1115 results about "Micelle" patented technology

The invention relates to the field of oil exploitation, and discloses a polymer with a heavy oil cold recovery function as well as a preparation method and application thereof. After the polymer disclosed by the invention enters a stratum, hydrophobic groups on a polymer chain can be adsorbed on an oil-water interface, the aggregation state of micelles is destroyed, the size of the micelles is greatly reduced, and released energy can provide energy required by emulsification. And meanwhile, after the amphiphilic groups are adsorbed to an oil-water interface, the tension of the oil-water interface is reduced, a low-surface-tension oil phase is automatically diffused to a high-surface-tension water phase, and spontaneous permeation emulsification viscosity reduction of the thick oil is realized without external force or under the low-power condition by virtue of the Malangori effect.

The present disclosure relates to methods, compositions and systems for droplet processing. For example, methods can include (a) providing a first emulsion comprising a first droplet population, wherein droplets of the first droplet population comprise a lysis reagent, and a second emulsion comprising a second droplet population, wherein a droplet of the second droplet population comprises i) a cell or a nucleus, and ii) a plurality of nucleic acid barcode molecules; (b) subjecting the first emulsion and second emulsion to conditions sufficient to transfer the lysis reagent to the second droplet population via micelles comprising the lysis reagent; and (c) lysing the cell or the nucleus within the droplet of the second droplet population with the lysis reagent.

A preparation method of a double-network versatile hydrogel with antibacterial and drug sequential release capabilities is provided in the present disclosure, belonging to the technical field of biological corneas. The preparation method includes the following steps: mixing filipin protein-methacrylate, glycidyl methacrylate functionalized quaternized chitosan, polydeoxyribonucleotide, and lithium phenyl(2,4,6-trimethylbenzoyl) phosphinate with drug-loaded micelles, followed by cross-linking under irradiation of ultraviolet to construct a double-network versatile hydrogel with antibacterial and drug sequential release capabilities.

The invention relates to an anti-oxidation composition based on a reverse micelle synergistic technology and a preparation method and application thereof, the anti-oxidation composition comprises a reverse micelle structure and an aqueous solution containing an anti-oxidation active matter, and the reverse micelle structure wraps the aqueous solution containing the anti-oxidation active matter. The reverse micelle structure is used for wrapping the water-soluble antioxidant active matter, oxidation or degradation discoloration of the water-soluble antioxidant active matter is prevented, after the antioxidant active matter such as hydroxytyrosol, ergothioneine and dipotassium glycyrrhizinate is wrapped by the reverse micelle, the stability and the effect are remarkably improved, and after the reverse micelle wrapping, the effect of the antioxidant active matter is improved by 17% or above compared with an aqueous solution before wrapping.

The invention belongs to the technical field of biomedical materials, and discloses injectable heterogeneous cascade nano-enzyme antibacterial hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: in a process of preparing cerium dioxide nano-enzyme by a reverse micelle method, introducing molybdenum disulfide nano-particles with a nano flower-shaped structure so as to deposit the cerium dioxide nano-enzyme on the surfaces of the molybdenum disulfide nano-particles in situ to obtain nano-composite particles; through electrostatic interaction, glucose oxidase is loaded on the surfaces of the nano composite particles to form a heterogeneous cascade nano enzyme material; the preparation method comprises the following steps: uniformly mixing sodium alginate and hyaluronic acid in water, and sequentially adding an NO donor, a heterogeneous cascade nano-enzyme material and a cross-linking agent to obtain the injectable heterogeneous cascade nano-enzyme antibacterial hydrogel. The preparation method is simple, and the injectable heterogeneous cascade nano-enzyme antibacterial hydrogel has a strong antibacterial effect and can be used for preparing the antibacterial hydrogel. Particularly, the compound has a remarkable killing effect on gram-negative bacteria and gram-positive bacteria.

The invention relates to an aloe extract nano-vesicle as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The aloe extract nano-vesicle provided by the invention is a nano-micelle formed by an aloe extract and tocopheryl acetate, the particle size of the aloe extract nano-vesicle is 280 to 500 nm, the Zeta potential of the aloe extract nano-vesicle is-10.12 to-11.34 mV, and the polydispersity coefficient of the aloe extract nano-vesicle is 0.239 to 0.434. The aloe extract nano-vesicle disclosed by the invention has a nano-scale size, and can easily penetrate through a skin barrier and enter skin cells, so that the moisturizing effect of the aloe extract nano-vesicle is achieved. The permeability of the moisturizing composition is far better than that of the traditional moisturizing composition, so that the required moisture can be more effectively provided for the skin. The aloe extract nano-vesicle can carry other active ingredients such as moisturizing factors to deeply permeate into skin, comprehensive care is provided for the skin, the texture and appearance of the skin are improved, the preparation process is simple, and the aloe extract nano-vesicle is suitable for technological production.

