154 results about "Ethylene Oxide Sterilization" patented technology

Skin antiseptic composition dispensers and methods of use are disclosed. The skin antiseptic composition dispenser may include a container with one or more walls that are substantially impermeable to ethylene oxide gas during normal ethylene oxide sterilization processes. In some embodiments, the container may include flexible walls free of metallic foil barrier layers. The containers may also include one or more vents in addition to one or more openings used to dispense the skin antiseptic composition within the container. The dispenser may include an applicator with a hydrophilic foam.

The invention discloses an ethylene oxide sterilizing and exhaust gas zero-emission treatment system. The ethylene oxide sterilizing and exhaust gas zero-emission treatment system comprises an ethylene oxide sterilizing device, an ethylene oxide exhaust gas chemical combination treatment device, a micro-biological degradation subsystem, a sedimentation filtering subsystem, a water purification pond and a biological monitoring subsystem. The factors such as concentration, temperature and pressure are considered and quantitative control for ethylene oxide sterilization is proposed, so that the ethylene oxide sterilizing efficiency is improved; a plurality of links are gradually used for hazard-free degradation of the ethylene oxide waste gas, so that the technical problem of ethylene oxide hazard-free emission is solved, and application and promotion of ethylene oxide sterilization are facilitated.

A method of packaging and sterilizing disposable articles for surgical operations, in which several surgical articles are packed in a first package that is packed in a transport package and thereafter transported to a plant for sterilizing with the aid of ethylene oxide, whereafter the first package is sterilized in this plant. A second package containing sterile packaged surgical articles of a type, that can not sustain sterilizing, or for other reasons should not be sterilized with ethylene oxide, is brought together with the first package before this package is packed into the transport package and before this package is transported to the sterilizing plant, the second package being impermeable to ethylene oxide. A transport package used in the method and a package for sterile packaged articles, which can not sustain sterilizing or should not be sterilized with ethylene oxide is also disclosed.

A hydrophilic copolymer is designed and synthesized by copolymerization of an acidic monomer and a second hydrophilic monomer. The copolymer is non-thrombogenic, hydrophilic and incorporates reactive functional groups. The copolymer can then be covalently attached to a primer/base coat through its functional groups, to form a durable lubricious coating on medical devices. A coating formed of the polymer on a surface is non-thrombogenic and non-cytotoxic. The coating shows good stability in gamma ray, e-beam and ethylene oxide sterilization.

The invention relates to an isolated organ preserving device and a preserving method thereof, and belongs to the technical field of medical equipment. The isolated organ preserving device is structurally characterized in that continuous mechanical irrigation and membrane oxygenation are adopted, an isolated organ continuously obtains nutrients and the oxygen supply, a cell metabolite is removed in time, and a cell microenvironment is better maintained, so that the function normality is ensured. The isolated organ preserving device disclosed by the invention can be used for directly contacting the organ perfusate and the organ perfusion instrument by adopting a disposable consumable material sterilized through epoxyethane, thereby meeting the requirement for sterility of a system. Besides, the isolated organ preserving device disclosed by the invention can be used for judging the consumption of the nutrients contained in the organ perfusate and the gathering degree of metabolic wastes by monitoring the pH value of the organ perfusate in real time and can be used for abandoning the organ perfusate after a certain standard is achieved and replacing the fresh organ perfusate, thereby further ensuring the possibility of long-time preservation; the isolated organ preserving device can be used for evaluating the damage condition of the isolated organ by monitoring the front and back perfusion pressure of the isolated organ in real time and converting the perfusion resistance by combining a flow number.

The invention discloses a device and a method for treating sterilized ethylene oxide waste gas. The device comprises a gas pump, a chemical combination device (101), a gas-liquid pump (102), a turbulent ball tower (103) and a diffuser (4). The gas pump conveys ethylene oxide waste gas to the chemical combination device, and the ethylene oxide waste gas is chemically combined in the chemical combination device; ethylene oxide waste gas and a sulfonation reaction agent have a sulfonation reaction in the chemical combination device, and ethylene oxide is oxidized into carbon dioxide and ethylene glycol; the generated carbon dioxide and residual ethylene oxide waste gas are exhausted into the turbulent ball tower; and the residual ethylene oxide waste gas is output into the turbulent ball tower through the gas-liquid pump and is fully mixed and dissolved with hot water pumped into the turbulent ball tower by the gas-liquid pump.

