1324 results about "Antibacterial coating" patented technology

This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

The present invention relates to metallic sheets having an improved antimicrobial property and also related to a method of manufacturing such sheets. More particularly, it relates to the continuous coating on metallic sheets with a resin composition containing antimicrobial additives. The surface of the metallic article is afforded antimicrobial properties by coating a liquid dispersion or solution of fine particles made of an antimicrobial ingredient on the surface of the metallic sheet dispersed in a uniform layer and cured or dried to affix to the metallic surface. The inorganic antibacterial particles are metal component-supporting oxides and zeolite powders. The inorganic antibacterial core particles have at least a primary surface coating of at least one metal or metal compound having antimicrobial properties. Roll coaters apply the coating. The metallic article generally includes sheet articles made of metals, for example, metallic sheets made of stainless steel, conventional steel sheets and aluminum sheets or plate.

The invention is directed to efficient methods for depositing highly adherent anti-microbial materials onto a wide range of surfaces. A controlled cathodic arc process is described, which results in enhanced adhesion of silver oxide to polymers and other surfaces, such as surfaces of medical devices. Deposition of anti-microbial materials directly onto the substrates is possible in a cost-effective manner that maintains high anti-microbial activity over several weeks when the coated devices are employed in vivo.

The invention generally is related to preventing or inhibiting microbial infections on live tissues or in relation to the use of medical articles. In one embodiment, the invention is directed to a method for forming an antimicrobial coating on live tissue or a medical article, such as, for example, a catheter. The method includes applying to a live tissue or a surface of a medical article an aqueous or non-aqueous composition that includes at least one silane of the general formula R1nSi(OR2)4-n wherein, n is an interger of 1 or 2, R1 generally is a lower alkyl group, a C6-C8 aryl group, or a functional group, such as vinyl, acrylic, amino, mercapto, or vinyl chloride functional group, and R2 generally is a lower alkyl group. A partial condensate of a silanol of the formula R1Si(OH)3 also can be used. The composition includes one or more additional ingredients. The method also includes reacting and / or curing the silane, in the presence of the one or more ingredients, thereby forming the antimicrobial coating.

The invention relates to an antibacterial medical catheter. The antibacterial medical catheter comprises a catheter body; an antibacterial coating is coated on inner and outer surfaces of the catheter body respectively and comprises an antibacterial agent and high polymer used as an antibacterial agent carrier, wherein the antibacterial agent accounts for 0.05 to 10 percent based on the total mass of the antibacterial coating. The invention also provides a preparation method for the antibacterial medical catheter. The method comprises the following steps of: treating the surface of a medical catheter; preparing a carrier solution; preparing an antibacterial solution, namely adding the antibacterial agent into the carrier solution, and stirring until a mixture is dispersed uniformly to obtain the antibacterial solution; forming a film, namely immersing the medical catheter of which the surface is treated in the antibacterial solution, and then lifting the medical catheter slowly to ensure that the antibacterial solution naturally flows along the surface of the medical catheter to form the uniform and smooth antibacterial coating; and drying. The antibacterial coating containing antibacterial components is deposited on the surface of the medical catheter and can effectively inhibit the growth of bacteria and exert the good antibacterial capacity for a long time.

The invention discloses a titanium alloy containing an antibacterial coating as well as a preparation method and application thereof. The titanium alloy deposited with nano-silver antibacterial coating on the surface is prepared by the following steps: preprocessing and sterilizing the surface of titanium alloy; then soaking the titanium alloy in a dopamine hydrochloride solution with mass-volume concentration of 1-10mg / mL for 12-36h to obtain titanium alloy deposited with a polydopamine thin film layer on the surface; and finally soaking the titanium alloy in a silver nitrate solution which is 5-100mmol / L in concentration for 12-36h. According to the titanium alloy disclosed by the invention, the titanium alloy is connected to silver nanoparticles by virtue of adhesion from self-polymerization of dopamine and adsorbed silver ions are reduced into nano-silver in situ through weak reducibility of the dopamine. Because of broad-spectrum antibacterial capacity of the nano-silver, an excellent antibacterial effect can be achieved with relatively low effect concentration. The invention provides new thinking for antibacterial modification of the titanium alloy, and can effectively promote application of a titanium alloy implant material in the fields of bone tissue repair and regeneration.

