501 results about "Gel matrix" patented technology

The present application provides a keratin and a nucleic acid sequence encoding the same. The present application further provides a keratin gel dressing comprising the keratin of the present application, bFGF and a gel matrix.

The invention belongs to the technical field of medical materials, and particularly relates to a tooth whitening composition and a preparation method thereof, the tooth whitening composition comprises the following components by weight: 5%-15% of hydrogen peroxide, 0.5%-1.5% of a gel matrix, 0.2%-1.0% of a thickener, 5%-10% of a humectant, 3%-8% of propylene glycol, 0.05%-0.2% of a chelating agent, 1%-3% of a sweetener, 0.1%-0.5% of sodium fluoride, and the balance of water. Aiming at the problems that an existing tooth whitening product is relatively low in pH value (most of 4.0-5.0), easy to irritate gingiva and sensitive in tooth manufacturing, and the existing tooth whitening product needs to be stored in a dark place at a low temperature and is short in whitening validity period, the pH value of the product is adjusted to 5.5-6.5, so that the product is close to oral saliva, the irritation can be reduced, the stability of the product can be ensured, the product is not easy to decompose, and the tooth whitening effect is good. Active ingredients are prevented from losing efficacy in advance, and the whitening validity period is prolonged.

The invention relates to the technical field of composite hydrogel preparation, in particular to a nano composite hydrogel preparation process based on a microfluidic technology. The gel comprises the following components in parts by mass: 50-70 parts of a gel matrix, 5-9 parts of a nano enhancement system, 8-14 parts of a functional carrier, 3-6 parts of a dynamic response system, 4-7 parts of a hyaluronic acid-sulfhydrylated heparin compound and 0.5-1.5 parts of L-ascorbyl palmitate. Precise mixing and directional arrangement of all component materials on a micro-level are realized through a microfluidic technology, so that a nano reinforcing system and a functional carrier are uniformly distributed in a gel matrix, the synergistic effect of all the components is fully exerted, the mechanical property and the biological function of the gel are effectively improved, and the preparation method is suitable for industrial production. And quaternized chitosan nanofibers, a dynamic response system for responding to external environment change and a hyaluronic acid-sulfhydrylated heparin compound for promoting angiogenesis are introduced, so that the gel has the biological functions of resisting bacteria and promoting angiogenesis through a synergistic effect.

The invention relates to the technical field of bird repelling agents, in particular to a bird repelling agent based on thiocyanuric acid and a preparation method thereof, and the bird repelling agent is prepared from the following raw materials: thiocyanuric acid, modified beta-cyclodextrin, a magnetic powder synergist, a gel matrix, a synergistic aid, a solvent and a surfactant. The invention discloses a bird repellent based on thiocyanuric acid and a preparation method thereof, thiocyanuric acid is included through monoisocyanate modified beta-cyclodextrin, a magnetic powder synergist and a gel matrix are combined to form a'molecular inclusion-magnetic response-gel fixation 'triple-action system, and the problems that an existing bird repellent is short in time efficiency and poor in weather resistance are solved. The release time of the bird repellent is prolonged, the high bird repelling rate is still kept under the conditions of high temperature and rainwater, and the bird repellent is suitable for scenes such as farmlands and electric power facilities and has remarkable technical progress and practical value.

The invention discloses a nanofiber interwoven composite gel membrane for carbon dioxide separation and a preparation method of the nanofiber interwoven composite gel membrane. The nanofiber interwoven composite gel membrane comprises a nanofiber interwoven framework and a carbon dioxide-philic gel matrix layer, wherein the surface of the nanofiber interwoven framework is coated with the carbon dioxide-philic gel matrix layer; the carbon dioxide-philic gel matrix layer is formed by in-situ polymerization and gelation of a precursor solution containing an oxidizing agent, a cross-linking agent and a functional monomer on the surface of the nanofiber interwoven skeleton. The nanofiber interwoven composite gel membrane provided by the invention has excellent carbon dioxide permeability and selectivity. The invention also discloses an application of the nanofiber interwoven composite gel membrane in separation of carbon dioxide.

