61 results about "Self assembling" patented technology

The invention discloses a modified graphite felt electrode for an all-vanadium redox flow battery and a preparation method of the modified graphite felt electrode, and belongs to the technical field of redox flow battery electrode materials. The preparation method comprises the following steps: graphite felt electrochemical oxidation etching treatment; self-assembling a conductive layer on the oxidized and etched graphite felt to obtain the graphite felt attached with the conductive layer; and loading a metal and nitrogen-doped carbon (M and NC) nano catalyst layer on the graphite felt attached with the conductive layer to obtain the modified graphite felt electrode. Various properties of the graphite felt are comprehensively improved through matrix treatment, structure change and load catalysis, mild electrochemical oxidation etching is adopted, a carbon fiber structure is protected, a self-assembled net-shaped conductive layer forms a stable conductive channel, the specific surface area is remarkably increased, a nitrogen-doped carbon shell is adopted to wrap metal nanodots to form an M-NC catalytic layer, and the specific surface area is remarkably increased. The catalyst layer is not easy to dissolve out, the capacity fading rate is obviously improved, the loading capacity of the catalyst layer on the reticular structure conducting layer with a larger specific surface area is larger, and meanwhile, the process is simple and low in cost.

Compositions and methods for filling tissue voids and defects with a self-assembling biopolymer configured to form a shape-retaining matrix are described.

To provide a method for determining when a natural therapeutic or beneficial product will exert its therapeutic or beneficial effect via a physiological mechanism of action.SOLUTION: The present invention relates to a new method that allows the evolution of medical technologies from the use of chemically or biologically defined artificial substances to self-assembling natural products obtained from natural raw materials by industrial processes that preserve their endogenous properties, thereby preserving their ability to interact with the networks of the living world (including humans), which natural products cannot be defined with classical qualitative and quantitative composition schemes. Thus, the present invention provides a new method for determining when a therapeutic or beneficial product exerts its therapeutic or beneficial effect via a physiological mechanism of action. This method provides the tools necessary for the skilled person to assess the mechanism of action of a therapeutic or beneficial product, which has become a relevant feature to assess with new developments in regulatory regimes for medical devices and nutraceuticals, for which there is no method available in the art.SELECTED DRAWING: None

The invention belongs to the technical field of biomedical engineering, and relates to a traditional Chinese medicine self-assembled nano material as well as a preparation method and application thereof. The traditional Chinese medicine self-assembled nano material is prepared from mineral traditional Chinese medicines and other traditional Chinese medicines, wherein the other traditional Chinese medicines are one or two of plant-derived traditional Chinese medicines and animal-derived traditional Chinese medicines; the traditional Chinese medicine self-assembled nano material has a T1 weighted nuclear magnetic resonance imaging function; the D50 particle size of the traditional Chinese medicine self-assembled nano material is 30 to 450 nm. The traditional Chinese medicine self-assembled nano material provided by the invention is high in biological safety and good in storage stability, has a T1 weighted nuclear magnetic resonance imaging function, and also has a treatment effect on specific tumors.

The present invention relates to new methods enabling the evolution of the medical arts passing from the use of artificial substances that are chemically or biologically defined to self-assembling natural entities, obtained from natural raw materials with industrial processes that preserve the endogenous properties thereof, thereby preserving their capability to interact with the networks of the living kingdom (including humans); wherein said natural entities cannot be defined with the classical quali-quantitative composition schemes. The invention therefore provides new methods for determining when a therapeutic or beneficial product exerts its therapeutic or beneficial effect through a physiological mode of action. This method provides a necessary tool for the skilled person to assess the mechanism of action of a therapeutic or beneficial product which, with the new developments in the regulatory framework for medical devices and food supplements has become a relevant feature to assess and for which no methods are available in the art.

