95 results about "Aorta aortic" patented technology

Apparatus and methods are provided for forming a working space on the interior wall of a blood vessel, such as the aorta. The working space is isolated from blood flow and permits creation of an anastomotic hole and subsequent suturing of the hole to form an end-to-side anastomosis, even while the heart is beating. The apparatus comprises tools including inflatable barriers, such as cup-shaped balloons, which engage the inner wall of the blood vessel with minimum trauma and maximum sealing. In a first embodiment, the inflatable barrier is introduced through a penetration at the site of the anastomotic attachment. In a second embodiment, the inflatable barrier is introduced through a second penetration axially spaced-apart from the site of the anastomotic attachment.

The invention discloses a method for forming an aortic stent graft. The method comprises the following steps: acquiring an image of aorta, and extracting a three-dimensional (3D) model of the aorta according to the image; extracting diameter characteristics of the aorta in the axial direction of the aorta of the 3D model; reconstructing an aortic vascular model according to the extracted diameter characteristics; 3D-printing a water-soluble vascular inner core according to the aortic vascular model; dip-coating a polymer film on a surface of the water-soluble vascular inner core; spirally weaving a metal mesh outside the treated water-soluble vascular inner core as a metal stent; bonding the polymer film and the metal stent, and then removing the water-soluble vascular inner core to obtain the aortic stent graft. The method provided by the invention can efficiently and accurately manufacture a vascular stent graft according to the actual size of a thoracic descending aorta of a patient based on a 3D printing technology, can effectively solve a detect that an existing equal-diameter vascular stent does not match a true vascular size of the patient, provides an effective medical means for treatment of acute vascular aneurysm, and has important clinical value.

A method automatically scores calcium in the aorta and other arteries of the body using calcium plaque definitions that include subject specific in vivo blood/muscle density measurements, subject specific voxel statistical parameters and 2D and 3D voxel connectivity criteria to automatically identify the plaques. The images are optionally calibrated with external phantoms or internal reference tissue. Aortic calcium is identified automatically without manual marking. Potential false plaques from bone are automatically excluded. A 3D coordinate system provides the specific coordinates of the detected plaques, which are displayed in a plaque map for follow-up exams or ease in plaque review.

The invention provides a model building method for dissection of aorta, a model and a surgery simulation detection method. The model building method includes acquiring CTA video data of the aorta of apatient; building a three-dimensional model for the dissection of aorta according to the acquired CTA video data; performing 3D printing according to the three-dimensional model to prepare a model for dissection of aorta by utilizing a transparent material having elasticity same as that of blood vessels of the patient; arranging a pressure sensor on the inner side of the wall of the aorta in themodel for dissection of aorta, and arranging a flow sensor at an aorta branch outlet of the model for dissection of aorta. Accordingly, a physician can perform surgery simulation before actual surgeries.

The invention discloses a method for estimating pulse pressure of a central aorta by using pressure pulse wave vibration signals of a tourniquet. The method comprises the steps of (I) providing an equation for estimating the pulse pressure of the central aorta; (II) measuring the pressure pulse wave vibration signals in the tourniquet, wherein the pressure pulse wave vibration signals comprise brachial artery systolic pressure, brachial artery diastolic pressure and the pressure pulse wave vibration signal waveforms in the tourniquet; (III) averaging the pressure pulse wave vibration signal waveforms and carrying out correction by using the systolic pressure and the diastolic pressure; (IV) analyzing the corrected pressure pulse wave vibration signal waveforms to obtain a plurality of characteristic signal values, wherein the characteristic signal values are independent estimating variables of the equation of the step (I); (V) substituting the numerical value of the estimating variables into the equation for estimating the pulse pressure of the central aorta to obtain the pulse pressure of the central aorta. The invention further provides a device for estimating the pulse pressure of the central aorta by using the pressure pulse wave vibration signals of the tourniquet by using the method.

Systems and methods are provided for evaluating an aorta of a patient. A medical image of an aorta of a patient is received. The aorta is segmented from the medical image. One or more measurement planes are identified on the segmented aorta. At least one measurement is calculated at each of the one or more measurement planes. The aorta of the patient is evaluated based on the at least one measurement calculated at each of the one or more measurement planes.

The invention discloses a method and device for detecting coronary artery stenosis functional ischemia based on FFR. The method comprises the following steps: constructing a three-dimensional structure of coronary artery, and determining the characteristic parameter corresponding to each sub-virtual coronary artery in a virtual coronary artery; determining a pressure difference between the inlet pressure of the sub-virtual coronary artery and the outlet pressure of the sub-virtual coronary artery under a congestion state based on the characteristic parameter, and determining the congestion average pressure of a virtual aorta corresponding to the virtual coronary artery under the congestion state; and calculating the fractional flow reserve of the sub-virtual coronary artery based on the pressure difference of each sub-virtual coronary artery and the congestion average pressure of the virtual aorta, and analyzing functional ischemia caused by the sub-virtual coronary artery stenosis based on the fractional flow reserve of each sub-virtual coronary artery. Visibly, implementation of the method can improve the determination accuracy of the fractional flow reserve (FFR) and reduce thedetermination duration so as to improve the detection accuracy and reduce the detection duration for functional ischemia caused by coronary artery stenosis.

