739 results about "Micelle" patented technology

The invention relates to the technical field of biological medicine, in particular to a ferroptosis inhibition type phospholipid-like material and application thereof. The ferroptosis inhibition type phospholipid-like material is one of the following structural general formulas (1)-(5). The biomimetic phospholipid-like ferroptosis inhibitor has a long retention characteristic in main positions (cell membranes, endoplasmic reticulum and other organelle membranes) of cell ferroptosis, so that the ferroptosis inhibition efficiency is remarkably improved. The novel phospholipid-like material not only can be used as an active drug molecule, but also can be used as a pharmaceutic adjuvant for constructing drug delivery carriers such as lipidosome and micelle and implant coatings, and is suitable for various administration routes such as oral administration, injection and local administration. The novel biomimetic ferroptosis inhibitor can efficiently relieve cell ferroptosis and has a wide application prospect in the field of treating or retarding ferroptosis-related diseases.

The invention discloses a high molecular weight poly (p-dioxanone) (PPDO) microsphere as well as a preparation method and application thereof. By adopting a double emulsification-solvent evaporation method, an amphiphilic polymer, such as poly (p-dioxanone) (PDO) or a copolymer of PDO and a hydrophilic fragment (such as mPEG and mPPG), is utilized to perform self-assembly on a two-phase interface formed by emulsification under the combined action of amphipathy and polyvinyl alcohol (PVA) to form a double-micelle protective layer, so that the degradation effect of water on PPDO in the microsphere forming process is effectively blocked, and the PPDO can be effectively degraded. And finally, the high-molecular-weight poly (p-dioxanone) microspheres with stable performance are obtained, so that the high-molecular-weight PPDO microspheres have long-term stability. The preparation method is high in operability, mild in condition and suitable for large-scale production, high-molecular-weight poly (p-dioxanone) microspheres are obtained, and the preparation method has wide application prospects in the aspects of tissue filling agents, drug carriers, tissue scaffolds and the like.

The invention provides a lipidosome STING agonist delivery system based on a PD-L1 antibody as well as a preparation method and application of the lipidosome STING agonist delivery system, and belongs to the technical field of medical biology. Preparing lipidosome by adopting an ethanol injection method and an ammonium sulfate gradient technology; the PD-L1 antibody and the STING agonist can be loaded at the same time; the liposome is prepared by adopting an ethanol injection method and an ammonium sulfate gradient technology, and the STING agonist can be wrapped in the liposome in an active drug loading manner; dSPE-PEG2000-NHS and a PD-L1 antibody are mixed and incubated according to a specific proportion by utilizing a post-insertion method to form an antibody conjugated micelle, and the antibody conjugated micelle is fused with a blank liposome to realize antibody modification; secondly, the nano-liposome has good drug carrier characteristics and can effectively protect the loaded drug, reduce the risk of enzymolysis of the drug and improve the stability of the drug in vivo, so that the liposome drug delivery system simultaneously loading the nano-liposome and the nano-liposome is successfully prepared.

This invention provides an environmentally friendly expandable polystyrene bead and its preparation process, belonging to the field of foaming material technology. The preparation process includes the following steps: S1, injecting 65.28g of deionized water into a reaction vessel, stirring, adding 0.13g of dispersant and 0.16g of composite stabilizer, dispersing for 20min, then adding 31.95g of styrene monomer and 0.3g of composite initiator, followed by the addition of pentane and SiO2 micelle composite to obtain a base solution; wherein the mass ratio of pentane to SiO2 micelle composite is 1:(0.2-0.3); the mass of pentane is 3.1%-3.2% of the mass of the base solution; S2, subjecting the base solution to stepwise heating at 86℃-140℃ with stirring, then stopping heating, continuing stirring, and allowing it to cool naturally to 40℃, then stopping stirring, with a total reaction time of 8.5-9.5h to obtain the reaction product; S3, discharging the material, washing the reaction product with warm water, filtering, and obtaining the environmentally friendly expandable polystyrene beads. This invention improves the average particle size of expandable polystyrene beads while reducing fine powder.