The present disclosure relates to a vaccine comprising at least one peptide antigen conjugate having the formula selected from PEG-[E1]-A-[E2]-[U]-H and H-[U]-[E1]-A-[E2]-PEG, wherein E1 is an N terminal extension, E2 is a C terminal extension, A is peptide antigen, H is hydrobhobic block, wherein one or more drug molecules (D) are optionally attached to each H directly or via a suitable linker X1; U is a linker, [ ] denotes the group is optional and - denotes that the two adjacent groups are directly attached to one another by a covalent bond or indirectly to one another via a suitable linker X. The vaccine is useful in treating or preventing a cancer, an autoimmune disease, an allergy, or an infectious disease.

The invention belongs to the technical fields of medical chemistry, new materials and nanotechnology, and relates to a novel diagnosis and treatment agent in the field of interdisciplinary, in particular to a preparation method of a reduction response activation < 19 > F magnetic resonance signal amplification self-degradation nanometer diagnosis and treatment micelle. Poly (benzyl carbamate) is obtained through condensation polymerization as a basic structure, then chemical modification is performed to obtain a self-degradable fluorine-containing amphiphilic block polymer, hydrophobic drug chlorin (Ce6) is loaded through self-assembly, the self-degradable fluorine-containing amphiphilic block polymer has the characteristic of responding to degradation of glutathione (GSH) at a tumor site, and on the basis of maintaining self-degradation of a hydrophobic chain segment of the nano-micelle, the self-degradable fluorine-containing amphiphilic block polymer can be used for preparing the self-degradable fluorine-containing amphiphilic block polymer. The nano-micelle loaded with Ce6 has the advantages that the nano-micelle loaded with Ce6 is used as a carrier, the characteristic of efficient 19F MR imaging is additionally endowed, under laser irradiation, the nano-micelle loaded with Ce6 can enhance a new scheme of breast cancer photodynamic therapy, the effects of responding to tumor microenvironment self-degradation drug release and 19F MRI signal amplification are achieved, and therefore diagnosis and treatment integration of breast cancer is achieved.

Described herein is a computer-implemented method for training a machine learning model for predicting one or more physiochemical properties of a nanoparticle. In some instances, the method includes receiving a set of data including nanoparticles, generating a descriptor and fingerprint for each nanoparticle in the set of data, creating a plurality of sets of training data and a plurality of sets of test data, training a machine learning model of an artificial intelligence (AI) system using the plurality of sets of training data, and predicting a property of the drug-excipient pair of the plurality of sets of test data based on drug-excipient pairs and property values of each drug-excipient pair of the plurality of sets of training data. Also described herein are excipients conjugated to a polyethylene glycol moiety, or pharmaceutically acceptable salts thereof. In some instances, the excipients may be used to form nanoparticles with a therapeutic compound.

The invention provides a left-handed torsion type II cellulose nanocrystal and right-handed chiral photon self-supporting transparent film as well as a preparation method and application thereof, and belongs to the technical field of nano materials. The method comprises the following steps: mixing type II cellulose with sulfuric acid, and carrying out hydrolysis reaction to obtain type II cellulose nanocrystals; the concentration of the sulfuric acid is greater than or equal to 60wt%; the type II cellulose nanocrystals are subjected to desulfurization treatment, the levorotation torsion type II cellulose nanocrystals are obtained, and the sulfur content in the levorotation torsion type II cellulose nanocrystals ranges from 0.450 wt% to 0.900 wt%. The torsional chiral amplification of the type II cellulose nanocrystal is realized through desulfurization treatment, and the obtained left-handed torsional type II cellulose nanocrystal has a rodlike left-handed torsional morphology, and has relatively strong capability of forming chiral nematic liquid crystal through evaporation-induced self-assembly; the right-handed chiral photon self-supporting transparent film can be formed by evaporation-induced self-assembly of the left-handed torsion type II cellulose nanocrystal.

The present disclosure relates to a vaccine comprising at least one peptide antigen conjugate having the formula selected from PEG-[E1]-A-[E2]-[U]-H and H-[U]-[E1]-A-[E2]-PEG, wherein E1 is an N terminal extension, E2 is a C terminal extension, A is peptide antigen, H is hydrobhobic block, wherein one or more drug molecules (D) are optionally attached to each H directly or via a suitable linker X1; U is a linker, [ ] denotes the group is optional and - denotes that the two adjacent groups are directly attached to one another by a covalent bond or indirectly to one another via a suitable linker X. The vaccine is useful in treating or preventing a cancer, an autoimmune disease, an allergy, or an infectious disease.

