Microflow System for Particle Separation and Analysis

a microflow system and particle technology, applied in chemical microanalysis, material testing goods, open gradient mangetic separators, etc., can solve the problems of high dilution of desired cell samples, low speed and sterility, and cell sorting by flow cytometry suffers, etc., to achieve the highest resolution of detection, easy integration, and high susceptibility sensitivity
US20070207548A1Inactive Publication Date: 2007-09-06INVERNESS MEDICAL SWITZERLAND GMBH
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
INVERNESS MEDICAL SWITZERLAND GMBH
Publication Date
2007-09-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

A micro flow system is provided for separating particles, comprising a microfabricated member having a flow channel (5) defined therein for guiding a flow of a fluid containing the particles through the flow channel, first inlet means (2) positioned at one end of the flow channel for entering the fluid into the flow channel, first outlet means (7) positioned at the other end of the flow channel for discharging the fluid from the flow channel, the flow of the fluid containing the particles being controlled in such a way that one particle at the time passes a cross section of the flow channel, the member being positioned in a field that is substantially perpendicular to a longitudinal axis of the flow channel so that particles residing in the flow channel and being susceptible to the field across the flow channel are deflected in the direction of the field. Further, a micro flow system is provided for analyzing components of a fluid comprising a microfabricated member having a flow channel defined therein for guiding a flow of a fluid through the flow channel, first inlet means for entering particles into the flow channel, first outlet means for discharging of fluid from the flow channel and a plurality of assay sites located in the flow channel and comprising immobilized reagents whereby the fluid may be analyzed for a plurality of components while residing in the flow channel.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a division of U.S. application Ser. No. 10 / 192,996, filed Jul. 9, 2002, now U.S. Pat. No. 7,138,269, which is a division of U.S. application Ser. No. 09 / 254,310, filed Dec. 16, 1999, now U.S. Pat. No. 6,432,630, which is the U.S. national stage of International Application No. PCT / DK97 / 00368, filed Sep. 4, 1997, which claims the benefit of DK Application No. 0953 / 96, filed Sep. 4, 1996, and of DK Application No. 0150 / 97, filed Feb. 10, 1997. Each of the aforementioned applications is hereby incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention relates to methods and apparatuses for detection, separation, sorting, and analysis of particles, such as cells, cell organelles, beads, molecules, such as Deoxyribonucleic acid (DNA), proteins, etc. in a fluid. In particular, the invention relates to particle separation by using different forces such as magnetic, electrophoretic, hydrodynamic and...

Claims

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