589 results about "Gel matrix" patented technology

The present application provides a keratin and a nucleic acid sequence encoding the same. The present application further provides a keratin gel dressing comprising the keratin of the present application, bFGF and a gel matrix.

The invention discloses an N-type gel ionic thermal battery, a quasi-solid gel electrolyte and a preparation method of the quasi-solid gel electrolyte, and belongs to the technical field of thermal regeneration batteries. The preparation method comprises the following steps: fully soaking polyacrylamide hydrogel in an electrolyte containing [Cu (NH3) 2] < + > / [Cu (NH3) 4] < 2 + > redox couple to obtain the quasi-solid gel electrolyte. And preparing the N-type gel ionic thermal battery by using the quasi-solid gel electrolyte. According to the prepared N-type gel ion thermal battery, the thermoelectric conversion performance such as thermoelectric potential and output power is remarkably improved through the synergistic effect of solvated structure entropy change generated by the oxidation-reduction reaction of the copper ammonia complex reaction couple and the quasi-solid gel electrolyte. The problems that research and development of an existing N-type gel ion thermal battery focuses on physical performance regulation and control of a gel matrix, thermoelectric contribution of an oxidation-reduction reaction cannot be effectively enhanced, and improvement of the Seebeck coefficient and the power density is limited can be effectively solved.

The invention belongs to the technical field of medical materials, and particularly relates to a tooth whitening composition and a preparation method thereof, the tooth whitening composition comprises the following components by weight: 5%-15% of hydrogen peroxide, 0.5%-1.5% of a gel matrix, 0.2%-1.0% of a thickener, 5%-10% of a humectant, 3%-8% of propylene glycol, 0.05%-0.2% of a chelating agent, 1%-3% of a sweetener, 0.1%-0.5% of sodium fluoride, and the balance of water. Aiming at the problems that an existing tooth whitening product is relatively low in pH value (most of 4.0-5.0), easy to irritate gingiva and sensitive in tooth manufacturing, and the existing tooth whitening product needs to be stored in a dark place at a low temperature and is short in whitening validity period, the pH value of the product is adjusted to 5.5-6.5, so that the product is close to oral saliva, the irritation can be reduced, the stability of the product can be ensured, the product is not easy to decompose, and the tooth whitening effect is good. Active ingredients are prevented from losing efficacy in advance, and the whitening validity period is prolonged.

The invention relates to colchicine transdermal delivery gel and a preparation method thereof. The colchicine transdermal delivery gel is prepared from the following components in percentage by weight: 0.3 percent to 0.7 percent of colchicine, 70.0 percent to 60.0 percent of a gel matrix, 29.5 percent to 39.5 percent of a dissolution promoter and 0 percent to 10 percent of a penetration enhancer. Wherein the gel matrix is prepared by dissolving a thickening agent in a mixed solvent of water and ethanol, the volume ratio of the water is 70%-10%, and the volume ratio of the ethanol is 30%-90%. According to the colchicine transdermal drug delivery gel provided by the invention, the colchicine transdermal drug delivery gel which is simple in formula and convenient to prepare is provided, and non-toxic and non-irritant materials are used, so that the irritation of colchicine oral preparations and injections is avoided, the toxic and side effects can be reduced, and relatively high drug delivery efficiency can be achieved.

The invention relates to the technical field of compositions, and provides a hair-blacking and hair-loss-preventing traditional Chinese medicine and trace element composition and a preparation method and application thereof.The preparation method includes the steps that traditional Chinese medicinal materials with the effects of nourishing the liver and kidney, nourishing blood and growing hair are selected, and a multi-step water extraction and alcohol extraction combined technology is adopted to prepare high-purity traditional Chinese medicine extract dry powder; meanwhile, soluble trace elements such as zinc, iron and copper are selected, the optimal proportion of the soluble trace elements, the iron and the copper is determined through a response surface optimization algorithm, and a synergistic activity system is formed. Then, a mixture of traditional Chinese medicines and trace elements is dissolved in a buffer solution, and the mixture is entrapped in lipidosome composed of phospholipid and cholesterol through an ultrasonic nanocrystallization process, so that a stable nanoscale composite carrier is prepared; and finally, uniformly mixing the liposome suspension with a gel matrix to prepare the liposome gel dosage form for scalp external use. The problems of random component proportion, poor permeability and lack of mechanism verification in the prior art are solved.

