239 results about "Gel matrix" patented technology

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The invention belongs to the technical field of biological medicine, and relates to an oral peptide drug delivery system based on a soybean trypsin inhibitor and core-shell hydrogel, the oral peptide drug delivery system comprises therapeutic polypeptide, KTI and a core-shell structure gel matrix, and the problems that an existing oral peptide delivery system is passively protected and drug burst release is remarkable are solved. A chitosan / sodium tripolyphosphate ionic cross-linked network forms an inner core, a sodium alginate / calcium ion'egg box 'structure cross-linked network forms a shell, and therapeutic polypeptides such as liraglutide and KTI are jointly embedded. Through the pH response characteristic and sequential release design of the core-shell structure, KTI is preferentially and rapidly released in the intestinal environment to inhibit local protease activity, then therapeutic polypeptide is slowly released, and active protection and synergistic interaction are achieved. The invention further provides a specific preparation method and parameters. The polypeptide has the advantages of stable structure in a gastric acid environment, targeted release in intestinal tracts, high encapsulation efficiency, capability of avoiding burst release and the like, and provides a new strategy for efficient delivery of oral polypeptide drugs.

This invention discloses a cellulose-based ion-conductive gel membrane and its preparation method, belonging to the technical field of flexible wearable electronic materials and sensors. Addressing the technical pain points of existing ion gels, such as easy dehydration and failure, insufficient mechanical properties, difficulty in film formation, and inability to synergistically optimize multiple performance indicators, this invention constructs a composite gel matrix by crosslinking sodium alginate and sodium carboxymethyl cellulose with calcium ions. The crosslinking density of the system is controlled by sodium carboxymethyl cellulose, and glycerol is used as a plasticizer to construct ion transport channels. A solid gel membrane free of free water is obtained through coating, crosslinking, room temperature equilibration, and drying dehydration. The raw materials of this invention are environmentally friendly, the preparation process is simple and controllable, and the resulting gel membrane possesses high tensile strength, high transparency, excellent ion conductivity, and environmental stability. It exhibits sensitive strain response and good linearity, and can be widely used in the field of flexible strain sensing.

The application discloses a salbutamol sulfate sustained-release tablet and a preparation process thereof. The preparation process comprises the following steps: drug micronization treatment, drug and ion exchange resin compounding, granulation with hydrophilic gel matrix material, gradient temperature control drying, total mixing after whole granulation, tabletting, double controlled-release coating, ladder solidification treatment and screening and packaging. Through the synergistic sustained-release effect of the ion exchange resin and the hydrophilic gel matrix material, the double controlled-release coating and the ladder solidification process, the application effectively inhibits drug burst release, realizes smooth and long-lasting release, reduces impurity content, and improves product stability and batch reproducibility. The obtained sustained-release tablet releases 20%-40% in 2 hours and 80% or more in 8 hours in a pH 6.8 phosphate buffer, and the quality is controllable, so the sustained-release tablet is suitable for industrial production.

The invention relates to the technical field of biological medicine, and discloses rapamycin-loaded microemulsion gel as well as a preparation method and application thereof. The preparation method of the microemulsion gel comprises the following steps: dissolving N, N-dimethyl octadecyl carboxymethyl chitosan in a water phase, then adding an oil phase, a cosurfactant and rapamycin, and stirring to obtain rapamycin-loaded microemulsion; the preparation method comprises the following steps: dissolving a high polymer material in a PBS solution, heating until the high polymer material is completely dissolved, then adding dopamine, stirring for reaction, and finally dialyzing and freeze-drying to obtain the adhesive. And adding a gel matrix containing a thickening agent and an adhesive into the microemulsion, and stirring to obtain the rapamycin-loaded microemulsion gel. According to the prepared microemulsion gel, transdermal drug delivery of hydrophobic drugs is achieved, testis are coated with the microemulsion gel loaded with rapamycin, the blocking effect of damp-heat stress on differentiation and development of testis interstitial cells can be relieved, and the functionality of a male reproduction endocrine system is recovered.

