76 results about "Amphiphile" patented technology

The present invention provide novel immunofiber compositions for protein or peptide purification and simple and cost-efficient methods and systems using these compositions. In some embodiments, the immunofibers comprise a customized Z-33 peptide derived from Staphylococcus aureus Protein A which is used to construct immuno-amphiphile molecules that assemble into immunofibers in aqueous solution with bioactive epitopes on the surface and have peptide or protein binding ability.

The present invention relates to a process for treating a liquid aqueous effluent by flotation, the aqueous effluent containing amphiphilic molecules, the process comprising: - a flotation step during which the aqueous effluent is introduced and circulated inside the chamber, and brought into contact with a bed of bubbles generated by a bubble-generating device, at least some of the amphiphilic molecules adhering to the surface of the bubbles, - a step of separating a floating phase located inside the chamber at the surface of the aqueous effluent, the floating phase containing the bubbles combined with the amphiphilic molecules that have risen to the surface of the aqueous effluent. During the flotation step, the aqueous effluent and the bubbles combined with the amphiphilic molecules entrained by the aqueous effluent pass through a retention system located inside the chamber and kept firmly connected thereto and comprising at least one retaining material.

A skin care composition that includes an emulsifier, a fatty amphiphile, a humectant, an emollient, and an aqueous carrier. The emulsifier includes an anionic surfactant and a non-ionic surfactant and at least a portion of the anionic surfactant, non-ionic surfactant, and fatty amphiphile form a lamellar gel network structure. The skin care composition can optionally include a polymer, such as an Caesalpinia Spinosa Gum / Ammonium AMPS Crosspolymer.

The invention discloses oxide solid electrolyte nanoparticles, a preparation method of the oxide solid electrolyte nanoparticles and application of the oxide solid electrolyte nanoparticles in a positive plate for an oxide solid electrolyte-based low-temperature battery. The oxide solid electrolyte nanoparticles are prepared by adding a novel amphiphilic molecule dispersing agent in a sanding process to realize perfect dispersion; the effect of stabilizing the nano particles is achieved; the amphiphilic molecular dispersing agent is alkane amidoxime; the positive plate comprises the following solid components; the solid component comprises a multifunctional polymer adhesive; the multifunctional polymer has at least two or more functional groups of a carboxylic acid group, a sulfonic acid group and an amidoxime amine group. According to the oxide solid electrolyte nanoparticle, the preparation method thereof and the positive plate for the oxide solid electrolyte-based low-temperature battery disclosed by the invention, the problem of agglomeration in the preparation process of the nanocrystallization solid electrolyte nanoparticle can be effectively solved, and a battery product with high stability and high low-temperature performance is obtained.

The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and / or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and / or biofilm-embedded microorganisms on a surface.

The invention relates to an HPLC-UV (High Performance Liquid Chromatography-Ultraviolet) detection method for components of amphotericin B lipidosome, which comprises the following steps: S1, providing a chromatographic column of which a stationary phase is a YMC Triart C18 column, regulating the pH (Potential of Hydrogen) of a mobile phase in the chromatographic column to 9 to 11 by using n-butylamine or triethylamine, and isocratically eluting the amphotericin B lipidosome at the temperature of 28 to 32 DEG C; s2, carrying out qualitative and quantitative analysis on sodium stearoyl phosphatidyl glycerol, hydrogenated soybean phosphatidylcholine, cholesterol and tocopherol in the amphotericin B liposome in an ultraviolet region of 200-240nm by virtue of HPLC-UV (High Performance Liquid Chromatography-Ultraviolet) on the basis of a reversed-phase partition chromatography principle; wherein the phase A of the mobile phase gradient is a mixture of methanol and acetonitrile, the phase B of the mobile phase gradient is ammonium acetate contained in water, and the volume ratio of the phase A to the phase B is 96: 4. The detection method provided by the invention can be used for simultaneously analyzing phospholipid, tocopherol and cholesterol in the amphotericin B lipidosome.

This invention relates to the field of ion-conducting membrane technology, and particularly to a wedge-shaped amphiphilic molecule, a biomimetic ion-conducting membrane, and its preparation method. The biomimetic ion-conducting membrane utilizes the self-assembly behavior of the wedge-shaped amphiphilic molecule to form a columnar mesocrystalline phase containing transport channels. This columnar structure is fixed within a membrane framework composed of methacrylate polymers using ultraviolet graft copolymerization to form an ion-transfer membrane. This membrane exhibits strong ion selectivity and conductivity, and its mechanism of action is similar to that of biological cell membranes. It can be used for the transport and separation of microparticle materials such as ions, small molecules, and micro-electronic conductors, showing broad application prospects in fields such as biology, medicine, and environmental analysis. Furthermore, its ion conductivity and chemical stability also demonstrate its potential application in proton exchange membrane fuel cells.

