24 results about "Self assembling" patented technology

Described herein is a computer-implemented method for training a machine learning model for predicting one or more physiochemical properties of a nanoparticle. In some instances, the method includes receiving a set of data including nanoparticles, generating a descriptor and fingerprint for each nanoparticle in the set of data, creating a plurality of sets of training data and a plurality of sets of test data, training a machine learning model of an artificial intelligence (AI) system using the plurality of sets of training data, and predicting a property of the drug-excipient pair of the plurality of sets of test data based on drug-excipient pairs and property values of each drug-excipient pair of the plurality of sets of training data. Also described herein are excipients conjugated to a polyethylene glycol moiety, or pharmaceutically acceptable salts thereof. In some instances, the excipients may be used to form nanoparticles with a therapeutic compound.

The present disclosure relates to a vaccine comprising at least one peptide antigen conjugate having the formula selected from PEG-[E1]-A-[E2]-[U]-H and H-[U]-[E1]-A-[E2]-PEG, wherein E1 is an N terminal extension, E2 is a C terminal extension, A is peptide antigen, H is hydrobhobic block, wherein one or more drug molecules (D) are optionally attached to each H directly or via a suitable linker X1; U is a linker, [ ] denotes the group is optional and - denotes that the two adjacent groups are directly attached to one another by a covalent bond or indirectly to one another via a suitable linker X. The vaccine is useful in treating or preventing a cancer, an autoimmune disease, an allergy, or an infectious disease.

The application provides a preparation method of a silicon-carbon composite negative electrode material, comprising the following steps: nanocrystallizing silicon material under a protective environment to obtain nanosilicon; self-assembling the nanosilicon with a first carbon source and a high polymer, and then adding a second carbon source to perform self-assembly, to obtain layered nanosilicon; granulating the layered nanosilicon to obtain a precursor; and sintering the precursor at a sintering temperature of 800 DEG C to 1200 DEG C to obtain the silicon-carbon composite negative electrode material. The application also provides a silicon-carbon composite negative electrode material and a battery comprising the same. The preparation method is simple in process, easy to control the process, and suitable for industrial production, and the prepared silicon-carbon composite negative electrode material can inhibit expansion and has improved conductivity and capacity.

The invention relates to the technical field of electrochemical sensors, in particular to an aptamer sensor, a preparation method of the aptamer sensor and a detection method of the aptamer sensor on metal ions, and the method comprises the following steps: S1, spin-coating photoresist on the surface of a gold electrode, performing soft baking, covering the surface of the photoresist with a mask plate, and performing exposure, then post-baking the photoresist, and constructing a detection site through developing solution treatment; s2, immersing the gold electrode into a zinc salt-containing benzyl alcohol solution, and circularly scanning potential under an oil bath condition to form a nano-porous gold structure; s3, depositing a reference electrode and a counter electrode at each detection site; s4, dispensing a specific aptamer solution of target metal ions at each detection site, self-assembling and fixing an aptamer through an Au-S bond, and performing room-temperature incubation; then flushing the aptamer by using a PBS (Phosphate Buffer Solution), and sealing a non-specific site of the aptamer by using 1mM of mercaptoethanol; according to the invention, high-precision synchronous fast detection of four kinds of target metal ions can be realized.

The application discloses self-assembled nanoparticles, a preparation method and application thereof, and exosome-wrapped nanomaterials containing the self-assembled nanoparticles and application thereof, wherein the self-assembled nanoparticles comprise schisandrol and chlorogenic acid, and the schisandrol and the chlorogenic acid are mixed to form nanoparticles. The self-assembled nanoparticles are formed by self-assembly of schisandrol and chlorogenic acid, the self-assembled nanoparticles have excellent antioxidant performance, the self-assembled nanoparticles are wrapped by exosomes to form nanomaterials, and the nanomaterials can treat liver injury and promote formation of specific immune tolerance.

The invention belongs to the technical field of nano luminescent materials, and particularly relates to a fluorescence-adjustable dual-state white light silicon dioxide matrix graphene oxide quantum dot composite material and a preparation method thereof. Comprising the following steps: mixing long-chain diamino silane with graphene oxide quantum dots, carrying out self-assembly to obtain a precursor solution, and carrying out a hydrothermal reaction. The composite material has a firm Si-O-C covalent bond, the structural rigidity is enhanced, a three-dimensional Si-O-Si network is formed, and fluorescence red shift is caused by tight stacking of graphene oxide quantum dots in a confinement environment. The material provided by the invention can regulate and control the load fraction of graphene oxide quantum dots, and change the relative intensity of blue and red light-emitting centers. In the adjusting process that the load fraction of the graphene oxide quantum dots is 7.0%-21.4%, the emission spectrum can be continuously adjusted and controlled from 2000k to 6000k, and when the load fraction is 7.0%, white fluorescence can be emitted in a liquid state or a solid state.