The invention relates to the technical field of biological medicine, in particular to a ferroptosis inhibition type phospholipid-like material and application thereof. The ferroptosis inhibition type phospholipid-like material is one of the following structural general formulas (1)-(5). The biomimetic phospholipid-like ferroptosis inhibitor has a long retention characteristic in main positions (cell membranes, endoplasmic reticulum and other organelle membranes) of cell ferroptosis, so that the ferroptosis inhibition efficiency is remarkably improved. The novel phospholipid-like material not only can be used as an active drug molecule, but also can be used as a pharmaceutic adjuvant for constructing drug delivery carriers such as lipidosome and micelle and implant coatings, and is suitable for various administration routes such as oral administration, injection and local administration. The novel biomimetic ferroptosis inhibitor can efficiently relieve cell ferroptosis and has a wide application prospect in the field of treating or retarding ferroptosis-related diseases.

The invention discloses an ultrashort-sequence antibacterial peptide rich in lysine and tryptophan, an antibacterial peptide hydrogel and application of the ultrashort-sequence antibacterial peptide and the antibacterial peptide hydrogel. The preparation method comprises the following steps: combining lysine and tryptophan to obtain polypeptide containing five or six amino acids; then amidation is carried out on the C terminal of the polypeptide, fatty acid chain modification is carried out on the N terminal and side chain amino groups, the ultra-short sequence antibacterial peptide rich in lysine and tryptophan is obtained, and the antibacterial peptide has broad-spectrum antibacterial activity for resisting gram-positive and gram-negative bacteria. An antibacterial peptide micelle self-assembly experiment shows that C12-2KW can be self-assembled into stable hydrogel in a 7.17 mu M PBS (Phosphate Buffer Solution), the hydrogel internally has a compact net-shaped structure, can completely cover the peritoneal injury surface and physically isolate the peritoneal injury surface from surrounding tissues, and has a good effect on treating wound infection caused by MRSA (Methicillin-Resistant Staphylococcus Aureus); meanwhile, the compound has the effect of resisting intestinal wall and abdominal wall adhesion after an operation, is low in toxicity, has a very good application prospect in the aspect of preparing clinical antibacterial drugs, and is expected to become a candidate drug of a novel antibiotic.

The invention discloses a composite solvent for removing organic sulfur in industrial synthesis gas and a preparation method thereof, and belongs to the technical field of separation and purification, the composite solvent comprises 40-60 parts of a main desulfurizer, 8-12 parts of a dynamic modifier, 5-15 parts of a mass transfer enhancer, 20-30 parts of a temperature-sensitive phase change skeleton and 8-14 parts of an auxiliary agent, and the auxiliary agent comprises an antioxidant, a corrosion inhibitor and a polar mixed solution. According to the present invention, the multistage pore channel micelle structure of the introduced mass transfer reinforcing agent provides the rich and efficient transmission channel for the diffusion of the sulfide, such that the diffusion rate of the sulfide penetrating the ionic liquid layer is substantially accelerated, and the liquid phase mass transfer coefficient is effectively improved; the core principle is that the diffusion path of sulfide molecules in the ionic liquid environment is optimized, the mass transfer bottleneck caused by high viscosity of the traditional ionic liquid is broken through, and excessive accumulation of the sulfide molecules on the surface of an ionic liquid layer due to mass transfer obstacle is avoided, so that the desulfurization efficiency is remarkably improved; the problem of slow mass transfer caused by high viscosity of the ionic liquid in the prior art is solved.

