27 results about "Abdominal aorta" patented technology

The balloon catheter blood pump comprises a pump body, a flow guide cone, a tail sleeve, a five-cavity catheter, a balloon and an impeller rotor assembly, the pump body comprises an inflow cage, a middle section and an outflow cage, the outflow cage end of the pump body is connected with the flow guide cone, the flow guide cone is connected with the tail sleeve, the tail sleeve is connected with the five-cavity catheter, and the five-cavity catheter is connected with the impeller rotor assembly. The two ends of the balloon are fixed to the middle section of the pump body in a sleeved mode, five round holes are formed in the cross section of the five-cavity catheter and include two flushing fluid perfusion holes, a wiring hole, a balloon injection hole and a center hole, the impeller rotor assembly comprises an impeller, an impeller shaft, a bearing and a flexible transmission shaft, and the impeller is installed at the far end of the impeller shaft and arranged in the pump body. A bearing is arranged between the impeller shaft and the inner wall of the flow guide cone, the near end of the impeller shaft is connected with the far end of a flexible transmission shaft, the flexible transmission shaft penetrates through the center hole, a gap a is reserved between the impeller shaft and the flow guide cone in the radial direction, and a gap b communicated with the gap a is reserved between the impeller and the flow guide cone in the axial direction.

Some embodiments of a rotational atherectomy device can remove (partially or completely) stenotic lesions in blood vessels by rotating one or more abrasive elements in an orbital path to abrade and breakdown the lesion. In particular implementations, multiple abrasive elements are arranged along a distal portion of a drive shaft with an improved configuration so as to facilitate both efficient navigation into vessels extending from the abdominal aorta such as the common iliac artery, the external iliac artery, the internal iliac artery, the profunda artery, the gluteal artery, and the pudental artery and effective orbital paths for abrading stenotic material in such vessels and junctions between such vessels.

The invention relates to the technical field of medical instruments, and discloses a disposable simple in-vitro transplantation renal artery perfusion apparatus which comprises a buckle seat, a panel and a perfusion tube, a perfusion tube mounting hole is formed in the middle of the panel, the perfusion tube is connected in the perfusion tube mounting hole in the middle of the panel in a penetrating mode, one end of the perfusion tube is connected with a perfusion tube, and the other end of the perfusion tube is connected with a drainage tube. The other end is inserted into the abdominal aorta; the buckle base comprises a bottom plate and side plates arranged at the two ends of the two sides of the bottom plate, a penetrating hole is formed in the middle of the bottom plate, and clamping grooves are formed in the inner sides of the side plates. The disposable simple in-vitro transplantation renal artery perfusion apparatus can be effectively fixed at an opening of an artery, perfusion can be carried out by connecting an infusion tube, assistance of other people is not needed, fixation is good, perfusate cannot leak out to cause waste, and intima of the artery cannot be damaged to cause series complications.

Some embodiments of a rotational atherectomy device can remove (partially or completely) stenotic lesions in blood vessels by rotating one or more abrasive elements in an orbital path to abrade and breakdown the lesion. In particular implementations, multiple abrasive elements are arranged along a distal portion of a drive shaft with an improved configuration so as to facilitate both efficient navigation into vessels extending from the abdominal aorta such as the common iliac artery, the external iliac artery, the internal iliac artery, the profunda artery, the gluteal artery, and the pudental artery and effective orbital paths for abrading stenotic material in such vessels and junctions between such vessels.

Described herein are pumps that linearly reciprocate to assist with circulating blood within the body of a patient. Red blood cell damage may be avoided or minimized by such linear pump movement. The linearly reciprocating movement may also generate a pulsatile pumping cycle that mimics the natural pumping cycle of the heart. The pumps may be configured to reside at various body locations. For example, the pumps may be situated within the right ventricle, the left ventricle, the ascending aorta, the descending aorta, the thoracic aorta, or the abdominal aorta. In some instances, the pump may be deployed within the venous circulation. In other instances, the pump may reside outside the patient.