The application provides a preparation method of a silicon-carbon composite negative electrode material, comprising the following steps: nanocrystallizing silicon material under a protective environment to obtain nanosilicon; self-assembling the nanosilicon with a first carbon source and a high polymer, and then adding a second carbon source to perform self-assembly, to obtain layered nanosilicon; granulating the layered nanosilicon to obtain a precursor; and sintering the precursor at a sintering temperature of 800 DEG C to 1200 DEG C to obtain the silicon-carbon composite negative electrode material. The application also provides a silicon-carbon composite negative electrode material and a battery comprising the same. The preparation method is simple in process, easy to control the process, and suitable for industrial production, and the prepared silicon-carbon composite negative electrode material can inhibit expansion and has improved conductivity and capacity.

A game network system having server interconnection structures and convergence algorithms for homogeneous n-dimensional integral coordinate summary address networks. A multidimensional area is defined with an integral coordinate system. Blocks of space are defined within the area with coordinate summary addresses. The coordinate summary addresses are mapped to server addresses so that different blocks of space can be independently stored on different servers. A tracker is used to coordinate the server to server connectivity. The network will attempt self-assembly as long as it is not in a converged state.

An example collapsible charging case for a pair of smart glasses comprises a foldable component that is configured to operate in two states, including: a folded state that defines a first internal volume, and an unfolded state that defines a second internal volume that is greater than the first interior volume, and the second interior volume being configured to house a pair of smart glasses. The collapsible charging case also includes a deployable mechanism configured to contact a nose bridge portion of a pair of smart glasses, and the deployable mechanism is configured to operate in two states, including: an undeployed state that occurs when the foldable component of the collapsible charging case is in the first foldable state, and a deployed state that occurs when the foldable component of the collapsible charging case is in the second foldable state.

The application provides a method for preparing a high-first-efficiency high-tapped-density silicon-carbon negative electrode material from photovoltaic crystalline silicon waste, and belongs to the technical fields of secondary recycling of silicon resources and lithium ion batteries. The method comprises the following steps: firstly, removing impurities from the photovoltaic crystalline silicon waste through pretreatment; secondly, constructing a lithium silicate solid electrolyte by performing in-situ prelithiation treatment on the pretreated photovoltaic crystalline silicon waste; thirdly, obtaining high-sphericity silicon-carbon microspheres by spraying and self-assembling the prelithiated silicon material; and finally, introducing the silicon-carbon microspheres into a dense carbon skeleton through fluidized bed carbon deposition to obtain a high-sphericity silicon-carbon negative electrode material with high first coulomb efficiency and high tapped density. The application provides a new idea and a new path for the value-added recycling of photovoltaic industrial crystalline silicon waste and the construction of high-performance lithium ion batteries.

The invention relates to the technical field of electrochemical sensors, in particular to an aptamer sensor, a preparation method of the aptamer sensor and a detection method of the aptamer sensor on metal ions, and the method comprises the following steps: S1, spin-coating photoresist on the surface of a gold electrode, performing soft baking, covering the surface of the photoresist with a mask plate, and performing exposure, then post-baking the photoresist, and constructing a detection site through developing solution treatment; s2, immersing the gold electrode into a zinc salt-containing benzyl alcohol solution, and circularly scanning potential under an oil bath condition to form a nano-porous gold structure; s3, depositing a reference electrode and a counter electrode at each detection site; s4, dispensing a specific aptamer solution of target metal ions at each detection site, self-assembling and fixing an aptamer through an Au-S bond, and performing room-temperature incubation; then flushing the aptamer by using a PBS (Phosphate Buffer Solution), and sealing a non-specific site of the aptamer by using 1mM of mercaptoethanol; according to the invention, high-precision synchronous fast detection of four kinds of target metal ions can be realized.