The invention discloses a preparation method of a high-strength semi-solid lithium battery diaphragm, and belongs to the technical field of battery diaphragms. The invention discloses a preparation method of a high-strength semi-solid lithium battery diaphragm. The preparation method comprises the following steps: S1, preparing an LLTO active skeleton with a 3D nano structure and preparing a gel matrix; s2, embedding the gel matrix into the active skeleton to form a rapid ion transport layer; s3, embedding the gel matrix into the inert skeleton to form a stable layer; and S4, combining the rapid ion transport layer and the stable layer together to form the semi-solid lithium battery diaphragm. The problems of battery deformation, liquid leakage and even low guarantee and safety performance caused by collision or high temperature in the using process in the prior art are solved, the performance of the semi-solid lithium battery diaphragm is enhanced, and the deformation of the internal structure of the battery is reduced, so that the overall stability of the battery is enhanced, and the service life of the battery is prolonged. Battery short circuit can be effectively prevented, and the battery is protected from being damaged, so that safe use of the battery is ensured.

The invention provides a production method of a konjak-series Qingqing diet, and belongs to the technical field of konjak-series Qingqing diet, and the production method comprises the following steps: forming a primary colloid through an accurately controlled hydration process, then introducing soybean and pea proteins, and carrying out thermal gelation treatment to construct a composite gel matrix; functional plant extracts such as curcumin, tea polyphenol and a grape seed extract are added, and the release efficiency of active ingredients is improved by adopting an ultrasonic-assisted extraction technology. The method further comprises the step of adding vitamin complex and calcium and magnesium trace elements, finally, high homogenization of the product is achieved through an innovative tree-shaped multi-cavity homogenization treatment mechanism, the mechanism adopts a minimum spanning tree algorithm to optimize a fluid transmission path, and the technical problem of efficient compounding of the konjak gel and the functional plant extract is successfully solved.

The invention relates to the technical field of composite hydrogel preparation, in particular to a nano composite hydrogel preparation process based on a microfluidic technology. The gel comprises the following components in parts by mass: 50-70 parts of a gel matrix, 5-9 parts of a nano enhancement system, 8-14 parts of a functional carrier, 3-6 parts of a dynamic response system, 4-7 parts of a hyaluronic acid-sulfhydrylated heparin compound and 0.5-1.5 parts of L-ascorbyl palmitate. Precise mixing and directional arrangement of all component materials on a micro-level are realized through a microfluidic technology, so that a nano reinforcing system and a functional carrier are uniformly distributed in a gel matrix, the synergistic effect of all the components is fully exerted, the mechanical property and the biological function of the gel are effectively improved, and the preparation method is suitable for industrial production. And quaternized chitosan nanofibers, a dynamic response system for responding to external environment change and a hyaluronic acid-sulfhydrylated heparin compound for promoting angiogenesis are introduced, so that the gel has the biological functions of resisting bacteria and promoting angiogenesis through a synergistic effect.

The invention discloses an active exosome stent coating based on traditional Chinese medicine enhanced secretion promotion and a preparation method and application thereof, and belongs to the technical field of biological medicine and interventional instruments. The stent coating comprises exosomes, wherein the exosomes comprise myocardial cell active exosomes and human mesenchymal stem cell active exosomes which are intensified and secreted by traditional Chinese medicines; wherein the traditional Chinese medicines comprise placenta extract, pilose antler extract, sheep myocardial peptide, sea cucumber peptide, lycium ruthenicum peptide, cnidium lactone, curculigo orchioides extract and morinda officinalis extract; the intervention concentration of each component added into cells is 2-50 [mu] g / mL; the light-cured gel matrix is prepared from methacrylated gelatin, a photoinitiator and polyether 127; tacrolimus; the final concentration of the exosome is 1 * 10 < 9 >-12 * 10 < 9 > particles / mL, and the final concentration of the tacrolimus is 5-25 mu g / mL. The coating can be coated on the surface of the poly-L-lactic acid degradable stent to prepare the degradable stent, and has obvious vascular repair promoting capability.