The utility model discloses a multifunctional bedside nasojejunum nutrition tube placement training device which comprises a head and neck bionic block, a nasopharyngeal cavity channel is arranged in the head and neck bionic block; the pleuroperitoneal cavity frame comprises a hard simulation frame and bionic skin covering the hard simulation frame. Wherein the head and neck bionic block and the pleuroperitoneal cavity frame are integrally formed or detachably connected. A bionic esophagus, a bionic stomach, a bionic duodenum and a part of bionic jejunum which are sequentially connected are arranged in the pleuroperitoneal cavity frame, and a bionic cardia and a bionic pylorus are arranged at the head end and the tail end of the bionic stomach respectively. A bionic inferior vena cava, a bionic abdominal aorta, a bionic mesenteric superior vein and a bionic mesenteric superior artery are further arranged in the pleuroperitoneal cavity frame; the bionic inferior vena cava and the bionic abdominal aorta are arranged on the rear sides of the bionic stomach and the bionic duodenum, the bottom ends are closed, and the head ends penetrate out of the bionic skin; the bottom ends of the bionic superior mesenteric vein and the bionic superior mesenteric artery are closed, and the head ends of the bionic superior mesenteric vein and the bionic superior mesenteric artery partially wrap the bionic duodenum and then penetrate out of the bionic skin.

The application discloses an ultrasonic imaging system for accurately collecting heart sections in any body position, which comprises a plurality of two-dimensional ultrasonic arrays randomly distributed in space, a multichannel ultrasonic signal collecting module and a three-dimensional ultrasonic imaging module; the plurality of two-dimensional ultrasonic arrays, the multichannel ultrasonic signal collecting module and the three-dimensional ultrasonic imaging module are sequentially connected; wherein the plurality of two-dimensional ultrasonic arrays comprises a plurality of ultrasonic transducer arrays forming sub-area line scanning or sub-area surface scanning or cross surface scanning; the application provides doctors with more detailed images, which is helpful for more accurately positioning and evaluating lesions; can solve the problems of difficulty in collecting correct imaging sections, imaging section changes in motion and the like in wearable ultrasonic heart imaging; is not only suitable for the heart, but also suitable for the brain, the liver, the kidney, the urinary bladder, the abdominal aorta, the inferior vena cava and the like human tissues and parts.

The balloon catheter blood pump comprises a pump body, a flow guide cone, a tail sleeve, a five-cavity catheter, a balloon and an impeller rotor assembly, the pump body comprises an inflow cage, a middle section and an outflow cage, the outflow cage end of the pump body is connected with the flow guide cone, the flow guide cone is connected with the tail sleeve, the tail sleeve is connected with the five-cavity catheter, and the five-cavity catheter is connected with the impeller rotor assembly. The two ends of the balloon are fixed to the middle section of the pump body in a sleeved mode, five round holes are formed in the cross section of the five-cavity catheter and include two flushing fluid filling holes, a wiring hole, a balloon injection hole and a center hole, the impeller rotor assembly comprises an impeller, an impeller shaft, a bearing and a flexible transmission shaft, the impeller is installed at the far end of the impeller shaft and arranged in the pump body, and the bearing is arranged at the far end of the impeller shaft. A bearing is arranged between the impeller shaft and the inner wall of the flow guide cone, the near end of the impeller shaft is connected with the far end of a flexible transmission shaft, the flexible transmission shaft penetrates through the center hole, a gap a is reserved between the impeller shaft and the flow guide cone in the radial direction, and a gap b communicated with the gap a is reserved between the impeller and the flow guide cone in the axial direction.

This invention relates to a vascular stent for the visceral region of the abdominal aorta, comprising an interconnected proximal non-degradable segment and a distal degradable segment. The proximal non-degradable segment includes a non-degradable metal skeleton and a covering structure. The distal degradable segment is a degradable bare skeleton. The proximal non-degradable segment corresponds to the location of the primary tear in the visceral region of the abdominal aorta, and the distal degradable segment corresponds to the location of branch vessels in the visceral region of the abdominal aorta. This invention is applicable to abdominal aortic dissection anatomical features, where the proximal stent segment is non-degradable and covered, while the distal visceral segment is degradable but not covered. It promotes false lumen thrombosis by sealing the primary tear through covering, while maintaining patency of branch vessels in the visceral segment by not covering. Simultaneously, a drug layer is attached to the covering of the proximal stent segment to actively promote intimal repair.

The utility model provides a catheter used for expanding a severe stenosis renal artery opening, the catheter is an elastic catheter, two ends of the catheter are respectively an input port and an output port, the catheter comprises a straight section, a bending section and an attacking section which sequentially extend between the input port and the output port, and the straight section is provided with an opening. The end, away from the input port, of the straight section extends towards one side in the radial direction to form the bent section and the straight section, and the included angle between the axis of the attack section and the axis of the straight section is not larger than 90 degrees. According to the catheter for expanding the severe stenosis renal artery opening, based on the anatomical structure relation between the renal artery and the aorta abdominalis, the attack section located at the head end of the catheter and the telecentric end of the aorta abdominalis form a right angle or an acute angle, and the appearance and the elasticity modulus of the attack section are limited, so that tension and stress of the bent section can be smoothly transferred; and therefore, the needle can easily and smoothly pass through the narrow section of artery during rolling and impact.