The invention discloses a preparation method of a starch-based gel color developing material for visual detection of airborne iodine nuclides, which comprises the following steps: adding starch, a polymer matrix material and a plasticizer into deionized water for soaking and uniformly stirring to obtain a starch-based gel matrix solution; placing the starch-based gel matrix solution at a certain temperature, and stirring to obtain gel paste; and injecting the gel paste liquid into a mold, and carrying out freeze-thaw cycle to obtain the starch-based gel color developing material for airborne iodine nuclide visual detection. The starch-based gel color developing material has the characteristics of quick response, stable color development and lasting color and luster for airborne iodine nuclide at normal temperature, has excellent mechanical strength, machinability and recycling performance, can be flexibly processed into forms such as a film and a test piece, or can be integrated in various detection devices, and has a wide application prospect. The method is suitable for places needing airborne iodine nuclide detection, such as nuclear medicine laboratories, nuclear facilities / nuclear equipment and the like, and meets the requirements of real-time visual detection and early warning.

The invention discloses bacteriostatic gel for gynecology and a preparation method thereof, and relates to the technical field of bacteriostatic gel. The antibacterial gel is prepared from a gel matrix, a plant extracting solution, antibacterial peptide, a humectant, astaxanthin microcapsules and a specific buffer solution. The buffer solution contains sodium citrate, hyaluronic acid and citric acid, and intelligent regulation and control of the drug release behavior of the astaxanthin microcapsule are realized by utilizing the synergistic effect of a hyaluronic acid and citric acid buffer system and preferably adopting hyaluronic acid compounded or modified with different molecular weights. The gel can maintain stable drug release in a normal vagina and pathological fluctuation pH environment, and trigger accelerated release in a high active oxygen inflammation environment, so that the problems that the release behavior is greatly influenced by environmental fluctuation and cannot adapt to different disease stages in the prior art are effectively solved, accurate and personalized drug delivery is realized, and the drug delivery efficiency is improved. The antibacterial agent has the advantages of good antibacterial effect and high environmental adaptability.

To provide a polyherb gel delivery device that maintains the stability and antioxidant activity of herbal ingredients, ensuring a long shelf life, controlled release of active ingredients, ease of use, and suitability for large-scale dietary supplement and functional food applications. The polyherb gel delivery device (100) comprises a gel matrix (102), an antioxidant barrier layer (104), and an outer container (106). The gel matrix (102) is centrally located and surrounded by the barrier layer (104), which is further surrounded by the outer container (106), forming an integrally connected multi-layer structure suitable for stably encapsulating the herb gel composition.

The invention discloses a blue copper peptide composition for repairing scars and a preparation method of the blue copper peptide composition, and belongs to the technical field of preparation of biological medicine preparations. The composition is prepared from freeze-dried powder of copper blue peptide, polyquaternium-73, asiaticoside, nicotinamide, polydimethylsiloxane, betaine-propylene glycol ionic liquid and a gel matrix. According to the invention, the blue copper peptide is coated in a permeation enhancing system constructed by the betaine-propylene glycol ionic liquid and the HEPES, so that the enzymolysis loss of the blue copper peptide is reduced, and the biological activity of the blue copper peptide is maintained; a temperature-sensitive gel matrix is constructed by carboxyl esterified modified sodium alginate and poloxamer, the carboxyl esterified modified sodium alginate is prepared by grafting n-butyl alcohol to a hydrophilic main chain of sodium alginate through a Fischer esterification method, the gel matrix is in a liquid state at normal temperature, after the gel matrix is smeared on a scar part, the gel matrix is converted into semi-solid gel under the influence of body temperature, and slow and continuous release of blue copper peptide can be achieved. The traditional Chinese medicine composition has the effect of repairing scars and is suitable for chronic scars needing long-term nursing.

