81 results about "Abdominal aneurysm" patented technology

Disclosed is a method and apparatus for treating bifurcations of the vascular system, such as abdominal aneurysms at the bifurcation of the aorta and iliac arteries. A tubular implant having a first section, a second section and a magnetic connection therebetween is positioned across the bifurcation such that the proximal ends of the first and second sections extends into a first iliac and a second iliac respectively. Deployment catheters are also disclosed.

A bilateral intra-aortic bypass graft and method and apparatus for repairing an abdominal aortic aneurysm includes two tubular grafts which are intraluminally delivered to the aorta and secured to the aorta by the expansion and deformation of two expandable and deformable tubular members.

An endoluminal device for affixation to a wall of a body lumen having a neck region defined by a relatively narrow width and a shoulder region that diverges from the neck region to a relatively wider width. The device comprises a shoulder portion, which may be part of a bulbous portion, having a diameter profile that conforms to the shoulder region, and, in some embodiments, a plurality of affixation members in an area of the device that typically extends from a distal end of the device through the shoulder portion. In one embodiment, the device comprises an endograft for repair of an aneurysm, such as an abdominal aortic aneurysm (AAA). Methods of using the endograft to inhibit continued diametric expansion of the aneurysm and to inhibit endoleak formation and migration of the endograft are also described.

The invention discloses application of FAM210B in the preparation of diagnostic tools for abdominal aortic aneurysm. Experiments prove that FAM210B has expression differences in normal control tissues and abdominal aortic aneurysm tissues; therefore, it is reckoned that FAM210B is a molecular marker for diagnosing abdominal aortic aneurysm. Experiments via in-vitro cultured cells prove that by accelerating the expression of FAM210B, it is possible to inhibit the apoptosis of human aortic smooth muscle cells; therefore, it is reckoned that FAM210B is a drug target for treating abdominal aortic aneurysm. As a new molecular marker for diagnosing and treating abdominal aortic aneurysm, the molecular marker has a promising clinical application prospect.

The invention relates to the field of biomedicine, in particular to the application of recombinant P-selectin glycoprotein ligand 1 as a target in preparation of drugs for preventing and/or treating aneurysms. PSGL-1 gene knockout mice are taken as a research object. Compared with wild-type mice, the PSGL-1 gene knockout mice has the characteristics that the incidence of thoracic aortic aneurysm and abdominal aortic aneurysm is significantly reduced, collagen deposition is reduced, elastic fiber breakage and smooth muscle cell degradation are significantly inhibited, infiltration of inflammatory cells is significantly reduced, and expression of inflammatory factors, fibrotic factors and adhesion molecules is significantly inhibited. In addition, the adhesion of peripheral blood mononuclearcells to endothelial cells in the absence of PSGL-1 is also significantly reduced. The invention reveals that the loss of PSGL-1 has the effect of inhibiting aneurysms, and a theoretical basis and clinical basis are provided for the role of PSGL-1 in studying new targets and new strategies for preventing and treating aneurysms.

The invention discloses a vascular covered stent with anti-thrombus/anti-tumor function and a preparation method thereof, the vascular covered stent is composed of a metal stent and a fabric covered film carrying drugs inside and outside respectively, and an outer layer of the covered film is provided with a drug bag interlayer. The covered film is loaded with an anti-thrombus drug through an inner layer and loaded with an anti-tumor drug through an outer layer drug bag interlayer; a covalent cross-linking technology is used; antithrombotic coating is carried out on the inner layer of the covered film; the inner layer of the covered film can resist thrombus and quickly endothelialize; curcumin and metformin microspheres are carried on the cavity interlayer of the outer layer of the covered film, anti-tumor treatment can be carried out on the aortic aneurysm, long-term slow release of medicine is achieved, restenosis is effectively prevented, tumor growth is inhibited, the risk of vascular rupture is reduced, and the covered stent is particularly suitable for abdominal aortic aneurysm patients.

The invention discloses an application of Adamtsl3 as a diagnosis and treatment marker for abdominal aortic aneurysm, and also discloses a reagent and a kit for detecting Adamtsl3. The invention further discloses a method and a medicine for treating abdominal aortic aneurysm. The above research achievements provide a new strategy and thought for clinically treating abdominal aortic aneurysm.