A coated medicine layer on the scaffold in arteria coronaria for preventing angiostenosis is prepared through dissolving the aliphatic polylactone and its copolymer is solvent, adding taxusol, stirring while dissolving, filtering, coating on the scaffold, evaporating the solvent, removing the solvent for 48 hr under vacuum, and disinfecting by epoxy ethane.

Skin antiseptic composition dispensers and methods of use are disclosed. The skin antiseptic composition dispenser may include a container with one or more walls that are substantially impermeable to ethylene oxide gas during normal ethylene oxide sterilization processes. In some embodiments, the container may include flexible walls free of metallic foil barrier layers. The containers may also include one or more vents in addition to one or more openings used to dispense the skin antiseptic composition within the container. The dispenser may include an applicator with a hydrophilic foam.

The medical collagen material is made through the processes of chondroitin sulfate crosslinking, high temperature vacuum drying and ethylene oxide. Is has stable molecule structure and better anti-seepage and anti-stick performance, and is used in repairing cerebral dura mater, spinal dura mater and peripheral nerve.

Water-based chemical indicator inks for ethylene oxide sterilization processes and methods for its use. The chemical indicator ink contains at least one pH indicator dye selected from the group consisting of Bromocresol green, Bromophenol blue, Methyl red, Ethyl orange, and combinations thereof. The pH indicator dye undergoes an irreversible color change when exposed to ethylene oxide vapor in the presence of low-temperature steam, but when exposed to other sterilization processes either does not undergo a color change or undergoes a color change that is different than is obtained when exposed to ethylene oxide.

The invention pertains to analyte sensors designed to include layered compositions that provide these sensors with enhanced functional and/or material properties including, for example, resistance to damage caused by ethylene oxide during sterilization processes. Embodiments of the invention include polyvinyl alcohol N-methyl-4(4′-formylstyryl)pyridinium (SbQ) polymer materials and methods for employing such materials during the ethylene oxide sterilization of glucose sensors.

The invention relates to a preparation method of an antigen-removing biological bone. The preparation method comprises bone block pretreatment, partial deproteinization treatment, irradiation treatment, organic matter removal, EDC/NHS crosslinking and drying sterilization. Bone particles are treated by irradiation to make proteins degenerated, then a mixed solution of a surface active agent and hydrogen peroxide is used for treating the irradiated bone particles, followed by a hypochlorite solution and a hydrogen peroxide solution are used for treating, and the deproteinized biological bone is obtained after ethylene oxide sterilization. The prepared bone material has a three-dimensional porous structure, has good capillary adsorption, can adsorb osteoblasts and protein factors after being implanted in bodies, and induces new bone formation; the bone material allows antigen components to be effectively removed, retains a part of collagen, and has better biocompatibility; and the bone material allows hydroxy apatite to have the crystallization degree of lower than 15% and exist in a weak crystallization morphology, has no other crystal phases, allows the carbonate content to be 4%-6%, has relatively high mechanical strength and good degradation, and is suitable for a repairing operation material for non load-bearing part bone coloboma.