This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and flngal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

This invention provides for a curable antimicrobial coating system comprising a base coating composition and a top coat coating composition wherein each contains and antimicrobial agent. The base coat forms a non-hydrophilic polymer layer and the top coat preferably forms a hydrophilic polymer layer or a non-hydrophilic polymer layer which does not preclude the release of the antimicrobial agent. This two-layer coating is especially designed for erosive environments and provides continual antimicrobial activity regardless of the stage of wear or erosion.

The invention discloses a method for preparing biomedical titanium and titanium alloy surface antibacterial coatings. The method comprises steps of firstly, processing the surface of a biomedical titanium or titanium alloy sample to be processed, immersing the biomedical titanium or titanium alloy sample in a glycol aqueous solution containing soluble fluoride and performing an anode oxidation treatment; secondly, immersing the biomedical titanium or titanium alloy sample after being subjected to the anode oxidation treatment in a silver nitrate solution, taking out the biomedical titanium or titanium alloy sample, using ultraviolet light radiation to process the biomedical titanium or titanium alloy sample and obtaining the silver-carrying biomedical titanium or titanium alloy sample; and performing a micro-arc oxidation treatment for the silver-carrying biomedical titanium or titanium alloy sample, performing ultrasonic cleaning and vacuum drying and obtaining the antibacterial coatings. The nano precoating layer preparation, the silver-carrying treatment and a micro-arc oxidation technology are combined, then a large amount of silver can be fixed on the biomedical titanium and titanium alloy sample surfaces and can be released slowly for a long time, the antibacterial performance of titanium and titanium alloys is greatly improved, the antibacterial effect can be kept for a long time, and the bacterial infection caused by the fact that a titanium and titanium alloy apparatus is embedded in a human body is greatly reduced or avoided.

A surgical instrument for use in a surgical site includes a first surface that is positionable within or near the surgical site and has an anti-bacterial coating disposed on the surface. The anti-microbial coating includes anti-microbial particles disposed in a polymer matrix wherein the anti-microbial particles are in sufficient concentration and are positioned to provide an anti-microbial effect at the surgical site. Bacterial growth is also inhibited on the coated surface of the instrument.

The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and / or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.

The invention is directed to efficient methods for depositing highly adherent anti-microbial materials onto a wide range of surfaces. A controlled cathodic arc process is described, which results in enhanced adhesion of silver oxide to polymers and other surfaces, such as surfaces of medical devices. Deposition of anti-microbial materials directly onto the substrates is possible in a cost-effective manner that maintains high anti-microbial activity over several weeks when the coated devices are employed in vivo.

An optical coating structure includes a substrate, an anti-reflective coating layer, a base coating layer, an antibacterial coating layer, and a protective coating layer. The anti-reflective coating layer is disposed on the substrate. The anti-reflective coating layer covers the substrate. The base coating layer covers the anti-reflective coating layer. The antibacterial coating layer is disposed on the base coating layer, and the antibacterial coating layer is an interlayer. The protective coating layer covers the antibacterial coating layer. A super-hydrophobic coating layer or an anti-fingerprint coating layer may cover the protective coating layer.

A vascular access device includes an antimicrobial coating that provides kink resistance to a catheter. The antimicrobial coating can extend along a length of the catheter to provide antimicrobial protection when the catheter is inserted into the patient's vasculature. The antimicrobial coating can also increase the effective diameter of the catheter to minimize the likelihood that the catheter will become kinked.