The invention belongs to the technical field of medical gel, and particularly relates to modified hydrogel for skin wound healing and a preparation method thereof.The modified hydrogel is prepared from, by weight, 2-5 parts of drug-loaded GDVLNs, 1-2 parts of chitosan, 0.6-1.5 parts of antioxidant, 0.2 part of LAP, 1.5 parts of MA, 18 parts of gel matrix and 100 parts of buffer solution, the drug-loaded GDVLNs prepared from the traditional Chinese medicine active ingredients and the ginseng vesicles have the functions of resisting oxidative stress, promoting angiogenesis, promoting cell proliferation and the like, and the MA modified hydrogel system can realize slow release and controlled release of the drug-loaded GDVLNs and play a long-acting healing promoting role.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention discloses injection type facial filler composition gel for medical beauty as well as a preparation method and application of the injection type facial filler composition gel, and belongs to the technical field of biomedical materials. The composition gel comprises a combined gel matrix and polycaprolactone microspheres, wherein the combined gel matrix comprises an aqueous solution for injection, sodium carboxymethyl cellulose and human recombinant collagen; according to the composition gel, a combined gel matrix and polycaprolactone microspheres are mixed according to a specific proportion, amino acid residues of human-derived recombinant collagen in the combined gel matrix serve as binding sites of cell surface receptors to improve the cell recognition and attachment capacity of the polycaprolactone microspheres, and the amino acid residues are organically combined with sodium carboxymethyl cellulose to improve the cell recognition and attachment capacity of the polycaprolactone microspheres. The durability and biocompatibility of the shaping effect of the human-derived recombinant collagen at the injection site are improved; the composition prepared by the invention is good in gel fluidity, high in elastic modulus and high in dynamic viscosity, and can meet the expected mechanical and rheological properties of a facial filling agent for cosmetic and plastic surgery.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

The invention relates to the technical field of food processing and making, and discloses a konjac food and a making method thereof, and the making method comprises the following steps: raw material pretreatment, swelling and dispersion, enzymolysis treatment, gel matrix preparation, flavor substance embedding, mixing and degassing, curing forming, ultrahigh pressure treatment and post-sterilization and packaging. In the invention, the konjac micro-powder is subjected to controllable enzymolysis through the compound bio-enzyme preparation, and the konjac micro-powder and the gel matrix liquid composed of carrageenan, gellan gum and curdlan gum in a specific ratio have a synergistic effect under a curing condition, so that the konjac colloid and the gel matrix are interwoven to form a compact and stable cementing system, and the texture of the konjac food is improved; according to the method, the plant-derived flavor extract is added, so that the taste of the plant-derived flavor extract is uniform and consistent, the defect that the traditional process product is unstable in texture or easily generates bad flavor is overcome, the plant-derived flavor extract is embedded by adopting beta-cyclodextrin, and the plant-derived flavor extract is converted into a microcapsule form through high-pressure homogenization and spray drying processes.

The invention belongs to the technical field of contact lens care, and provides temperature-sensitive contact lens eye-moistening gel and a preparation method thereof. The temperature-sensitive contact lens eye-moistening gel is prepared from the following raw materials in parts by mass: a gel matrix, a surfactant, an osmotic pressure regulator, an active component, a chelating agent, a buffering agent and the balance of injection water, the composition of the gel matrix is defined. Chitosan, sodium hyaluronate and polyvinyl alcohol are compounded to serve as a gel matrix, a polyelectrolyte compound is formed, gelation time is shortened, gel strength and swelling resistance are improved, biocompatibility is improved, and drug-loaded delivery of active ingredients is achieved; the gel matrix and the surfactant are reasonably selected, the viscosity of the solution is increased, the gelation time is shortened, the excellent effect of relieving eye fatigue and dryness is achieved, the wearing comfort of the contact lens is remarkably improved, and the oxygen permeation effect of the contact lens is not obviously reduced after gel forming.

