Processes and formulations are provided that are capable of protecting, stabilizing, and / or topically delivering one or more bio-affecting compounds. More particularly, the invention relates to processes of making a composition having a host compound capable of accepting one or more bio-affecting guest compounds, and new compositions formed by the processes. The processes and formulations can be used to protect and stabilize bio-affecting compounds of widely-different
solubility characteristics. The processes include formulating a host composition having a host capable of accepting a guest, the processes comprising mixing, in any order: (i) a non-ionic surfactant s elected from the group consisting of compounds having a
chemical structure: where "-CH-O-CH-" represents an
epoxide group, where Ra and Rb are hydrocarbons that can be the same or different, where at least one of the Ra and Rb hydrocarbons includes an
epoxide group within 3 carbons of the
hydrocarbon attachment to contribute to the desired hydrolypid balance of 7-9, where Rc is
hydrogen or a
methyl group, and where Rd is a
methylene group (-CH2-), an
ethyl group (-CH2-CH2-), or a structurally equivalent link with a
bond length range about the same as or shorter than that provided by an
ethyl group, and having a hydro-lipid balance in the range of 7-9; (ii) an amphoteric surfactant selected from the group consisting of organic compounds having the
chemical formula NH3-R-COOH, where R is a straight, branched, or
aromatic hydrocarbon structure having 6-24 carbons; (iii) a
solvent for the amphoteric surfactant; (iv) an aromatic selected from the group consisting of compounds having at least one aromatic five or six-member ring; (v) an
aluminum cation; (vi) a Lewis acid that is not a Bronsted-Lowry acid; and (vii) a Bronsted-Lowry acid. According to a further aspect of the invention, one or more compounds are selected to be sequentially mixed with the host composition to form a stable molecular environment, which is sometimes referred to herein as a process of
molecular stacking.