), and feasibility is provided for long-time low-temperature transfer and transplantation of organs. The preserving fluid can be used for static preservation or perfusion preservation of various organs such as kidney, liver, heart, pancreas, lung, small intestine, skin and the like.

To provide a system and method for ventilating an organ.SOLUTION: Provided are a system and method for maintaining vitality of an organ (1029) ex vivo, such as a lung, through negative pressure ventilation (NPV) and perfusion. The system includes fluidically coupled components: an organ enclosure (107), a diaphragm enclosure (109), an actuator / pump (105), a valve (112), a reservoir (103), and a perfusion system. The actuator can displace a precise amount of a working fluid that displaces a precise amount of a sterile support fluid. The sterile fluid travels between the diaphragm enclosure and the organ enclosure, thereby ventilating the organ within an organ chamber. The perfusion system circulates a perfusion fluid through the organ.SELECTED DRAWING: Figure 1

The invention belongs to the field of medical equipment, and provides an organ perfusion device, which comprises a liquid storage bin, a perfusion device and a control device, the organ bin is used for storing isolated organs; the pump is used for driving perfusate; the perfusion pipeline is used for perfusion of an isolated organ, is provided with two or more flow division pipelines and is used for perfusion and flow division; the temperature maintaining system is used for maintaining the perfusate and the isolated organ at different temperatures; the oxygenator is used for oxygenating the perfusate; the central control system is used for system control; the perfusion pipeline is driven by the pump to extract perfusion liquid from the liquid storage bin to perfuse the isolated organ in the organ bin. Metabolic waste can be prevented from entering circulation again through one-way perfusion, low-temperature and normal-temperature double-phase automatic switching is achieved, one-way tidal perfusion is achieved, the device structure is obviously simplified, and the overall performance such as safety, stability and portability is improved.

The invention discloses a lens anterior-posterior capsule polisher, which is characterized in that a cleaning part is communicated with a pipeline part to form an integrated instrument. One part of the surface of the cleaning part is provided with a frosted part, and the other part of the surface is provided with a plurality of through holes. The frosted part can polish the anterior lens capsule by utilizing friction force, residual lens cortex and epithelial cells are removed, the postoperative lens capsular bag contraction probability is reduced, and the stability of the intraocular lens and the postoperative vision durability are enhanced. The through hole is matched with the pipeline part, and when the free end of the pipeline part is connected with intraocular perfusate, the perfusate can be sprayed through the through hole in multiple angles and multiple directions to wash and polish the posterior capsule. Compared with a bald needle head used in an existing water polishing technology, the polisher is wider and more uniform in flushing, operation safety can be effectively improved, postoperative vision and visual quality are improved, and the occurrence rate of posterior cataract is reduced. By means of the design, front and rear capsule membranes are polished through a single instrument, frequent instrument replacement in an operation is avoided, operation steps are simplified, and the operation effect and safety are improved.

The utility model discloses a filling system. The filling system comprises a first material barrel used for containing liquid materials and a second material barrel used for containing granular materials, the first material barrel is connected with a first pipeline, the second material barrel is connected with a second pipeline, the first pipeline is provided with a first pump body used for pumping liquid materials, the second pipeline is provided with a second pump body used for pumping granular materials, and the first pipeline and the second pipeline are separately arranged. According to the filling system provided by the embodiment of the utility model, the first pipeline for filling the liquid material and the second pipeline for filling the granular material are separately arranged, so that the filling amount is accurate when a product with particulate matters is filled, and the liquid material and the granular material are provided with independent conveying pipelines, so that the production efficiency is improved. The interference of hydrodynamic factors can be reduced, and the situation of pipeline blockage is reduced.

The invention relates to a system for storing or cultivating organ or tissue models and its use. The system is designed for verifying the functionality of the harvested organ or tissue models and allowing them to be processed. The system can be used for cultivating organ and / or tissue models harvested from donors and / or prepared using other techniques, such as using 3D and / or 4D bioprinting or electrospinning techniques, and comprises a chamber (2) for the organ or tissue models, which is equipped with means for measuring and adjusting the temperature of the perfusion liquid in the chamber, a perfusion liquid container (1), which is equipped with means for measuring and adjusting the temperature of the perfusion liquid therein, means (4) for measuring the glucose concentration in the perfusion liquid and adding glucose to the perfusion liquid in a metered amount, means (3) for measuring the pH of the perfusion liquid and adding a substance for adjusting the pH of the perfusion liquid in a metered amount, means for non-contact mixing of the perfusion liquid, and means for measuring and controlling the flow parameters of the perfusion liquid.

