Vascular covered stent with anti-thrombus/anti-tumor function and preparation method thereof

Abstract

The invention discloses a vascular covered stent with anti-thrombus / anti-tumor function and a preparation method thereof, the vascular covered stent is composed of a metal stent and a fabric covered film carrying drugs inside and outside respectively, and an outer layer of the covered film is provided with a drug bag interlayer. The covered film is loaded with an anti-thrombus drug through an inner layer and loaded with an anti-tumor drug through an outer layer drug bag interlayer; a covalent cross-linking technology is used; antithrombotic coating is carried out on the inner layer of the covered film; the inner layer of the covered film can resist thrombus and quickly endothelialize; curcumin and metformin microspheres are carried on the cavity interlayer of the outer layer of the covered film, anti-tumor treatment can be carried out on the aortic aneurysm, long-term slow release of medicine is achieved, restenosis is effectively prevented, tumor growth is inhibited, the risk of vascular rupture is reduced, and the covered stent is particularly suitable for abdominal aortic aneurysm patients.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an anti-thrombotic / anti-tumor function vascular covered stent and a preparation method thereof. Background technique [0002] An aneurysm is a persistent dilation of the vessel wall caused by damage to the weakened artery wall. This disease often occurs in the aorta and main arteries of the lower extremities. Vascular stent implantation is one of the effective methods of minimally invasive surgery for the treatment of cardiovascular diseases. The advantages are small trauma, low risk, fast recovery and relatively low cost. Vascular stents refer to implantable medical devices that can provide sufficient mechanical support for blood vessels, maintain patency in blood vessels, and complete blood vessel repair tasks without causing local or systemic tissue damage. [0003] Common vascular stents include bare stents, drug-coated stents, and covered stents. F...

AI Technical Summary

Problems solved by technology

The method of coating the drug is ultrasonic spraying. Since there are many factors that affect the effect of ultrasonic atomization spraying equipment, such as: liquid viscosity, mixing degree of different components and dynamic characteristics of the liquid, etc., the use of this method has too many restrictions on the drug used. Therefore, the application of the method is difficult

Moreover, the drug coated by this method will burst into release, and has no obvious inhibitory effect on thrombus formation.

Moreover, the covered stent does not have the dual functions of anti-tumor and anti-thrombotic, and it is prone to problems such as poor biocompatibility, restenosis, and poor endothelialization in mid- and long-term clinical trials, resulting in 15-20% of patients with postoperative Complications requiring secondary surgery

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