The invention relates to the technical field of bird repelling agents, in particular to a bird repelling agent based on thiocyanuric acid and a preparation method thereof, and the bird repelling agent is prepared from the following raw materials: thiocyanuric acid, modified beta-cyclodextrin, a magnetic powder synergist, a gel matrix, a synergistic aid, a solvent and a surfactant. The invention discloses a bird repellent based on thiocyanuric acid and a preparation method thereof, thiocyanuric acid is included through monoisocyanate modified beta-cyclodextrin, a magnetic powder synergist and a gel matrix are combined to form a'molecular inclusion-magnetic response-gel fixation 'triple-action system, and the problems that an existing bird repellent is short in time efficiency and poor in weather resistance are solved. The release time of the bird repellent is prolonged, the high bird repelling rate is still kept under the conditions of high temperature and rainwater, and the bird repellent is suitable for scenes such as farmlands and electric power facilities and has remarkable technical progress and practical value.

The invention discloses a nanofiber interwoven composite gel membrane for carbon dioxide separation and a preparation method of the nanofiber interwoven composite gel membrane. The nanofiber interwoven composite gel membrane comprises a nanofiber interwoven framework and a carbon dioxide-philic gel matrix layer, wherein the surface of the nanofiber interwoven framework is coated with the carbon dioxide-philic gel matrix layer; the carbon dioxide-philic gel matrix layer is formed by in-situ polymerization and gelation of a precursor solution containing an oxidizing agent, a cross-linking agent and a functional monomer on the surface of the nanofiber interwoven skeleton. The nanofiber interwoven composite gel membrane provided by the invention has excellent carbon dioxide permeability and selectivity. The invention also discloses an application of the nanofiber interwoven composite gel membrane in separation of carbon dioxide.

The invention belongs to the technical field of medical gel, and particularly relates to modified hydrogel for skin wound healing and a preparation method thereof.The modified hydrogel is prepared from, by weight, 2-5 parts of drug-loaded GDVLNs, 1-2 parts of chitosan, 0.6-1.5 parts of antioxidant, 0.2 part of LAP, 1.5 parts of MA, 18 parts of gel matrix and 100 parts of buffer solution, the drug-loaded GDVLNs prepared from the traditional Chinese medicine active ingredients and the ginseng vesicles have the functions of resisting oxidative stress, promoting angiogenesis, promoting cell proliferation and the like, and the MA modified hydrogel system can realize slow release and controlled release of the drug-loaded GDVLNs and play a long-acting healing promoting role.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The present disclosure relates to a field of biomedical technology. Embodiments of the present disclosure provide a leonurine nanocomposite hydrogel and preparation method and application thereof, including: dissolving dopamine (DA) monomers and inducing oxidation and self-polymerization of the DA to obtain polydopamine (PDA) nanoparticles, grafting thiol polyethylene glycol folic acid (SH-PEG-FA) on a surface of the PDA nanoparticles to obtain folic acid polydopamine (FA-PDA) nanocarriers; loading a leonurine (Leon) using the FA-PDA nanocarriers of the step 1 to obtain FA-PDA@Leon; encapsulating the FA-PDA@Leon of the step 2 into a gel matrix to obtain gel@FA-PDA@Leon hydrogel.

The invention discloses injection type facial filler composition gel for medical beauty as well as a preparation method and application of the injection type facial filler composition gel, and belongs to the technical field of biomedical materials. The composition gel comprises a combined gel matrix and polycaprolactone microspheres, wherein the combined gel matrix comprises an aqueous solution for injection, sodium carboxymethyl cellulose and human recombinant collagen; according to the composition gel, a combined gel matrix and polycaprolactone microspheres are mixed according to a specific proportion, amino acid residues of human-derived recombinant collagen in the combined gel matrix serve as binding sites of cell surface receptors to improve the cell recognition and attachment capacity of the polycaprolactone microspheres, and the amino acid residues are organically combined with sodium carboxymethyl cellulose to improve the cell recognition and attachment capacity of the polycaprolactone microspheres. The durability and biocompatibility of the shaping effect of the human-derived recombinant collagen at the injection site are improved; the composition prepared by the invention is good in gel fluidity, high in elastic modulus and high in dynamic viscosity, and can meet the expected mechanical and rheological properties of a facial filling agent for cosmetic and plastic surgery.