The invention provides a natural extracellular matrix biological membrane. The natural extracellular matrix biological membrane is prepared through the steps that natural extracellular matrix after antigen removal is taken as a material, 2-10 layers of monolayer materials with the same specification are placed in a staggered or parallel stacking manner, all the layers attach to each other tightly by adopting clamps, freeze-drying treatment is carried out under the vacuum condition, then the materials are placed in a vacuum oven to be subjected to dehydrothermal treatment, and finally, the extracellular matrix biological membrane is subjected to cobalt-60 irradiation or ethylene oxide sterilization. The natural extracellular matrix material is subjected to a series of antigen removal treatment, thus the biological membrane matrix material with a certain three-dimensional space structure is obtained, the biological membrane matrix material is then subjected to freeze-drying and dehydrothermal treatment, so that the biological membrane matrix material is subjected to intramolecular dehydration crosslinking, the spatial structure is reinforced, the obtained material has high rehydration stability, and the surgical operation is enabled to be more convenient. Meanwhile, the material has long degradation time in the body, the hydrophobicity and mechanical strength are increased, and thus the natural extracellular matrix biological membrane has great significance in isolating the anti-adhesion stress tissue with long repairing period.

Normal saline and other infusate solutions for infusion into the body of a patient during medical treatment are disclosed. In particular, infusates are disclosed that are formulated to resist changes to the pH of the solution when subjected to sterilization procedures that employ ethylene oxide gas. In one embodiment, a buffered infusate suitable for disposal in a syringe or other container is disclosed. The syringe is sterilizable using ethylene oxide. The buffered infusate comprises an aqueous solution that is disposed in the syringe and is suitable for infusion into a body of a patient. A buffer component is added to the aqueous solution to form a buffered solution. The buffer component is configured to resist a change in the pH of the buffered solution upon exposure of the buffered solution to the ethylene oxide during sterilization of the syringe.

The invention belongs to the field of biological materials and discloses an extracellular matrix support material and a preparation method thereof. The extracellular matrix support material disclosed by the invention is prepared into a three-dimensional porous support material with a certain pore diameter and porosity through performing in-vitro monolayer high-density culture on immature rabbit bone marrow mesenchymal stem cells and collecting extracellular matrixes secreted by the immature rabbit bone marrow mesenchymal stem cells by applying the freeze-drying technology and a proper cross-linking agent. The material can be trimmed into proper sizes and shapes according to a cartilage defect zone or the requirement of an in-vitro experiment, and the material is sterilized by ethylene oxide to obtain an integral packaging bag. As the stem cells are used as material sources of an extracellular matrix support, the extracellular matrix support material disclosed by the invention is wide in tissue source and strong in multiplication capacity, therefore, the extracellular matrix support material can obtain enough cell quantity per se, and the problems of social ethics involved by embryonic stem cells are avoided.

The invention discloses an oral administration pharmaceutical composition for treating chronic nasal sinusitis, which is prepared from raw astragalus root 30g, Chinese angelica root 12g, Ligusticum wallichii 10g, ledebouriella root 6g, root of ballon flower 15g, flower bud of lily magnolia 10g, dahurian angelica root 12g, cordate houttuynia 15g, honeysuckle flower 15g and licorice root 6g.

The invention provides a disposable hemodialysis nursing bag, which consists of a hemodialysis catheter log-in disposal nursing bag, a hemodialysis catheter log-out disposal nursing bag and an internal fistula puncture nursing bag, wherein the hemodialysis catheter log-in disposal nursing bag and the hemodialysis catheter log-out disposal nursing bag are formed by combining a disposable bed patch pocket, rubber gloves, non-woven fabric treatment towels, iodophor gauze, alcohol gauze, alcohol cotton balls, sterile gauze, needle cylinders, sterile paste, adhesive tapes, catheter caps, disposable treatment discs and an external packaging bag; the internal fistula puncture nursing bag is formed by combining a disposable bed patch pocket, a non-woven fabric treatment towel, rubber gloves, iodophor cotton swabs, dried cotton balls, sterile paste, adhesive tapes, disposable treatment discs and an external packaging bag; and the objects in the three nursing bags are stacked in the respective external packaging bags, are sealed integrally and are sterilized by ethylene oxide. In the disposable hemodialysis nursing bag, all objects are sterilized integrally and can be used while being torn, so that the sterile state in the operating process is ensured, and the chance of cross inflection is reduced; and the objects are not needed to be disinfected independently periodically, so labor and material resources are saved, the using cost is reduced, and the disposable hemodialysis nursing bag is easy, convenient and safe to operate.

