95results about "Chemical microanalysis" patented technology

A system for filling a substrate having at least one chamber with a liquid sample is provided. The system in one embodiment includes a substrate defining a network of passageways including at least one chamber for the liquid sample, and an adapter. The adapter includes a fill reservoir for the liquid sample, a vacuum port for attachment to a vacuum source, and at least two channels. One channel allows a vacuum to be imparted to the network, and the other channel allows the liquid sample to be introduced into the network. The system also includes a mechanism that sequentially closes and opens at least one of the channels so that a vacuum can first be introduced to the substrate and thereafter the liquid sample introduced to the substrate for permitting the vacuum to urge the liquid sample to flow from the fill reservoir into the substrate. An apparatus for positioning a substrate with a plurality of sample detection chambers in a detection unit is also provided.

The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. In accordance with the present invention, there is provided a method of concentrating an analyte within a microfluidic analysis system, comprising the steps of: a) providing a main channel having a trapping zone suitable for trapping packing material; b) providing a slurry of a reagent treated packing material prepared in a solution having a predetermined composition of a solvent; c) inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone so as to load said trapping zone and form a packed bed of said packing material; d) and flowing a sample containing analytes through said packed bed, said reagent acting to concentrate at least some of said analytes within said trapping zone. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.

A volume sensor-free microdosing device comprises a pressure chamber which is at least partly delimited by a displacer, an actuating device for actuating the displacer, the volume of the pressure chamber being adapted to the changed by actuating the displacer, a media reservoir which is in fluid communication with the pressure chamber, an outlet opening which is in fluid communication with the pressure chamber, and a control mechanism. The control mechanism drives the microdosing device in such a way that a small change of volume of the pressure chamber volume is effected per unit time by a movement of the displacer from a first position to a predetermined second position, the second position of the displacer defining a larger volume of the pressure chamber than the first position, so as to suck a fluid volume into the pressure chamber, and that, in a second phase, a large volume change of the pressure chamber volume is effected per unit time by a movement of the displacer from the second position to the first position, so as to eject a defined fluid volume from the outlet opening in this way.

Minute or infinitesimal amounts of fluid can be accurately delivered through microchannels formed in an elastic polymeric substrate. External (mechanical) force is applied on the substrate to progressively squeeze the microchannel along its length to push or pull the fluid through the microchannel. Fluids can be delivered at a constant rate and amount regardless of the kind of the fluid since fluid delivery is not affected by the physical properties of the fluid. The delivery rate of the fluid is determined in the ranges between femtoliters/sec and milliliters/sec by the size of the microchannel and the area of the substrate being pressed by the applied external (mechanical) force. Such techniques of fluid delivery can be applied to various fields including lab-on-a-chip technology, monitoring of chemical and biological processing, portable analyzing instruments, fine chemistry, clinical diagnosis and development of new medicines.

The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.

A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.

This invention relates to technology for analyzing a specific component in a sample liquid, and provides an analyzing tool and an analyzing apparatus. Analyzing tool (Y) includes a liquid inlet (61) at a central portion of the tool and a plurality of channels (51) which communicate with liquid inlet (61) and move the sample liquid introduced through liquid inlet (61) by capillary action from the central portion towards a peripheral portion of the tool. Each channel (51) extends linearly for example from the central portion towards the peripheral portion, and the plurality of channels (51) are arranged radially.

The invention relates to a molecular engram polymer, which is used for metal ion detection. The engram and elution objects are metal complex ions; engram geometric dimensioning and combination point location of the polymer are matched with the specificity of the metal complex ions; the polymer is synthesized in-situ on metal membrane surface of a quartz microbalance and a surface plasma resonance device, the metal complex ions are eluted, the metal ions to be detected are processed by complexation and then are selectively absorbed by the molecular engram polymer, and finally the type and content of the metal ions are detected. In the invention, metal ion complexation is adopted to enlarge small changes of metal ion volume by a large extent, template molecular geometric structure memory performance of the molecular engram polymer is utilized to realize high preferential adsorption to improve metal ion detection selectivity effectively, and mass increase and geometric dimensioning enlargement caused by metal ion complexation help further improve sensitivity and antijamming capability of metal ion detection.

