776 results about "Particle separation" patented technology

A particle separation member (40) is provided for use with a cyclone separator (30). The particle separation member (40) divides the separator (30) into a cyclone chamber (46) and a particle receiving chamber (50). The cyclone chamber (46) and the particle receiving chamber (50) communicating via a plurality of apertures (52) in the particle separation member (40).

This invention is based on size and mass separation of suspended particles, including biological matter, which are made to flow in a spiral channel. On the spiral sections, the inward directed transverse pressure field from fluid shear competes with the outward directed centrifugal force to allow for separation of particles. At high velocity, centrifugal force dominates and particles move outward. At low velocities, transverse pressure dominates and the particles move inward. The magnitudes of the two opposing forces depend on flow velocity, particle size, radius of curvature of the spiral section, channel dimensions, and viscosity of the fluid. At the end of the spiral channel, a parallel array of outlets collects separated particles. For any particle size, the required channel dimension is determined by estimating the transit time to reach the side-wall. This time is a function of flow velocity, channel width, viscosity, and radius of curvature. Larger particles may reach the channel wall earlier than the smaller particles which need more time to reach the side wall. Thus a spiral channel may be envisioned by placing multiple outlets along the channel. This technique is inherently scalable over a large size range from sub-millimeter down to 1 μm.

The invention relates to the immunoassay medical field, particularly provides a magnetic particle separation chemiluminescence immunoassay assay kit and a preparation method thereof used for detecting disease related markers. The kit of the invention comprises: 1) a calibrator; 2) magnetic particles which are coated with streptavidin; 3) disease related marker antibodies of enzyme markers and biotin markers; and 4) a chemiluminescence substrate. Further, the method for preparing the kit according to the invention includes the following steps: 1) pure raw materials are used to prepare the calibrator; 2) the streptavidin is used to coat the magnetic particles; 3) the mixed liquid of the enzyme and the biotin markers are prepared; 4) the calibrator, the chemiluminescence substrate as well as the mixed liquid of the enzyme and the biotin markers are packaged in a separated way; and 5) a finished product is packaged. The kit has the advantages of convenience, rapidness, sensitivity, stability, and the like.

A microfluidic separation device includes a microchannel formed in a substrate and being defined at least by a bottom surface, a first side wall, and second side wall. Fluid containing particles or cells is flowed through the microchannel from an upstream end to a downstream end. The downstream end terminates in a plurality of branch channels. A plurality of vertically-oriented electrodes are disposed on the first wall and on the second wall opposite to the first wall. A voltage source is connected to the plurality of opposing electrodes to drive the electrodes. The opposing, vertically-oriented electrodes may be used to focus a heterogeneous population of particles or cells for subsequent downstream separation via additional electrodes placed on one of the side walls. Alternatively, the opposing, vertically-oriented electrodes may be used to spatially separate a heterogeneous population of particles or cells for later collection in one or more of the branch channels.

The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.

A method and apparatus for acoustically enhanced particle separation uses a chamber through which flows a fluid containing particles to be separated. A porous medium is disposed within the chamber. A transducer mounted on one wall of the chamber is powered to impose on the porous medium an acoustic field that is resonant to the chamber when filled with the fluid. Under the influence of the resonant acoustic field, the porous medium is able to trap particles substantially smaller than the average pore size of the medium. When the acoustic field is deactivated, the flowing fluid flushes the trapped particles from the porous medium and regenerates the medium. A collection circuit for harvesting the particles flushed from the porous medium is disclosed. Aluminum mesh, polyester foam, and unconsolidated glass beads are disclosed as porous media.

The present invention relates to an exhaust gas treatment system for an exhaust system of an internal combustion engine, and comprises a basic housing and an add-on housing mounted thereon so it is at least partially detachable. The basic housing contains at least one inlet pipe which can be connected to the exhaust system and leads into the basic housing, at least one outlet pipe which can be connected to the exhaust system and leads out of the basic housing, at least one SCR catalyst and at least one oxidizing catalytic converter. The add-on housing contains at least one particle separation device and at least one reducing agent feed mechanism.

The present invention provides a method and apparatus for economically filtering air into swine farms and other animal enclosures. Advantageously, the invention substantially reduces the risk to airborne transfer of disease into animal enclosures. In one embodiment, a method for providing clean air to an animal enclosure includes providing an animal enclosure having an animal containing volume for containing a plurality of animals, removing air from the internal volume via at least one exhaust fan, and filtering air being pulled into the enclosure by the at least one exhaust fan using a fully sealed filter, the fully sealed filter having a particle separation sufficiently efficient to prevent detection of live (PRRS-) virus downstream the of filter, using polymerase chain reaction (PCR) analysis of samples collected with a cyclonic aerosol collector.

A cyclone separator assembly comprises a cyclone separator that removes large particles of dirt from a working airstream as it flows through the cyclone separator, and the separated large particles of dirt are deposited into a dirt cup. The cyclone separator assembly further includes a fine particle separation member comprising a plurality of apertures for separating fine particles of dirt from air in the cyclone separator or the dirt cup.