The invention relates to the technical field of cosmetics and transdermal drug delivery, in particular to a resveratrol-tocoxolam nano-micelle and application of the resveratrol-tocoxolam nano-micelle in preparation of antioxidant and skin whitening products. The preparation method comprises the following steps: adding resveratrol or a derivative thereof into a first organic solvent (the weight percentage is 0.1-2%), and heating and dissolving at a first temperature of 80-100 DEG C to obtain a first solution; adding tocoxolam into the first solution, mixing (the weight percentage is 0.5-20%), and heating and dissolving at a second temperature (80-100 DEG C) to obtain a second solution; adding the second solution into the deionized water at a first rate (1mL / min to 3mL / min), and stirring and dispersing at a third temperature (50 DEG C to 70 DEG C); the nano-micelle is high in stability, excellent in transdermal absorption performance and good in anti-light aging effect, and has good skin whitening and anti-oxidation effects.

Disclosed are a preparation method for a SiO2 aerogel and a SiO2 aerogel, and belongs to the technical field of chemical coatings. The preparation method for the SiO2 aerogel comprises the following steps: S100: uniformly mixing an inorganic silicon source, water, a surfactant and an acid catalyst, and gelating the mixture to obtain a wet gel; S200: uniformly mixing a surfactant, a cosolvent and a low-surface-tension solvent to obtain a reverse micelle extraction solution; S300: mixing the wet gel obtained in the step S100 with the reverse micelle extraction solution obtained in the step S200, and soaking the mixture to obtain a gel; and S400: drying the gel obtained in the step S300 to obtain the SiO2 aerogel.

The invention discloses a ceramic artificial bone material and a preparation method thereof, and belongs to the technical field of ceramic material preparation. The method comprises the following steps: constructing an amphiphilic micelle system through a PEG-PLA (Polyethylene Glycol-Polylactic Acid) block copolymer, firstly preparing a micelle solution, then applying the micelle solution to precursor slurry preparation and PLGA pore-forming agent pretreatment (solving the problems of compatibility and agglomeration) in stages, molding and drying, and then carrying out gradient sintering (removing an auxiliary agent at low temperature and promoting densification at high temperature) to obtain the product. The method solves the problems of poor compatibility of a pore-forming agent and a precursor, powder agglomeration and uneven pore structure in a traditional process, and the obtained material has a three-dimensionally communicated and uniformly distributed micropore structure and is uniform in component.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

The invention relates to the technical field of the Internet of Things, and discloses a soil stabilizer production monitoring method and system based on the Internet of Things. The method comprises the following steps: deploying an Internet of Things sensor network at the positions of a raw material mixer, a reaction kettle and a compaction forming machine of the soil stabilizer production line, and collecting original monitoring data in the production process; creating a staged monitoring strategy according to the original monitoring data of the production process; differential sampling frequency control is carried out on the Internet of Things sensor network, and a production process target parameter set is obtained; identifying abnormal fluctuation of electrolyte concentration change, micellar formation state and crystal water fixing efficiency based on the production process target parameter set to obtain production quality risk early warning information; and a corresponding production process parameter adjustment scheme is generated by combining the demand difference of the performance of the soil stabilizer in different application scenes. According to the invention, the problems of signal interference and data acquisition blind areas in traditional monitoring are solved, and intelligent and accurate regulation and control of process parameters are realized.

Disclosed are compositions comprising a lipid polymer excipient and AmB or an AmB derivative. The lipid polymer excipient can form micelles when formulated with AmB or the AmB derivative and can solubilize and stabilize the drug. Also disclosed are methods of treating a fungal infection using the compositions.

The invention relates to nano-scale reverse micelle oil capable of promoting permeation, realizing targeted delivery and enhancing vitriol and a preparation method of the nano-scale reverse micelle oil. The nano-scale reverse micelle oil comprises a boro, a nonionic surfactant, short-chain alcohol, long-chain alcohol and grease. The preparation method comprises the following steps: mixing and stirring the glassine, the short-chain alcohol and the long-chain alcohol, then adding the nonionic surfactant, continuously stirring, and finally adding the grease and stirring to obtain the nano-scale reverse micelle oil. The nanoscale reverse micelle oil is clear and transparent in appearance, the average particle size is smaller than 300 nm, and the nanoscale reverse micelle oil has good stability; a good permeation promoting effect is achieved, and the transdermal absorption amount of the glassine can be greatly improved. The bose oil can be added into a pure oil system, and the application field of bose oil is expanded.