Relateing to the field of antibacterial materials, the invention specifically provides an efficient and environmentally-friendly antibacterial and mildewproof inorganic composite nano-powder slurry obtained through compounding nano-magnesium oxide and other nano-inorganic materials and its preparation method. The nano-powder slurry takes nano-magnesium oxide as the main body, which is then compounded with one or more inorganic materials of nano-zinc oxide, nano-titanium oxide, nano-copper oxide, nano-cuprous oxide, nano-silver oxide, nano-zinc sulfide, nano-zirconium oxide, nano-yttrium oxide, nano-alumina, and nano-calcium oxide so as to form the nano-powder slurry, which comprises, by weight percent: 0.1-40% of nano-magnesium oxide, 0.01-40% of other inorganic materials, 0.5-12% of a polymeric dispersant, and the balance a solvent. In the method, a nano-inorganic material enters a solution composed of the polymeric dispersant and the solvent by means of high speed dispersion according to a predetermined proportion, and after ball milling, the composite nano-powder slurry can be obtained. The composite nano-powder slurry can be applied in antibacterial coatings, deodorants, textiles, paper products, plastics, rubbers, water treatment agents, ship protective agents, cosmetics and other aspects.

The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.

The invention discloses a catheter with super-lubricity antibacterial coatings and a manufacturing method for the catheter. The catheter comprises a body part, an outer wall coating and an inner wall coating, wherein the body part is inserted into a human body; the outer wall coating attaches to the outer wall of the body part; and the inner wall coating attaches to the inner wall of the body part. The outer wall coating comprises an outer antibacterial layer, an outer controlled-release layer and an outer lubricating layer in sequence from inside to outside, wherein the outer antibacterial layer attaches to the surface of the outer wall of the body part, the outer controlled-release layer attaches to the outer antibacterial layer, and the outer lubricating layer attaches to the outer controlled-release layer. The inner wall coating comprises an inner antibacterial layer, an inner controlled-release layer and an inner lubricating layer in sequence from inside to outside, wherein the inner antibacterial layer attaches to the surface of the inner wall of the body part, the inner controlled-release layer attaches to the inner antibacterial layer, and the inner lubricating layer attaches to the inner controlled-release layer. The outer antibacterial layer and the inner antibacterial layer respectively comprise inorganic salt containing Ag<+>, Zn<2+> or Cu<2+> ions; the outer controlled-release layer and the inner controlled-release layer respectively comprise an organic chelate of inert metal; and the outer lubricating layer and the inner lubricating layer respectively comprise hydrophilic gel. After the technical scheme is adopted, the catheter has a sustainable and stable antibacterial function, and the coatings can firmly attach to the surface of the catheter.

The embodiment of the invention discloses a preparation method of nano-silver dispersion liquid. The preparation method comprises the following steps that thickening agents and dispersing agents are added into pure water or deionized water, then, soluble silver salt is dissolved in solution, and the silver salt solution is obtained; and under the stirring effect, silver complexing agents are firstly added into the silver salt solution, then, reducing agents are added, or silver complexing reduction agents are directly added, the reaction is carried out for at least 12 hours under the condition of room temperature to 90 DEG C, silver ions in the silver salt solution are reduced into metal silver, the nano-silver dispersion liquid is obtained, the silver complexing agents and the silver complexing reduction agents can form the chemical bonding with the nano-silver particle surface, and in addition, functional groups with the cross linking effect are reserved. The invention correspondingly provides the nano-silver dispersion liquid prepared by the method. The process of the preparation method is simple, the stability of the prepared nano-silver dispersion liquid is good, nano-silver particles are uniform, the application is convenient, and the bonding force of the nano-silver and substrates is high. In addition, the invention also provides a preparation method of a nano-silver antibacterial coating.

A sustained and controlled release form of iodine is achieved by a complex of polyvinyl alcohol starch and iodine, characterized by the PVA based coating being insoluble in boiling water. The polyvinyl alcohol is in the form of a coating reacted with varying types of non-mineral acid containing catalysts / curing or insolubilizing agents deposited on cellulose sponge or other substrates and subsequently complexed with iodine. These cost effective sponges or wipers are topically applied as a solid state antimicrobial device, which releases controlled amounts of iodine on contact sufficient to kill germ cells, and leaves minimal residue.

A catheter for human or animal vascular engagement is provided. The catheter has at least one interior lumen defined by a sidewall having an exterior circumferential. A titanium surface area is positioned along the circumferential surface entirely or at one or both ends to enhance lubricity. Additionally included may be an anti pathogenic and / or anti microbial surface area positioned adjacent to the titanium surface area of the circumferential surface.