An pair of aseptically packed underclothes able to be directly worn is composed of the underclothes and its packing bag. Its preparing method includes such steps as putting the underclothes in a packing bag, sealing, and vacuum sterilizing in an ethylene oxide (EO) sterilizer at 0-100 deg.C under -85-80 Kpa and 30-100% RH for 3-12 hr.

The present invention discloses one kind of interactive medical wet dressing and its preparation process and application. The dressing includes one water absorbing core layer and one hydrophobic face layer. The water absorbing core layer consists of fibrous lining material and high hydroscopicity material of polyacrylate, PVA, polyacrylic acid or acrylic acid-acrylamide copolymer; and the hydrophobic face layer is fabric of Dacron, capron, acrylon, etc. The dressing has moisture permeability of 30-70 g/hr.sq cm, low material consumption, low cost, small thickness and great liquid absorption. It is prepared through dispersing high hydroscopicity material grains between two layers of lining, spraying small amount of water, hot pressing at 100-140 deg.c to form the composite water absorbing layer; setting the water absorbing core between two layers of hydrophobic material, sealing at 135-170 deg.c and sterilizing. The dressing is used for wound.

The invention belongs to the technical field of a medical intraocular lens, and particularly relates to a self-cleaning intraocular lens and a preparation method thereof. The preparation method comprises the specific steps of: (1) flushing the surface of an intraocular lens material with sterile double-distilled water, and blow-drying the surface of the intraocular lens material with nitrogen flow; (2) carrying out modification on the surface of the intraocular lens material by utilizing a plasma beam, and filling in O2 to form an oxygen ion beam to impact the surface of the intraocular lens to generate free radicals, so that a certain convex micro-nano structure is formed on the surface of the intraocular lens; (3) grafting the surface of the intraocular lens material, which is subjectedto plasma beam processing, with a PDMS (Polydimethylsiloxane) molecular chain by utilizing a chemical vapor deposition method; and (4) carrying out ethylene oxide sterilization packaging on the grafted self-cleaning intraocular lens. According to the preparation method of the intraocular lens, a coating based on self-cleaning ''similar liquid'' is formed on the surface; and according to the method, optical transparency of the intraocular lens can be kept for the post-cataract surgery, related complications such as posterior capsular opacity and the like can be prevented and treated, and guarantee can be provided for health of cataract patients.

The invention discloses an ethylene oxide sterilization process, comprising the following steps: 1) anti-explosion pretreatment; 2) sterilization treatment: first filling a sterilization cabinet withgaseous ethylene oxide, and then filling nitrogen gas into the sterilization cabinet, while turning on the gas circulation system of the sterilization cabinet, so that the gas in the cabinet is uniformly distributed, and a to-be-sterilized product stands in the sterilization cabinet for 5-8 hours continuously; 3) sterilization post-treatment. In the above manner, the pre-explosion treatment is adopted to replace the oxygen gas in the sterilization cabinet to ensure that the ethylene oxide gas is out of an explosion limit; in the sterilization process, the gaseous ethylene oxide is filled withnitrogen gas and gas flows in a circulation manner via the gas circulation system, so that ethylene oxide can penetrate into a product better to improve sterilization effect; after sterilization, nitrogen cleaning and air cleaning are performed to remove the ethylene oxide gas in the cabinet, to avoid gas volatilization to affect the health of operators or an explosion caused by oxygen gas contactwith naked light during opening of the cabinet, capable of significantly improving the safety of sterilization of ethylene oxide.

Nonwoven laminate products having improved wet peel strength after aging and ethylene oxide sterilization, and improved drape and softness, which are suitable for medical, surgical and hygienic applications, are produced by laminating one or more nonwoven substrates on one or both sides of a cast film. The cast film is produced using conventional extrusion processes, such as co-extrusion. Multiple extruders are used to process and melt different polymers and then specially designed selector plugs and feed-blocks are used to combine the different polymers into different layers to form a multiple layer structure such as A-B, A-B-A, A-B-C, A-B-B-A, etc.