The invention discloses a novel compound rapid surface anesthetic and a preparation method thereof, and belongs to the field of pharmaceutical preparations. According to the anesthetic, core anesthetic components of lidocaine and tetracaine are compounded with propylene glycol-laurocapram synergistic penetration enhancer, menthol auxiliary penetration enhancer, carbomer 980 gel matrix, triethanolamine pH regulator, glycerol humectant, panthenol soothing agent, purified water and the like, a surface smearing agent is prepared through a specific process, and the anesthetic can be administered in combination with an iontophoresis technology. Compared with the existing surface anesthetic for the cosmetic surgery, the surface anesthetic disclosed by the invention solves the problems of slow effect taking and poor effect, can realize rapid penetration of local skin, has short anesthesia effect taking time, long duration and good effect, has no obvious irritation to the skin, has good product stability, can effectively reduce the drug toxicity, and has a good application prospect. The device is suitable for surface anesthesia of non-surgical medical beauty items such as skin beauty, laser treatment and water-light micro-needles.

The invention discloses a preparation method and application of a composite phase-change gel material, and the composite phase-change gel material is prepared by combining an organic phase-change material, an inorganic phase-change material or a combination of the organic phase-change material and the inorganic phase-change material with a nucleating agent, a cross-linking agent and a porous material and optimizing a process. The phase-change gel material with high phase-change latent heat, long-acting cooling, excellent shape stability, good flexibility and cycle durability is prepared. A polyurethane gel matrix is adopted, the material is endowed with good flexibility and toughness, high thermal storage capacity is provided through an organic phase-change material, and meanwhile, due to introduction of an inorganic phase-change material, the morphological stability is improved, and the cooling duration is optimized. The porous material is adopted to fix the phase-change material through the capillary adsorption effect, leakage is prevented, the heat conductivity is improved, and the cooling rate is increased. The material prepared by the process can be stably cooled for 2-4 hours within the range of 24-33 DEG C, is suitable for cooling pads, pillows, summer sleeping mats and other products, and has excellent use performance and market application prospects.

The invention provides hydrogel with a wound healing function and a preparation method thereof.The hydrogel is prepared from, by mass, 50-70 parts of basic gel matrix, 20-30 parts of natural medicine extract and 8-10 parts of bioactive ingredients; the natural medicine extract comprises superfine pearl powder, a semen cassiae extract, an aloe extract, a cortex phellodendri extract, a honeysuckle flower extract, a dandelion extract, a centipede extract, a fructus forsythiae extract and a green tea extract; the bioactive components comprise epidermal growth factors, heparin sodium, mussel mucin and nano-silver ions; on the basis of a commercially available compound cortex phellodendri liniment, further research and development are carried out, the superfine pearl powder, the semen cassiae extract, the aloe extract, the green tea extract and other natural medicine components are added, the optimal proportion is selected, and the basic gel matrix, the bioactive components and the like are combined, so that the wound healing rate, the antibacterial rate and the water holding rate of the hydrogel are remarkably improved finally.

The invention discloses gel with antibacterial and anti-inflammatory effects and a preparation method thereof, and belongs to the technical field of gel for decontamination. The gel is prepared from the following components in parts by weight: 10 to 25 parts of an abelmoschus manihot flavone extract, 10 to 30 parts of an abelmoschus manihot polysaccharide extract, 1 to 3 parts of a gel matrix, 5 to 10 parts of a humectant, 5 to 10 parts of a surfactant and 0.2 to 1 part of a preservative. The flavone and the polysaccharide are separated from the abelmoschus manihot through an ultrasonic-assisted extraction technology, and a stable hydrogel system is formed by combining the flavone and the polysaccharide with a gel matrix. By optimizing the extraction process of the active ingredients of the abelmoschus manihot and combining a gel delivery system, the synergistic antibacterial and anti-inflammatory effects of flavone and polysaccharide are achieved, and the product is stable in performance, high in safety and suitable for clinical and family decontamination scenes.

