Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of active antibacterial composite coating on surface of titanium and titanium alloy medical instrument

A technology for medical devices and composite coatings, which is applied in the direction of surface reaction electrolytic coatings, coatings, electrolytic coatings, etc., to achieve the effects of large content, good repeatability, and improved antibacterial properties

Active Publication Date: 2012-09-19
NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
View PDF4 Cites 28 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing surface modification technology is still difficult to accurately realize these functions.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of active antibacterial composite coating on surface of titanium and titanium alloy medical instrument
  • Preparation method of active antibacterial composite coating on surface of titanium and titanium alloy medical instrument

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Step 1. Surface pretreatment of pure titanium medical devices to be treated:

[0036] 101. Surface cleaning treatment: ultrasonically clean the pure titanium medical device to be treated with distilled water, dilute hydrochloric acid solution, acetone (analytical grade) and absolute ethanol (analytical grade) in sequence, and the time for each ultrasonic cleaning is 20 minutes. The pure titanium medical device after ultrasonic cleaning is dried at a temperature of 40°C; the mass concentration of the dilute hydrochloric acid solution is 2%;

[0037]102. Alkali heat treatment: completely immerse the pure titanium medical device after drying in 101 in the NaOH solution with a concentration of 5mol / L, heat the NaOH solution to 50°C and keep it warm for 24h, take out the pure titanium medical device after cooling and use deionized clean with water;

[0038] Step 2, preparation of antibacterial active composite coating:

[0039] 201. Prepare a stable dispersed aqueous solut...

Embodiment 2

[0049] Step 1. Surface pretreatment of medical Ti6Al4V (ELI) titanium alloy medical devices to be treated:

[0050] 101. Surface cleaning treatment: Ultrasonic cleaning of Ti6Al4V (ELI) titanium alloy medical instruments to be treated with distilled water, dilute hydrochloric acid solution, acetone (analytical pure) and absolute ethanol (analytical pure) in sequence, and the time for each ultrasonic cleaning All for 30 minutes, drying the medical Ti6Al4V (ELI) titanium alloy medical device after ultrasonic cleaning at a temperature of 80°C; the mass concentration of the dilute hydrochloric acid solution is 3%;

[0051] 102. Alkali heat treatment: completely immerse the medical Ti6Al4V (ELI) titanium alloy medical device dried in 101 in the NaOH solution with a concentration of 7mol / L, heat the NaOH solution to 50°C and keep it warm for 30h, and take out the medical Ti6Al4V after cooling (ELI) titanium alloy medical devices and cleaned with deionized water;

[0052] Step 2, pr...

Embodiment 3

[0063] Step 1. Surface pretreatment of medical Ti6Al7Nb titanium alloy medical devices to be treated:

[0064] 101. Surface cleaning treatment: ultrasonically clean the Ti6Al7Nb titanium alloy medical device to be treated with distilled water, dilute hydrochloric acid solution, acetone (analytical pure) and absolute ethanol (analytical pure) in sequence, and the time for each ultrasonic cleaning is 20 minutes , drying the Ti6Al7Nb titanium alloy medical device for medical use after ultrasonic cleaning at a temperature of 60°C; the mass concentration of the dilute hydrochloric acid solution is 2.5%;

[0065] 102. Alkali heat treatment: completely immerse the medical Ti6Al7Nb titanium alloy medical device dried in 101 in the NaOH solution with a concentration of 10mol / L, heat the NaOH solution to 80°C and keep it warm for 24h, and take out the medical Ti6Al7Nb titanium alloy medical device after cooling. Instruments were cleaned with deionized water;

[0066] Step 2, preparatio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of an active antibacterial composite coating on the surface of titanium and titanium alloy medical instrument. The method includes the following steps: firstly, carrying out ultrasonic washing on the titanium or titanium alloy medical instrument to be treated and then immersing the titanium or titanium alloy medical instrument in NaOH solution for alkali-heat treatment; secondly, carrying out microarc oxidation treatment on the titanium or titanium alloy medical instrument in an electrolyte solution which contains biological active elements and antibacterial ingredients; carrying out hydro-thermal treatment on the titanium or titanium alloy medical instrument, and finally drying under vacuum condition. In such a way, the active antibacterial composite coating can be obtained. In the preparation method, a nano-silver / titanium dioxide composite antibacterial agent is adopted to form the antibacterial coating on the surface of titanium or titanium alloy matrix, and the antibacterial coating has long antibacterial effect to bacteria commonly seen at an operation wound of a person and has adhesion resistance to common inflammatory bacteria. Meanwhile, the active ingredients such as Ca and P in the coating can improve the biological activity and speeds up the osseointegration, and thereby the antibacterial performance, the clinical curing effect and the application range of the titanium and titanium alloy medical instrument are improved by a large margin.

Description

technical field [0001] The invention belongs to the technical field of surface modification of surgically implanted titanium and titanium alloys, and in particular relates to a method for preparing a surface active antibacterial composite coating of titanium and titanium alloy medical instruments. Background technique [0002] Long-term implantation of biomedical materials into the human body will cause bacteria and other microorganisms to adhere to their surfaces, resulting in infection. This type of infection is called "Biomaterial-Centered Infection (BCI)". With the widespread application of human implant medical devices such as artificial joints and dental implants, bacterial infectious diseases caused by medical devices have become one of the important issues concerned by various clinical departments. BCI not only has a high incidence rate, more importantly, after BCI occurs, it will cause poor healing and even lead to death. The occurrence of the BCI phenomenon not on...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C25D11/26A61L27/30
Inventor 余森于振涛韩建业牛金龙刘春潮张亚峰袁思波
Owner NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com