The invention discloses an antibiotic bone cement chain bead manufacturing device and method. A body of the manufacturing device is of a rectangular structure, two rows of several grooves are longitudinally formed in the body, and wire grooves are formed in the portion, corresponding to the grooves, of the body. The antibiotic bone cement chain bead manufacturing method comprises the steps of 1, selecting the antibiotic bone cement chain bead manufacturing device with the matched specification according to the size of a bone cement chain bead actually required by an operation; 2, uniformly mixing antibiotics and bone cement according to the weight ratio of 1:20, and adding purified water to blend the materials into a mixture; 3, filling the grooves formed in the antibiotic bone cement chain bead manufacturing device with the mixture prepared in step 2, and then pressuring wires into the wire grooves; 4, manufacturing the bone cement chain bead. The antibiotic bone cement chain bead manufacturing device and method have the advantages that the bone cement chain bead with the corresponding specification can be implanted into any part of the body according to the demands of the operation, the bone cement chain bead is convenient to take out, the pain of a patient can be alleviated, the cost of the bone cement chain bead is lower than that of a commercialized bone cement chain bead,and more bone cement chain beads can be manufactured within an effective time.