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The invention discloses a special ergothioneine-containing skin repair hydrogel for pets and a preparation method of the special ergothioneine-containing skin repair hydrogel, and belongs to the technical field of pet skin care hydrogels. The invention relates to a skin care product which comprises the following components in parts by weight: 1.6-3.8 parts of a functional active component consisting of ergothioneine, quaternized chitosan and oat beta-glucan, 0.15-0.35 part of a cross-linking agent, 5-10 parts of 1, 3-propylene glycol, 5-10 parts of glycerol, 0.2-0.5 part of a preservative and the balance of water, totaling 100 parts. Through precise compatibility of functional active components and synergistic construction of the ionic cross-linked gel matrix, systematic integration of three effects of oxidation resistance, bacteria resistance and healing promotion is achieved, and the technical problems that an existing pet skin care product is single in function, insufficient in synergy and limited in repairing effect are solved.

The invention relates to the field of gel matrices and scaffold development; in particular for use in the field of tissue engineering and regenerative medicine (TERM) and provides for a water insoluble, thermo- stable, crosslinked gelatin matrix. The fabricated matrices of the invention can be applied directly into or onto the defect and the regenerative processes are allowed to take place according to the natural healing steps.

The invention discloses a pH response type multifunctional hydrogel dressing and a preparation method and application thereof, and belongs to the field of medical hydrogel dressings, the pH response type antibacterial hydrogel provided by the invention comprises the following components: a gel matrix, a cross-linking agent and a natural antibacterial active component; firstly, a bond is formed through a Schiff base reaction, so that the gel can be responded and released in a wound acid environment; and then connecting natural active antibacterial drugs such as caffeic acid, tannic acid or luteolin through boric acid ester bonds to obtain the pH-responsive antibacterial hydrogel. The pH-responsive antibacterial hydrogel prepared by the invention has good absorption capacity, a porous structure, adjustable mechanical strength and biocompatibility, also has good antibacterial, anti-inflammatory and anti-oxidation effects, provides a simple and effective method for repairing chronic wounds, and has good application prospects.

The invention discloses a ZIF-67 sodium alginate composite gel bead and a preparation method and application thereof, and belongs to the technical field of environmental functional materials.The preparation method comprises the steps that sodium alginate serves as a gel raw material and is evenly mixed in water, and a sodium alginate precursor liquid is formed; the preparation method comprises the following steps: taking acrylamide and a vinyl monomer as raw materials, adding a cross-linking agent, and dissolving in water to obtain a gel matrix solution; adding the sodium alginate precursor liquid into the gel matrix liquid to obtain primary gel beads, radiating the primary gel beads by adopting a 60Co gamma ray source, inducing free radicals to generate and initiating a graft copolymerization reaction of monomers on a network of the primary gel beads to obtain the cross-linked gel beads. And sequentially immersing the cross-linked gel beads into a soluble cobalt salt solution and a 2-methylimidazole solution to obtain the ZIF-67 sodium alginate composite gel beads.

The invention provides a nicotine-containing gel and a preparation method thereof. The nicotine-containing gel comprises the following components: a nicotine microcapsule, a penetrant, a gel matrix, a flavoring agent and water. The gel has excellent biocompatibility and slow release performance through combination of the nicotine microcapsules and the gel matrix, the skin permeability of nicotine can be improved by adding the penetrant, and the gel has the advantages of freshening the oral cavity and keeping fragrance for a long time by adding the flavoring agent. Therefore, a new consumption choice can be provided for smoking cessation groups and patients needing nicotine medicine.