The utility model discloses an aorta abdominalis covered stent and a stent system, and belongs to the technical field of aorta abdominalis covered stents. The utility model provides an aorta abdominalis covered stent which comprises a stent body, and a first through hole, a second through hole and a third through hole are formed in the stent body in the longitudinal direction of a cylinder. The middle section of the support body is provided with an open groove, the second through hole and the third through hole are broken through the open groove, and the first through hole is not broken through the open groove. Therefore, according to the aorta abdominalis covered stent, the aorta abdominalis stent can be communicated with the four branch arteries. The first through hole is not affected by the open groove and penetrates through the stent body, and therefore it can be guaranteed that blood in the aorta abdominalis is smooth all the time. The slotting does not need to be customized according to the condition of a patient, and professional batch production can be realized, so that the manufacturing efficiency and the use reliability are improved.

The vessel forceps comprise a first forceps handle and a second forceps handle, the upper side of the first forceps handle is provided with a rectangular groove, the inner side of the rectangular groove is rotatably connected with a rotating shaft, the rotating shaft is fixedly connected with the second forceps handle, and the rotating shaft is fixedly connected with the second forceps handle. Handle parts are fixedly connected to the outer sides of the first plier handle and the second plier handle, a first clamping block is fixedly connected to one side of the first plier handle, a second clamping block is fixedly connected to the side, close to the first clamping block, of the second plier handle, and a first plier head is fixedly connected to the right side of the first plier handle. According to the vessel forceps suitable for abdominal aorta blocking and catheterization, by arranging the first forceps handle, the second forceps handle, the mounting plate, the side blocks, the contact plates, the pulling plate, the first spring, the second spring, the clamping rod and the clamping hole, when the first forceps head and the second forceps head block a blood vessel, the multiple contact plates can conveniently and rapidly extrude a suction tube through movement of the pulling plate, the blood vessel blocking effect is improved, and operation is easy.

The invention provides a covered stent system for curing total aortic dissection, which comprises a main stent, a large crevasse plugging device and a non-clogging blood flow branch stent, the main stent is used for blocking the crevasse, the main stent comprises a main stent skeleton and a micropore covering film, the large crevasse plugging device is wrapped in the main stent, and the micropore covering film is arranged in the main stent skeleton. The microporous stent is used for supporting the structure of a lesion position with a large crevasse, and the microporous stent is used for enabling some small branch passages to be unblocked; however, if a large crevasse exists at a non-branch position, the micropore of the micropore stent still causes the expansion of the interlayer, and at the moment, a large crevasse plugging device needs to be used. According to the invention, full aorta continuous treatment is realized: the main stent is designed to cover the whole course of thoracico-abdominal aorta and can be connected with an implanted individualized thoracico-aorta stent system to form a complete treatment scheme of the full aorta.

The invention relates to application of an Arteridin gene as a biomarker in preparation of a product for auxiliary diagnosis of abdominal aortic aneurysm, clinical specimens and animal experiments find that the expression of Arteridin in occurrence of abdominal aortic aneurysm is remarkably increased, which indicates that Arteridin can be used as the biomarker for auxiliary diagnosis of abdominal aortic aneurysm; the invention also relates to a product for down-regulating the expression of Arterin and an application of the product in preparation of drugs for treating abdominal aortic aneurysm, the product comprises siRNA and shRNA of a targeted Arterin gene and AAV for coding the sequence of the shRNA, and after specific knockdown of Arterin by smooth muscle cells is realized, in an Elatase-induced abdominal aortic mouse model, the expression of Arterin is reduced, and the expression of Arterin is reduced. The diameter of the aneurysm is reduced, the occurrence rate is reduced, the elastin destruction degree is reduced, the expression quantity of vascular remodeling genes MMP2 and MMP9 is reduced, and the difference is obvious compared with that of a control group; the result shows that Arteridin is expected to become a target spot for treating abdominal aortic aneurysm.