An improved technique for particle separation is provided. A serpentine structure is utilized in a continuous fluid flow environment to allow for suitable separation of particles to occur in a manner that does not require external application of forces to initiate the separation. The geometry of the serpentine structure and associated forces generated in connection with fluid flow therein suffice.

A laminar or cyclonic particle separator for gas, liquid-liquid and fluidizable solids separation comprised of a section with a non-metallic housing having an annulus and a chamber, an optional anode cooled with a first coolant in and a first coolant out disposed in the chamber, a DC or pulsating DC power source connected to the anode, at least one magnetic coil disposed adjacent the chamber and cooled with a second coolant, a high voltage pulsating DC power source connected to the magnetic coil, and a fluid (gas, liquid or fluidizable solids) inlet port connected to the housing, and also a section with a non-metallic separator tube connected to the housing and disposed within the housing, a first fluid outlet connected to the annulus through the housing. This device can then separate a stream rich in a targeted element (first fluid) and a stream lean in a targeted element (second fluid) from the device and thus discharge a stream almost free of the targeted element or almost 100% the targeted element.

The present invention relates to a centrifuge apparatus. The centrifuge apparatus is operable at certain predetermined parameters depending upon a product to be separated and is useable with a plurality of rotor assemblies. For example, a first rotor assembly of said plurality of rotor assemblies includes a first core having a first core configuration which is contained within a rotor housing of the first rotor assembly to define a first volume capacity such that the product passing through the first rotor assembly having the first volume capacity during rotation of the first rotor assembly in the centrifuge apparatus achieves a first particle separation of the product. A second rotor assembly of said plurality of rotor assemblies includes a second core having a second core configuration which is contained with a rotor housing of the second rotor assembly to define a second volume capacity such that product passing through the second rotor assembly having the second volume capacity during rotation of the second rotor assembly in the centrifuge apparatus achieves a second particle separation of the product. It is observed that the second particle separation is a linear change with respect to the first particle separation.

The present invention relates to magnetic particle separators using micromachined magnetic arrays and more particularly, to magnetic particle separators or manipulators using controlled magnetization on micromachined magnetic arrays for the separation of cells and other biological materials. The present invention also pertains to using such devices for the separation and analysis of biological materials for immunoassays, DNA sequencing, protein analysis, and biochemical detection applications. The present invention can also be viewed as a novel method for fabricating fully integrated permanent magnet components within any microelectromechanical system (“MEMS”) structures. The present invention also provides a magnetic particle separation and manipulation system for rapid separation and accurate manipulation of magnetic particles in two-dimensional electromagnetic arrays, which utilize high throughput biological analyses. A disposable cartridge can be produced in low cost using a low cost substrate such as plastic or other polymer, glass, or metal. Magnetic flux is generated by conventional or micromachined electromagnets a platform system consisting of magnetic flux sources, magnetic flux guidance, and a microprocessor control interface. By controlling direction of electric currents into inductors on the platform system, arbitrary magnetic poles can be generated on Permalloy structures of the cartridge to separate and manipulate magnetic particles. The magnetic particle separator and manipulator in the present invention can be easily combined with automated detection systems such as a fluorescent monitoring system.

A magnetic particle separator (10) suitable for separating magnetic and non-magnetic particles from a thermal fluid flowing in a heating system. The magnetic particle separator (10) comprises a hollow body (10A, 10B) configured with an upper particle separation chamber (11) and for circulation of the thermal fluid between an inlet and an outlet port (12, 13), and a quieting chamber (15) beneath the particle separation chamber (11) for accumulation of the particles separated from the fluid: an annular support element (21) for permanent magnets (18) being removably fastened outside the quieting chamber (15) of the separator (10).

The present invention relates to a method of particle separation comprising preparing a suspension of particles containing at least one recognizable target particle in a suspending solution, labeling the target particle with a conjugate marker, wherein the conjugate marker comprises at least one recognition unit for the recognizable target particle and at least one peroxidase enzyme, contacting a gelatin surface with the suspending solution, adding developer to the suspending solution in contact with the gelatin surface and in the presence of phenol to attach the target particle to the gelatin surface, and washing the gelatin surface to remove unattached particles. The method may also include detecting the presence of the target particle on the gelatin surface as well as detaching and recovering the attached particles after removal of the non-target particles.

A spiral inertial filtration device is capable of high-throughput (1 mL/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude. Large fractions of sample fluid are removed from a microchannel without disruption of concentrated particle streams by taking advantage of particle focusing in inertial spiral microfluidics, which is achieved by balancing inertial lift forces and Dean drag forces. To enable the calculation of channel geometries in the device for specific concentration factors, an equivalent circuit model was developed and experimentally validated. Large particle concentration factors were achieved by maintaining either average fluid velocity or Dean number throughout the entire length of the channel during the incremental removal of sample fluid. Also provided is the ability to simultaneously separate more than one particle from the same sample.