An intravascular device and methods of using the same are provided. An expandable portion includes struts movable between a collapsed position and an expanded position, and tissue modification element(s), each having a lower portion residing within or attached to one of the struts, an upper portion which extends outwardly from an outer surface of the strut and physically interacts with tissue during use. Irrigation and / or suction device(s) are provided for providing at least one of irrigation fluid and suction force at the expandable portion when operated.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

This invention relates to a method and application for enriching circulating tumor cells (CTCs) based on ambient temperature mechanical perfusion technology, belonging to the field of biomedical technology. The method comprises the following steps: flushing the liver resected during liver transplantation via the portal vein and hepatic artery, connecting it to an ambient temperature mechanical perfusion loop, and performing in vitro perfusion using simulated blood perfusion fluid; when perfusion exceeds 2 hours and the lactate content drops to <5 mmol / L, collecting the simulated blood perfusion fluid; and sequentially subjecting the simulated blood perfusion fluid to centrifugation, red blood cell removal, and white blood cell removal to obtain enriched circulating tumor cells (CTCs) for liver cancer. A human liver cancer ex vivo organ perfusion model is constructed using NMP technology to fully recreate the tumor microenvironment and CTC generation process, and the large volume of perfusion fluid is processed to achieve efficient enrichment of CTCs.

The subject matter of the present invention is a perfusion fluid in the form of an oil-in-water PFC nanoemulsion, methods of producing this perfusion fluid, and its use in particular for organ perfusion and as a blood substitute preparation.

The application provides a safe and effective water seal bottle for closed drainage of thoracic cavity, a liquid storage cavity is connected with the right top end of a U-shaped negative pressure display, the middle part of a right tube is connected with a water seal cavity, the top end of a left tube is communicated with atmosphere, and a thoracic cavity effusion and gas drainage tube is arranged on the top of the liquid storage cavity; the top of the water seal cavity is sequentially connected with a drainage flow control valve, a negative pressure adjusting valve and a negative pressure generator; a first floating ball float rod in the liquid storage cavity penetrates through a first connecting tube upward and is fixed to an outer shell; a second floating ball is arranged on the upper end of the left tube, and a third floating ball is arranged on the top end of the right tube. The first connecting tube is provided with a one-way valve; the negative pressure display and the water seal cavity are filled with liquid, the liquid surface is higher than the right side of the negative pressure display when there is no negative pressure, the liquid is connected with the water seal cavity, and a slanting tube is arranged below the liquid surface of the water seal cavity; the application is injected with standard water when leaving the factory, liquid does not need to be injected into the water seal cavity and the negative pressure observation cavity when being used, and the application is provided with an over-negative pressure automatic protection function, a slanting tube observer and a flow adjusting valve, is convenient to move and carry, and prevents the liquid in the liquid storage cavity from flowing back.

Disclosed in the present application are a blood pumping device, a motor, and a ventricular assist device. The blood pumping device is used for pumping blood. The blood pumping device comprises a motor, a first pipe and a second pipe; the motor comprises a stator assembly, the stator assembly comprising a core, and the core enclosing to form an accommodating cavity; a first circulation cavity is formed in the core, and a second circulation cavity communicated with the first circulation cavity is formed in the core and / or in the accommodating cavity; the first pipe is communicated with the first circulation cavity, and the second pipe is communicated with the second circulation cavity; one of the first pipe and the second pipe serves as a perfusion pipe, and the other one serves as a backflow pipe; and the perfusion pipe is used for conveying a perfusate to the motor, and the backflow pipe is used for discharging the perfusate in the motor.

The present application relates to a kind of arthroscopic approach water leakage prevention device, including the elastic cover with dome structure, the sealing valve being arranged in the center position of cover and negative pressure suction mechanism, sealing valve has the conical hollow structure extending to base direction and gradually reducing outer diameter, reverse compensation sealing is realized using joint cavity infusion liquid pressure, cover base edge is equipped with flexible sealing skirt, by the negative pressure interface connection external negative pressure source, so that cover and skin form negative pressure sealing space, the device can be connected in series by negative pressure interface multiple occluder, and equipped with detachable guide rod auxiliary coaxial positioning.The present application uses non-insertion type surface adsorption occlusion, effectively solve the space interference and tissue damage problem in multiple tunnel operation, realize the dynamic water stop of pressure self-adaption, with the advantages of simple operation, sealing stable, strong dissection adaptability, can significantly improve the operation visual clarity and maintain joint cavity pressure stability.