This invention relates to the field of pharmaceutical technology. The invention provides a traditional Chinese medicine gel, comprising, by weight percentage: 0.5-5% traditional Chinese medicine exosomes, 5-15% traditional Chinese medicine extracts, 10-25% gel matrix, 1-5% transdermal penetration enhancer, 2-8% moisturizer, 0.1-0.5% preservative, 0.05-0.3% pH adjuster, and the balance deionized water. The traditional Chinese medicine gel prepared using the technical solution of this invention uses traditional Chinese medicine exosomes as the core active ingredient, combined with traditional Chinese medicine extracts, and leverages the advantages of a gel formulation to achieve highly efficient transdermal absorption of the active ingredients. It can specifically treat acne caused by internal dampness, and is highly safe, stable, and easy to use.

The invention discloses a solid waste-based micro-nano radiation cooling coating and a preparation method thereof.The preparation method comprises the steps that fly ash and coal gangue serve as main solid waste raw materials, and after being subjected to ultra-fining and silane modification, the main solid waste raw materials and a phosphate exciting agent are subjected to chemical action to form an inorganic micro-nano gel matrix; nano-silica (SiO2) and barium sulfate (BaSO4) are cooperatively introduced as a spectrum regulation functional filler, and a multi-scale scattering structure and an intermediate infrared radiation channel are constructed, so that the radiation cooling effect of high solar reflectivity and high infrared emissivity is realized. The prepared coating has excellent spectral selectivity (the solar reflectivity is larger than or equal to 0.88, and the mid-infrared emissivity is larger than or equal to 0.95), high weather resistance (the 500-hour ultraviolet aging retention rate is larger than or equal to 95%) and remarkable passive cooling capacity (the temperature drop can reach 5-8 DEG C). The raw materials are wide in source, the preparation process is simple, a large amount of building solid waste or industrial solid waste can be utilized, the low-cost and high-performance green radiation cooling coating is achieved, and a technical path capable of being popularized on a large scale is provided for building outer wall energy-saving transformation and urban heat island relieving.

This invention belongs to the field of traditional Chinese medicine adhesive bandage technology, specifically relating to a Shengji Yuhong Ointment, its preparation method, and a medicated film adhesive bandage. The Shengji Yuhong Ointment has a hydrogel structure, comprising raw materials, a gel matrix, and nano-zinc oxide or silver sulfadiazine nanoparticles. The raw materials include the following components by weight: 13-17 parts Angelica dahurica, 34-38 parts Glycyrrhiza uralensis, 58-62 parts Angelica sinensis root, 10-14 parts Dragon's Blood, 4-8 parts Lithospermum erythrorhizon, and 0.2-0.25 parts Musk-β-cyclodextrin inclusion complex powder or Musk nanoliposome powder. The matrix comprises the following components by weight: 245-255 parts sesame oil, 57-63 parts beeswax, 93-103 parts polymer material, 37-43 parts plasticizer, 3-8 parts penetration enhancer, and 0.8-1.2 parts preservative. The Shengji Yuhong Ointment of this invention is used in medicated film adhesive bandages, is convenient to use, and is particularly suitable for chronic, difficult-to-heal ulcers and acute wounds requiring accelerated healing.

The invention provides a medical beauty-grade sensitive skin repair dressing with a gamma-polyglutamic acid controlled release function, and belongs to the technical field of biomedical materials. The repair dressing is composed of controlled release microspheres dispersed in a matrix material, the controlled release microspheres take modified gamma-polyglutamic acid as an active core material and a biocompatible high polymer material as a wall material, and the matrix material comprises a medical grade gel matrix, a moisturizing component and an anti-inflammatory soothing component. The gamma-polyglutamic acid is subjected to acylation or graft modification to improve the stability and biocompatibility of the gamma-polyglutamic acid, and 12-72h gradient release of the gamma-polyglutamic acid is realized by virtue of the controlled release microspheres prepared by virtue of an emulsification-crosslinking method or a solvent evaporation method; meanwhile, through the synergistic matching of the matrix components, the dressing is endowed with the moisturizing, anti-inflammatory and soothing effects. The dressing can effectively reduce wound inflammatory response after medical art, promote epidermal cell proliferation and improve the water content and barrier function of a sensitive skin cuticle, and is suitable for scenes of wound repair after medical art, sensitive skin barrier reconstruction and the like.

