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42results about How to "The preparation process is simple and economical" patented technology

Method for preparing freeze-drying particle preparation for injection

The invention relates to the technical field of medicaments. The existing process for preparing particle preparations such as a lipid film comprises the step of dissolving a medicament into the oil for injection to form milky microspheres, so the prepared particle preparations have the defects of low medicament-loading amount, poor stability, large using amount of auxiliary materials and large toxic and side effect. The invention provides a method for preparing a freeze-drying particle preparation for injection, which comprises the following steps: firstly, dissolving water-insoluble medicinal powder into a volatile water-soluble organic solvent to form molecular medicinal solution, and then dispersing the molecular medicinal solution into the water for injection to form fluffy soft aggregate mixed suspension; and then adding a small amount of injection-grade auxiliary material such as dispersant and the like into the suspension, and obtaining the freeze-drying particle preparation for injection through a certain preparation process. The particle preparation prepared by the preparation method has the characteristics of small using amount of auxiliary materials, high medicament-loading amount, good stability, simple preparation process and the like. The preparation method of the invention has broad practicability, and basically can meet the preparation requirement of most water-insoluble powdery medicinal particle preparations.
Owner:高保安

Method for preparing biomedical titanium and titanium alloy surface antibacterial coatings

The invention discloses a method for preparing biomedical titanium and titanium alloy surface antibacterial coatings. The method comprises steps of firstly, processing the surface of a biomedical titanium or titanium alloy sample to be processed, immersing the biomedical titanium or titanium alloy sample in a glycol aqueous solution containing soluble fluoride and performing an anode oxidation treatment; secondly, immersing the biomedical titanium or titanium alloy sample after being subjected to the anode oxidation treatment in a silver nitrate solution, taking out the biomedical titanium or titanium alloy sample, using ultraviolet light radiation to process the biomedical titanium or titanium alloy sample and obtaining the silver-carrying biomedical titanium or titanium alloy sample; and performing a micro-arc oxidation treatment for the silver-carrying biomedical titanium or titanium alloy sample, performing ultrasonic cleaning and vacuum drying and obtaining the antibacterial coatings. The nano precoating layer preparation, the silver-carrying treatment and a micro-arc oxidation technology are combined, then a large amount of silver can be fixed on the biomedical titanium and titanium alloy sample surfaces and can be released slowly for a long time, the antibacterial performance of titanium and titanium alloys is greatly improved, the antibacterial effect can be kept for a long time, and the bacterial infection caused by the fact that a titanium and titanium alloy apparatus is embedded in a human body is greatly reduced or avoided.
Owner:NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH

Preparation method of Erchen drug extract with antitumor-resisting activity and preparation thereof

The invention relates to a preparation method of an Erchen drug extract with antitumor-resisting activity and a preparation thereof, and belongs to the technical field of Chinese pharmaceutical manufacturing. The preparation method of the Erchen drug extract comprises the following steps: matching Erchen drug decoction prepared from rhizoma pinelliae, pericarpium citri reticulatae, poria and liquorice root according to ancient herbal formula dosage, adding water for decocting, filtering and carrying out vacuum concentration on the decoction; adding ethanol into the concentrated solution subjected to decoction, dissolving ethanol precipitation and dialyzing; carrying out vacuum concentration on the intra-dialysate and then carrying out vacuum drying to obtain the Erchen drug extract with the antitumor-resisting activity. According to the Erchen drug extract with the antitumor-resisting activity, disclosed by the invention, the extractive yield is high, the polysaccharide content of theextract is higher than 75 percent and the antitumor activity of the Erchen drug extract is better than that of Erchen drug decoction. An excipient is added into the Erchen drug extract to obtain the Erchen drug extract preparation with the antitumor activity; compared with traditional Erchen drug decoction, the preparation prepared by adding the excipient into the Erchen drug extract has the advantages of good anti-tumor effects, convenience in administration, improvement on the compliance of patients and capability of being widely used. The preparation method disclosed by the invention has the advantages of simple and feasible process and suitability for industrialized mass production.
Owner:YANGZHOU UNIV

High-performance flame-retardant cable sheath material and preparation method thereof

The invention discloses a high-performance flame-retardant cable sheath material and a preparation method thereof. The material comprises the following components in percentage by mass: 25-35% of matrix resin (ethylene-vinyl acetate copolymer (EVA) resin), 55-60% of flame retardant, 0.5-1.5% of coupling agent, 2.5-3.5% of lubricant, 0.1-0.2% of antioxidant and 5-10% of compatilizer. The matrix resin is an ethylene-vinyl acetate copolymer (EVA) resin; the flame retardant comprises Mg(OH)2 and Al(OH)3; the coupling agent is a silane coupling agent; the lubricant comprises silicone and calcium stearate; the antioxidant is B-215; and the compatilizer is maleic anhydride graft. The flame-retardant cable sheath material disclosed by the invention is suitable to be used as an external sheath material of an information transmission cable for rail transportation, and has the advantages of excellent flame-retardant function, ultrahigh oxygen index and higher physical properties; and the oxygen index is up to 40, which is much higher than the flame-retardancy oxygen index of not higher than 30 in industry. The preparation method has the advantages of simple and economical preparation technique, environmental protection and energy saving, and has broad market prospects.
Owner:上海三承高分子材料科技有限公司