The invention discloses a method for preparing a one-dimensional nano-structure magnetic material through magnetic nano-particle self-assembly, and belongs to the technical field of nano-material preparation. The method for preparing the one-dimensional nano-structure magnetic material through magnetic nano-particle self-assembly comprises the following steps: mixing a magnetic nano-particle precursor, a surfactant and a solvent to obtain a mixed solution, and inducing the magnetic nano-particle precursor to realize self-assembly through a heating reaction to obtain the one-dimensional nano-structure magnetic material. According to the method for forming the one-dimensional nano-structure magnetic material by driving self-assembly based on the spontaneous magnetic dipole interaction of the magnetic nanoparticles without an external magnetic field provided by the invention, the magnetic anisotropy and the magnetic dipole interaction are enhanced by regulating and controlling the particle spacing through parameters, and the magnetic nanoparticles are induced to be connected end to end, so that the one-dimensional nano-structure magnetic material is formed. And self-assembling to form a nanometer chain structure with a controllable length. The method is simple in structure and has good expandability and universality.

Described herein is a computer-implemented method for training a machine learning model for predicting one or more physiochemical properties of a nanoparticle. In some instances, the method includes receiving a set of data including nanoparticles, generating a descriptor and fingerprint for each nanoparticle in the set of data, creating a plurality of sets of training data and a plurality of sets of test data, training a machine learning model of an artificial intelligence (AI) system using the plurality of sets of training data, and predicting a property of the drug-excipient pair of the plurality of sets of test data based on drug-excipient pairs and property values of each drug-excipient pair of the plurality of sets of training data. Also described herein are excipients conjugated to a polyethylene glycol moiety, or pharmaceutically acceptable salts thereof. In some instances, the excipients may be used to form nanoparticles with a therapeutic compound.

The application relates to a preparation method of a magnesium alloy surface super-hydrophobic coating, which comprises the following steps: (1) constructing a micro-arc porous magnesium oxide coating on the surface of the magnesium alloy through a micro-arc oxidation technology; (2) immersing the magnesium alloy with the micro-arc porous magnesium oxide coating on the surface in a ferrous ion solution, then carrying out hydrothermal treatment in pure water, and obtaining the magnesium alloy with Mg-Fe layered double hydroxide nanosheets on the surface; (3) immersing the magnesium alloy with the Mg-Fe layered double hydroxide nanosheets on the surface in the ferrous ion solution, self-assembling iron hydroxyl nanosheets on the Mg-Fe layered double hydroxide nanosheets, and obtaining the magnesium alloy with secondary micro-nano rough structures on the surface; and (4) carrying out thermal reduction treatment on the magnesium alloy with the secondary micro-nano rough structures on the surface in a reducing atmosphere, and obtaining the magnesium alloy with the super-hydrophobic coating on the surface.

The invention belongs to the technical field of high-performance thermal management materials, and discloses a high-thermal-conductivity hexagonal boron nitride-based composite film and a preparation method thereof.The composite film is composed of a hexagonal boron nitride (h-BN) nanosheet layer and a graphitized carbonaceous layer formed after a polyhydroxy aromatic compound is subjected to heat treatment, the graphitized carbonaceous layer is bridged between the hexagonal boron nitride nanosheet layers. The preparation method comprises the following steps: mixing an h-BN nanosheet and a polyhydroxy aromatic compound in a solvent to form a mixed dispersion liquid, self-assembling the h-BN nanosheet and the polyhydroxy aromatic compound into a highly-oriented prefabricated film through a vacuum filtration technology, drying, and carrying out heat treatment in an inert atmosphere to graphitize the polyhydroxy aromatic compound to obtain the composite film. The in-plane heat conductivity coefficient of the film is larger than 200 W / (m.K), and the film has excellent flexibility and mechanical strength and is especially suitable for efficient heat dissipation of 5G communication, high-power chips and flexible electronic equipment.

A modular micro-factory swarm for autonomous urban construction is disclosed. Each unit is a self-assembling robotic tile that (i) 3D-prints structural elements from locally characterized feedstock, (ii) powers itself via a dual renewable system (deployable photovoltaic array and hydrogen electrolysis / fuel-cell), and (iii) communicates over a mesh network for coordinated tasking. A cost-based planner assigns paths and jobs to minimize energy, time, and terrain risk. After each extrusion, the tile runs on-board structural checks (ultrasonic echo and vibrational resonance) and records pass / fail metrics. Build provenance is bound cryptographically: a hardware security module signs a build object identifier that hashes tile ID, task node, material signature, time, and location; signed records are committed to a distributed ledger. Actuation is gated by location-specific consent tokens verified against policy maps before printing proceeds. The architecture enables peer-to-peer orchestration, verifiable quality control, and closed-loop energy autonomy, reducing reliance on infrastructure and supervision.