The present invention discloses a controlled-release type polymeric ferric sulfate water treatment agent and its preparation method, belonging to the technical field of water treatment functional materials. The water treatment agent consists of polymeric ferric sulfate, an iron ion color indicator, a gel matrix, a cross-linking calcium agent, amino diatomaceous earth, a pore-forming agent and an inert filler. The preparation method includes: first preparing a network gel, then preparing soft materials, and finally obtaining the product through pill-making and drying. The present invention realizes the slow release and controllability of polymeric ferric sulfate, and the color indicator can directly reflect the consumption state of polymeric ferric sulfate, facilitating storage, transportation, dosing and recovery.

The invention relates to the technical field of gels, and particularly discloses a wound repair gel responding to a wound surface microenvironment and a preparation method thereof, the gel is prepared from the following raw materials in percentage by mass: 3.0%-6.0% of a response gel matrix, 0.5%-2.0% of an active pharmaceutical ingredient, 0.5%-1.2% of a bionic repair component, 2.0%-4.0% of a moisturizing and stabilizing agent and the balance of water for injection. The response gel matrix comprises oxidized sodium alginate and methylacryloylated chitosan, the active drug component comprises a pH sensitive antibacterial drug and an enzyme sensitive healing promoting drug, and the bionic repairing component is a compound of recombinant human collagen and zinc sulfate. Bacterial reproduction is timely inhibited and infection is controlled at the early stage of wound healing; after entering the later healing stage, the composition continuously promotes epithelial cell proliferation and tissue regeneration, and meanwhile, the composition can remarkably promote tissue regeneration, reduce scar formation and realize antibacterial and healing-promoting synergy.

The invention discloses a nano-realgar temperature-sensitive gel preparation for intratumor injection as well as a preparation method and application of the nano-realgar temperature-sensitive gel preparation. The preparation method comprises the following steps: S1, obtaining a nano-realgar suspension with the mass concentration of 0.1%-5%; s2, adding a dispersing agent into the nano-realgar suspension, performing ultrasonic uniform mixing in an ice bath, and performing vacuum freeze drying to obtain nano-realgar freeze-dried powder; wherein the mass of the dispersing agent is 0.01%-0.2% of the mass of the nano realgar suspension; s3, obtaining a temperature-sensitive gel matrix, adding the nano-realgar freeze-dried powder into the temperature-sensitive gel matrix, and performing ice-bath ultrasonic treatment to obtain a nano-realgar temperature-sensitive gel preparation; wherein the mass of the nano realgar freeze-dried powder is 0.1%-5% of the mass of the temperature-sensitive gel matrix. The method provided by the invention is simple in equipment, low in cost and suitable for industrialization; the preparation can realize local slow drug release in tumors, has long action time, and avoids the problems of low bioavailability and systemic toxicity of realgar.

The invention discloses a mosquito luring agent gel composition as well as a preparation method and application thereof, and relates to the technical field of daily chemical industry. The composition provided by the invention has a gel dosage form and comprises a gel matrix and a long-acting mosquito-luring component, the long-acting mosquito-luring active component is mainly tea-flavor ketone, meanwhile, sodium benzoate is added to be compounded with the tea-flavor ketone, and the sodium benzoate can realize slow release of the tea-flavor ketone through intermolecular interaction with the tea-flavor ketone. Meanwhile, the introduction of sodium benzoate can also adjust the microstructure of the obtained gel, has important influence on the texture of the gel, and can improve the stability of the gel. Based on the introduction of sodium benzoate and the gel formulation, the water-retaining property of the gel and the slow release of tea flavor ketone are remarkably improved, the durability of mosquito trapping activity is prolonged, the mosquito trapping rate within 72 hours is stabilized to be 58% or above, the reduction degree is not higher than 27.5% compared with the mosquito trapping rate after 24 hours, and the gel has excellent large-scale application prospects.