A kind of Erchen extract with anti-tumor activity and its preparation method

The invention relates to a preparation method of Erchen extract with antitumor activity and its preparation, which belongs to the technical field of traditional Chinese medicine pharmacy. The Erchen Decoction composed of Pinellia, Tangerine Peel, Poria, and Licorice is formulated according to the dosage ratio of ancient Chinese medicine, decocted with water, filtered, concentrated decoction under reduced pressure, adding ethanol to the decoction concentrated solution, dissolving the ethanol precipitate and dialyzing , Concentrate the dialysate under reduced pressure and then dry it in vacuum to obtain Erchen extract with anti-tumor activity. Through the present invention, the extract has a high yield, its polysaccharide content is higher than 75%, and its antitumor activity is better than that of Erchen Decoction. Erchen extract is added to excipients to make Erchen extract preparations with anti-tumor activity. Compared with the traditional water decoction of Erchen Decoction, the preparation made by adding Erchen extracts to excipients is more effective. The anti-tumor effect is good, and it is convenient to take, which increases the compliance of patients and can be widely used. The inventive process is simple and easy to implement, and is suitable for large-scale industrial production.
Owner:YANGZHOU UNIV

Preparation method of active antibacterial composite coating on surface of titanium and titanium alloy medical instrument

The invention discloses a preparation method of an active antibacterial composite coating on the surface of titanium and titanium alloy medical instrument. The method includes the following steps: firstly, carrying out ultrasonic washing on the titanium or titanium alloy medical instrument to be treated and then immersing the titanium or titanium alloy medical instrument in NaOH solution for alkali-heat treatment; secondly, carrying out microarc oxidation treatment on the titanium or titanium alloy medical instrument in an electrolyte solution which contains biological active elements and antibacterial ingredients; carrying out hydro-thermal treatment on the titanium or titanium alloy medical instrument, and finally drying under vacuum condition. In such a way, the active antibacterial composite coating can be obtained. In the preparation method, a nano-silver / titanium dioxide composite antibacterial agent is adopted to form the antibacterial coating on the surface of titanium or titanium alloy matrix, and the antibacterial coating has long antibacterial effect to bacteria commonly seen at an operation wound of a person and has adhesion resistance to common inflammatory bacteria. Meanwhile, the active ingredients such as Ca and P in the coating can improve the biological activity and speeds up the osseointegration, and thereby the antibacterial performance, the clinical curing effect and the application range of the titanium and titanium alloy medical instrument are improved by a large margin.
Owner:NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH

Method for preparing freeze-drying particle preparation for injection

The invention relates to the technical field of medicaments. The existing process for preparing particle preparations such as a lipid film comprises the step of dissolving a medicament into the oil for injection to form milky microspheres, so the prepared particle preparations have the defects of low medicament-loading amount, poor stability, large using amount of auxiliary materials and large toxic and side effect. The invention provides a method for preparing a freeze-drying particle preparation for injection, which comprises the following steps: firstly, dissolving water-insoluble medicinal powder into a volatile water-soluble organic solvent to form molecular medicinal solution, and then dispersing the molecular medicinal solution into the water for injection to form fluffy soft aggregate mixed suspension; and then adding a small amount of injection-grade auxiliary material such as dispersant and the like into the suspension, and obtaining the freeze-drying particle preparation for injection through a certain preparation process. The particle preparation prepared by the preparation method has the characteristics of small using amount of auxiliary materials, high medicament-loading amount, good stability, simple preparation process and the like. The preparation method of the invention has broad practicability, and basically can meet the preparation requirement of most water-insoluble powdery medicinal particle preparations.
Owner:高保安

A kind of preparation method of high thermal conductivity composite filler and polymer-based composite material thereof

The invention provides a preparation method of a high thermal conductivity composite filling material and a polymer matrix composite material of the high thermal conductivity composite filling material. The high thermal conductivity composite filling material comprises a sheet-shaped heat conductive filling material and a spheroidic heat conductive filling material; and the surface of the spheroidic heat conductive filling material is coated with the sheet-shaped heat conductive filling material. The preparation method comprises following steps: the sheet-shaped heat conductive filling material and the spheroidic heat conductive filling material are subjected to surface modification respectively, and are dispersed in an organic solvent for heating stirring, so that chemical reaction and bond connection among reactive groups from the filling materials are realized, and self assembling is carried out so as to obtain a structure similar to sesame seed balls, wherein the surface of the spheroidic heat conductive filling material is coated with the sheet-shaped heat conductive filling material. The unique structure is capable of realizing formation of high efficiency heat conductive paths in a composite material filled with the high thermal conductivity composite filling material, so that adding of a small amount of the high thermal conductivity two-dimensional sheet-shaped fillingmaterial is capable of improving the thermal conductivity of the polymer matrix composite material obviously, and heat conduction requirements of preparation of electrical and electronic equipment canbe satisfied.
Owner:SHANGHAI JIAOTONG UNIV
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