428 results about "Micelle" patented technology

This invention provides an environmentally friendly expandable polystyrene bead and its preparation process, belonging to the field of foaming material technology. The preparation process includes the following steps: S1, injecting 65.28g of deionized water into a reaction vessel, stirring, adding 0.13g of dispersant and 0.16g of composite stabilizer, dispersing for 20min, then adding 31.95g of styrene monomer and 0.3g of composite initiator, followed by the addition of pentane and SiO2 micelle composite to obtain a base solution; wherein the mass ratio of pentane to SiO2 micelle composite is 1:(0.2-0.3); the mass of pentane is 3.1%-3.2% of the mass of the base solution; S2, subjecting the base solution to stepwise heating at 86℃-140℃ with stirring, then stopping heating, continuing stirring, and allowing it to cool naturally to 40℃, then stopping stirring, with a total reaction time of 8.5-9.5h to obtain the reaction product; S3, discharging the material, washing the reaction product with warm water, filtering, and obtaining the environmentally friendly expandable polystyrene beads. This invention improves the average particle size of expandable polystyrene beads while reducing fine powder.

The invention relates to the technical field of biomacromolecule separation and purification engineering, and discloses a chromatographic separation method for removing endotoxin in a vaccine preparation, which comprises the following steps: preparing an equilibrium buffer solution containing citrate with specific concentration and L-arginine hydrochloride; providing a mixed mode chromatography medium with hydrophobic and ion exchange complex ligands and balancing with a buffer; according to the method, through the synergistic effect of 8.0-12.0 mmol / L of citrate and 150-250 mmol / L of L-arginine hydrochloride, the endotoxin micelle structure is destroyed and is induced to be dissociated into monomers, and meanwhile, L-arginine is used for inhibiting monomer aggregation, so that the monomers are diffused into inner holes of the medium in a small size to be adsorbed, and the endotoxin micelle structure is separated into the medium. Therefore, the problem of separation caused by size overlapping of endotoxin micelles and antigens is solved, and double breakthrough of deep removal of endotoxin and high recovery rate of antigens is realized.

The preparation method comprises the following steps: S1, hydrophilic-hydrophobic bi-component modification reaction: dissolving a styrene-maleic anhydride copolymer, hydrophilic polyethylene glycol monomethyl ether and hydrophobic long-chain alkyl alcohol in butanone according to a ratio, adding a catalyst, stirring, reacting, filtering, washing, and drying to obtain the dispersing agent for the lithium battery diaphragm based on the modified benzyl resin micelle. Performing ester exchange reaction on anhydride bonds of the styrene-maleic anhydride copolymer and polyether hydroxyl and alkyl alcohol hydroxyl respectively to obtain a modified intermediate; s2, neutralization reaction: dropwise adding organic alkali into the modified intermediate, and adjusting the pH value to obtain a modified SMA solution containing carboxylate groups; s3, preparing nano-micelles: dropwise adding the modified SMA solution into deionized water, and stirring to enable the modified SMA solution to be self-assembled to form the nano-micelles, so as to obtain nano-micelle dispersion liquid; and S4, dispersing agent forming: stirring the nano-micelle dispersion liquid to remove butanone so as to obtain the water-based dispersing agent.

The invention discloses a high-wear-resistance nano filler modified rubber material and a preparation method thereof, and belongs to the technical field of rubber material modification. The preparation method comprises the following steps: by taking water-soluble polyacrylic acid micelles as a template, controlling the hydrolysis rate of tetraethyl orthosilicate by regulating and controlling the dosage of ammonia water, so as to prepare hollow SiO2 nanoparticles with a porous shell layer and a stable structure; and then synergistic modification is carried out through a PEG-PLA block copolymer and a silane coupling agent KH550, so that the dispersity and compatibility of particles are improved. And blending and banburying the modified porous hollow SiO2 particles and butadiene styrene rubber slurry, and carrying out vulcanization molding to obtain the modified rubber material. The wear resistance and tensile strength of the rubber are improved, good elasticity and elongation at break are kept, high strength, high wear resistance and high toughness are considered, and the process is mild and controllable.