The application discloses self-assembled nanoparticles, a preparation method and application thereof, and exosome-wrapped nanomaterials containing the self-assembled nanoparticles and application thereof, wherein the self-assembled nanoparticles comprise schisandrol and chlorogenic acid, and the schisandrol and the chlorogenic acid are mixed to form nanoparticles. The self-assembled nanoparticles are formed by self-assembly of schisandrol and chlorogenic acid, the self-assembled nanoparticles have excellent antioxidant performance, the self-assembled nanoparticles are wrapped by exosomes to form nanomaterials, and the nanomaterials can treat liver injury and promote formation of specific immune tolerance.

An example collapsible charging case for a pair of smart glasses comprises a foldable component that is configured to operate in two states, including: a folded state that defines a first internal volume, and an unfolded state that defines a second internal volume that is greater than the first interior volume, and the second interior volume being configured to house a pair of smart glasses. The collapsible charging case also includes a deployable mechanism configured to contact a nose bridge portion of a pair of smart glasses, and the deployable mechanism is configured to operate in two states, including: an undeployed state that occurs when the foldable component of the collapsible charging case is in the first foldable state, and a deployed state that occurs when the foldable component of the collapsible charging case is in the second foldable state.

The invention belongs to the technical field of nano luminescent materials, and particularly relates to a fluorescence-adjustable dual-state white light silicon dioxide matrix graphene oxide quantum dot composite material and a preparation method thereof. Comprising the following steps: mixing long-chain diamino silane with graphene oxide quantum dots, carrying out self-assembly to obtain a precursor solution, and carrying out a hydrothermal reaction. The composite material has a firm Si-O-C covalent bond, the structural rigidity is enhanced, a three-dimensional Si-O-Si network is formed, and fluorescence red shift is caused by tight stacking of graphene oxide quantum dots in a confinement environment. The material provided by the invention can regulate and control the load fraction of graphene oxide quantum dots, and change the relative intensity of blue and red light-emitting centers. In the adjusting process that the load fraction of the graphene oxide quantum dots is 7.0%-21.4%, the emission spectrum can be continuously adjusted and controlled from 2000k to 6000k, and when the load fraction is 7.0%, white fluorescence can be emitted in a liquid state or a solid state.

A preparation method of a nano-taper field emission cathode, comprising the following steps: (1) cleaning a silicon wafer substrate, and then performing metal ion implantation on the upper layer of the silicon substrate after drying; (2) depositing SiO2 on the substrate in step 1 as a mask layer; (3) self-assembling polystyrene microspheres on the surface of the substrate in step 2; (4) etching the SiO2 layer to form a nano-pillar mask structure through first plasma etching; (5) cleaning the sample piece through solvent ultrasonic cleaning, and then performing etching cleaning through a plasma adhesive remover; (6) performing dry etching on the Si substrate material by taking the SiO2 nano-pattern structure as a mask, i.e. second plasma etching, and finally performing ultrasonic cleaning to obtain the nano-taper field emission cathode. The method improves the conductive performance of the tip, is more conducive to electron emission, and the nano material is more stable and is not easy to fall off after multiple emissions.

This invention belongs to the field of micro-nanostructures and relates to a method for preparing a periodic array of nanotip open-ring 3D structures. This method involves self-assembling polystyrene nanospheres after depositing a reflective layer and a support layer on a silicon substrate. Reactive ion etching is then used to reduce the nanosphere volume. Subsequently, two tilted magnetron sputtering steps are performed. The deposited noble metal is etched using a reactive ion etcher. After removing the nanosphere mask, a periodic array of nanotip open-ring 3D structures is obtained. This method features a simple preparation process, good uniformity, high order, and strong repeatability, and has broad application potential in fields such as SERS and photoelectric performance testing.

The invention relates to the technical field of nano materials, in particular to a preparation method of a light response type ultrathin organic vesicle. The structural formula of the amphiphilic peptoid molecule is as shown in formula I: # imgabs0 #; and the light response type ultrathin organic vesicle prepared by self-assembling the amphiphilic peptoid molecule has excellent light response characteristic, so that the amphiphilic peptoid molecule has wide application prospect in preparation of a catalyst carrier.