Systems and methods are provided for delivering a therapeutic treatment to a target population of cells (including, but not limited to, tumors, eyeballs, pancreatic tissue, liver tissue, and lung tissue) in a subject. The system includes an injectable aqueous solution in a vial enclosed with a septum. The solution comprises particles containing a therapeutic agent and having a coating surrounding the therapeutic agent, the coating comprising chitosan to provide controlled release of the agent from the particles. The solution also comprises a chitosan polymer in the form of a polymer gel matrix, further providing controlled release of the particles from the aqueous gel environment. There is also provided a method of making a freeze-dried powder placed in a vial containing a chitosan polymer and chitosan-coated particles, the powder when mixed with water forming the above injectable aqueous solution with particles and chitosan gel.

The invention discloses a temperature-sensitive gel preparation containing a glutaminase inhibitor as well as a preparation method and application of the temperature-sensitive gel preparation, and belongs to the technical field of biological medicines. The temperature-sensitive gel preparation comprises outer-layer gel and inner-layer gel, the inner-layer gel is coated with the outer-layer gel, the outer-layer gel accounts for 40-75% of the total mass of the temperature-sensitive gel preparation, and the inner-layer gel accounts for 25-60% of the total mass of the temperature-sensitive gel preparation; the outer-layer gel is prepared from the following raw materials: an outer-layer gel matrix, a glutaminase inhibitor, a photosensitizer and a stabilizer; the raw materials of the inner-layer gel comprise an inner-layer gel matrix and an immune checkpoint inhibitor. According to the temperature-sensitive gel preparation, through photo-thermal control, the glutaminase inhibitor is firstly released to relieve the immunosuppression state, then the immune checkpoint inhibitor is released to kill tumors, and the glutaminase inhibitor and the immune checkpoint inhibitor act synergistically, so that efficient anti-tumor immunotherapy is achieved.

The invention provides a long-acting brexpiprazole in-situ gel injection and a preparation method thereof. The long-acting brexpiprazole in-situ gel injection is an injectable sustained-release preparation prepared by taking a polylactic acid-glycolic acid copolymer (PLGA) and poloxamer as gel matrixes, dissolving brexpiprazole in an amphiphilic solvent and adding an additive. The long-acting brexpiprazole in-situ gel injection prepared by the invention has good mechanical properties, and the drug release time can be maintained for 1 month. The preparation is simple in preparation process, low in equipment requirement and suitable for industrial production.

The invention relates to an active pharmaceutical ingredient for repairing oral mucosa and a preparation method of the active pharmaceutical ingredient, and belongs to the technical field of biological medicine, and the active pharmaceutical ingredient comprises an amanita aurantiaca mycelium active peptide-myrobalan polyphenol composite entrapment substance, a dendrobium nobile callus extract, sorbitol, menthol, a gel matrix and the like. The amanita aurantiaca mycelium active peptide-myrobalan polyphenol composite entrapment substance is obtained by entrapment of a compound of amanita aurantiaca mycelium active peptide and myrobalan polyphenol through a sodium alginate-dopamine grafted copolymer; the amanita aurantiaca mycelium active peptide is obtained by performing common enzymolysis on the mycelium of amanita aurantiaca through bromelain and bacillus subtilis protease. The dendrobium nobile callus extract is obtained by inducing slices of dendrobium nobile seedling leaves with 2, 4-D and 6-BA, extracting and purifying. The gel matrix is prepared from modified konjac glucomannan and carboxymethyl chitosan. All the components form an anti-inflammatory, proliferative and remodeled closed-loop repair system, and the anti-degradation stability and the adhesion long-term effect are improved.