The invention provides a multifunctional flexible electronic device based on ionic liquid gel and patterned liquid metal and a preparation method. The preparation method comprises the following steps: firstly preparing ionic liquid gel with excellent performance as an upper substrate and a lower substrate of the flexible electronic device, then forming a high-resolution conductive pattern on the ionic liquid gel through a template printing method by using liquid metal alloy subjected to surface modification, and finally curing and packaging by using another layer of ionic liquid gel. According to the flexible electronic device, the modified particles are introduced to be mixed with the liquid metal, the flexible electronic device with the tensile adjustable resistance change characteristic is prepared, and meanwhile, the conductive patterns form firm interface bonding with the gel matrix through hydrogen bonds formed between the gallium with the oxidized surface and carboxyl of the ionic gel. Even if the prepared multifunctional flexible electronic device is stretched and released, the composite material can keep continuous contact with the base material, so that stable electric connection is maintained, and the method is suitable for the fields of wearable electronics and flexible electronics.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

The invention relates to the technical field of food processing and making, and discloses a konjac food and a making method thereof, and the making method comprises the following steps: raw material pretreatment, swelling and dispersion, enzymolysis treatment, gel matrix preparation, flavor substance embedding, mixing and degassing, curing forming, ultrahigh pressure treatment and post-sterilization and packaging. In the invention, the konjac micro-powder is subjected to controllable enzymolysis through the compound bio-enzyme preparation, and the konjac micro-powder and the gel matrix liquid composed of carrageenan, gellan gum and curdlan gum in a specific ratio have a synergistic effect under a curing condition, so that the konjac colloid and the gel matrix are interwoven to form a compact and stable cementing system, and the texture of the konjac food is improved; according to the method, the plant-derived flavor extract is added, so that the taste of the plant-derived flavor extract is uniform and consistent, the defect that the traditional process product is unstable in texture or easily generates bad flavor is overcome, the plant-derived flavor extract is embedded by adopting beta-cyclodextrin, and the plant-derived flavor extract is converted into a microcapsule form through high-pressure homogenization and spray drying processes.

The invention discloses a quick and long-acting gynecological antibacterial gel and a preparation method thereof. According to the formula of the gynecological antibacterial gel, a plurality of key components are selected and combined, and the gynecological antibacterial gel specifically comprises the following components in parts by weight: 5-15 parts of poloxamer, 0.5-1 part of carbomer, 0.5-1 part of N, N-dicarboxymethyl alanine trisodium salt, 0.2-0.1 part of carboxymethyl cellulose and 50-250ppm stable chlorine dioxide powder. The preparation method of the gynecological antibacterial gel comprises the five steps of chlorine dioxide chelating solution preparation, gel matrix preparation, gel forming, pH value adjustment and finished product packaging, all the steps are accurately controlled, and the product quality is ensured. The invention provides a gynecological gel product which is high in initial flowability, can be quickly gelated in vivo and has a quick long-acting antibacterial function, solves the problems of non-ideal antibacterial effect, inconvenience in use, insufficient safety and the like of an existing gynecological nursing product, ensures the safety and stability of the product, overcomes many defects of a traditional product, and has a good application prospect. And a better choice is provided for female reproductive health care.

The invention discloses a near-field dynamics simulation method for low-speed impact fracture of ultra-high performance concrete, which comprises the following steps: establishing a completely discrete model of a UHPC component, and realizing coupling of a concrete gel matrix and steel fibers through an Embedded method; a transition unit is introduced, a classic finite element unit and a PeriFEM local unit are connected through keys, force on the keys is modified, and coupling of the two methods is achieved; a continuous local unit is introduced, a motion equation of the local unit is deduced by adopting an explicit central difference algorithm, and an explicit algorithm based on the continuous local unit is constructed and used for solving the motion equation and calculating the damage condition of the UHPC matrix. According to the simulation method provided by the invention, the fracture process of the UHPC under low-speed impact can be effectively simulated, and a new solution of near-field dynamics and finite element coupling is provided.