The invention provides a preparation method of a cellulose-based water-induced deformation and color-changing film. Water-induced deformation and color-changing response are realized synergistically. The film is mainly prepared from the following components in parts by weight: 16.67 to 25 parts of hydrophilic micelle, 33.33 to 50 parts of absolute ethyl alcohol, 10 to 16 parts of modified cellulose, 12.5 to 20 parts of cross-linking agent and 2.5 to 4 parts of red dye. The cellulose-based water-induced deformation and color-changing film can realize deformation and color-changing response at the same time, the water absorption rate and the water absorption capacity of the two surfaces of the film are regulated and controlled by utilizing the content difference of hydrophilic micelles in the upper surface and the lower surface of the film, and the water-induced deformation response of the film is realized. Meanwhile, after the thin film absorbs water and swells, the microstructure arrangement in the thin film is changed due to the increase of the volume, so that incident light generates a stronger scattering effect in the material, and the hydrochromic behavior of the thin film is realized. The cellulose-based water-induced deformation and color-changing film has synergistic deformation and color-changing response to water stimulation, and has great application potential in the fields of actuators, wearable electronic equipment, intelligent robots and the like.

The invention relates to the technical field of biomacromolecule separation and purification engineering, and discloses a chromatographic separation method for removing endotoxin in a vaccine preparation, which comprises the following steps: preparing an equilibrium buffer solution containing citrate with specific concentration and L-arginine hydrochloride; providing a mixed mode chromatography medium with hydrophobic and ion exchange complex ligands and balancing with a buffer; according to the method, through the synergistic effect of 8.0-12.0 mmol / L of citrate and 150-250 mmol / L of L-arginine hydrochloride, the endotoxin micelle structure is destroyed and is induced to be dissociated into monomers, and meanwhile, L-arginine is used for inhibiting monomer aggregation, so that the monomers are diffused into inner holes of the medium in a small size to be adsorbed, and the endotoxin micelle structure is separated into the medium. Therefore, the problem of separation caused by size overlapping of endotoxin micelles and antigens is solved, and double breakthrough of deep removal of endotoxin and high recovery rate of antigens is realized.

The invention discloses a multi-cavity mesoporous carbon nanosphere battery material and a preparation method and application thereof, and belongs to the technical field of ion batteries, the method comprises the following steps: mixing a cosolvent and a surfactant, and stirring until the cosolvent and the surfactant are dissolved; adding a carbon source monomer, and stirring until dissolving; adding a pore-foaming agent, and stirring to form a suspension; and finally, adding a hydrogen bond catalyst, and after the stirring reaction is finished, washing, freeze-drying and carbonizing to obtain the multi-cavity mesoporous carbon nanosphere battery material. The problems of poor micelle stability and low repeatability of a traditional soft template method are solved through cooperative regulation and control of catalysis of the hydrogen bond catalyst and precise assembly time. By simply controlling the reaction time, a product with the multi-cavity structure reaching 65.3%-92.5% is stably and repeatedly prepared and far exceeds 31.7% of that of a non-catalytic system, and precise customization of the microstructure of the material is achieved. The multi-cavity structure can better buffer the volume change caused by sodium ion intercalation / deintercalation in the charging and discharging process, and is beneficial to maintaining the structural integrity of the electrode material.

The invention discloses non-activation low-cost high-magnification asphalt-based porous carbon and a preparation method and application thereof.The preparation method comprises the steps that tar with high aromatic hydrocarbon content is subjected to a cross-linking oxidation reaction in an oxygen-containing atmosphere, and oxygen modified asphalt rich in hydroxyl and carboxyl polar functional groups is obtained; the preparation method comprises the following steps: jointly mixing oxygen modified asphalt, a soft template dispersant and a water-organic mixed solvent, and realizing uniform dispersion of the mixture in a mixed phase by utilizing the interaction of a polar functional group on the surface of the oxygen modified asphalt and the soft template dispersant; through a synergistic self-assembly reaction under a hydrothermal condition, core-shell structure micelles are formed by utilizing polarity gradient guidance of a mixed solvent, and precise regulation and control of the pore diameter are realized; after the reaction, carrying out solid-liquid separation, washing and drying to obtain a porous carbon precursor with a mesoporous framework; and performing low-temperature carbonization treatment on the porous carbon precursor in a protective atmosphere, and promoting low-temperature aromatization of asphalt molecules by using hydroxyl radicals introduced in a hydrothermal process to form the asphalt-based porous carbon with a pi-enriched conjugated structure.