The present application relates to a kind of adjustable bending delivery system for delivering implant into human body, the adjustable bending delivery system includes conveyor and bending device, the conveyor includes delivery sheath tube, the bending device includes bending sheath tube, the bending sheath tube distal end can be bent to make the bending device distal end be bent, the delivery sheath tube distal end can be accessed into human body from the artery on one leg, the bending device distal end can be accessed into human body from the artery on another leg, when the delivery sheath tube and the bending device distal end are pushed to abdominal aorta, the delivery sheath tube and the bending device distal end can cooperate in abdominal aorta, so that the bending sheath tube can drive the delivery sheath tube to be bent after bending.The adjustable bending delivery system provided by the present application requires smaller bending force, higher bending sensitivity, more stable bending process, more accurate bending direction, and better overall bending effect.

Devices, systems, and methods for patient-specific, custom-designed fenestrated implants. Various examples involve abdominal aortic stent-grafts with custom-designed fenestration features for perfusion of the renal arteries, mesenteric arteries, and / or celiac trunk arteries.

The invention discloses a conveying device for implanting an intrusive axial flow blood pump into an aorta abdominalis. The conveying device comprises a sheath tube, a sheath base assembly and a bypass extension tube assembly. The sheath base assembly comprises an operating handle, a sealing gasket and a gland, the bypass extension tube assembly comprises a Luer taper and a drainage tube, the operating handle is provided with a through hole, a drainage hole communicated with the through hole is formed in one side of the operating handle, the drainage tube is installed in the drainage hole, the sheath tube is installed at the far end of the operating handle, and the gland is connected with the near end of the operating handle by pressing the sealing gasket. The gland is connected with the locking cap through threads, the locking cap is connected with the handle end of the axial flow blood pump through the sterile sleeve, the axial flow blood pump penetrates through the sheath base assembly, is arranged in the sheath tube and is connected and positioned through the gland, and then the axial flow blood pump and the conveying device are implanted into the body of a patient in a percutaneous mode. And the sterile sleeve is operated to slowly withdraw the conveying device, so that the elastic bracket of the axial flow blood pump is released.

The application discloses application of Danshen-Gegen vesicle-like nanoparticles and belongs to the technical field of biological medicine. The Danshen-Gegen vesicle-like nanoparticles (SPVLNs) are extracted and purified from Danshen-Gegen decoction liquid by using a differential super-high-speed centrifugation method. The SPVLNs have good blood compatibility. When the SPVLNs are applied to treating abdominal aortic aneurysm, the SPVLNs can obviously relieve thickening of a blood vessel wall, reduce infiltrative cells of an arterial media and an adventitia, improve reduction and fracture of elastic fibers of the blood vessel wall, increase stretchability of the elastic fibers of the blood vessel wall, reduce contents of tissue muscle fibers and collagen fibers, reduce a fibrosis degree of the collagen fibers, obviously improve pathological changes of a mouse abdominal aorta caused by Ang II, and are safe and non-toxic.

The invention provides application of an adeno-associated virus overexpressing CTH in preparation of drugs for extravascular treatment of abdominal aortic aneurysm. When the adeno-associated virus overexpressing CTH is applied to the periphery of abdominal aortic aneurysm, fracture of elastic fibers of abdominal aorta can be reduced, collagen deposition can be reduced, infiltration of macrophages (CD68) can be reduced, secretion of matrix metalloproteinase can be reduced, degradation of extracellular matrixes can be reduced, and occurrence and development of AAA can be relieved.

A method for the treatment of a patient for the purpose of lowering blood pressure and / or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed.

The invention discloses an ECMO arterial duct for improving limb far-end blood supply, and relates to the technical field of medical instruments, and the ECMO arterial duct is technically characterized in that the ECMO arterial duct comprises a duct main body adopting an integrated double-cavity separation design, and a circulation support cavity and a far-end perfusion cavity which are not communicated with each other are formed. The tail end opening of the circulation supporting cavity is used for supplying blood to aorta abdominalis, and the side wall of the far-end perfusion cavity is provided with a side hole for supplying blood to the far end of the limb. An annular blocking water bag is arranged on the outer wall of the catheter and can be attached to the inner wall of a blood vessel after being filled, two-cavity blood flow is separated, backflow is prevented, and the far-end perfusion efficiency is improved. The in-vitro section is provided with a flow limiting device and a flow sensing device which are connected in series, and real-time monitoring and closed-loop regulation and control of blood flow are achieved. Circulation support and limb far-end perfusion can be synchronously completed through single puncture, puncture injury and operation risks are reduced, and the risk of lower limb ischemia caused by indwelling delay of a far-end perfusion tube due to untimely evaluation or wrong evaluation is avoided. The problem of limb far-end ischemia after ECMO catheterization is effectively solved.