The invention is applicable to the technical field of energy conversion, and provides a multifunctional flexible ionic gel generator and a preparation method thereof, and the multifunctional flexible ionic gel generator comprises an upper layer carbon electrode, a flexible ionic gel layer and a lower layer carbon electrode which are sequentially connected from top to bottom. The preparation method of the flexible ionic gel layer comprises the following steps: mixing a matrix material, a thermoelectric response material, a moisture absorption material and deionized water, carrying out a cross-linking reaction, and standing in a mold to obtain the flexible ionic gel layer. Lithium chloride, sodium polystyrenesulfonate and other materials are introduced into an acrylamide and carboxymethyl cellulose hydrogel matrix, simple crosslinking is performed to form flexible ionic gel, and meanwhile low-grade heat energy and moisture energy are collected and converted into electric energy. On the basis of cooperation of thermoelectricity and moisture power generation, collection of chemical energy and response to pressure are completed, and multiple functions are achieved.

The invention relates to the technical field of medicine, and discloses an artemisinin external gel composition as well as a preparation method and application thereof, the gel composition comprises 0.1-5 parts of artemisinin, 1-20 parts of a solubilizer, 0.5-15 parts of a gel matrix, 5-30 parts of a penetration enhancer, 0.01-1 part of a stabilizer, 0.01-2 parts of a pH regulator, 0.05-1.5 parts of a preservative, 1-15 parts of a humectant and purified water. According to the technical scheme, a peroxide bridge structure of artemisinin is used for removing active oxygen, the multiple effects of resisting inflammation, resisting oxidation, resisting bacteria, promoting repair and resisting scars are achieved by regulating and controlling channels such as NF-kappa B and TGF-beta, and meanwhile, a gel matrix maintains a moist environment of a wound surface and promotes transdermal absorption of drugs. Experiments prove that the composition can reduce MDA content of wound surfaces, increase SOD activity, inhibit IL-6, TNF-alpha and other inflammatory factors, reduce collagen deposition and inhibit bacterial growth, can effectively improve the pathological process of scalds and burns, and provides a novel multi-mechanism synergistic external composition for clinical treatment.

This invention belongs to the field of medical experimental technology, specifically relating to a dental pre-anesthesia device based on an edible matrix, its preparation method, and its application. The device includes a handheld stick, a sugar ball, and a receiving box with a through hole. The box contains a gel anesthetic, which consists of an outer layer of sustained-release gel matrix and an inner anesthetic gel unit. The sustained-release gel matrix is ​​made of gelatin, pectin, or sodium alginate and is ring-shaped to conform to tooth shape. The anesthetic gel unit contains components such as lidocaine hydrochloride, chitosan, and carbomer 980, exhibiting high adhesiveness. Preparation involves first obtaining the anesthetic gel unit, then encapsulating it with the sustained-release gel matrix and coating it with sugar, and finally assembling the device. This device, through its edible matrix and sugar coating, transforms the anesthesia process into a "candy-eating" experience, significantly reducing patient fear, precisely conforming to the teeth and gingival margin, preventing anesthetic leakage, and improving the safety and effectiveness of anesthesia, making it particularly suitable for pediatric dental pre-anesthesia.