The preparation method comprises the following steps: S1, hydrophilic-hydrophobic bi-component modification reaction: dissolving a styrene-maleic anhydride copolymer, hydrophilic polyethylene glycol monomethyl ether and hydrophobic long-chain alkyl alcohol in butanone according to a ratio, adding a catalyst, stirring, reacting, filtering, washing, and drying to obtain the dispersing agent for the lithium battery diaphragm based on the modified benzyl resin micelle. Performing ester exchange reaction on anhydride bonds of the styrene-maleic anhydride copolymer and polyether hydroxyl and alkyl alcohol hydroxyl respectively to obtain a modified intermediate; s2, neutralization reaction: dropwise adding organic alkali into the modified intermediate, and adjusting the pH value to obtain a modified SMA solution containing carboxylate groups; s3, preparing nano-micelles: dropwise adding the modified SMA solution into deionized water, and stirring to enable the modified SMA solution to be self-assembled to form the nano-micelles, so as to obtain nano-micelle dispersion liquid; and S4, dispersing agent forming: stirring the nano-micelle dispersion liquid to remove butanone so as to obtain the water-based dispersing agent.

The invention discloses a high-wear-resistance nano filler modified rubber material and a preparation method thereof, and belongs to the technical field of rubber material modification. The preparation method comprises the following steps: by taking water-soluble polyacrylic acid micelles as a template, controlling the hydrolysis rate of tetraethyl orthosilicate by regulating and controlling the dosage of ammonia water, so as to prepare hollow SiO2 nanoparticles with a porous shell layer and a stable structure; and then synergistic modification is carried out through a PEG-PLA block copolymer and a silane coupling agent KH550, so that the dispersity and compatibility of particles are improved. And blending and banburying the modified porous hollow SiO2 particles and butadiene styrene rubber slurry, and carrying out vulcanization molding to obtain the modified rubber material. The wear resistance and tensile strength of the rubber are improved, good elasticity and elongation at break are kept, high strength, high wear resistance and high toughness are considered, and the process is mild and controllable.

The invention relates to the field of microbial fermentation food, and discloses application of lactobacillus plantarum, a prune fermentation product, a preparation method of the prune fermentation product and a prune fermentation strain. A strain of lactobacillus plantarum with better performance is obtained from the nature, the preservation number is CCTCC NO: M 20242280, and after the lactobacillus plantarum is used for fermenting the prune subjected to enzymolysis, compared with other fermentation strains and fermentation products without fermentation strains, the obtained fermentation product has the advantages that the fermentation yield is increased, and the yield is increased. The pancreatic lipase inhibition rate and the cholesterol micelle solubility inhibition rate are remarkably improved, and the compound shows extremely excellent activity of improving blood fat. The invention not only provides an effective, time-saving and energy-saving preparation process method of the prune fermented product, but also provides a wide foundation for further application of the prune.

The invention belongs to the technical field of tumor treatment, and particularly relates to a metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle and a preparation method and application thereof.The mesoporous organic silicon nanoparticle (MON) is prepared through a micelle / precursor co-template assembly method, then amination modification, carboxylation modification and drug co-loading are further conducted on the mesoporous organic silicon nanoparticle (MON), and the metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle is obtained. The DQMCTH nano-particles are prepared through the steps that DQMCTH nano-particles are taken as a raw material, a copper salt solution and a tannic acid (TA) solution are added and mixed, then a coordination complexation reaction is conducted, hyaluronic acid (HA) is added for modification, and the DQMCTH nano-particles obtained through the method are in a sphere-like shape, regular in shape, uniform in distribution and free of obvious dendritic branches and central radial pore channels. The polypeptide is effectively protected by MPN and is subjected to HA targeted modification; more importantly, the DQMCTH nanoparticles prepared by the method disclosed by the invention show pH / GSH / HAase triple sensitive drug release, and cell and animal experiment results show that the DQMCTH nanoparticles prepared by the method disclosed by the invention have relatively high anti-tumor activity on a drug-resistant breast cancer model.

The application discloses a drug-loaded micelle capable of effectively crossing the blood-brain barrier, which is an amphiphilic conjugate composed of a reduction-sensitive paclitaxel prodrug and a nucleic acid complex, wherein the reduction-sensitive paclitaxel prodrug is used as a hydrophobic part, and the nucleic acid complex is used as a hydrophilic part, and the drug-loaded micelle is self-assembled in an aqueous environment; the reduction-sensitive paclitaxel prodrug is formed by the reaction of paclitaxel and a disulfide bond-containing linker; and the nucleic acid complex is formed by connecting an antisense oligonucleotide and an interfering RNA through a DNA bridge. The drug-loaded micelle exhibits superior blood-brain barrier penetration, effectively realizes enrichment in brain tumors, solves the problem of low blood-brain barrier penetration efficiency of existing nano-carriers, and provides an effective basis for brain drug delivery and brain diseases such as brain tumor imaging and treatment.

