The invention discloses a medical supply first-aid case. The medical supply first-aid case comprises a case door, a handle, a rotating shaft, a first-aid case body, a medicine storage box, a semiconductor refrigerator, a motor, a heat dissipating fan, a temperature controller, a storage battery, a partition plate, an upper cover, sterilization lamps, a buckle, three switches, a temperature sensor, a display screen and a processor. The three switches are the sterilization lamp control switch, the temperature control switch and the motor control switch respectively, ultraviolet sterilization lamps serve as the sterilization lamps, a shock-proof pad is arranged below the motor, an LED display screen serves as the display screen, and a P-type semiconductor and an R-type semiconductor are adopted as semiconductors of the semiconductor refrigerator. By arranging the semiconductor refrigerator, the case can carry special-demand medicine, an existing first-aid case is greatly optimized, and the demands of the people are met.