The invention relates to the technical field of oral membranes, in particular to a multilayer oral membrane and a preparation method thereof. The invention provides an oral membrane composition, which comprises semeglutide and pharmaceutically acceptable auxiliary materials, and is characterized in that the composition is formed by combining a drug-containing biological adhesion layer and a backing layer, and the backing layer mainly comprises a membrane forming material, a solvent and a plasticizer; the drug-containing biological adhesion layer mainly comprises semeglutide, a film-forming material, an adhesive, a pH regulator, a flavoring agent and a solvent. By preparing the double-layer oral membrane, the semeglutide is administrated through the oral cavity, and after the insoluble or slowly eroded / dissolved backing layer (preventing saliva from dissolving the medicine) and the adhesive layer containing the main medicine are combined together, the one-way delivery of the main medicine can be realized; through experiments, it is accidentally found that when temperature-sensitive materials such as poloxamer are added to be combined with a conventional adhesive for use, the residence time of the medicine in the oral mucosa can be remarkably prolonged, the curative effect of the medicine is improved, and the main mechanism is that after the medicine is administered, in the oral temperature environment, after the medicine makes contact with mucus on the surface of the oral mucosa, the oral mucosa does not adhere to the oral mucosa. And after the entanglement and piling effects among poloxamer micelles are intensified to form gel, the gel and a conventional adhesive are cooperated to improve the adhesion between the oral membrane and the oral mucosa. Besides, the medicine can be removed at any time, blood sugar can be better controlled, T2DM complications can be better reduced, a more ideal taking mode is provided for weight loss patients, and a new administration mode is provided for reducing blood sugar and reducing weight. The prepared oral cavity membrane is small in size, light in weight, thin, convenient to apply, carry and transport, safe and environmentally friendly to use and capable of meeting the requirements of old people and travelers.

The invention discloses a high molecular weight poly (p-dioxanone) (PPDO) microsphere as well as a preparation method and application thereof. By adopting a double emulsification-solvent evaporation method, an amphiphilic polymer, such as poly (p-dioxanone) (PDO) or a copolymer of PDO and a hydrophilic fragment (such as mPEG and mPPG), is utilized to perform self-assembly on a two-phase interface formed by emulsification under the combined action of amphipathy and polyvinyl alcohol (PVA) to form a double-micelle protective layer, so that the degradation effect of water on PPDO in the microsphere forming process is effectively blocked, and the PPDO can be effectively degraded. And finally, the high-molecular-weight poly (p-dioxanone) microspheres with stable performance are obtained, so that the high-molecular-weight PPDO microspheres have long-term stability. The preparation method is high in operability, mild in condition and suitable for large-scale production, high-molecular-weight poly (p-dioxanone) microspheres are obtained, and the preparation method has wide application prospects in the aspects of tissue filling agents, drug carriers, tissue scaffolds and the like.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a cyclophosphamide ternary nano-micelle and a preparation method thereof.The cyclophosphamide ternary nano-micelle prepared through the method can be used for treating malignant lymphoma, multiple myeloma, leukemia, breast cancer, ovarian cancer, cervical cancer, prostatic cancer, colon cancer, bronchial cancer, lung cancer and the like. Reasonable preparation steps and a preparation formula are adopted, the use of an organic reagent is reduced, the irritation of cyclophosphamide is reduced and the stability of the micelle is improved by adjusting a freeze-drying technology, and the cyclophosphamide micelle adopts amphiphilic macromolecules as a carrier material, so that the drug loading capacity and the stability of the micelle are obviously improved, and the bioavailability of the micelle is improved. The ternary nano-micelle system has the advantages that the solubility of cyclophosphamide is improved, the in-vivo bioavailability is increased, the preparation method is simple, the micelle performance is stable, and large-scale industrial production is facilitated.

The invention provides a lipidosome STING agonist delivery system based on a PD-L1 antibody as well as a preparation method and application of the lipidosome STING agonist delivery system, and belongs to the technical field of medical biology. Preparing lipidosome by adopting an ethanol injection method and an ammonium sulfate gradient technology; the PD-L1 antibody and the STING agonist can be loaded at the same time; the liposome is prepared by adopting an ethanol injection method and an ammonium sulfate gradient technology, and the STING agonist can be wrapped in the liposome in an active drug loading manner; dSPE-PEG2000-NHS and a PD-L1 antibody are mixed and incubated according to a specific proportion by utilizing a post-insertion method to form an antibody conjugated micelle, and the antibody conjugated micelle is fused with a blank liposome to realize antibody modification; secondly, the nano-liposome has good drug carrier characteristics and can effectively protect the loaded drug, reduce the risk of enzymolysis of the drug and improve the stability of the drug in vivo, so that the liposome drug delivery system simultaneously loading the nano-liposome and the nano-liposome is successfully prepared.

The present invention addresses the problem of providing a novel transparent cleaning agent having high cleaning power and excellent long-term stability even when containing water. The transparent cleaning agent for solving the problem of the present invention is characterized by being of a water-containing reverse micelle type containing the following components (A) to (F). (A) an ester of a fatty acid having 8-10 carbon atoms and a polyglycerol; (B) an ester of a branched fatty acid having 14-22 carbon atoms and / or an unsaturated fatty acid and a polyglycerol; (C) an aliphatic alcohol and / or fatty acid that is liquid at 25 DEG C; (D) an oil agent (excluding component (C)) containing a hydrocarbon oil; (E) more than 0% and 10% by mass or less of water; and (F) a polyol.