The invention belongs to the technical field of tumor treatment, and particularly relates to a metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle and a preparation method and application thereof.The mesoporous organic silicon nanoparticle (MON) is prepared through a micelle / precursor co-template assembly method, then amination modification, carboxylation modification and drug co-loading are further conducted on the mesoporous organic silicon nanoparticle (MON), and the metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle is obtained. The DQMCTH nano-particles are prepared through the steps that DQMCTH nano-particles are taken as a raw material, a copper salt solution and a tannic acid (TA) solution are added and mixed, then a coordination complexation reaction is conducted, hyaluronic acid (HA) is added for modification, and the DQMCTH nano-particles obtained through the method are in a sphere-like shape, regular in shape, uniform in distribution and free of obvious dendritic branches and central radial pore channels. The polypeptide is effectively protected by MPN and is subjected to HA targeted modification; more importantly, the DQMCTH nanoparticles prepared by the method disclosed by the invention show pH / GSH / HAase triple sensitive drug release, and cell and animal experiment results show that the DQMCTH nanoparticles prepared by the method disclosed by the invention have relatively high anti-tumor activity on a drug-resistant breast cancer model.

The application discloses a drug-loaded micelle capable of effectively crossing the blood-brain barrier, which is an amphiphilic conjugate composed of a reduction-sensitive paclitaxel prodrug and a nucleic acid complex, wherein the reduction-sensitive paclitaxel prodrug is used as a hydrophobic part, and the nucleic acid complex is used as a hydrophilic part, and the drug-loaded micelle is self-assembled in an aqueous environment; the reduction-sensitive paclitaxel prodrug is formed by the reaction of paclitaxel and a disulfide bond-containing linker; and the nucleic acid complex is formed by connecting an antisense oligonucleotide and an interfering RNA through a DNA bridge. The drug-loaded micelle exhibits superior blood-brain barrier penetration, effectively realizes enrichment in brain tumors, solves the problem of low blood-brain barrier penetration efficiency of existing nano-carriers, and provides an effective basis for brain drug delivery and brain diseases such as brain tumor imaging and treatment.

The invention belongs to the technical field of coatings, and discloses a corrosion-resistant high-impact-resistant electrophoretic coating and a preparation method thereof. The coating comprises a cationic water-based resin emulsion, flaky nano clay with epoxy groups grafted on the surface, a curing agent, a cosolvent and a functional additive, the core of the method is that through electric field driving in the electrophoretic deposition process, resin micelles and modified nano clay form a bionic micro-nano laminated structure in which hard inorganic sheet layers and flexible organic layers are alternately arranged on the surface of a cathode in situ, and interface bonding between the sheet layers is enhanced through chemical bonding. The bionic micro-nano laminated structure with clear periodicity and a chemical bonding interface is constructed through an in-situ co-deposition technology driven by an electric field, and the contradictions that hardness and toughness cannot be achieved at the same time and impact resistance and corrosion resistance are difficult to cooperate in the prior art are solved; the method is suitable for the high-end industrial fields such as automobile bodies, high-speed rail bogies, offshore wind power towers and the like with strict requirements on comprehensive protection performance.

The invention provides a spraying film agent and a preparation method thereof. The spraying film agent comprises a phase A and a phase B, wherein the phase A is uniformly dispersed in the phase B; wherein the phase A is a water-in-oil structure microsphere, and the water-in-oil structure microsphere is formed by wrapping a water-soluble active substance with a surfactant; and the phase B comprises a low-polarity organic solvent and a film-forming agent. On the basis of a reverse micelle technology, a water-soluble active substance is wrapped by a surfactant to form a water-in-oil structure microsphere, in the structure, the hydrophilic end of the surfactant inwards forms a water pool for accommodating the water-soluble active substance, and the hydrophobic end of the surfactant outwards enables the water-soluble active substance to be uniformly dispersed in a low-polarity solvent; therefore, the uniform and stable dispersion of the water-soluble active substance in the low-polarity solvent phase is realized. The contradictions that a traditional water-soluble polymer matrix is slow in film forming and water-soluble active ingredients cannot be stably dispersed in a low-polarity quick-drying solvent are solved.