The invention belongs to the technical field of contact lens care, and provides temperature-sensitive contact lens eye-moistening gel and a preparation method thereof. The temperature-sensitive contact lens eye-moistening gel is prepared from the following raw materials in parts by mass: a gel matrix, a surfactant, an osmotic pressure regulator, an active component, a chelating agent, a buffering agent and the balance of injection water, the composition of the gel matrix is defined. Chitosan, sodium hyaluronate and polyvinyl alcohol are compounded to serve as a gel matrix, a polyelectrolyte compound is formed, gelation time is shortened, gel strength and swelling resistance are improved, biocompatibility is improved, and drug-loaded delivery of active ingredients is achieved; the gel matrix and the surfactant are reasonably selected, the viscosity of the solution is increased, the gelation time is shortened, the excellent effect of relieving eye fatigue and dryness is achieved, the wearing comfort of the contact lens is remarkably improved, and the oxygen permeation effect of the contact lens is not obviously reduced after gel forming.

The invention discloses a novel compound rapid surface anesthetic and a preparation method thereof, and belongs to the field of pharmaceutical preparations. According to the anesthetic, core anesthetic components of lidocaine and tetracaine are compounded with propylene glycol-laurocapram synergistic penetration enhancer, menthol auxiliary penetration enhancer, carbomer 980 gel matrix, triethanolamine pH regulator, glycerol humectant, panthenol soothing agent, purified water and the like, a surface smearing agent is prepared through a specific process, and the anesthetic can be administered in combination with an iontophoresis technology. Compared with the existing surface anesthetic for the cosmetic surgery, the surface anesthetic disclosed by the invention solves the problems of slow effect taking and poor effect, can realize rapid penetration of local skin, has short anesthesia effect taking time, long duration and good effect, has no obvious irritation to the skin, has good product stability, can effectively reduce the drug toxicity, and has a good application prospect. The device is suitable for surface anesthesia of non-surgical medical beauty items such as skin beauty, laser treatment and water-light micro-needles.

The invention discloses a preparation method and application of a composite phase-change gel material, and the composite phase-change gel material is prepared by combining an organic phase-change material, an inorganic phase-change material or a combination of the organic phase-change material and the inorganic phase-change material with a nucleating agent, a cross-linking agent and a porous material and optimizing a process. The phase-change gel material with high phase-change latent heat, long-acting cooling, excellent shape stability, good flexibility and cycle durability is prepared. A polyurethane gel matrix is adopted, the material is endowed with good flexibility and toughness, high thermal storage capacity is provided through an organic phase-change material, and meanwhile, due to introduction of an inorganic phase-change material, the morphological stability is improved, and the cooling duration is optimized. The porous material is adopted to fix the phase-change material through the capillary adsorption effect, leakage is prevented, the heat conductivity is improved, and the cooling rate is increased. The material prepared by the process can be stably cooled for 2-4 hours within the range of 24-33 DEG C, is suitable for cooling pads, pillows, summer sleeping mats and other products, and has excellent use performance and market application prospects.

The invention discloses gynecological gel as well as a preparation method and application thereof, and belongs to the technical field of gynecological gels, carbomer of a high-molecular polymer is mainly used as a main gel matrix, and on the basis that carbomer is used as the main gel matrix, a humectant glycerol, a stabilizer and a film-forming agent sodium alginate are matched, so that the gynecological gel is prepared. Gel is prepared from a semi-finished product of gel, a lubricant polyethylene glycol 4000 and a pH regulator triethanolamine, ethylparaben and purified water are added into the semi-finished product of gel, the gel further comprises a botanical medicine extract capable of inducing diuresis and resisting viruses for gynecology, and an antibacterial agent for treating Escherichia coli, Candida albicans, Candida albicans and Candida albicans is added into the semi-finished product of gel. The invention relates to an antibacterial Chinese patent medicine extract for inhibiting staphylococcus aureus. A layer of protective gel film is formed on the vaginal wall to physically isolate the vaginal wall from external bacteria, so that pathogenic microorganisms are prevented from colonization, and the vaginal gel conforms to the market development trend and the medication concept of modern people and has profound significance.

The invention provides hydrogel with a wound healing function and a preparation method thereof.The hydrogel is prepared from, by mass, 50-70 parts of basic gel matrix, 20-30 parts of natural medicine extract and 8-10 parts of bioactive ingredients; the natural medicine extract comprises superfine pearl powder, a semen cassiae extract, an aloe extract, a cortex phellodendri extract, a honeysuckle flower extract, a dandelion extract, a centipede extract, a fructus forsythiae extract and a green tea extract; the bioactive components comprise epidermal growth factors, heparin sodium, mussel mucin and nano-silver ions; on the basis of a commercially available compound cortex phellodendri liniment, further research and development are carried out, the superfine pearl powder, the semen cassiae extract, the aloe extract, the green tea extract and other natural medicine components are added, the optimal proportion is selected, and the basic gel matrix, the bioactive components and the like are combined, so that the wound healing rate, the antibacterial rate and the water holding rate of the hydrogel are remarkably improved finally.