This invention provides an environmentally friendly expandable polystyrene bead and its preparation process, belonging to the field of foaming material technology. The preparation process includes the following steps: S1, injecting 65.28g of deionized water into a reaction vessel, stirring, adding 0.13g of dispersant and 0.16g of composite stabilizer, dispersing for 20min, then adding 31.95g of styrene monomer and 0.3g of composite initiator, followed by the addition of pentane and SiO2 micelle composite to obtain a base solution; wherein the mass ratio of pentane to SiO2 micelle composite is 1:(0.2-0.3); the mass of pentane is 3.1%-3.2% of the mass of the base solution; S2, subjecting the base solution to stepwise heating at 86℃-140℃ with stirring, then stopping heating, continuing stirring, and allowing it to cool naturally to 40℃, then stopping stirring, with a total reaction time of 8.5-9.5h to obtain the reaction product; S3, discharging the material, washing the reaction product with warm water, filtering, and obtaining the environmentally friendly expandable polystyrene beads. This invention improves the average particle size of expandable polystyrene beads while reducing fine powder.

The present invention relates to the technical field of oilfield chemistry, and provides a wormlike supramolecular associated micelle, a hydrophobic associated copolymer and a preparation method thereof, the wormlike supramolecular associated micelle comprises a soft template, a hydrophobic functional monomer 1, a hydrophobic functional monomer 2 and a polarity regulator, the soft template is a long-chain molecular polymer and has an active functional group, and the polarity regulator is a hydrophobic functional monomer 2. The hydrophobic functional monomer 1 is an anionic-nonionic surfactant with polymerizable double bonds, the hydrophobic functional monomer 2 is a cationic-nonionic surfactant with polymerizable double bonds, and the polarity regulator is a micromolecular organic compound. The problems of poor resistance reduction, sand carrying capacity and the like of the fracturing fluid in the construction process due to dissociation of a polymer molecular network structure and sudden reduction of rheological property and viscoelasticity are solved.

The invention discloses a fruit and vegetable extract extraction method combined with ultrasonic enhancement, and particularly relates to the field of fruit and vegetable extract extraction.The fruit and vegetable extract extraction method comprises the steps that a composite micelle structure formed by saccharides and functional factors in fruit and vegetable raw materials is recognized as a structure obstacle before extraction, and a directional unbinding path is constructed according to the binding configuration and structural responsiveness of the structure obstacle; to generate a group of ultrasonically extracted target components; and constructing an ultrasonic cooperative transmission path with continuous penetrability and cavitation energy focusing capability by taking the sound response condition and the foam interference characteristic of the liquid phase environment in which the target component group is located as dynamic parameters. By constructing a multi-dimensional synergistic extraction process of a sugar-phenol deconstruction path, a cavitation energy penetration path and a migration enrichment feedback path, the problems of low functional component release efficiency and difficult purity control caused by superposition of a wrapping effect and an acoustic resistance barrier in a high-sugar system are solved.

The invention discloses emblic leafflower fruit polysaccharide with sugar-controlling and lipid-lowering activity as well as a preparation method and application of the emblic leafflower fruit polysaccharide. The polysaccharide is prepared by taking fresh phyllanthus emblica pulp as a raw material through hot water extraction, yeast fermentation, desorption after XAD-16 macroporous resin adsorption, alcohol precipitation, ultrafiltration and DEAE-52 cellulose column purification. The low-molecular-weight gulcomannan is separated from phyllanthus emblica for the first time, and monosaccharide composition of the gulcomannan mainly comprises glucose, mannose and galactose and contains trace rhamnose and xylose. The polysaccharide has sugar-controlling and lipid-lowering active action targets in the whole digestive tract (the upper digestive tract: glycolipid digestion and absorption enzymes alpha-amylase, alpha-glucosidase and pancreatic lipase inhibitory activity, starch hydrolysis delay, bile acid adsorption capacity and cholesterol micelle dissolution inhibition capacity; in the lower digestive tract, the multiplication promoting capacity of glycolipid metabolism-related probiotics) shows extremely high biological activity, and can be applied to food and health care products.