The invention belongs to the technical field of biological medicine, and particularly relates to a nano vaccine based on GD2 mimetic peptide as well as a preparation method and application of the nano vaccine. The nano vaccine provided by the invention comprises a GD2 mimetic peptide, an STING agonist and a polymer carrier, wherein the STING agonist is used as an immunologic adjuvant. The antigen peptide (GD2 mimic peptide 47-LDA) and the adjuvant (STING agonist) are wrapped in the micelle to prepare the nano vaccine GD2-NV, so that the druggability of the antigen peptide and the STING agonist is improved, and the accumulation of drug tumors and drainage lymph node parts is improved. Besides, the nano vaccine can respond to a lysosome acid environment, realize lysosome escape, enhance antigen cross presentation of DC, activate an STING pathway, improve infiltration and activation degrees of CD8 + T cells, induce lasting humoral immune response and inhibit growth and recurrence of tumors, and is good in biological safety.

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The invention belongs to the technical field of preparation of high polymer materials, and provides a lithium ion sieve HMO (at) PPSH hydrogel with SDS micelle mediated swelling enhanced adsorption, and a preparation method and application of the lithium ion sieve HMO (at) PPSH hydrogel. The preparation method comprises the following steps: mixing MnCO3 and Li2CO3 according to a molar ratio of Li / Mn of 1.33: 1.67, and carrying out heat treatment in air at 500 DEG C for 4 hours to obtain a precursor LMO; the preparation method comprises the following steps: preparing a PVA solution and an SDS solution, mixing the PVA solution, the SDS solution, AM, MBA and LMO, and obtaining a solution A after bubbles disappear; adding an ammonium persulfate solution into the solution A, and reacting at 60 DEG C for 6-8 hours to obtain LMO-coated PPSH; and soaking the LMO-coated PPSH in an HCl solution, and washing with deionized water to obtain the HMO-coated PPSH composite material. And the adsorption content of 30% HMO coated PPSH is up to 52.79 mg / g. And the extraction efficiency of Li < + > in natural seawater is up to 98.12%, and the adsorbent still has high adsorption capacity under 10 times of adsorption-desorption circulation.

The application relates to the technical field of food processing, and particularly discloses a preparation method of high-dietary-fiber konjac beverage, which comprises the following steps: dispersing konjac powder in deoxygenated deionized water, and performing gradient temperature rising and segmented shearing swelling treatment under the protection of inert gas; adding calcium ions into the swelling slurry to perform a micro-crosslinking reaction; performing high-pressure micro-jet nanometer homogenization; performing high-pressure pulsed electric field sterilization treatment on the nanometer micellar dispersion liquid; allowing the slurry after sterilization to stand; and mixing the beverage base liquid with sterile auxiliary materials, and then performing sterile filling. The application adopts gradient temperature rising and segmented shearing swelling treatment to regulate the disentangled state of konjac glucomannan molecular chains, cooperates with calcium ion micro-crosslinking to form controllable intramolecular crosslinking structures, and then converts the nanometer-scale dietary fiber micelles through high-pressure micro-jet nanometer homogenization, so that long-term physical stability and microbial safety of a low-viscosity system are realized while the integrity of the dietary fiber structure is maintained.

In one aspect, the disclosure relates to immunogenic compositions comprising a semisynthetic saponin adjuvant (VSA) including, but not limited to, VSA-1 and VSA-2, derived from a Momordica saponin and at least one antigen. In a further aspect, the immunogenic compositions can include other known adjuvants, emulsifiers, and / or surface-active agents and can be formulated as liposomes, micelles, emulsions, and the like. Also disclosed are methods of eliciting effective immune responses to viral, bacterial, protozoal, and neoplastic diseases using the disclosed immunogenic compositions.