Disclosed in the present application are an in-plane controllably grown germanium nanowire, a preparation method therefor, and the use thereof. The method comprises: obtaining a strip-shaped platform structure on a silicon germanium substrate; pretreating the silicon germanium substrate having the strip-shaped platform structure; and using a molecular beam epitaxy growth technique to sequentially grow a silicon germanium buffer layer, a silicon spacer layer, a pure germanium layer and a silicon cap layer on the silicon germanium substrate having the strip-shaped platform structure, so as to prepare a germanium nanowire. The problem of a germanium nanowire grown by means of self-assembling having excessively high contact resistance and reduced material mobility due to inter-diffusion of materials is overcome; and good ohmic contact can be formed with contact metal at a low temperature, and a thousand-level low-temperature mobility is achieved, which are conducive to the extension of quantum dot devices and the increase in the number of spin bits.

An electromagnetic shielding graphene composite film includes a graphene base material having a surface attached with a nano-metal oxide. The electromagnetic shielding graphene composite film shows an electromagnetic wave transmittance of no more than 60 dB and an electromagnetic wave reflectance that ranges from 0 to 10 dB in a frequency range of 5 to 15 GHz. This indicates that the graphene base material shows electromagnetic shielding performance. A method of preparing an electromagnetic shielding graphene composite film is also provided and includes steps of: immersing a metal plate in a graphene oxide solution to induce a reaction, wherein a graphene base material which is self-assembling is formed on the metal plate; removing the metal plate from the graphene oxide solution and delaminating the metal plate using dilute hydrochloric acid to separate the graphene base material from the metal plate; and obtaining the electromagnetic shielding graphene composite film.

The present invention relates to a method for producing three-dimensional semiconductor nanoparticles from self-assembling metal nanoparticles. The method combines the deposition of a metal on a semiconductor substrate using physical deposition techniques with reactive-ion plasma attacks on the metal-semiconductor assembly. The method is simple, fast and economical and dispenses with the need for lithographic processes.

The present application relates to the technical field of electrode material, and particularly relates to a self-supporting silicon-carbon composite negative electrode material and a preparation method and application thereof.The self-supporting silicon-carbon composite negative electrode material is prepared by the following steps: subjecting a nano-silicon material to an amino treatment, then self-assembling the nano-silicon material and graphene oxide in a water-based solvent through electrostatic attraction to form a stable three-dimensional crosslinked network structure, and finally obtaining the self-supporting silicon-carbon composite negative electrode material through vacuum filtration and heat treatment.The self-supporting silicon-carbon composite negative electrode material provided by the present application improves the energy density of a battery, can effectively inhibit the volume expansion of silicon during charging and discharging, improves the structural stability and cycle life of an electrode, and improves the rate performance of the electrode, and therefore has a wide application prospect.

The application discloses an ordered supramolecular organic framework with uniform and adjustable pore size and a preparation method thereof, and the structural general formula of the supramolecular organic framework is shown in the formula, wherein the polymerization degree n is 5, 10, 20, 30 or 40. The method comprises the following steps: performing active polymerization on a phenyl isocyanide monomer by using a three-arm alkyne-Pd (II) catalyst to obtain a three-arm phenyl isocyanide polymer, performing a Pd (II)-mediated Sonogashira cross-coupling reaction on a functional urea pyrimidinone monomer of the alkyne to functionalize a terminal end of the three-arm phenyl isocyanide polymer after polymerization, then adding a reagent A to perform a reaction, and performing self-assembly driven by intermolecular hydrogen bonds of terminal Upy units to obtain the ordered supramolecular organic framework. The preparation method of the supramolecular organic framework is simple in operation and simple in synthesis, and has great potential application value in the fields of biomedicine, nanotechnology, intelligent materials, photoelectric materials and the like.

The application relates to the field of multifunctional sensor preparation, in particular to a multifunctional pressure-gas sensor and a preparation method and application thereof. The preparation method comprises the following steps: copper nanowires and silver nanowires are dissolved in an alcohol solution, graphene oxide aqueous solution is added into the alcohol solution, ultrasonic stirring is carried out, and a graphene oxide-copper oxide nanowire-silver nanowire mixed solution is obtained; a reducing agent solution is added into the prepared mixed solution, and after hydrothermal self-assembly, freeze-drying is carried out; the freeze-dried product is subjected to cyclic-heat treatment in an air fryer, and a graphene oxide-copper oxide nanowire-silver nanowire aerogel is obtained. The application utilizes the efficient self-assembly of two-dimensional graphene and one-dimensional copper nanowires and silver nanowires to construct a unique three-dimensional conductive network, and utilizes the difference between the oxidation potentials of the two metal materials to in-situ generate copper oxide nanowires from the copper nanowires, realize specific recognition of ammonia gas, and manufacture a sensor to realize pressure detection and ammonia gas detection.