The invention discloses a method for preparing a one-dimensional nano-structure magnetic material through magnetic nano-particle self-assembly, and belongs to the technical field of nano-material preparation. The method for preparing the one-dimensional nano-structure magnetic material through magnetic nano-particle self-assembly comprises the following steps: mixing a magnetic nano-particle precursor, a surfactant and a solvent to obtain a mixed solution, and inducing the magnetic nano-particle precursor to realize self-assembly through a heating reaction to obtain the one-dimensional nano-structure magnetic material. According to the method for forming the one-dimensional nano-structure magnetic material by driving self-assembly based on the spontaneous magnetic dipole interaction of the magnetic nanoparticles without an external magnetic field provided by the invention, the magnetic anisotropy and the magnetic dipole interaction are enhanced by regulating and controlling the particle spacing through parameters, and the magnetic nanoparticles are induced to be connected end to end, so that the one-dimensional nano-structure magnetic material is formed. And self-assembling to form a nanometer chain structure with a controllable length. The method is simple in structure and has good expandability and universality.

The present invention indicates a self-assembling container for the transport and storage of food. It is composed of a boxed body and a lid, the boxed body being configured to assume a flat configuration, suitable for storage (when the containers are empty), and an assembled configuration, suitable for transporting food. An interesting feature is that no instructions are needed to achieve the assembled configuration. The device, in its flat configuration, which is raised in the center (being conformed with a slightly convex bottom), is squashed by the weight of the food that is intended to be transported, for example a pizza; this pressure brings the base to a flat shape and raises the four edges, closing the sides; at the same time, the foldable corners that connect the four lateral edges to each other retract towards the inside of the box. The base of each shelf has a number of evapotranspiration rises to allow the circulation of hot air released by the food, avoiding condensation, and in the case of stacking a plurality of containers, one on top of the other, the heat will transfer from one shelf to the other thanks to the internal ventilation holes. Finally, a lid suitable for closing the last container at the top of the stack is then supplied separately.

The invention belongs to the technical field of lignin nano materials, and particularly discloses a low-cost method for preparing nano lignin. The method comprises the following steps: dispersing a lignin raw material through a mixed solution of ethanol, gamma-valerolactone and water, stirring a lignin solution, pumping water into the lignin solution through a peristaltic pump, self-assembling to form nano lignin, and finally centrifuging the mixed solution to precipitate nano lignin particles. The obtained nano lignin has a uniform particle size of 200-600nm, and is in the shape of a solid or hollow sphere.

Described herein is a computer-implemented method for training a machine learning model for predicting one or more physiochemical properties of a nanoparticle. In some instances, the method includes receiving a set of data including nanoparticles, generating a descriptor and fingerprint for each nanoparticle in the set of data, creating a plurality of sets of training data and a plurality of sets of test data, training a machine learning model of an artificial intelligence (AI) system using the plurality of sets of training data, and predicting a property of the drug-excipient pair of the plurality of sets of test data based on drug-excipient pairs and property values of each drug-excipient pair of the plurality of sets of training data. Also described herein are excipients conjugated to a polyethylene glycol moiety, or pharmaceutically acceptable salts thereof. In some instances, the excipients may be used to form nanoparticles with a therapeutic compound.

The present invention relates to new methods enabling the evolution of the medical arts passing from the use of artificial substances that are chemically or biologically defined to self-assembling natural entities, obtained from natural raw materials with industrial processes that preserve the endogenous properties thereof, thereby preserving their capability to interact with the networks of the living kingdom (including humans); wherein said natural entities cannot be defined with the classical quali-quantitative composition schemes. The invention therefore provides new methods for determining when a therapeutic or beneficial product exerts its therapeutic or beneficial effect through a physiological mode of action. This method provides a necessary tool for the skilled person to assess the mechanism of action of a therapeutic or beneficial product which, with the new developments in the regulatory framework for medical devices and food supplements has become a relevant feature to assess and for which no methods are available in the art.