The invention provides macroporous silicon dioxide with the surface covalently expressed by single-layer branched polyethyleneimine and a preparation method of the macroporous silicon dioxide. The preparation method comprises the following steps: mixing and stirring branched polyethyleneimine and an aqueous solution of a water-soluble anionic surfactant to obtain a supramolecular micelle system; the preparation method comprises the following steps: mixing tetraethoxysiloxane, glycidoxypropyltrimethoxysilane and an optional organic solvent to form a siloxane solution; dropwise adding a siloxane solution into the supramolecular micelle system under stirring to obtain a concentrated emulsion; and incubating the concentrated emulsion at normal temperature, crushing, washing and drying in vacuum. According to the synthesis of surface polyaminated silicon dioxide, due to the use of a small amount of glycidoxypropyltrimethoxysilane, branched polyethyleneimine can form a small amount of covalent bonds with silicon dioxide so as to be fixed on the pore surface, and meanwhile, a large amount of active amino hydrogen of polyethyleneimine can be retained; the hydrolysis rate of the siloxane can be adjusted by the polarity of the organic solvent.

The present application relates to the technical field of biological materials, in particular to a light-responsive drug gel carrier and a preparation method thereof, in order to improve the controlled release function of the hydrogel material, the methyl methacrylate nitrobenzene compound containing nitrobenzene structure, hydantoin structure and propylene structure is prepared first, under the action of a photoinitiator, the double bond is crosslinked with methyl methacrylate and ethylene glycol methacrylate to form a hydrophilic gel network, so that the drug gel carrier is obtained; wherein the nitrobenzene structure has photosensitivity, and the crosslinking structure will be broken under ultraviolet irradiation, thereby reducing the stability of the gel material, destroying the rearrangement of the gel micelle structure, and realizing the release of the loaded drug; and the hydantoin structure introduced in the methyl methacrylate nitrobenzene compound also has good antibacterial performance, which can effectively avoid wound infection and improve wound recovery.

The present invention provides an aqueous formulation comprising fullerene, structured water having a three-dimensional helical structure of polygonal water molecules with hollow cavities, dissolved hydrogen, a mineral, and an additive. The formulation provides a stable and biocompatible fullerene, which can be surrounded by micelles. The aqueous formulation has long term stability, thereby maintaining the concentration of hydrogen dissolved in the aqueous formulation over time. Also provided are methods of treating cancer comprising administering to a subject in need thereof an aqueous formulation comprising a fullerene, structured water having a three-dimensional helical structure of polygonal water molecules of hollow cavities, dissolved hydrogen, a mineral, and an additive.

The application belongs to the technical field of biological medicine, and particularly relates to a biomimetic nano delivery system based on MRSA outer vesicle coating and application thereof. The application first couples chitosan oligosaccharide and monocarboxylated curcumin through an amide reaction to synthesize an amphiphilic polymer carrier, then loads vancomycin, daptomycin and other drugs through self-assembly to obtain a drug micelle, and finally coats the drug micelle with MRSA outer vesicle to successfully prepare a targeted biomimetic nano delivery system. The prepared biomimetic nano delivery system has excellent antibacterial effect, can realize targeted delivery and long-acting release of antibacterial drugs at an infection site, and is expected to overcome the bottleneck of drug resistance and insufficient drug penetration in traditional treatment, and provides a potential solution for the treatment of diseases such as periprosthetic infection.