An endoscope includes a handle including a handle housing, an irrigation inlet port adapted to receive irrigation fluid, and an irrigation channel; and an insertion cord extending distally from the handle. The insertion cord includes an insertion tube; a bending section extending from the insertion tube; a distal tip extending from the bending section and including a tip housing; a camera at least partially enclosed in the tip housing; interstitial space within the insertion tube in fluid communication with the irrigation channel; and at least one interstitial flow opening in fluid communication with the interstitial space and adapted to discharge the irrigation fluid.

The invention relates to the technical field of medical instruments, and particularly discloses a catheter handle, a catheter pump and a catheter pump system. According to the catheter handle, the perfusion liquid inflow connector, the artery pressure measuring liquid inlet connector, the artery pressure measuring liquid outlet connector and the catheter connector are arranged on the perfusion support, the perfusion liquid outflow connector is arranged on the coupling support, the perfusion support and the coupling support are large in size, and therefore the connectors can be conveniently arranged; the number of parts is reduced, so that the machining process of the guide pipe device is simplified; besides, the artery pressure measuring liquid inlet connector and the artery pressure measuring liquid outlet connector are arranged on the perfusion stent, the connectors can be conveniently arranged, an independent aorta pressure sensing channel is formed, and compared with the prior art, flowing of perfusion liquid used for sensing the aorta pressure is not prone to being interfered by other factors, and the perfusate can be used for sensing the aorta pressure. And thus, the aortic pressure sensing precision is improved.

Serum albumin is an important molecule in human and animal blood. It provides oncotic pressure and acts as a transportation agent, delivering nutrients from the blood to the tissue and removing waste products from the tissue to the blood. This invention describes an organ preservation and / or perfusion solution which comprises acetylated serum albumin, as well as method of making and using such a solution, and uses of acetylated serum albumin itself. The acetylated serum albumin utilised in the present invention can protect the vascular endothelium during perfusion of an isolated organ or tissue.

The application discloses an ultrasonic emulsification perfusion assembly, which comprises a metal connector, a plastic needle tube arranged in the metal connector, a metal perfusion sleeve provided with a water inlet and a perfusion port, and a plastic clamping perfusion sleeve which is sleeved outside the metal perfusion sleeve and forms a liquid storage space, wherein the water inlet is arranged in the liquid storage space. The application has the following beneficial effects: the slender needle head of the plastic needle tube can improve the stability of the anterior chamber and reduce the probability of surge occurrence; the relatively soft plastic needle head tip can also reduce the probability of puncturing the lens capsule; the metal perfusion sleeve effectively separates the ultrasonic emulsification needle tube body from the extrusion of the incision, greatly reduces or even eliminates the incision burn caused by ultrasonic friction; the relatively hard metal perfusion sleeve effectively prevents the perfusion liquid from being reduced or blocked due to the extrusion or distortion of the incision, thereby improving the stability of the anterior chamber and reducing the probability of surge occurrence.

The present disclosure describes techniques for providing directed instillation or irrigation of fluid during wound therapy to deliver cleansing fluid precisely onto a wound to improve wound cleansing. Directed instillation or irrigation of fluid onto wounds using techniques of the present disclosure can accelerate wound healing and provide improved patient outcomes. One example of the present disclosure is a device for providing directed fluid irrigation to a wound. The device can include an irrigation tube extending between a first end and a second end, with the second end having a perforated section or a non-perforated closed section. The device can further include a foam structure arranged around the perforated section, with the foam structure being configured to dispense fluid received from the perforated section uniformly into a wound for cleansing. The perforated section can include a plurality of perforations or a plurality of perforated irrigation tubes in examples.

The application provides a blood pressure data acquisition mechanism, an electronic device, a medical catheter and an ablation system, which comprises a pressure sensor, a first valve, a second valve and a fluid passage, the opening and closing states of the first valve and the second valve are opposite; one end of the first valve is connected with the fluid passage, the other end of the first valve is used for being connected with a perfusion pump, when the first valve is in an open state and the second valve is in a closed state, the perfusion pump is connected with the fluid passage in communication to provide perfusion liquid to the fluid passage; the pressure sensor is connected with the fluid passage through the second valve, when the second valve is opened and the first valve is in a closed state, the pressure sensor is connected with the fluid passage in communication to acquire blood pressure data in a blood vessel where a target target point is located. The application can accurately acquire blood pressure data in the blood vessel while reducing damage in a surgical process, thereby laying a good foundation for realizing targeted ablation.

A composition and method for perfusing tissue. A perfusate is composed of an endothelial cell stabilizer. thrombocyte concentrate (TC). The perfusate may further comprise a protein solution that may be an albumin-based solution or fresh frozen plasma (FFP). The perfusate composition may further comprise red blood cells. The perfusate composition may be perfused through an organ that has been removed from an organ donor and is being prepared for transport and transplant into a recipient. The perfusate composition may be perfused through an organ using a machine perfusion device.