A transport system for transporting and handling microtiter plates, for use in high throughput screening, diagnosis and/or combinatorial chemistry, comprising modules with devices for preparing specimens and/or introducing specimens, and/or for optical readout and/or for plate storage and/or devices for further processing steps or readout steps. The system includes an inter-modular transport system for transporting the microtiter plates between the different devices and at least one central transport system for asynchronous plate transfer between individual modules via input and output buffers.

Disclosed are preloaded analysis modules comprising reagents disposed within a barrier material capable of liberating the reagents, at a time advantageous to a reaction scheme, when exposed to certain activation conditions or reagents. Also disclosed are related methods for analyzing samples with such modules.

The invention belongs to the technical field of analysis, and specifically relates to a method for determining a polyether polyol hydroxyl value. The method comprises the steps of enabling alcohol and acetic anhydride to generate an esterification reaction by utilizing sodium acetate as a catalyst to generate ester and acetic acid, adding water to excess acetic anhydride to hydrolyze to generate acetic acid, neutralizing the acetic acid by utilizing aqueous alkali, adding excess aqueous alkali to cause the ester to generate a saponification reaction; after the saponification reaction is finished, titrating the residual alkali by utilizing acid solution; carrying out a blank test under the same conditions, and computing the content of hydroxyl in alcohol, wherein a difference of acid solutions consumed by the blank test and a sample is the amount of the alkali consumed by the saponification reaction of the ester. The method for determining the alcohol hydroxyl value can be applied to determining the amount of the hydroxyl value in the alcohol, and the accuracy and reproducibility are higher.

The illustrated invention defines an analytical titration chip comprising an optically transparent substrate such as glass or plastic that defines a fluid inlet port, plural microfluidic sample carrying channels communicating with the inlet, and plural titration chambers fluidly communicating with the channels. Each titration chamber contains a different concentration of the same titrant to define a spectrum or range of titrations. An air management chamber is in fluid communication with the titration chambers to facilitate capillary flow of fluid into the titration chambers.

A method for measuring vanadium in vanadium-nitrogen alloy belongs to the technical field of analytical chemistry. The advantages of this method lie in that the reagents used in the determination process are few in type, the time is short, the operation is simple, and the method has high precision and accuracy, and is especially suitable for the analysis of a large number of samples. The present invention adopts mixed acid to dissolve the sample, under the acidity of 12% to 25%, adding ammonium persulfate to oxidize vanadium (IV) to pentavalent, using N-phenyl-substituted anthranilic acid as an indicator, using ferrous ammonium sulfate as an indicator Standard solution titration. Chromium, manganese and cerium do not interfere with the determination.

A channel (140) is divised into portions (142, 144). The sidewalls of each channel portion (142, 144) have surface charges of opposite polarity. The two channel portions (142, 144) are physically connected together by a salt bridge (133), such as a glass frit or gel layer. The salt bridge (133) separates the fluids in channel (140) from an ionic fluid reservoir (135). To impart electroosmotic and electrophoretic forces along the channel (140) between parts A and B, respectively. Additionally, a third electrode (137) is placed in the reservoir (135).

The manufacture method for micro-flow injector chemical luminous chip comprises: with silicon piece, PDMS and SU-8 photoresist as material, manufacturing micro-channel and interfaces by standard micro-manufacturing technique; manufacturing mold structure by standard photo-etching technique, using molding cast and solidification technology to prepare the micro-chip structure; finally, irreversible packing the channel. This invention is simple and reliable, and is high sensitive with a little sample.