The application belongs to the technical field of secondary batteries, and more particularly relates to a low-temperature microemulsion electrolyte, a preparation method and application thereof. The low-temperature microemulsion electrolyte comprises an electrolyte salt, a symmetrical cyclic ether solvent, a highly chlorinated solvent insoluble in the symmetrical cyclic ether solvent, and a chlorinated ether solvent for dispersing the highly chlorinated solvent in the symmetrical cyclic ether solvent in the form of micelles. Through synergistic effect of the components, an electrolyte system with high ion conductivity, electrode interface stability and wide temperature range adaptability is constructed, effectively solving the core problems of kinetic sluggishness, poor interface stability and short cycle life of the secondary battery in an ultra-low temperature environment. The electrolyte remains liquid at -70 DEG C, and exhibits excellent cycle stability in a wide temperature range of -40 DEG C to 25 DEG C, giving the battery excellent wide temperature range adaptability, breaking the low-temperature performance bottleneck of the secondary battery, and having a broad application prospect.

The present application relates to the technical field of pharmaceutical equipment, and particularly relates to a kind of oscillation type reduced pressure distillation waterization equipment for preparing complex injection, such as micelle, liposome, microsphere and the like, which comprises: oscillation cavity, multiple partitions are arranged in the oscillation cavity, vibration device is arranged at the bottom of the oscillation cavity, for wave type or hinged plate type vibration of the oscillation cavity;Evaporation box, the evaporation box is the cavity structure arranged on each partition, the bottom of any one end is provided with a discharge interface, the top is connected with the vacuum feed pipe penetrating the outer wall of the oscillation cavity, the vacuum feed pipe is connected with the valve pipeline connected with the vacuum pump through the interface;In addition, the evaporation box is provided with a heater at the bottom.The present application uses multiple evaporation boxes to replace rotary evaporation round bottom flask, expands the one-time evaporation capacity, realizes the scale-up production of related pharmaceutical preparations in industrial production, forms ideal film layer at the bottom of the box by vacuum pump and heater, and also integrates the whole preparation method of film waterization into the equipment, avoids the risk of material pollution in transfer.

This invention relates to the field of baby bath gel technology, specifically to a moisturizing baby bath gel and its preparation method. It comprises, by weight percentage: 10.0%~30.0% of a complex amphoteric surfactant system, 5.0%~15.0% of an amino acid surfactant, 2.0%~10.0% of a nano-moisturizing oil system containing petrolatum nano-oils, 0.5%~2.0% of a conditioning agent, 1.0%~5.0% of plant extracts, and the balance being an aqueous matrix. The complex amphoteric system is composed of a low-impurity coconut oil-based amphoteric diethylene glycol and sodium lauroyl amphoteric acetate synthesized in a two-step temperature-controlled process. This invention abandons strongly irritating anionic surfactants and high-dose polymeric thickeners, utilizing the synergistic construction of a dense worm-like micelle network by two amphoteric surfactants. This not only achieves long-term stable suspension of petrolatum nano-oils in an extremely mild system, but also targets and deposits oils during emulsification during bathing, achieving a combined cleansing and conditioning experience with an extremely gentle, tear-free safety.

The invention belongs to the technical field of mineral flotation, and particularly relates to a collecting agent for niobium mineral flotation and a preparation method and application of the collecting agent. Hydroximic acid groups of the hydroximic acid medicament are chelated with Nb < 5 + > on the surface of the niobium mineral to form a stable chelate; and through the synergistic effect of the dihydroxamic acid groups on the surface of the niobium mineral, the adsorption effect is enhanced. Moreover, the hydroximic acid medicament and the nonionic surfactant form stable micelles on the surface of the mineral, so that the hydrophobicity of the surface of the mineral is improved, and the enhanced recovery and efficient enrichment of the niobium mineral are realized. The prepared collecting agent is easy to dissolve in water, has good selectivity, high collecting capacity and wide adaptability to Bayan obo niobium minerals during flotation operation, can meet the requirements of various flotation processes, and can effectively collect niobium minerals under the condition that other gangue ores are not collected.