The invention provides abdominal aortic aneurysm animal models and a building method thereof. According to the abdominal aortic aneurysm animal models, erythropoietin is used as an inducer. The abdominal aortic aneurysm animal models are short in model building time and high in tumor formation rate, no surgical operations are needed, only intraperitoneal injection is needed, trauma to animals is little, the technical requirements of experimenters are low, the operability is high, no mice with specific genes knocked out are needed, and the abdominal aortic aneurysm animal models can be achievedwith the wild-type mice (animals).

The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.

The invention belongs to the field of image data processing, particularly relates to a blood vessel registration method, system and device for an intravascular aneurysm operation, and aims at solvingthe problems that a registration image generated by an existing image registration technology is fuzzy, long in consumed time and much in interference. The method comprises the following steps: converting an acquired CTA image into an aorta blood vessel three-dimensional image, further converting the aorta blood vessel three-dimensional image into an aorta blood vessel two-dimensional image, converting a DSA image into an aorta blood vessel binary image, and obtaining a registered image through a blood vessel registration network based on deep learning, wherein the blood vessel registration network is constructed based on the regression device sub-network, the space transformation sub-network and the re-sampling sub-network. According to the invention, the problem that the DSA image is blurred in the operation can be solved, the abdominal aortic aneurysm position can be found more quickly and accurately in the current X-ray transmission image, and the requirement for assisting a doctorin the intravascular aneurysm repair operation in real time can be met.

The invention discloses (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-benzyl-2-acrylamide (AG490 for short) of the following formula in the prevention and treatment of abdominal aortic aneurysm the use of. In the CaCl2-induced abdominal aortic aneurysm model, AG490 can not only prevent the occurrence of abdominal aortic aneurysm, but also prevent the progressive development of abdominal aortic aneurysm; AG490 can significantly inhibit the expression and activity of matrix metalloproteinases, and alleviate the effect of this proteolytic enzyme on the abdominal aortic aneurysm model. The destruction and degradation of vascular tissue maintains the relative integrity of vascular structure; AG490 can reduce the expression of vascular α-smooth muscle actin (α-SMA) and reduce the deposition of vascular adventitial collagen.

A system includes a probe configured to transmit ultrasound signals directed to a target blood vessel and receive echo information associated with the transmitted ultrasound signals. The system also includes at least one processing device configured to process the received echo information and generating a three-dimensional ultrasound image of the target blood vessel; obtain a three-dimensional vascular model corresponding to the target blood vessel; identify a best-fit of the three-dimensional vascular model onto the three-dimensional target image; store the best fit of the three-dimensional vascular model as a segmentation result; and calculate, based on the segmentation result, measurements for the target blood vessel.

The invention relates to a modular stent with branches for treating thoracoabdominal aortic aneurysm, and belongs to the technical field of medical instruments. The stent is a covered stent and comprises a descending aorta region near-end anchoring module, a visceral artery region branch graft module and an abdominal aorta region far-end anchoring module which are communicated in sequence; the number of the descending aorta area near-end anchoring module is at least one. The invention provides a modular endovascular graft with branches for treating thoracico-abdominal aortic aneurysm of Asian people. Through modularization and different combination modes, anatomical structures of various thoracico-abdominal aortic aneurysms can be adapted, and the time required by customization can be effectively avoided; visceral arteries and renal arteries can be reconstructed through branches; sufficient friction force is provided for graft anchoring and bridging through combined anchoring, branch selection is facilitated through a guide wire guiding area, and operation difficulty and the time are reduced. Therefore, the thoracico-abdominal aortic aneurysm is effectively treated, the operation time is shortened, and adverse reactions of contrast agents are reduced.

The present invention provides methods for detecting and/or treating a subject having an aneurysm or at risk for developing an aneurysm. It has been discovered that a key metabolite of the kynurenine (Kyn) pathway, a major route for the metabolism of essential amino acid tryptophan (Trp) into nicotinamide adenine dinucleotide (NAD+), plays a critical role in the formation of aneurysms, for example abdominal aortic aneurysms. In particular, it has been discovered that 3-Hydroxyanthranilic acid (3-HAA), a product of kynureninase (KYNU), plays a causative role in the formation of aneurysms by, for example exerting pro-inflammatory effects on vascular smooth muscle cells. It has further been discovered that elevated levels of 3-HAA are indicative of the presence and/or progression of an aneurysm, and 3-HAA levels correlate with the size (aortic diameter) of the aneurysm.