An implantable surgical device including an elongated flexible inflatable portion, an elongated flexible and substantially inextensible band portion. The band portion has a distal end, a proximal end and a longitudinal axis therebetween. The band portion is attached to the inflatable portion along an inner face thereof. The band portion and / or the inflatable portion is at least partially coated with an anti-microbial coating.

The invention discloses a graphene oxide / polymer composite antibacterial material and a preparation method thereof. The composite antibacterial material is characterized in that a polymer is subjected to surface modification and then is combined with graphene oxide dispersed in water, thus obtaining a graphene oxide antibacterial coating bonded on a polymer matrix, wherein the thickness of the antibacterial coating is 1 to 50nm. The preparation method of the graphene oxide / polymer composite antibacterial material comprises the following steps: firstly, performing ultrasonic cleaning on the polymer; secondly, performing surface modification on the polymer subjected to ultrasonic cleaning; thirdly, immersing an activated polymer matrix into a coupling agent solution and soaking; fourthly, taking out the soaked polymer, leaching with deionized water, then putting into a graphene oxide suspension liquid for 0.2 to 24 hours, taking out, leaching and naturally drying in air to obtain the graphene oxide / polymer composite antibacterial material. The invention designs and prepares the composite antibacterial material by taking graphene oxide as an antibacterial ingredient; the composite antibacterial material has a transparent antibacterial layer, is excellent in antibacterial property and is firmly bonded with the matrix.

The invention relates to a method for preparing an antimicrobial medical polymer material, comprising the following steps: fixing a medical polymer material into a vacuum chamber of plasma equipment, vacuumizing, preheating, introducing gas, starting the power supply of a treating platform, treating to obtain a medical polymer material with high surface activity, grafting a silane coupling agent to the surface of the modified surface with hyperreactivity to form an SAM (self-assembled monolayer), and capturing silver ions in the solution by the SAM in the following electroless plating process to prepare an antimicrobial coating which has strong binding force relative to the matrix of the polymer material. The method is easy to operate, can not affect the physical and chemical properties of the material and ensure that the antimicrobial coating can be firmly combined with the matrix of the polymer material. The obtained antimicrobial medical polymer material has a stable surface structure and durable antibacterial properties.

Provided is an antimicrobial coating material comprising one or more biocides encapsulated in inorganic-organic shells. The antimicrobial coating material can be applied on porous materials or porous media to form and antimicrobial coating without changing the physical properties and the functions of porous materials or porous media. The coating provides a durable, multi-level antimicrobial performance at high temperature through contact-killing, release-killing, anti-adhesion and self-cleaning. Also provided is a method of producing the antimicrobial coating material.

The invention discloses a preparation method of an active antibacterial composite coating on the surface of titanium and titanium alloy medical instrument. The method includes the following steps: firstly, carrying out ultrasonic washing on the titanium or titanium alloy medical instrument to be treated and then immersing the titanium or titanium alloy medical instrument in NaOH solution for alkali-heat treatment; secondly, carrying out microarc oxidation treatment on the titanium or titanium alloy medical instrument in an electrolyte solution which contains biological active elements and antibacterial ingredients; carrying out hydro-thermal treatment on the titanium or titanium alloy medical instrument, and finally drying under vacuum condition. In such a way, the active antibacterial composite coating can be obtained. In the preparation method, a nano-silver / titanium dioxide composite antibacterial agent is adopted to form the antibacterial coating on the surface of titanium or titanium alloy matrix, and the antibacterial coating has long antibacterial effect to bacteria commonly seen at an operation wound of a person and has adhesion resistance to common inflammatory bacteria. Meanwhile, the active ingredients such as Ca and P in the coating can improve the biological activity and speeds up the osseointegration, and thereby the antibacterial performance, the clinical curing effect and the application range of the titanium and titanium alloy medical instrument are improved by a large margin.