An aortic artery measuring probe, device and a method of measuring the diameter of the aortic artery are provided. The aortic artery measuring device includes the aortic artery measuring probe and a signal processing module electrically connected to the aortic artery measuring probe. The aortic artery measuring probe includes a flexible substrate and a sensor array disposed thereon, wherein the sensor array includes M×N ultra-wideband sensors. The ultra-wideband sensors is positioned on a subject and the flexible substrate is deformed to a profile conforming to the profile of the subject. The ultra-wideband sensors transmit a radio wave into the subject and then the radio wave is reflected by a tissue interface of the artery wall of the aortic artery to form a reflected signal. The ultra-wideband sensors receive the reflected signal and the signal processing module analyzes the reflected signal to define the diameter of the aortic artery.

The invention relates to a covered stent used in a chest great vessel cavity. Compared with the prior art, the defects that a covered stent is incapable of overcoming straightening force and is poor in practicability are overcome. The covered stent comprises artificial blood vessels (1) and support frames (2), wherein each artificial blood vessel (1) comprises a plurality of straight pipes and a plurality of pleated pipes; the straight pipes are connected at intervals through the pleated pipes; the support frames (2) are wrapped on each straight pipe respectively; the straight pipes are arranged at the two ends of each artificial blood vessel (1) respectively. The covered stent has certain longitudinal stretching deformation capacity, can fit the physiological bending of an aorta, and eliminates the straightening force after a traditional stent is bent, so that the blood vessel wall of the aorta is uniformly stressed.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 2 (Mnk2) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<-/-> mouse and an Mnk2<-/->ApoE<-/-> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<-/-> mouse, the gene defect of the Mnk2 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk2 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the Mnk2, the Mnk2 can be used as a drug target for screening a medicament for preventing, relieving and/or treating the atherosclerosis and an inhibitor of the Mnk2 can be used for preparing the medicament for preventing, relieving and/or treating the atherosclerosis.

The invention discloses a function and an application of a blood shear stress responding protein 1 (RECS1) in treatment of atherosclerosis and belongs to the field of functions and applications of genes. In the invention, an ApoE -/- mouse and an RECS1 -/- ApoE -/- mouse are employed as experimental subjects and an atherosclerosis model is obtained through high-fat diet induction. A result proves that compared with the ApoE -/- mouse, a RECS1 gene defect can significantly reduce a plague area in aorta, enhance stability of aortic sinus plagues and significantly alleviate inflammatory response, which indicate that the RECS1 in the atherosclerosis mainly has effects of promoting formation of a plague in the aorta, especially promoting the atherosclerosis. On the basis of the functions of the RECS1, the RECS1, as a drug target, can be used for screening a drug for preventing, alleviating and/or treating the atherosclerosis. An inhibitor of the RECS1 can be used for preparing a drug for preventing, alleviating and/or treating the atherosclerosis.

The invention discloses a heart valve stent and a heart valve prosthesis. The heart valve stent comprises a stent main body, which comprises mutually connected grid structure units, wherein the stentmain body is divided into an inflow channel, a transition section and an outflow channel in the axial direction, the inflow channel, the transition section and the outflow channel are connected in sequence, the stent further comprises a limiting structure connected with the stent main body, and the limiting structure is distributed on the outflow channel or the transition section in the circumferential direction, and is provided with a first projection part for limiting the stent from moving from the inflow channel to the outflow channel. According to the invention, the limiting structure is arranged on the outflow channel of the stent, so that the stent can be prevented from moving towards the outflow channel under the scouring of blood flow; the inflow channel of the stent is arranged toadapt to the shape of the native tissue, and the outer skirt edge is arranged in the circumferential direction of the outer side of the inflow channel at the position attached to the native tissue, so that perivalvular leakage can be effectively prevented while the valve is prevented from moving towards the inflow channel; and the size of the inflow channel of the stent can be small so as to effectively prevent atrioventricular block, and the size of the outflow channel can be small so as to reduce the compression on the aorta.

The invention discloses function and application of signal regulatory protein 1 (SHPS1) treating atherosclerosis, and belongs to the field of functions and application of genes. According to the technical scheme, an ApoE<-/-> mouse and a SHPS1<-/->ApoE<-/-> mouse are taken as experiment objects, atherosclerotic models are obtained through high-fat diet induction, and results show that compared with the ApoE<-/-> mouse, SHPS1 gene defect leads to substantial reduction of the aorta plaque area, stability enhancement of aortic sinus plaque and mitigation of inflammation reaction. The results show that SHPS1 mainly has the effects of promoting formation of aorta plaque area and especially promoting atherosclerosis in the functions of atherosclerosis. Aiming at the above functions of SHPS1, SHPS1 can be used as a medicine target and is applied to screen medicines for preventing, alleviating and/or treating atherosclerosis, and an inhibitor of SHPS1 is applicable to prepare medicines for preventing, alleviating and/or treating atherosclerosis.

The embodiment of the invention provides a coronary artery origin abnormity judgment method and device, and the method comprises the steps: carrying out the detection of a coronary artery angiography image, obtaining the artery position information in the coronary artery angiography image, enabling the artery position information to at least comprise the position information of an aorta and the center line of the coronary artery, the position information of the aorta is used for limiting the area of the aorta in the coronary artery angiography image, and the center line is a curve representing the topological structure of the coronary artery; determining key points in the coronary artery angiography image based on the artery position information; and based on the position relationship between the artery position information and the key points, determining the abnormal origin condition of the coronary artery. The method can automatically determine the abnormal origin condition of the coronary artery, the calculation time is short, the judgment is clear and convenient, and the method is used for assisting a doctor in diagnosing the coronary artery.