The invention belongs to the technical field of coatings, and discloses a corrosion-resistant high-impact-resistant electrophoretic coating and a preparation method thereof. The coating comprises a cationic water-based resin emulsion, flaky nano clay with epoxy groups grafted on the surface, a curing agent, a cosolvent and a functional additive, the core of the method is that through electric field driving in the electrophoretic deposition process, resin micelles and modified nano clay form a bionic micro-nano laminated structure in which hard inorganic sheet layers and flexible organic layers are alternately arranged on the surface of a cathode in situ, and interface bonding between the sheet layers is enhanced through chemical bonding. The bionic micro-nano laminated structure with clear periodicity and a chemical bonding interface is constructed through an in-situ co-deposition technology driven by an electric field, and the contradictions that hardness and toughness cannot be achieved at the same time and impact resistance and corrosion resistance are difficult to cooperate in the prior art are solved; the method is suitable for the high-end industrial fields such as automobile bodies, high-speed rail bogies, offshore wind power towers and the like with strict requirements on comprehensive protection performance.

The invention provides a spraying film agent and a preparation method thereof. The spraying film agent comprises a phase A and a phase B, wherein the phase A is uniformly dispersed in the phase B; wherein the phase A is a water-in-oil structure microsphere, and the water-in-oil structure microsphere is formed by wrapping a water-soluble active substance with a surfactant; and the phase B comprises a low-polarity organic solvent and a film-forming agent. On the basis of a reverse micelle technology, a water-soluble active substance is wrapped by a surfactant to form a water-in-oil structure microsphere, in the structure, the hydrophilic end of the surfactant inwards forms a water pool for accommodating the water-soluble active substance, and the hydrophobic end of the surfactant outwards enables the water-soluble active substance to be uniformly dispersed in a low-polarity solvent; therefore, the uniform and stable dispersion of the water-soluble active substance in the low-polarity solvent phase is realized. The contradictions that a traditional water-soluble polymer matrix is slow in film forming and water-soluble active ingredients cannot be stably dispersed in a low-polarity quick-drying solvent are solved.

The invention belongs to the technical field of negative electrode materials, and relates to a nitrogen-doped carbon-coated titanium niobate negative electrode material and a preparation method and application thereof. According to the preparation method, a nano structure is regulated and controlled by virtue of a synergistic effect of'rigid frames + dynamic micelles' of a hard template and a soft template, the hard template provides a rigid space confinement by virtue of ordered mesopores, a niobium source precursor and a titanium source precursor are anchored, and titanium niobate is forced to grow in a pore channel along the axial direction; the soft template is self-assembled into micelles in an organic-water system, channels formed in the hard template are filled with the micelles, the deposition interfacial tension of a precursor is adjusted through the hydrophobic-hydrophilic effect, and the micelles and the hard template are jointly induced to form a'nanotube + mesoporous' multilevel structure.

The invention discloses multifunctional hydrogel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method of the multifunctional hydrogel comprises the following steps: preparing an HAMA solution, a PVA solution and a MnO2 solution, constructing C18 / SDS / NaCl micelles, concentrating, mixing the components, adding a photoinitiator, carrying out ultraviolet curing, and carrying out circulating freeze thawing and cationic crosslinking to obtain a final product. The hydrogel disclosed by the invention has physiological-adaptive mechanical properties, strong adhesion in air / water, 99.8% of staphylococcus aureus resistance rate and 23.6% of ROS clearance rate in 12 hours, nearly 100% healing of mouse diabetic ulcer can be realized in 16 days, and the hydrogel is suitable for repairing chronic difficult-to-heal wounds and has remarkable clinical application value.

The invention belongs to the technical field of biological medicine, and particularly relates to a nano vaccine based on GD2 mimetic peptide as well as a preparation method and application of the nano vaccine. The nano vaccine provided by the invention comprises a GD2 mimetic peptide, an STING agonist and a polymer carrier, wherein the STING agonist is used as an immunologic adjuvant. The antigen peptide (GD2 mimic peptide 47-LDA) and the adjuvant (STING agonist) are wrapped in the micelle to prepare the nano vaccine GD2-NV, so that the druggability of the antigen peptide and the STING agonist is improved, and the accumulation of drug tumors and drainage lymph node parts is improved. Besides, the nano vaccine can respond to a lysosome acid environment, realize lysosome escape, enhance antigen cross presentation of DC, activate an STING pathway, improve infiltration and activation degrees of CD8 + T cells, induce lasting humoral immune response and inhibit growth and recurrence of tumors, and is good in biological safety.