The invention provides a temperature-sensitive gel composition for slowly releasing nitric oxide as well as a preparation method and application thereof, and relates to the technical field of medical gels, the temperature-sensitive gel composition comprises the following components: a temperature-sensitive gel matrix, an NO donor composition, and an optional pH regulator and oxidant; wherein the temperature-sensitive gel matrix comprises the following components: a temperature-sensitive matrix, a phase-change temperature regulator and a solvent, after the temperature-sensitive gel preparation is used, NO gas can be slowly released, the release time can last for more than 12 hours, and the temperature-sensitive gel preparation has a remarkable curative effect in the aspect of long-acting bacteriostasis.

A solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet. A method of making a solid oral immediate release formulation of LSD by lyophilizing a flash frozen stock solution of LSD and excipients, including a non-gelling matrix former, filler, and binder in a pre-formed mold, and forming an orally disintegrating tablet. A method of treating an individual by administering a solid oral immediate release formulation of LSD, wherein the composition is produced by lyophilization of a feedstock in a pre-formed mold to form an orally disintegrating tablet and treating the individual.

The invention belongs to the technical field of biological medicine, and relates to an oral peptide drug delivery system based on a soybean trypsin inhibitor and core-shell hydrogel, the oral peptide drug delivery system comprises therapeutic polypeptide, KTI and a core-shell structure gel matrix, and the problems that an existing oral peptide delivery system is passively protected and drug burst release is remarkable are solved. A chitosan / sodium tripolyphosphate ionic cross-linked network forms an inner core, a sodium alginate / calcium ion'egg box 'structure cross-linked network forms a shell, and therapeutic polypeptides such as liraglutide and KTI are jointly embedded. Through the pH response characteristic and sequential release design of the core-shell structure, KTI is preferentially and rapidly released in the intestinal environment to inhibit local protease activity, then therapeutic polypeptide is slowly released, and active protection and synergistic interaction are achieved. The invention further provides a specific preparation method and parameters. The polypeptide has the advantages of stable structure in a gastric acid environment, targeted release in intestinal tracts, high encapsulation efficiency, capability of avoiding burst release and the like, and provides a new strategy for efficient delivery of oral polypeptide drugs.

The invention relates to the technical field of biomedical materials, in particular to medical bioglass wound repair gel and a preparation method and application thereof, and the preparation method comprises the following steps: mixing sodium carboxymethyl cellulose or a substitute thereof with glycerol or a substitute thereof to form a pre-dispersion system; adding water to dissolve and homogenize the pre-dispersed system; dissolving sodium dihydrogen phosphate or a substitute thereof in water to ensure that the electrolyte is completely dissolved; pouring an electrolyte solution into the pre-dispersion system to form a gel matrix; adding the bioactive glass into the gel matrix, so that the bioactive glass is dispersed in the gel; transferring the gel into a homogenizer, so that the gel is uniformly ground; and putting the gel into a vacuum degasser, removing bubbles, and finally filling and sterilizing to obtain the gel. In the nursing of various non-chronic wounds and surrounding skin, an effective physical barrier is formed, a suitable microenvironment is created for wound healing, wound healing is accelerated, scar formation is reduced, and the rehabilitation experience of a patient is improved.

This invention discloses a cellulose-based ion-conductive gel membrane and its preparation method, belonging to the technical field of flexible wearable electronic materials and sensors. Addressing the technical pain points of existing ion gels, such as easy dehydration and failure, insufficient mechanical properties, difficulty in film formation, and inability to synergistically optimize multiple performance indicators, this invention constructs a composite gel matrix by crosslinking sodium alginate and sodium carboxymethyl cellulose with calcium ions. The crosslinking density of the system is controlled by sodium carboxymethyl cellulose, and glycerol is used as a plasticizer to construct ion transport channels. A solid gel membrane free of free water is obtained through coating, crosslinking, room temperature equilibration, and drying dehydration. The raw materials of this invention are environmentally friendly, the preparation process is simple and controllable, and the resulting gel membrane possesses high tensile strength, high transparency, excellent ion conductivity, and environmental stability. It exhibits sensitive strain response and good linearity, and can be widely used in the field of flexible strain sensing.