The invention provides application of an adeno-associated virus overexpressing CBX3 in preparation of a medicine for extravascular treatment of abdominal aortic aneurysm. When the adeno-associated virus overexpressing CBX3 is applied to the periphery of abdominal aortic aneurysm, fracture of elastic fibers of abdominal aorta can be reduced, collagen deposition can be reduced, infiltration of macrophages (CD68) can be reduced, secretion of matrix metalloproteinase can be reduced, degradation of extracellular matrixes can be reduced, and occurrence and development of AAA can be relieved.

The application provides a rat uterine perfusion model and a construction method and application thereof, and belongs to the technical field of animal models. The construction method comprises the following steps: ligating blood vessels at a left kidney of a dead pregnant rat, blood vessels at a bifurcation of the upper end of the left kidney, bifurcation of the upper side and both sides of the internal iliac artery and the internal iliac vein, the right kidney and the bifurcation of the abdominal aorta and the posterior vena cava, and then inserting a tube into the abdominal aorta and the posterior vena cava, and pumping perfusion liquid from the abdominal aorta to obtain the model. The model forms a reproductive artery-placenta-fetus-placenta-reproductive vein circulation, maximally guarantees placental activity, and retains complete placental tissue. The model is simple to prepare and easy to obtain, can more truly and accurately simulate the circulation process of maternal body temperature and complete nutrients in the placenta supplied to the fetus through the mother and the placenta in the whole permeability experiment, and thus more objectively studies the permeability of a compound in the placenta, and is more reliable than a human placental perfusion model.

The invention relates to PMX-53 nano drug-loaded particles and application thereof in treatment of thoracic aorta diseases, and belongs to the technical field of biological medicines. The Fe3O4 (at) PDA-PMX-53 nano drug-loaded particle disclosed by the invention comprises a superparamagnetic ferroferric oxide nano particle, a polydopamine shell and a complement C5a receptor inhibitor PMX-53, wherein the superparamagnetic ferroferric oxide nano particle is coated with the polydopamine shell, and the complement C5a receptor inhibitor PMX-53 is covalently connected to the polydopamine shell. According to the PMX-53 nano drug-loaded particle disclosed by the invention, a drug is guided to be specifically enriched on the inner surface of a blood vessel of a thoracic aorta by utilizing a magnetic targeting technology on the premise of overcoming a blood flow shearing force, so that the drug deeply permeates into a middle membrane layer and is used for treating thoracic aortic diseases, particularly C5a-mediated thoracic aortic diseases, such as thoracic aortic aneurysm and (TAAD); while the treatment effect is improved, the distribution of the medicine in the aorta abdominalis is effectively reduced, so that the side effects are avoided.

The utility model discloses a pelvic trauma comprehensive treatment teaching simulation device which comprises a pelvic module and an iliac artery module. The pelvis module is made of a hard material; the pelvis module is composed of a plurality of separated fracture simulation units which are detachably connected together; the separated fracture simulation unit comprises a first unit consisting of sacrum; the iliac artery module comprises an iliac artery system module and a blood vessel intervention training module used in cooperation with the iliac artery system module. The iliac artery system module is of an integrated structure made of a transparent rubber material and comprises an abdominal aorta section, a common iliac artery section, an internal iliac artery section and an external iliac artery section. And the common iliac artery section or the external iliac artery section of the iliac artery system module is detachably connected with the first unit. According to the utility model, multi-type pelvic fracture simulation, multi-system injury collaborative reduction and comprehensive treatment whole-process training can be realized, and systematicness and clinical fitting degree of trauma treatment training can be effectively improved.

The invention relates to an abdominal aortic aneurysm filling assembly based on a shape memory high polymer material and a treatment system, and the abdominal aortic aneurysm filling assembly comprises a filling part which comprises at least two unit sections which are connected in sequence, and a binding ring is hooped between every two adjacent unit sections; the interventional catheter is used for containing the filling piece, the far-end portion of the interventional catheter is configured to be capable of being spirally wound around a space axis, and in the loading state, all the unit sections are sequentially arranged in the extending direction of the interventional catheter; the delivery tube is arranged in the intervention catheter in a sliding and penetrating mode and used for providing abutting force towards the far end side for the filling piece in the releasing process. According to the abdominal aortic aneurysm filling assembly, all the unit sections can be arranged on the periphery of the trunk of the abdominal aortic covered stent in advance, the surgical operation process is simplified, all the unit sections are arranged relatively orderly after being released and expanded, the space filling rate is high, and the surgical treatment effect is further improved.