Abdominal aortic aneurysm animal models and building method thereof

Abstract

The invention provides abdominal aortic aneurysm animal models and a building method thereof. According to the abdominal aortic aneurysm animal models, erythropoietin is used as an inducer. The abdominal aortic aneurysm animal models are short in model building time and high in tumor formation rate, no surgical operations are needed, only intraperitoneal injection is needed, trauma to animals is little, the technical requirements of experimenters are low, the operability is high, no mice with specific genes knocked out are needed, and the abdominal aortic aneurysm animal models can be achievedwith the wild-type mice (animals).

Description

technical field [0001] The invention relates to the field of animal model construction, in particular to an abdominal aortic aneurysm animal model and a construction method thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Abdominal aortic aneurysm (AAA) is a serious macrovascular disease with high morbidity, high mortality, low detection rate, and low control rate. AAA is defined as local dilation of the abdominal aorta with a diameter exceeding 30 mm. Although some authors define AAA as the diameter of the abdominal aorta greater than 50% of the normal diameter, the normal value of the abdominal aorta varies greatly in different individuals and is often used in c...

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Problems solved by technology

Conversely, high plasma EPO concentrations increase risk of new-onset heart failure

In addition, clinical studies have shown that one-third of AAA patients undergoing endovascular abdominal aortic repair suffer from anemia, and their hemoglobin level is independently negatively correlated with the size of AAA, but the mechanism is not clear

A recent experimental study of angiotensin II (Ang II) infusion in hyperlipidemic mice found that inhibition of hypoxia-inducible factor-1α (HIF-1α) attenuates AAA progression

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