The invention discloses gel with antibacterial and anti-inflammatory effects and a preparation method thereof, and belongs to the technical field of gel for decontamination. The gel is prepared from the following components in parts by weight: 10 to 25 parts of an abelmoschus manihot flavone extract, 10 to 30 parts of an abelmoschus manihot polysaccharide extract, 1 to 3 parts of a gel matrix, 5 to 10 parts of a humectant, 5 to 10 parts of a surfactant and 0.2 to 1 part of a preservative. The flavone and the polysaccharide are separated from the abelmoschus manihot through an ultrasonic-assisted extraction technology, and a stable hydrogel system is formed by combining the flavone and the polysaccharide with a gel matrix. By optimizing the extraction process of the active ingredients of the abelmoschus manihot and combining a gel delivery system, the synergistic antibacterial and anti-inflammatory effects of flavone and polysaccharide are achieved, and the product is stable in performance, high in safety and suitable for clinical and family decontamination scenes.

The invention relates to the technical field of medical sutures, and particularly discloses a PDO barb suture with an antibacterial coating and a preparation method of the PDO barb suture. According to the PDO barb suture line with the antibacterial coating, a PDO mixed suture line base body with good mechanical performance is obtained by blending, spinning and weaving L-polylactic acid and poly (p-dioxanone) according to a certain proportion; hyaluronic acid is used as a gel matrix, 4-(oxirane-2-yl methoxyl) butyl acrylate is grafted to hyaluronic acid for alkenyl modification, then the hyaluronic acid is mixed with quercetin-3-O-glucoside and TCS-ZIF-8 loaded with oridonin, and the antibacterial gel coating is obtained. And finally, dipping the PDO mixed suture line matrix into the antibacterial gel coating and carrying out ultraviolet irradiation in the presence of a photoinitiator to prepare the PDO mixed suture line. The suture line prepared by the invention has the advantages of smooth coating, efficient and lasting antibacterial performance, high strength, good flexibility, small friction force and high operability.

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The invention relates to a temperature-sensitive gel nose drop and a preparation method and application thereof, and belongs to the technical field of biological medicines.The temperature-sensitive gel nose drop is composed of a temperature-sensitive gel matrix, active ingredients and pharmaceutic adjuvants, the temperature-sensitive gel matrix comprises poloxamer 407 and poloxamer 188, the active ingredients comprise matrine and oxymatrine, and the pharmaceutic adjuvants comprise the temperature-sensitive gel matrix, the active ingredients and the pharmaceutic adjuvants. The pharmaceutic adjuvants comprise one or more of a solvent, a humectant, an antioxidant, a preservative, a wetting agent, a thickening agent, a coloring agent, a wetting agent and a buffering agent. The temperature-sensitive gel nose drop disclosed by the invention is simple in preparation process, controllable in cost and suitable for large-scale production. The thermo-sensitive gel nose drop can improve the expression level of serum IgE, IL-4 and IFN-gamma, improves the symptom of allergic rhinitis by correcting Th1 / Th2 imbalance, is suitable for clinical treatment and prevention of allergic rhinitis, and has a remarkable clinical application prospect.

The invention discloses a special ergothioneine-containing skin repair hydrogel for pets and a preparation method of the special ergothioneine-containing skin repair hydrogel, and belongs to the technical field of pet skin care hydrogels. The invention relates to a skin care product which comprises the following components in parts by weight: 1.6-3.8 parts of a functional active component consisting of ergothioneine, quaternized chitosan and oat beta-glucan, 0.15-0.35 part of a cross-linking agent, 5-10 parts of 1, 3-propylene glycol, 5-10 parts of glycerol, 0.2-0.5 part of a preservative and the balance of water, totaling 100 parts. Through precise compatibility of functional active components and synergistic construction of the ionic cross-linked gel matrix, systematic integration of three effects of oxidation resistance, bacteria resistance and healing promotion is achieved, and the technical problems that an existing pet skin care product is single in function, insufficient in synergy and limited in repairing effect are solved.