The invention relates to the technical field of cosmetics and transdermal drug delivery, in particular to a resveratrol-tocoxolam nano-micelle and application of the resveratrol-tocoxolam nano-micelle in preparation of antioxidant and skin whitening products. The preparation method comprises the following steps: adding resveratrol or a derivative thereof into a first organic solvent (the weight percentage is 0.1-2%), and heating and dissolving at a first temperature of 80-100 DEG C to obtain a first solution; adding tocoxolam into the first solution, mixing (the weight percentage is 0.5-20%), and heating and dissolving at a second temperature (80-100 DEG C) to obtain a second solution; adding the second solution into the deionized water at a first rate (1mL / min to 3mL / min), and stirring and dispersing at a third temperature (50 DEG C to 70 DEG C); the nano-micelle is high in stability, excellent in transdermal absorption performance and good in anti-light aging effect, and has good skin whitening and anti-oxidation effects.

The invention discloses a manganese-cobalt bimetallic mesoporous molecular sieve integral photo-thermal evaporator and a preparation method and application thereof. Melamine sponge is used as a supporting framework, a molecular sieve catalyst is cross-linked, cured and loaded on the surface of the sponge and in pore channels through sodium alginate and CaCl2, the three-dimensional porous evaporator is formed, and the molecular sieve catalyst is a manganese-cobalt bimetal loaded mesoporous silica microsphere material. Mesoporous silica microspheres MS rich in manganese ions are prepared through a metal coordination micelle self-assembly strategy, then the adhesion characteristic of dopamine hydrochloride is utilized, a cobalt substance is uniformly loaded on the surface of the MS, and calcination is performed in a nitrogen atmosphere to form a metal coupled nanocarbon embedded molecular sieve catalyst; the molecular sieve catalyst and the photo-thermal evaporator can synchronously realize photocatalytic degradation of various pollutants and solar-driven water regeneration, have efficient catalytic performance and photo-thermal conversion performance, can be recycled for multiple times, and have great application prospects.

The invention relates to the technical field of micellar processing, in particular to a two-section type translation conveyor which comprises a machine frame and a sliding frame installed on the machine frame in a sliding mode and further comprises a moving frame installed on the sliding frame in a sliding mode. The tipping bucket is movably mounted on the moving frame; the weighing mechanism is arranged at the bottom of the sliding frame; the partition plates are axially, symmetrically and fixedly mounted on the two sides of the tipping bucket, and vertical grooves are formed in the partition plates; the lifting plate is movably mounted on one side of the partition plate; the rotating rod is rotationally mounted on one side of the lifting plate, and a clamping groove is formed in the rotating rod; the clamping plate movably sleeves the outer side of the rotating rod and is movably clamped with the clamping groove, the clamping plate and the clamping groove rotate coaxially, and a plurality of sawteeth are arranged on the clamping plate; the driving assembly is arranged on one side of the lifting plate and used for driving the two clamping plates to get close to each other. According to the two-section type translation conveyor provided by the invention, through cooperation of a plurality of components such as the movable rod, the movable frame, the limiting rod, the inclined groove and the straight groove, the clamping plates get close to each other, so that micelles can be clamped and pulled, and the micelles in the tipping bucket are dispersed.

To provide a novel method for oil-water separation of an oil-in-water suspension and an oil-water separation device.SOLUTION: A method for oil-water separation is provided, comprising: contacting an oil-in-water suspension with water, which may contain microbubbles, such that a suspension-rich phase is positioned above and a water-rich phase is positioned below; supplying new microbubbles to the water-rich phase so as to prevent uniform mixing between the suspension-rich phase and the water-rich phase; and floating microbubbles having adsorbed micelles in the suspension. Also provided is an oil-water separation device comprising: a separation tank that houses an oil-in-water suspension and water, which may contain microbubbles, such that a suspension-rich phase is positioned above and a water-rich phase is positioned below; and a microbubble generator that generates microbubbles to be supplied into the separation tank, wherein the microbubble generator is disposed such that the generated microbubbles are supplied to the water-rich phase, and the interior of the separation tank is not stirred during microbubble generation in a manner of preventing uniformity inside the tank.SELECTED DRAWING: Figure 1

Proposed is a conductive hydrogel including a micelle and a metal-organic framework / surfactant composite.