According to the water-soluble scribing liquid for wafer blade cutting and the preparation method of the water-soluble scribing liquid, the ionic liquid is introduced to achieve the synergistic effect with the anionic surfactant and the Gemini cationic surfactant, the interfacial tension of a blade and a wafer can be effectively reduced, scratches and damage to the surface of the blade and the surface of the wafer are reduced, and in addition, the water-soluble scribing liquid can be used for wafer blade cutting. The polar groups can adsorb chips through the electrostatic interaction, coalescence and removal are carried out through the micelle compatibilization effect of the surfactant, the chips are prevented from being adsorbed on the surfaces of the blade and the wafer, and the blade and the wafer are prevented from rusting in the machining process.

The invention relates to an ROS-responsive macrophage-chondrocyte dual-targeting nano-micelle and a preparation method and application thereof, HA capable of targeting and highly expressing CD44 cells is taken as a carrier skeleton, chemical coupling with TK and CUR is carried out in sequence, self-assembly is carried out through intermolecular force to form a stable nano-micelle, and drugs JPH203 and KGN are entrapped at the same time, so that efficient loading and targeting delivery are realized. The HA can be specifically combined with RAW264.7 macrophages and articular cartilage cells for highly expressing a CD44 receptor in an inflammatory state, and is actively delivered in a targeting manner. The ROS response characteristic of TK is utilized, oxidative fracture is carried out in an OA high ROS microenvironment, and micelles are triggered to disintegrate and release drugs accurately. The released JPH203 can inhibit an inflammatory mTOR pathway and effectively resist inflammation, and KGN is beneficial to promoting cartilage cell proliferation and effectively collecting and promoting differentiation of mesenchymal stem cells into cartilage cells, so that in-situ cartilage regeneration is realized, and a more efficient solution with low side effects is provided for osteoarthritis treatment.

The invention provides nucleic acid base composite nano-particles and a preparation method thereof. The preparation method comprises the following steps: taking PDMA and an acrylate adenine monomer as raw materials, carrying out polymerization to obtain a diblock polymer, taking the diblock polymer and a coumarin monomer as raw materials, carrying out polymerization to obtain PA, and assembling the PA into a nucleated cross-linked nano-micelle; pDMA and an acrylate thymine monomer are used as raw materials and polymerized to obtain a block polymer, and the block polymer is assembled into the nano-micelle; and mixing the core cross-linked nano-micelles with the nano-micelles, and interacting to obtain the composite nano-particles. According to the preparation method disclosed by the invention, the core-crosslinked nano-micelle containing adenine is constructed, and the nano-micelle has poly (N, N-dimethylacrylamide) with a hydrophilic block, and the poly (N, N-dimethylacrylamide) can stably exist in an aqueous solution; and mixing the core-crosslinked nano-micelles with the nano-micelles to obtain the composite nano-particles through biologically excited nuclear-base interaction.

The invention provides a double-protein-containing enteral total nutrient composition, a suspension and a preparation method thereof, and belongs to the technical field of nutritious foods. The invention relates to a double-protein enteral total nutrient composition, which is prepared from the following components in parts by mass: 2 to 5 parts of protein, 1.9 to 4.4 parts of fat, 7 to 26 parts of carbohydrate, 0.01 to 0.2 part of compound vitamin, 0.07 to 0.3 part of compound mineral substance, 0.01 to 0.1 part of essence and 0.01 to 1 part of compound stabilizer. Vegetable protein (soybean protein isolate) and animal protein (sodium caseinate) are adopted according to a certain scientific ratio, the problem that emulsion protein micelles are unstable due to thermal polymerization of the vegetable protein in a mixed liquid system is effectively solved, no full-nutrient liquid product added with the vegetable protein exists in the market at present, the market blank is filled, and the market prospect is wide. The problems of incomplete nutrition, uniformity of double proteins, heating stability and storage stability caused by a single protein source are effectively solved.