The disclosure features amphiphilic ligand conjugates including an EGFR peptide as well as immune cells modified with EGFR receptors. The disclosure also features compositions and methods of using the same, for example, to stimulate proliferation of T cell receptor expressing cells.

The present invention is directed to a transparent scalp composition comprising about 0.5% to about 30% by weight of discrete particles, the discrete particles comprising anhydrous particles and an aqueous phase of the transparent scalp composition, the anhydrous particles comprising one or more fatty amphiphiles selected from the group consisting of fatty alcohols, fatty esters, fatty acids, fatty amides, and mixtures thereof, and one or more surfactants selected from the group consisting of cationic, anionic, nonionic, zwitterionic, or mixtures thereof, the anhydrous particles comprising one or more scalp active agents, the discrete particles having a size of about 200 micrometers to about 25,000 micrometers, and an aqueous phase comprising a water-soluble polymer and an aqueous carrier, the transparent scalp composition having a pH of about 3.5 to about 7.0.

To provide amphiphilic gemcitabine prodrugs or amphiphilic prodrugs of other biologically active molecules with the capacity to make liquid crystalline nanostructured nanoparticles, and uses thereof to treat animals, including humans.SOLUTION: The invention provides compounds such as 2'-deoxy-2',2'-difluoro-N4-(((cis-9, octadecenyl)oxy)carbonyl) cytidine (Gem-oleyl).SELECTED DRAWING: None

This invention relates to the field of hydrogen peroxide gel technology, specifically to a hydrogen peroxide gel containing amphiphilic Bola molecules and its preparation method. The gel comprises, by mass percentage: 93-99.4 wt% of a hydrogen peroxide aqueous solution (30-98%); 0.5-5 wt% of a gelling agent; and 0.1-2 wt% of a stabilizer. The gelling agent is an amphiphilic Bola molecule, HDGA, synthesized with glutamic acid as the hydrophilic head group and a long alkyl chain as the hydrophobic chain. The preparation method involves heating and cooling HDGA in a hydrogen peroxide solution system to obtain a hydrogen peroxide hydrogel with a three-dimensional network structure. The preparation method provided by this invention is simple, and the prepared hydrogen peroxide hydrogel exhibits stable low-temperature performance, is easy to store and transport, and shows enhanced flowability after shearing, making it convenient for use.

The present invention relates to platinum (IV) prodrug lipid-based amphiphiles and compositions thereof. In particular, it relates to cisplatin, oxaliplatin and carboplatin prodrugs with the capacity to make stable liquid crystalline nanoparticles and crystalline nanoparticles, and uses thereof to treat cancer in animals, including humans.

An oral care composition containing a gel phase, an abrasive, and a fluoride source. The gel network phase contains a fatty amphiphile and phase separation is not visually perceptible in the oral care composition.

The invention relates to the technical field of food processing, and discloses fatty acid balanced and homogenized emulsified grease and a preparation method thereof.The emulsified grease is oil-in-water type nano-emulsion and comprises an oily component and a water component which are composed of DHA source grease, ALA source grease, MUFA source grease and medium chain triglyceride according to a specific proportion, the preparation method comprises the following steps: preparing an oily component and a water-based component, carrying out high-shear pre-emulsification, carrying out interface self-optimization treatment, and carrying out high-shear pre-emulsification on the oily component and the water-based component according to the trend that a system is converted to a lower interface free energy state. And the pH response type antioxidant amphiphilic molecule which is more stable in thermodynamics can replace the surfactant which is preferentially adsorbed in dynamics in the pre-emulsification stage. By combining the structure of the amphiphilic molecule with an interface self-optimization process and cooperating with other antioxidants in the oil phase and the water phase, the physical stability and oxidation stability of an emulsion system rich in unsaturated fatty acid are remarkably improved.

In certain embodiments, the present invention provides novel antibody purification methods and systems using a potentially simple and cost-efficient means. In some embodiments, customized Z-33 derived from Staphylococcus aureus Protein A is used to construct immuno-amphiphile molecules which can assemble into immunofibers in aqueous solution with bioactive epitopes on the surface and have IgG binding ability.

This invention discloses a method for preparing a composite flotation reagent using biomass hydrothermal liquefaction products, comprising the following steps: Raw material preparation: providing biomass raw materials rich in lipids or proteins; Catalytic hydrothermal liquefaction: placing the biomass raw materials and a composite catalyst in a reactor, reacting at a temperature of 250-350℃ and a pressure of 4-20 MPa, wherein the water content of the biomass raw materials is 70-95%, and the composite catalyst contains alkaline components, metal oxide components, and rare earth element components; Product separation: separating the reaction products into oil and water to obtain bio-crude oil containing amphiphilic molecules; Flotation application: applying the bio-crude oil as a composite flotation reagent to mineral flotation, where the bio-crude oil simultaneously functions as a frother and a collector. This invention uses waste biomass as raw material to prepare a composite flotation reagent with both frother and collector functions, realizing the resource utilization of waste and the green upgrading of flotation reagents, and has the characteristics of wide raw material sources, excellent reagent performance, and environmental friendliness.