The invention relates to a full desaeration system of a chromatogram high-performance total analysis on-line monitoring device and a desaeration process of the full desaeration system. The invention adopts the oil sample quantitiveness for oil path circulation, can calculate the circulation times required by cleaning so as to achieve the cleaning of dead oil of the system; meanwhile, the inventionadopts a method which combines direct oil return and oil discharge, thereby fully returning the rest oil sample to a transformer.

The invention discloses a method for detecting a mixed acid solution in the manufacturing process of a polycrystalline silicon solar cell. The method is used for detecting a mixed acid system which consists of hydrofluoric acid, nitric acid and fluorosilicic acid. The method comprises the following steps of: detecting the total acid concentration of the solution by using an acid-base neutralization method; heating and boiling the solution which is subjected to acid-base neutralization, decomposing fluorosilicate to generate hydrogen ions, determining the content of the hydrogen ions by alkali liquor titration, and thus obtaining the concentration of the fluorosilicic acid by calculation; detecting the concentration of the nitric acid in the mixed acid solution by using an oxidation-reduction titration method; and subtracting the concentration of the fluorosilicic acid and the concentration of the nitric acid from the total acid concentration, and thus obtaining the concentration of the hydrofluoric acid. The method is simple in flow, easy to operate and low in economic investment and can be applied to long-term monitoring of a texturing process and an etching process in the production process of the polycrystalline silicon solar cell and stability of equipment, manpower resources are saved, high-end equipment is eliminated, detection accuracy can be over 95 percent.

The invention relates to a chromium ion detection agent, and specifically relates to a preparation method of a Cr<3+> color indicator based on a rhodamine B-diethylene triamine derivative. According to the invention, a rhodamine B-diethylene triamine derivative is synthesized by using rhodamine B and diethylene triamine. A water-ethanol mixed solution based on the rhodamine B-diethylene triamine derivative can be used as a Cr<3+> color indicator. The high-efficiency color indicator used for rapidly analyzing specific Cr<3+> content in water sample has high anti-interference capacity against other metal ions (Cu<2+>, Zn<2+>, Fe<3+>, Cd<2+>, Pb<2+>, Hg<2+>, Mn<2+>, Fe<2+>, Ba<2+>, and Ag<+>). An applicable pH range is from weakly acidic to neutral. The color indicator is an ideal Cr<3+> color indicator. A response time of the Cr<3+> color indicator upon Cr<3+> is 5min, and a lower detection limit is 5.2*10<-7>mol/L. The color indicator provided by the invention has the advantages such as simple synthesis process, low cost, simple operation, good selectivity, high sensitivity, high response speed, low detection limit, wide application prospect, and the like. The color indicator can be used in complicated sample real-time and rapid detection, and can be used in semi-quantitative detections of micro/trace Cr<3+> in environment samples of different sources.

The present invention relates to a method of manufacturing an analytical tool, where the method includes a reagent member forming process for preparing a reagent member containing a reagent to react with a specific component contained in sample liquid. The reagent member forming process includes a plurality of applying and drying steps in which material liquid containing a reagent is applied and then the material liquid is dried. The applying and drying steps may be performed with use of material liquid containing the same reagent, for example. The applying and drying steps are performed 2-200 times, for example.

The invention relates to a gas constant pressure capacity tester used for hydride quantitative analysis. The gas constant pressure capacity tester includes a constant pressure controller, a comb tube, graduated tubes, a constant pressure funnel and a reaction container. Specifically, the comb tube includes an upper comb tube and a lower comb tube that are vertically symmetrical and are connected by the graduated tubes. The upper comb tube and the lower comb tube are respectively connected to the constant pressure funnel and the constant pressure controller. The constant pressure funnel and the reaction container are in sealed connection so as to form a sealed system. The gas constant pressure capacity tester provided in the invention has the advantages of easy manufacturing, high accuracy, convenient operation, and good repeatability, etc., and can make a hydride quantitative analysis method simple, accurate, and rapid.