The application discloses a salbutamol sulfate sustained-release tablet and a preparation process thereof. The preparation process comprises the following steps: drug micronization treatment, drug and ion exchange resin compounding, granulation with hydrophilic gel matrix material, gradient temperature control drying, total mixing after whole granulation, tabletting, double controlled-release coating, ladder solidification treatment and screening and packaging. Through the synergistic sustained-release effect of the ion exchange resin and the hydrophilic gel matrix material, the double controlled-release coating and the ladder solidification process, the application effectively inhibits drug burst release, realizes smooth and long-lasting release, reduces impurity content, and improves product stability and batch reproducibility. The obtained sustained-release tablet releases 20%-40% in 2 hours and 80% or more in 8 hours in a pH 6.8 phosphate buffer, and the quality is controllable, so the sustained-release tablet is suitable for industrial production.

The invention relates to the technical field of medical gel preparation, in particular to propolis temperature-sensitive in-situ gel as well as a preparation method and application thereof. A gel matrix is screened by adopting a single factor test, a prescription is optimized by adopting a star point design-effect surface method, and the quality of the propolis temperature-sensitive gel is evaluated. The optimal prescription of the propolis temperature-sensitive vaginal gel obtained through experimental optimization is as follows: 22.9% of poloxamer 407, 1.8% of poloxamer P188, 5.4% of polyethylene glycol 400 and 5% of propolis, the gelling temperature before dilution is 25 DEG C, and the gelling temperature after dilution is 37 DEG C. Quality evaluation results show that the antibacterial agent is stable in property, proper in gelling temperature and good in antibacterial activity. The prepared propolis temperature-sensitive vaginal gel is stable in process, uniform in appearance, controllable in quality and good in slow-release effect and antibacterial effect.

The invention discloses a feed for feeding cordyceps sinensis host hepialus larvae as well as a preparation method and application of the feed, and relates to the technical field of artificial feeds. The feed comprises the following components in parts by weight: 5-20 parts of beer yeast powder and / or casein, 30-80 parts of wheat germ powder, 20-40 parts of carrot powder, 0.2-5 parts of a modified preservative, 0.05-0.2 part of antibiotics, 0.2-5 parts of vitamins, 0.01-1 part of edible oil, 6-15 parts of agar and 200-400 parts of water. The modified preservative is composed of a chitosan oligosaccharide-natamycin compound subjected to plasma activation treatment and potassium sorbate according to the ratio of 1: 3-1: 5; a modified preservative composed of a chitosan oligosaccharide-natamycin compound subjected to plasma activation treatment and potassium sorbate is adopted, a porous microsphere structure is formed through a specific preparation process, and the contact area of the preservative and the feed is greatly increased. Agar and water form a gel matrix at a specific temperature, and nutritional ingredients and the like are injected into a coaxial micro-fluidic device, so that the preservative effect of the feed is remarkably enhanced.

The present invention relates to the field of oral orthodontic care materials, specifically providing a gel composite for removable retainers, as well as a preparation method and application thereof. The gel composite of the present invention comprises a gel matrix and microcapsule units; the gel matrix comprises a thickener, an organic acid component, and an additive; and the microcapsule units comprise: a core material, a first layer of wall material coating at least a portion of the surface of the core material, and a second layer of wall material coating at least a portion of the surface of the first layer of wall material. This application utilizes a combination of microcapsule units and a gel matrix. After the product is coated on the inner surface of a removable retainer, the gel gradually releases enzymes, probiotics, and trace metal ions, thereby resolving the challenges of stability and release control of probiotics and enzymes in the oral environment while also ensuring antibacterial properties, comfort, and ease of use.