In an approach to improve three-dimensional (3D) manufacturing, methods determine, based on shape and dimensions of a hollow portion of a three-dimensional (3D) object, to create the 3D object using self-assembling cube robots submerged in a photosensitive resin tank. Additionally, methods instruct the self-assembling cube robots to collaborate to form an approximate shape of the hollow portion of the 3D object. Further, methods causing an ultraviolet (UV) projection system to emit holographic light beams around a structure of the self-assembling cube robots to create the 3D object with the hollow portion.

The present application relates to a self-assembling molecule, a perovskite solar cell, a photovoltaic module, a power generation device, and an electric device. The perovskite solar cell comprises a first electrode, a functional layer, a perovskite light-absorbing layer, and a second electrode stacked in a thickness direction of the perovskite solar cell. The functional layer comprises the self-assembling molecule, and the self-assembling molecule comprise a hole extraction group. The maximum size of the self-assembling molecule in a first direction is a first size, the maximum size of the self-assembling molecule in a second direction is a second size, and the maximum size of the self-assembling molecule in a third direction is a third size, wherein at least one of the first size, the second size, and the third size is greater than or equal to 1.6 nm, and any two of the first direction, the second direction, and the third direction are perpendicular to each other. The photoelectric conversion efficiency and device stability of the perovskite solar cell in the present application can be effectively improved.

In an approach to improve three-dimensional (3D) manufacturing, methods determine, based on shape and dimensions of a hollow portion of a three-dimensional (3D) object, to create the 3D object using self-assembling cube robots submerged in a photosensitive resin tank. Additionally, methods instruct the self-assembling cube robots to collaborate to form an approximate shape of the hollow portion of the 3D object. Further, methods causing an ultraviolet (UV) projection system to emit holographic light beams around a structure of the self-assembling cube robots to create the 3D object with the hollow portion.

The invention discloses a two-dimensional graphene oxide / cellulose thermal response composite membrane and a preparation method and application thereof, and belongs to the technical field of two-dimensional thermal response composite membrane materials and aqueous zinc ion battery thermal management, the preparation method comprises the following steps: uniformly mixing a graphene oxide aqueous dispersion and a cellulose aqueous dispersion to obtain a mixed solution; and carrying out vacuum filtration and self-assembly on the mixed solution to prepare the two-dimensional graphene oxide / cellulose thermal response composite membrane. The prepared two-dimensional graphene oxide / cellulose composite film has good mechanical performance and reversible thermal response performance, can be used for thermal protection management of a zinc ion battery, and realizes reversible thermal shutdown in a high-temperature environment.

This invention relates to the field of biomedical materials technology, and discloses a cerium-doped mesoporous bioactive glass and its preparation method. The cerium-doped mesoporous bioactive glass comprises a SiO₂-CaO-P₂O₅ glass network and cerium element doped in the glass network; the cerium-doped mesoporous bioactive glass has an amorphous mesoporous structure. This cerium-doped mesoporous bioactive glass is prepared by employing a sol-gel method combined with a water-in-oil self-assembly strategy. Using hexadecylpyridine bromide as a template agent, urea as a slow-release alkali source, and triethanolamine as a reaction regulator, a stable emulsion is constructed in an aqueous system, followed by the sequential introduction of silicon, phosphorus, calcium, and cerium sources. This successfully achieves in-situ uniform doping of cerium element in the mesoporous bioactive glass network framework. Furthermore, this method requires no subsequent modification steps, and a multifunctional material with an amorphous mesoporous structure, Ce³⁺ / Ce⁴⁺ mixed valence state, and controllable CeO₂ nanocrystal distribution can be obtained in one step.

The invention relates to the technical field of nano-drug delivery, and discloses a traditional Chinese medicinal material essence extracted hair restorer based on a nanotechnology, which comprises the following components in percentage by mass: 1.0-5.0% of molecularly imprinted herbal-protein-mineral hybridized nanoflower with the particle size of 150-300nm, the molecularly imprinted herbal-protein-mineral hybrid nanoflower is formed by in-situ biomineralization self-assembly of a hydrolyzed silk fibroin skeleton, a metal phosphate skeleton and a compound herbal extract in the presence of L-malic acid. Hydrolyzed silk fibroin and mineral components are adopted as a framework, and a compound herbal extract is synchronously and efficiently embedded when nanoparticles are formed by using an in-situ biomineralization technology, so that organic fusion of animal, mineral and plant essences is realized, and the problems that a traditional adsorption method is low in drug loading capacity and easy to fall off are solved; the nano-carrier can carry sufficient nutrition repairing components, and a solid foundation is laid for the nano-carrier to penetrate through the skin barrier subsequently.