The invention discloses a Vismodegib and BMS-1 co-loaded bionic nano delivery system as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. According to the preparation method disclosed by the invention, Vismodegib and BMS-1 are prepared into a nano-micelle core, and then red blood cell vesicles are utilized to prepare the bionic nano delivery system co-loaded with Vismodegib and BMS-1. Experiments prove that the bionic nano delivery system prepared by the invention inhibits the growth of mouse in-situ tumors and the formation of lung / liver tumor metastasis lesions, and the effect is obviously superior to that of Vismodegib or BMS-1 used alone, Vismodegib and BMS-1 combined use and Vismodegib or BMS-1 loaded nano delivery carriers. The invention provides a new idea for clinical treatment of triple negative breast cancer.

The present application relates to a kind of supramolecular surfactants based on fluorine-fluorine interaction, belong to supramolecular coordination chemistry, surface modification engineering and hydrophobic coating technical field.The esterification reaction of perfluorooctanoic acid and high molecular weight polypropylene glycol is carried out in the present application to prepare flexible ligand PFOA-PPG-PFOA, the ligand can be bent, form supramolecular micelles by fluorine-fluorine interaction with the help of zinc ion in solvent, and self-assemble into a kind of supramolecular surfactants based on fluorine-fluorine interaction.The active agent can be applied in the field of hydrophobic coating, coating has the characteristics of imitating lotus leaf structure and hydrophobic wax, and has good hydrophobic performance.

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The invention belongs to the technical fields of medical chemistry, new materials and nanotechnology, and relates to a novel diagnosis and treatment agent in the field of interdisciplinary, in particular to a preparation method of a reduction response activation < 19 > F magnetic resonance signal amplification self-degradation nanometer diagnosis and treatment micelle. Poly (benzyl carbamate) is obtained through condensation polymerization as a basic structure, then chemical modification is performed to obtain a self-degradable fluorine-containing amphiphilic block polymer, hydrophobic drug chlorin (Ce6) is loaded through self-assembly, the self-degradable fluorine-containing amphiphilic block polymer has the characteristic of responding to degradation of glutathione (GSH) at a tumor site, and on the basis of maintaining self-degradation of a hydrophobic chain segment of the nano-micelle, the self-degradable fluorine-containing amphiphilic block polymer can be used for preparing the self-degradable fluorine-containing amphiphilic block polymer. The nano-micelle loaded with Ce6 has the advantages that the nano-micelle loaded with Ce6 is used as a carrier, the characteristic of efficient 19F MR imaging is additionally endowed, under laser irradiation, the nano-micelle loaded with Ce6 can enhance a new scheme of breast cancer photodynamic therapy, the effects of responding to tumor microenvironment self-degradation drug release and 19F MRI signal amplification are achieved, and therefore diagnosis and treatment integration of breast cancer is achieved.

The invention belongs to the technical field of preparation of high polymer materials, and provides a lithium ion sieve HMO (at) PPSH hydrogel with SDS micelle mediated swelling enhanced adsorption, and a preparation method and application of the lithium ion sieve HMO (at) PPSH hydrogel. The preparation method comprises the following steps: mixing MnCO3 and Li2CO3 according to a molar ratio of Li / Mn of 1.33: 1.67, and carrying out heat treatment in air at 500 DEG C for 4 hours to obtain a precursor LMO; the preparation method comprises the following steps: preparing a PVA solution and an SDS solution, mixing the PVA solution, the SDS solution, AM, MBA and LMO, and obtaining a solution A after bubbles disappear; adding an ammonium persulfate solution into the solution A, and reacting at 60 DEG C for 6-8 hours to obtain LMO-coated PPSH; and soaking the LMO-coated PPSH in an HCl solution, and washing with deionized water to obtain the HMO-coated PPSH composite material. And the adsorption content of 30% HMO coated PPSH is up to 52.79 mg / g. And the extraction efficiency of Li < + > in natural seawater is up to 98.12%, and the adsorbent still has high adsorption capacity under 10 times of adsorption-desorption circulation.