Disclosed are a preparation method for a SiO2 aerogel and a SiO2 aerogel, and belongs to the technical field of chemical coatings. The preparation method for the SiO2 aerogel comprises the following steps: S100: uniformly mixing an inorganic silicon source, water, a surfactant and an acid catalyst, and gelating the mixture to obtain a wet gel; S200: uniformly mixing a surfactant, a cosolvent and a low-surface-tension solvent to obtain a reverse micelle extraction solution; S300: mixing the wet gel obtained in the step S100 with the reverse micelle extraction solution obtained in the step S200, and soaking the mixture to obtain a gel; and S400: drying the gel obtained in the step S300 to obtain the SiO2 aerogel.

The invention discloses a ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method comprises the following steps: constructing an amphiphilic micelle system through a PEG-PLA (Polyethylene Glycol-Polylactic Acid) block copolymer, firstly preparing a micelle solution, then applying the micelle solution to precursor slurry preparation and PLGA pore-forming agent pretreatment (solving the problems of compatibility and agglomeration) in stages, molding and drying, and then carrying out gradient sintering (removing an auxiliary agent at low temperature and promoting densification at high temperature) to obtain the product. The method solves the problems of poor compatibility of a pore-forming agent and a precursor, powder agglomeration and uneven pore structure in a traditional process, and the obtained material has a three-dimensionally communicated and uniformly distributed micropore structure and is uniform in component.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

The invention discloses an asymmetric magnetic mesoporous carbon superstructure material as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing Fe3O4amp; a SiO2 alcohol dispersion liquid; (2) preparing Fe3O4 < 4 > amp; the preparation method comprises the following steps: preparing a SiO2 (at) micro single micelle superstructure alcohol solution; (3) preparing Fe3O4 < 4 > amp; a SiO2 (at) C superstructure material; the specific surface area of the material is 87-116 m < 2 > / g, the aperture is 22.8-50 nm, and the length is 330-400 nm. The material is applied to catalytic degradation of organic dyes. The method has the beneficial effects that the surface chemical property is more active, the hydrophilicity and the catalytic degradation capability are stronger, the method is suitable for chemical catalytic degradation, the whole synthesis process is simple and convenient to operate, and intermediate byproducts cannot be generated to cause secondary pollution; in addition, in the dopamine carbonization process, high-temperature carbonization is carried out in nitrogen (inert atmosphere), and the operation is safe; by adjusting the type of the PS-PVP-PEO single micelle, accurate control of the mesoporous size can be realized, so that the PS-PVP-PEO single micelle is suitable for catalytic degradation of organic pollutants with different molecular weights, and selective catalytic degradation is realized.

The invention relates to the technical field of food processing, in particular to antioxidant nano collagen peptide powder and a preparation method thereof.The antioxidant nano collagen peptide powder is prepared by forming antioxidant micelles wrapping collagen peptide through collagen peptide liquid and a complex antioxidant, loading the antioxidant micelles on a porous carrier and then conducting cross-linking through transglutaminase; tea polyphenol and whey protein are covalently combined to prepare a composite antioxidant, rapid free radical neutralization, lactoferrin inhibition of an oxidation source and synergistic effect of collagen peptide self-antioxidant groups are provided, multistage barrier design is combined, oxygen diffusion is isolated through a micelle hydrophobic core, and the contact area of micelles and the outside is reduced through physical adsorption of a porous carrier, so that the anti-oxidation effect of the collagen peptide is improved. Finally, the micelles are fixed in the carrier by utilizing an enzyme cross-linked network, so that the antioxidant nano collagen peptide powder has efficient and long-acting antioxidant capacity.

The invention relates to the technical field of the Internet of Things, and discloses a soil stabilizer production monitoring method and system based on the Internet of Things. The method comprises the following steps: deploying an Internet of Things sensor network at the positions of a raw material mixer, a reaction kettle and a compaction forming machine of the soil stabilizer production line, and collecting original monitoring data in the production process; creating a staged monitoring strategy according to the original monitoring data of the production process; differential sampling frequency control is carried out on the Internet of Things sensor network, and a production process target parameter set is obtained; identifying abnormal fluctuation of electrolyte concentration change, micellar formation state and crystal water fixing efficiency based on the production process target parameter set to obtain production quality risk early warning information; and a corresponding production process parameter adjustment scheme is generated by combining the demand difference of the performance of the soil stabilizer in different application scenes. According to the invention, the problems of signal interference and data acquisition blind areas in traditional monitoring are solved, and intelligent and accurate regulation and control of process parameters are realized.

Disclosed are compositions comprising a lipid polymer excipient and AmB or an AmB derivative. The lipid polymer excipient can form micelles when formulated with AmB or the AmB derivative and can solubilize and stabilize the drug. Also disclosed are methods of treating a fungal infection using the compositions.