The present invention relates to organ perfusion systems that can be used at room temperature. The organ perfusion systems do not comprise a temperature controller. In some embodiments, the organ perfusion systems do not comprise a cleaning device for cleaning the perfusion fluid. The perfusion fluid can comprise Williams' medium E. The organ perfusion systems can be portable and can be used to preserving an organ, preventing ischemic damage in an organ, or recovering an ischemically damaged organ.

Systems and methods are provided herein for preparing a non-naturally-occurring preparation of DNA from perfusion fluid or flush, the preparation being useful for assessing transplantation outcomes of a donor organ or donor tissue which was perfused with the perfusion fluid or prepared for transplantation with flush. The preparation may also be useful for evaluating quality of the organ or tissue. Analysis of the DNA may be used to make clinical decisions. Analysis of the DNA may also be used for adaptive control of a mechanical perfusion system used for preserving the organ or tissue, by generating and executing appropriate parameter adjustments based on characteristics of the sampled DNA.

The invention relates to an organ perfusion device (1), which in one embodiment comprises: a perfusion fluid container (2); an oxygenator (4) in fluid communication with the perfusion fluid container (2) by means of a deoxygenated perfusion fluid supply line (LI) comprising a pump (5); an organ container (3) in fluid communication with the oxygenator (4) by means of a primary oxygenated perfusion fluid supply line (L2) and in fluid communication with the perfusion fluid container (2) by means of a deoxygenated perfusion fluid discharge line (L7) and a seeping perfusion fluid discharge line (L8); and a set (17) of syringe pumps in fluid communication with the perfusion fluid container (2). The primary oxygenated perfusion fluid supply line (L2) comprises an arterial filter (51) in fluid communication with the perfusion fluid container (2), a perfusion fluid heat exchanger (6) with a perfusion fluid temperature sensor, a pH sensor (8), a dissolved oxygen sensor (9), a flow sensor (10) and a pressure transducer (11). The deoxygenated perfusion fluid discharge line (L7) comprises a pressure transducer (21), a throttle valve (22), a dissolved oxygen sensor (23) and a sampling unit (24). The invention also relates to an organ perfusion container (3).

A parathyroid gland perfusion preservation device is provided, which relates to the field of human organ preservation technologies. The device includes a parathyroid gland preservation box, a perfusion liquid circulation system and a control system. The parathyroid gland preservation box defines a space for placing parathyroid glands. The perfusion liquid circulation system is connected to the parathyroid glands stored in the parathyroid gland preservation box through inlet pipes, indwelling needles and a reflux pipe to supply perfusion liquid to the parathyroid glands. The control system is electrically connected to components of the perfusion liquid circulation system, and configured to receive a working state signal of the components of the perfusion liquid circulation system, and send a control instruction to the components of the perfusion liquid circulation system according to the working state signal. The device can achieve in vitro preservation of parathyroid glands, and can effectively protect the parathyroid glands.

A device for transporting an organ or tissue. The device comprises a container for containing the organ or tissue and a pneumatic pump for pumping a perfusion fluid in order circulating the perfusion fluid through the organ or tissue. The device comprises a holder for holding at least one gas vessel comprising pressurised gas. The pressurised gas is used to create a pulsating gas flow to the pump for pumping the perfusion fluid.

The application belongs to the technical field of frozen section, and particularly relates to an animal blood vessel tissue frozen embedding and sectioning and spatial transcriptome sequencing method. In the first aspect, the application provides an animal blood vessel tissue frozen embedding method, wherein a first buffer is used to replace blood in an animal body; a blood vessel is peeled off and surrounding tissues are removed; a perfusion liquid is used to perfuse the blood vessel to obtain a perfused blood vessel, the perfusion liquid comprising OCT and a second buffer; and a plurality of perfused blood vessels are embedded in the same OCT embedding block and then rapidly frozen. The blood vessel is peeled off from the tissue and embedded alone, and a plurality of blood vessels in each embedding block are laid flat after sectioning to ensure that the chip surface is covered with sufficient blood vessel structures, thereby solving the problems of small volume of blood vessel tissue, small number of cells, small amount of RNA and difficulty in spatial transcriptome sequencing and the like.

A three-dimensional (3D) lymphoid tissue model is provided, the model including a cellularized stromal compartment and a plurality of cellularized compartments including lymphocytes disposed within the stromal compartment; and a controlled fluid perfusion system configured to perfuse the model with a perfusion fluid. Methods of fabricating a 3D lymphoid tissue model and producing antibodies with the 3D lymphoid tissue model are also provided.