The invention relates to a modified antibiotic sweat-resistant plastic for keyboards and mice, and a preparation method thereof. The method comprises the following steps: mixing matrix resin with a high performance composite antiseptic, adding a certain amount of an antioxidant, a flexibilizer, a coupling agent and other assistant to cooperate with highlight master batch, extruding through a double screw extruder, carrying out low temperature die heat hot cutting granulation, and drying to prepare the plastic. The matrix resin is PP, ABS, HIPS, PET or PC. The preparation method has the following advantages: an inorganic and organic combination composite antibiotic technology is adopted, so the singleness of an inorganic antiseptic is solved, and easy elution, poor heat resistance and other disadvantages of an organic antiseptic are solved; the antiseptic is directly combined with a raw material to realizes one shot molding during manufacturing without adhesion to an antibiotic coat, so the process flow is simplified, the cost is reduced, and the shedding problem of the coat is solved; and a fluorine-containing acrylic copolymer is added in the processing process, so the above material has the advantages of certain hydrophobic and oleophobic characteristics, easy surface cleaning, effective avoiding of oil and dust accumulation, and prevention of breeding of bacteria.

The invention discloses a nano-silver loaded graphene antibacterial agent, a graphene in-situ reduction nano-silver loaded water-based antibacterial coating, and a preparation method of coating. The nano-silver loaded graphene antibacterial agent is prepared from the following components: graphene oxide, silver nitrate, polyvinylpyrrolidone and sodium borohydride. The graphene in-situ reduction nano-silver loaded water-based antibacterial coating o is prepared from the following raw materials in parts by weight: 25-35 parts of water, 30-40 parts of acrylic resin, 20-30 parts of polyurethane resin, 2-3 parts of the nano-silver loaded graphene antibacterial agent, 1.5-2.5 parts of a dispersant, 1-1.5 parts of a curing agent, 0.8-1 part of a defoamer, 0.5-0.8 part of film formation aid and 0.5-0.8 part of levelling agent. Under the combined action of graphene and nano-silver, the antibacterial efficiency, the antibacterial time and the antibacterial property of the coating can be greatlyimproved; the coating is excellent in antibacterial effect, long in antibacterial time, free of toxicity, free of pollution, high in water resistance and weather resistance, and high in adhesion; thenano-silver is loaded in graphene in situ, is incapable of settling, and can be uniformly dispersed in emulsion.

The invention belongs to the field of chemical coatings, and particularly relates to a graphene nano-silver antibacterial coating and a preparation method thereof. The graphene nano-silver antibacterial coating comprises water, cellulose, a wetting agent, an antifreezing agent, a thickening agent, a defoaming agent, titanium dioxide slurry, filler slurry, a multifunctional amine auxiliary, emulsion, a sterilizing agent, a coalescing agent, a flatting agent, a formaldehyde-resistant auxiliary, and a silver-bearing antibacterial agent, and the silver-bearing antibacterial agent is graphene nano-silver dispersion liquid. According to the graphene nano-silver antibacterial coating and the preparation method thereof, a traditional formula is improved, the specially-made graphene nano-silver dispersion liquid is added to the formula, and the antibacterial effect is achieved. Nano silver can further destroy a microorganism electron transmission system, a respiratory system and a material transfer system. When the activity of thalli is lost, the nano silver can be dissociated out of the thalli and repeatedly conducts sterilization activities, and therefore the long-acting antibacterial function of the coating can be maintained. The nano silver can exert the lasting antibacterial effect by slowly releasing Ag<+>.

The invention discloses an application of a cationized polysaccharide, particularly an application of a cationized polysaccharide in preparation of antibacterial biomembrane agents, antibacterial coating / spraying agents for biological medical devices, and antibacterial functional materials. The cationized polysaccharide is a polysaccharide having positive charges and is prepared by reacting a natural polysaccharide with a quaternary ammonium salt or a polyamine compound. The cationized polysaccharide can interact with negative-charge polysaccharides in bacteria and biomembrane extracellular matrixes, has excellent sterilization effects, and can be applied well in chronic inflammation diseases, devices for external use or device surface antibiosis, and antibacterial biological materials such as daily chemical products, package products and household paper containing cationized polysaccharides.