The present invention provides a process for preparing cross-linked 
sodium hyaluronate microspheres capable of being adopted as an emboliaztion agent by adopting 
sodium hyaluronate as a 
raw material. The process comprises the following steps: preparing a 
sodium hyaluronate alkaline solution gel with a concentration of 10-30% g / ml; adding the 
sodium hyaluronate alkaline solution gel to an emulsifier-containing 
oil phase, and carrying out high speed emulsification through a shearing 
machine, wherein an emulsification speed is 500-2000 rpm, and a time is 10-20 min; adding a certain amount of a cross-linking agent, stirring for 4-6 h at a 
room temperature, carrying out a cross-linking reaction, and standing overnight after completing the reaction, wherein a 
mass percentage of the cross-linking agent in the 
oil phase is 0.2-2%; and adopting a water-soluble 
organic solvent to wash to remove the 
oil phase remained on the surface of the microspheres, and finally 
drying to obtain the cross-linked 
sodium hyaluronate microspheres. According to the present invention, the preparation process is simple; and the size of the obtained microspheres is suitable for routine 
blood vessel emboliaztion, and the obtained microspheres have characteristics of controllable particle size, good 
microsphere shape, easy screening, elasticity, expandibility, no toxic-
side effect on 
human body, good 
biocompatibility, good biodegradability, and ensured 
clinical safety.