The invention discloses a traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and a preparation method of the traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicine compositions for fading scars. 5 to 15 parts of a gel matrix; 10 to 25 parts of an oil phase component; 3-8 parts of an emulsifier and a thickener; and the balance of water. Wherein the active traditional Chinese medicine component consists of 1-5 parts of calculus bovis factitius, 1-3 parts of artificial musk, 3-10 parts of cowherb seed, 3-10 parts of golden cypress, 2-8 parts of frankincense and 2-8 parts of myrrh. The traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and the preparation method of the traditional Chinese medicine composition have the beneficial effects that the traditional Chinese medicine composition for inhibiting and fading scar hyperplasia and the preparation method of the traditional Chinese medicine composition are provided, all the medicines are combined to jointly achieve the effects of promoting blood circulation to remove blood stasis, dredging collaterals, removing stasis, resisting inflammation and promoting tissue regeneration and directly refer to the pathogenesis core of scar hyperplasia, and an oil-in-water (O / W) latex dosage form is adopted, so that the traditional Chinese medicine composition has the refreshing effect of gel and the moistening effect of cream, and is easy to coat and good in air permeability.

The invention relates to the technical field of biological medicine, in particular to an exosome medicine preparation for treating knee osteoarthritis and a preparation method thereof, and the exosome medicine preparation is characterized in that an exosome is derived from mesenchymal stem cells subjected to three-dimensional culture in a first hydrogel matrix containing sodium alginate and hyaluronic acid; flurbiprofen or a pharmaceutically acceptable salt or ester thereof; and a pharmaceutically acceptable second gel matrix. Sodium alginate and hyaluronic acid composite hydrogel serves as a three-dimensional culture carrier of mesenchymal stem cells, a joint microenvironment is simulated to induce stem cells to secrete high-activity exosomes rich in key functional nucleic acid and active protein, meanwhile, the exosomes are scientifically compounded with flurbiprofen, and synergistic mechanisms of anti-inflammatory analgesia and tissue repair are achieved; and a local slow-release delivery system is constructed through the second gel matrix, so that long-acting stable release of active ingredients is realized, the systemic side effect of the medicine is reduced, the bioavailability of the exosome is improved, and the problems of obvious side effect, limited repair effect and the like in the prior art are solved.

The invention discloses composite aerogel loaded with active vesicles as well as a preparation method and application thereof.The composite aerogel loaded with the active vesicles comprises cordate houttuynia source vesicle-like nanoparticles and a three-dimensional porous aerogel substrate, carboxymethyl cellulose (CMC), collagen (Collagen) and carboxyl chitosan (Carboxychitosan) are introduced, a composite aerogel matrix suitable for the oral environment is constructed, and the composite aerogel loaded with the active vesicles is prepared. A three-dimensional porous structure is formed by combining a directional quick freezing and freeze drying process, and HDVLNs are uniformly loaded into the three-dimensional porous structure, so that structural protection, positioned delivery and continuous release of the vesicles are realized, a brand new technical approach is provided for solving key bottlenecks of poor local retention, non-lasting effect and the like of the HDVLNs, and the preparation method has a wide application prospect. Therefore, a novel efficient and safe biological material solution is provided for prevention and treatment of oral inflammatory diseases.

The invention provides a traditional Chinese medicine compound external preparation for invigorating the kidney and strengthening Yang and a preparation method thereof, belongs to the technical field of traditional Chinese medicine preparations, and aims to solve the problems that the bioavailability of the first-pass effect of existing oral administration is low, and effective components of external ointment are difficult to penetrate through the skin. The preparation is a composite gel containing a penetration enhancer and a temperature-sensitive gel matrix, and the traditional Chinese medicine compound at least comprises various active ingredients of male silkworm moth, centipede, epimedium, rhizoma curculiginis, cistanche, schisandra chinensis, semen cuscutae, polygala tenuifolia, fructus cnidii, semen allii tuberosi, actinolite, sulfur, venenum bufonis, amethyst and borneol. According to the preparation disclosed by the invention, the transdermal permeation rate and the cumulative permeation amount of various active ingredients in the compound are improved in order of magnitude, so that an effective treatment concentration can be ensured to be reached in an in-vitro local or in-vivo system. In clinical application, the traditional Chinese medicine composition has better effect taking speed and treatment effect than external application or oral administration of traditional prescriptions with the same name.