Preparation method of active antibacterial composite coating on surface of titanium and titanium alloy medical instrument

A technology for medical devices and composite coatings, which is applied in the direction of surface reaction electrolytic coatings, coatings, electrolytic coatings, etc., to achieve the effects of large content, good repeatability, and improved antibacterial properties

Active Publication Date: 2012-09-19
NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing surface modification technology i

Method used

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  • Preparation method of active antibacterial composite coating on surface of titanium and titanium alloy medical instrument
  • Preparation method of active antibacterial composite coating on surface of titanium and titanium alloy medical instrument

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Step 1. Surface pretreatment of pure titanium medical devices to be treated:

[0036] 101. Surface cleaning treatment: ultrasonically clean the pure titanium medical device to be treated with distilled water, dilute hydrochloric acid solution, acetone (analytical grade) and absolute ethanol (analytical grade) in sequence, and the time for each ultrasonic cleaning is 20 minutes. The pure titanium medical device after ultrasonic cleaning is dried at a temperature of 40°C; the mass concentration of the dilute hydrochloric acid solution is 2%;

[0037]102. Alkali heat treatment: completely immerse the pure titanium medical device after drying in 101 in the NaOH solution with a concentration of 5mol / L, heat the NaOH solution to 50°C and keep it warm for 24h, take out the pure titanium medical device after cooling and use deionized clean with water;

[0038] Step 2, preparation of antibacterial active composite coating:

[0039] 201. Prepare a stable dispersed aqueous solut...

Embodiment 2

[0049] Step 1. Surface pretreatment of medical Ti6Al4V (ELI) titanium alloy medical devices to be treated:

[0050] 101. Surface cleaning treatment: Ultrasonic cleaning of Ti6Al4V (ELI) titanium alloy medical instruments to be treated with distilled water, dilute hydrochloric acid solution, acetone (analytical pure) and absolute ethanol (analytical pure) in sequence, and the time for each ultrasonic cleaning All for 30 minutes, drying the medical Ti6Al4V (ELI) titanium alloy medical device after ultrasonic cleaning at a temperature of 80°C; the mass concentration of the dilute hydrochloric acid solution is 3%;

[0051] 102. Alkali heat treatment: completely immerse the medical Ti6Al4V (ELI) titanium alloy medical device dried in 101 in the NaOH solution with a concentration of 7mol / L, heat the NaOH solution to 50°C and keep it warm for 30h, and take out the medical Ti6Al4V after cooling (ELI) titanium alloy medical devices and cleaned with deionized water;

[0052] Step 2, pr...

Embodiment 3

[0063] Step 1. Surface pretreatment of medical Ti6Al7Nb titanium alloy medical devices to be treated:

[0064] 101. Surface cleaning treatment: ultrasonically clean the Ti6Al7Nb titanium alloy medical device to be treated with distilled water, dilute hydrochloric acid solution, acetone (analytical pure) and absolute ethanol (analytical pure) in sequence, and the time for each ultrasonic cleaning is 20 minutes , drying the Ti6Al7Nb titanium alloy medical device for medical use after ultrasonic cleaning at a temperature of 60°C; the mass concentration of the dilute hydrochloric acid solution is 2.5%;

[0065] 102. Alkali heat treatment: completely immerse the medical Ti6Al7Nb titanium alloy medical device dried in 101 in the NaOH solution with a concentration of 10mol / L, heat the NaOH solution to 80°C and keep it warm for 24h, and take out the medical Ti6Al7Nb titanium alloy medical device after cooling. Instruments were cleaned with deionized water;

[0066] Step 2, preparatio...

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Abstract

The invention discloses a preparation method of an active antibacterial composite coating on the surface of titanium and titanium alloy medical instrument. The method includes the following steps: firstly, carrying out ultrasonic washing on the titanium or titanium alloy medical instrument to be treated and then immersing the titanium or titanium alloy medical instrument in NaOH solution for alkali-heat treatment; secondly, carrying out microarc oxidation treatment on the titanium or titanium alloy medical instrument in an electrolyte solution which contains biological active elements and antibacterial ingredients; carrying out hydro-thermal treatment on the titanium or titanium alloy medical instrument, and finally drying under vacuum condition. In such a way, the active antibacterial composite coating can be obtained. In the preparation method, a nano-silver/ titanium dioxide composite antibacterial agent is adopted to form the antibacterial coating on the surface of titanium or titanium alloy matrix, and the antibacterial coating has long antibacterial effect to bacteria commonly seen at an operation wound of a person and has adhesion resistance to common inflammatory bacteria. Meanwhile, the active ingredients such as Ca and P in the coating can improve the biological activity and speeds up the osseointegration, and thereby the antibacterial performance, the clinical curing effect and the application range of the titanium and titanium alloy medical instrument are improved by a large margin.

Description

technical field [0001] The invention belongs to the technical field of surface modification of surgically implanted titanium and titanium alloys, and in particular relates to a method for preparing a surface active antibacterial composite coating of titanium and titanium alloy medical instruments. Background technique [0002] Long-term implantation of biomedical materials into the human body will cause bacteria and other microorganisms to adhere to their surfaces, resulting in infection. This type of infection is called "Biomaterial-Centered Infection (BCI)". With the widespread application of human implant medical devices such as artificial joints and dental implants, bacterial infectious diseases caused by medical devices have become one of the important issues concerned by various clinical departments. BCI not only has a high incidence rate, more importantly, after BCI occurs, it will cause poor healing and even lead to death. The occurrence of the BCI phenomenon not on...

Claims

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Application Information

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IPC IPC(8): C25D11/26A61L27/30
Inventor 余森于振涛韩建业牛金龙刘春潮张亚峰袁思波
Owner NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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