The application discloses a pH response core-shell structure encapsulated insulin nanomicelle and a preparation method thereof. The encapsulated insulin mass accounts for 91% of the total mass of the insulin dissolved in an acidic aqueous solution, and the encapsulated insulin mass accounts for 13% of the mass of the encapsulated insulin nanomicelle. The average particle size of the micelle is 190 nm, and the Zeta potential is -19 mV. The nanomicelle is stable, the encapsulation efficiency and the drug loading capacity of the encapsulated insulin are 91% and 13% respectively, the cumulative release of the insulin mass percentage in a simulated human gastric juice environment with pH=1.2 for 2 h, 4 h and 10 h is 12%, 14% and 20% respectively, and the release of the insulin mass percentage in a simulated human intestinal juice environment with pH=7.4 for 2 h and 10 h is 55% and 77% respectively. Compared with the pH response block located in the core of the encapsulated insulin nanomicelle, the pH response block located in the shell of the encapsulated insulin nanomicelle has high stability in the simulated human gastric juice and has a slow-release behavior in the simulated human intestinal juice, and is more suitable for the bioavailability of the oral insulin of the human body.

This invention discloses a coated modified zinc powder and its preparation method, belonging to the field of metal powder surface modification technology. The coated modified zinc powder uses zinc powder as its core, with a water-soluble polyacrylic acid (PAA) micelle layer formed by aqueous dissolution and ethanol-induced precipitation. This micelle layer is insoluble in ethanol but soluble in water. The preparation method includes zinc powder pretreatment, PAA aqueous dissolution, micelle coating, and post-treatment steps. The key step is to inhibit micelle agglomeration by intermittently replenishing deionized water, achieving uniform coating. This invention solves the contradictions of existing zinc powder oxidation, agglomeration, and storage and use. The modified zinc powder exhibits significantly improved storage stability, rapid removal of the micelle layer in the aqueous phase during use to restore its intrinsic activity, and excellent dispersion performance. The process is simple and easily scalable, making it suitable for anti-corrosion coatings, chemical catalysis, and other fields.

This invention relates to the field of lyophilized formulation technology, specifically disclosing an esupagglutide α-nano-lyophilized micelle and its preparation method. The micelles of this invention utilize polylactic-co-hydroxyacetic acid copolymer and sodium phosphatidylglycerol as micelle carriers, with arginine and cysteine ​​providing branching synergistic effects. Homogenization via film formation and low-temperature lyophilization yield lyophilized nano-micelle powder. The nano-micelle powder reduces protein oxidative decomposition during lyophilization, decreases impurity fragments, and reduces various non-fucose glycosylation, basic components (succinimide, methionine oxidation products), N-terminal deletion, Asn deamidation, and Met and Trp residue oxidation impurities that affect product quality. Product quality analysis and animal experiments after reconstitution show good resistance to impurities and degradation risk. The reconstituted esupagglutide α-nano-micelle system exhibits better stability and sustained-release properties, enhancing the hypoglycemic sustained-release effect 72 hours after injection, significantly improving upon conventional non-micelle formulations.

The invention belongs to the field of hydraulic transmission materials, and provides a preparation method of biodegradable water-ethylene glycol flame-retardant hydraulic fluid. According to the invention, a core-shell micelle structure with a volume median particle size of 80 to 200 nanometers is constructed by adopting a collaborative design of an A1 succinate micelle intermediate and a B1 fatty acid alcohol amine salt anti-wear and anti-rust agent; the performance combination that the kinematic viscosity at 40 DEG C is 36-60 square millimeters per second, the viscosity index is larger than or equal to 140, and the pH value is 8.0-9.5 is achieved, the contradiction between low-temperature fluidity and high viscosity index, between nano-micelle stability and high-pressure abrasion resistance and rust resistance, and between long-term chemical stability and high biodegradability of a traditional water-ethylene glycol hydraulic medium is solved, and the water-ethylene glycol hydraulic medium is suitable for large-scale production. The 28-day biodegradation rate is larger than or equal to 60%, and the lubricating oil has the advantages of being flame-retardant, environmentally friendly and excellent in anti-wear and anti-rust performance, is suitable for a hydraulic system with the rated pressure ranging from 5 MPa to 35 MPa, and has the wide application value.