The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and / or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and / or biofilm-embedded microorganisms on a surface.

The invention belongs to the technical field of biology, and particularly discloses preparation of temperature response composite magnetic beads and application of the temperature response composite magnetic beads in exosome separation. The preparation method comprises the following steps: S1, preparing magnetic particles of which the surfaces are modified with polar functional groups; s2, coating the surfaces of the magnetic particles obtained in the S1 with a phase change material shell layer, resuspending the magnetic particles in an amphiphilic molecule solution, and carrying out a rotation reaction to obtain temperature response composite magnetic beads containing polar functional groups on the surfaces; and S3, coupling an aptamer on the surface of the temperature response composite magnetic bead containing the polar functional group on the surface obtained in the S2 to obtain the aptamer-coupled temperature response composite magnetic bead. The invention discloses preparation of a temperature-responsive composite magnetic bead and application of the temperature-responsive composite magnetic bead in exosome separation, the temperature-responsive composite magnetic bead can improve the capture efficiency and release efficiency of exosomes, improve the yield and purity of the exosomes and maintain the complete morphology of the exosomes, and is suitable for separation of exosomes from multiple sample sources.

The invention discloses a preparation method and application of super-amphiphilic molecular nanoparticles under a high solid condition, and belongs to the technical field of biology. The preparation method comprises the following steps: preparing a high-concentration curcumin-cyclodextrin inclusion compound by combining a heating stirring method with ultrasound; adding the inclusion compound into a high-concentration alkalized sodium caseinate solution, and continuously adding food-grade sodium hydroxide to maintain the pH value of the system; performing ultrasonic treatment on the mixture, acidifying, performing high-pressure homogenization, centrifuging, adding maltodextrin, and performing spray drying to obtain the curcumin nanoparticles. And redissolving the obtained nanoparticles, and adding sodium erythorbate, sodium hexametaphosphate, sucrose and polyglycerol fatty acid ester to obtain the beverage. According to the powder prepared by the method, the content of super-amphiphilic molecule solids is remarkably increased, so that the cost of large-scale spray drying is reduced; the beverage obtained by redissolving has relatively good physical and chemical stability and shelf life.

Zwitterionic dendrimers and zwitterionic polymers and methods of making the zwitterionic dendrimers / polymers are provided herein. Also provided are amphiphilic dendrimers and amphiphilic telodendrimers with one or more zwitterionic dendron / polymer / linear group(s) / moiety(s) covalently bonded thereto. The amphiphilic dendrimers and amphiphilic telodendrimers are useful in protein binding and drug delivery. The amphiphilic dendrimers and amphiphilic telodendrimers are used in methods of treatment and / or imaging.

The present disclosure provides an engineered amphiphilic composition (for example, a lipid nanoparticle) comprising multiple CD47 proteins and at least one amphiphile. The disclosure further provides methods for enhancing the phagocytic function of macrophages by contacting the macrophages with macrophages with the engineered amphiphilic composition. The disclosure further provides methods for treating cancer by administering the engineered amphiphilic composition to a patient in need thereof.

In certain embodiments, the present invention provides novel antibody purification methods and systems using a potentially simple and cost-efficient means. In some embodiments, customized Z-33 derived from Staphylococcus aureus Protein A is used to construct immuno-amphiphile molecules which can assemble into immunofibers in aqueous solution with bioactive epitopes on the surface and have IgG binding ability.

The present invention relates to the use of a known enzyme ‘denominated as a Starmerella bombicola lactone esterase (Sble)’ to perform a transesterification and / or hydrolysis reaction. More specifically the Sble enzyme performs a transesterification and / or hydrolysis reaction on bola amphiphilic glycolipids. The invention indeed discloses that said Sble is capable to convert bola sophorolipids into lactonic and / or acidic sophorolipids and saccharides, and, that yeast strains containing a non-functional or dysfunctional Sble enzyme and / or a disabled sble gene and / or not containing the sble gene produce (acetylated) bola amphiphilic glycolipids. In addition, the invention further discloses a method to produce non-acetylated (bola) amphiphilic glycolipids via rendering acetyltransferase enzymes At1, At2 and At3 non-functional or dysfunctional in the latter yeast strains and / or by modifying strains so that they do not contain the acetyltransferase αt1, αt2 and αt3 gene(s) and / or by strains not containing the αt1, αt2 and αt3 gene(s). Moreover, upon rendering the glucosyltransferase B (UgtB1) non-functional or dysfunctional in the abovementioned strains and / or upon removing and / or disabling the ugtB1 gene and / or by strains not containing the ugtB1 gene these produce acetylated and / or non-acetylated bola amphiphilic glucolipids. The invention further discloses a method to produce non-acetylated glycolipids via rendering acetyltransferase enzymes At1, At2 and / or At3 non-functional or dysfunctional and / or removing and / or disabling the glycolipid acetyltransferase genes in glycolipid producing yeast strains and / or by strains not containing the αt1, αt2 and αt3 gene(s).