The application relates to a preparation method of a magnesium alloy surface super-hydrophobic coating, which comprises the following steps: (1) constructing a micro-arc porous magnesium oxide coating on the surface of the magnesium alloy through a micro-arc oxidation technology; (2) immersing the magnesium alloy with the micro-arc porous magnesium oxide coating on the surface in a ferrous ion solution, then carrying out hydrothermal treatment in pure water, and obtaining the magnesium alloy with Mg-Fe layered double hydroxide nanosheets on the surface; (3) immersing the magnesium alloy with the Mg-Fe layered double hydroxide nanosheets on the surface in the ferrous ion solution, self-assembling iron hydroxyl nanosheets on the Mg-Fe layered double hydroxide nanosheets, and obtaining the magnesium alloy with secondary micro-nano rough structures on the surface; and (4) carrying out thermal reduction treatment on the magnesium alloy with the secondary micro-nano rough structures on the surface in a reducing atmosphere, and obtaining the magnesium alloy with the super-hydrophobic coating on the surface.

The invention relates to material science, and aims to provide a preparation method of a bismaleimide triazine resin composite material containing modified filler. Comprising the following steps: carrying out self-assembly on transition metal nitrate and imidazole ligands to obtain a porous nano material ZIFs with a three-dimensional structure; then reacting with ethyl silicate under a heating condition to obtain a porous nano material coated with a SiO2 shell layer; carrying out a reaction with a pre-hydrolyzed silane coupling agent so as to obtain silane coupling agent graft modified nano powder; the preparation method comprises the following steps: by taking bismaleimide resin and cyanate ester resin as matrixes and the modified nano powder as filler, removing an organic solvent and bubbles after prepolymerization, and curing to obtain the bismaleimide triazine resin composite material containing the modified nano filler. The prepared composite material has the advantages of low dielectric loss, low dielectric constant, high thermal decomposition temperature and high glass transition temperature; and the preparation process is simple, high in repeatability and suitable for industrial mass production.

The invention belongs to the technical field of high-performance thermal management materials, and discloses a high-thermal-conductivity hexagonal boron nitride-based composite film and a preparation method thereof.The composite film is composed of a hexagonal boron nitride (h-BN) nanosheet layer and a graphitized carbonaceous layer formed after a polyhydroxy aromatic compound is subjected to heat treatment, the graphitized carbonaceous layer is bridged between the hexagonal boron nitride nanosheet layers. The preparation method comprises the following steps: mixing an h-BN nanosheet and a polyhydroxy aromatic compound in a solvent to form a mixed dispersion liquid, self-assembling the h-BN nanosheet and the polyhydroxy aromatic compound into a highly-oriented prefabricated film through a vacuum filtration technology, drying, and carrying out heat treatment in an inert atmosphere to graphitize the polyhydroxy aromatic compound to obtain the composite film. The in-plane heat conductivity coefficient of the film is larger than 200 W / (m.K), and the film has excellent flexibility and mechanical strength and is especially suitable for efficient heat dissipation of 5G communication, high-power chips and flexible electronic equipment.

A modular micro-factory swarm for autonomous urban construction is disclosed. Each unit is a self-assembling robotic tile that (i) 3D-prints structural elements from locally characterized feedstock, (ii) powers itself via a dual renewable system (deployable photovoltaic array and hydrogen electrolysis / fuel-cell), and (iii) communicates over a mesh network for coordinated tasking. A cost-based planner assigns paths and jobs to minimize energy, time, and terrain risk. After each extrusion, the tile runs on-board structural checks (ultrasonic echo and vibrational resonance) and records pass / fail metrics. Build provenance is bound cryptographically: a hardware security module signs a build object identifier that hashes tile ID, task node, material signature, time, and location; signed records are committed to a distributed ledger. Actuation is gated by location-specific consent tokens verified against policy maps before printing proceeds. The architecture enables peer-to-peer orchestration, verifiable quality control, and closed-loop energy autonomy, reducing reliance on infrastructure and supervision.