A filter element is disclosed made from a gathered paper web that may be crimped, embossed, and / or corrugated. In accordance with the present disclosure, the paper web is treated with at least two different additives. The first additive comprises amphiphilic molecules, having hydrophilic and hydrophobic ends such as a ketene dimer that has one or more branching groups. The second additive, on the other hand, may comprise a polymer component such as a polyalkylene glycol. The filter element may also be treated with a polyamine or an amino acid or salt thereof. In one embodiment, the filter element may be incorporated into the filter of a smoking article. The two additives together may improve smoke taste, reduce some smoke phenols, and reduce some smoke carbonyls.

Disclosed herein are compounds comprising an albumin binding domain and a mutant or wild type p53 peptide, as well as pharmaceutically acceptable salts of the compounds. In addition, methods for inducing an immune response in a subject and methods of administering such compounds to induce an immune response in a subject are disclosed herein.

Disclosed herein are polyadenosine, polythymidine, polyguanosine, and / or polycytosine nucleic acid sequences, as well as interferon stimulatory DNA and immunostimulatory herpes simplex virus sequences, that may be conjugated to an albumin-binding domain, as well as pharmaceutically acceptable salts thereof. Furthermore, disclosed herein are methods for inducing an immune response in a subject, and methods of administering the polyadenosine, polythymidine, polyguanosine, and / or polycytosine nucleic acid sequences conjugated to an albumin-binding domain and an antigen to induce an immune response in a subject.

A cleansing composition comprising a detersive surfactant; an aqueous carrier; from about 0.5% to about 30% by weight of the cleansing composition of discrete particles comprising anhydrous particles and an aqueous phase, and wherein said anhydrous particles comprise: one or more fatty amphiphile selected from the group consisting of fatty alcohol, fatty ester, fatty acid, fatty amide and mixtures thereof; of one or more secondary surfactants selected from the group consisting of anionic, nonionic, zwitterionic, cationic or mixtures thereof. Wherein the discrete particle of the cleansing composition has a size from about 500 microns to about 7000 microns, and wherein the cleansing composition has a % transmittance of about 75% or higher.

Devices and methods for using changes in the orientation of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including amphiphilic analytes, are disclosed. The dispersed liquid crystal domains are defined by an interface, and one or more nanoparticles or nanoparticle-containing complexes are adsorbed to the interface. As a result of the adsorption of the nanoparticles or nanoparticle-containing complexes at the interface, the microdomains are stabilized, and resist coalescing for extended periods of time, unlike previously known devices using liquid crystal emulsions for analyte detection.When the dispersed liquid crystal microdomains are exposed to the test sample, any changes in the orientation of the liquid crystal microdomains (such as from the bipolar to radial) are detected. Such changes in orientation signal the presence of analyte in the test sample, and the proportion of liquid crystal microdomains exhibiting the change in orientation is correlated with the quantity of analyte in the test sample. The nanoparticle used, the amphiphile used in the nanoparticle-containing complex, or both may be selected to optimize the sensitivity and / or selectivity of the device for a given analyte.

The present disclosure generally relates to electrode slurry compositions, including those comprising an electrode active material; a binder; and a microemulsion comprising an aqueous phase, a water-immiscible phase, and an amphiphile, wherein the electrode active material and binder are incorporated within the microemulsion, which can be used to prepare electrodes, including for the production of electrochemical cells.

The present invention proposes the preparation of a dendritic amphiphile and in-situ loaded catalytic precious metal nanoclusters. The in-situ loaded catalytic precious metal nanoclusters are prepared by a high internal phase ratio emulsion method using the dendritic amphiphile. The nanoclusters are used as efficient, broad-spectrum, recyclable catalytic materials. The dendritic amphiphile of the present invention can directly modulate loaded precious metal nanoclusters in one kettle; since the molecular weight of the dendritic polymer is very large and the migration energy barrier is very high, it is unlikely to fall off during use; precious metal nanoclusters stabilized by weak ligands are realized, ensuring the high catalytic activity of the nanoclusters; and can be synthesized under slightly acidic conditions, which can not only increase the specific surface area of ​​the material, but also enable the dendritic body to function as a single molecule template, and can modulate metal nanoclusters with more uniform sizes.