11 results about "Afterload" patented technology

The invention discloses a microfluidic system for studying prevention and treatment of internal fistula dysfunction by hand pump intervention, and belongs to the technical field of cytomechanics biology microfluidic experimental devices for internal arteriovenous fistula health and rehabilitation. The system comprises a feedback control system, a fluid loading system, a multi-channel optical imaging system, a micro-fluidic chip, a detection system and a post-load system. The micro-fluidic chip is designed into a Y-shaped structure based on the geometric structure of the AVF. The fluid loading system is combined with the feedback control system and the after-load system, and WSS distribution characteristics corresponding to the endothelial surface of the AVF anastomosis position under different hand pump intervention conditions can be reproduced at the intersection of the Y-shaped chips. The system can accurately and comprehensively reproduce the distribution characteristics of the WSS on the endothelial surface at the AVF anastomosis position under the condition of hand pump intervention with different intensities and frequencies, can simply and intelligently carry out cell mechanics biology experiments, and provides a foundation for revealing a potential mechanics biology mechanism for preventing and treating internal fistula power loss through hand pump intervention. And a miniaturized, objective, standardized, quantitative and automatic experiment platform is provided.

In an embodiment herein, an aortopulmonary stimulation device is provided including a first electrode sleeve array including a first sleeve body having a first end and a second end and at least one electrode, the sleeve body configured for inserting around the aorta, or the pulmonary trunk, or both. The at least one electrode for positioning on or near the aorta, on or near the pulmonary artery, or both, the first end of the sleeve body configured for affixing to the second end of the sleeve body. The device may further include one or more leads associated with the electrode sleeve array for delivering electrical stimulation thereto; and a control unit for associating with the one or more leads for controlling the electrical stimulation delivered thereto, wherein electrical stimulation decreases afterload.

An apparatus (1) for ex-vivo measurement of performance of a donor heart (2) has a heart holder (6) in a receptacle (7) for holding a human donor heart and a bag (17) for placement into a left ventricle of the heart. The bag has a bag interior space communicating with an interior space of a fluid tight, compressible and expandable container (19. The apparatus further includes a sensor (21) for measuring compression and expansion of the container. Using the apparatus, cardiac output can be measured by measuring expansion and contraction of the container. A method for ex-vivo measurement of performance of a donor heart is also described. The method may include controlling the preload and / or the afterload.

The application discloses a kind of pulsatile ventricular assist device's hemodynamic test system, and test system includes: left atrial cavity, left ventricular cavity, aortic cavity, venous cavity and pulsatile blood flow generator module.The two ends of aortic valve module are connected with left ventricular cavity and aortic cavity respectively;Ventricular assist device passes through aortic cavity, aortic valve module and left ventricular cavity in turn by the sealing tool of aortic cavity, and respectively makes blunt head be placed in left ventricular cavity and bidirectional valve be placed in aortic cavity;Pulsatile blood flow generator module is connected left ventricular cavity, and left ventricular cavity is filled with liquid, and by reciprocating movement of piston extruding left ventricular model, to simulate the flow rule of human blood.The test system of the application can be used to simulate the preload and afterload of pulsatile ventricular assist device, detect the hemodynamic performance of ventricular assist device after implanting in human body, help ventricular assist device structure optimization and controller design.

Disclosed are an ultrasound imaging device and a quantitative evaluation method for myocardial biomechanical properties. By means of processing cardiac ultrasonic echo data, at least one of an intercept of a dispersion curve of a mechanical wave, a slope of the dispersion curve, an elastic modulus, a viscous modulus, an anisotropy parameter, a coupling parameter between a second evaluation parameter and a preload, and a coupling parameter between the second evaluation parameter and an afterload can be obtained. These parameters can evaluate myocardial biomechanical properties of the heart from different dimensions, thereby facilitating a doctor to quantitatively evaluate the myocardium.

The application discloses a magnetic suspension pulse counterpulsation extracorporeal membrane oxygenation system and a control method thereof, and belongs to the technical field of medical equipment. The system comprises a magnetic suspension blood pump, an oxygenator, a blood pump controller, and an electrocardio and pulse signal acquisition and analysis unit, which continuously collects electrocardiogram data and arterial pressure waveform data of a patient in a predetermined window period to form original data packets with time stamps. The electrocardio and pulse signal acquisition and analysis unit is used for collecting electrocardio signals and / or arterial pressure waveform signals of the patient in real time. The application simulates the hemodynamic effect of in-vivo balloon counterpulsation through the rotation speed control of the extracorporeal magnetic suspension blood pump, realizes pulsatile perfusion synchronized with the heart cycle, solves the problem of increased afterload caused by non-pulsatile blood flow of a traditional extracorporeal membrane oxygenation system, and fundamentally eliminates the risks of hemolysis, platelet destruction, thrombosis and vascular injury caused by the in-vessel balloon.

The present invention relates to the technical field of medical instruments. Provided are a sequential balloon pulsatile blood pump for an artificial uterus, and a system and a method. The blood pump comprises: a pump body, which is arranged in a blood flow circuit of an artificial placenta and comprises a first pump chamber and a second pump chamber, wherein the first pump chamber and the second pump chamber are connected in parallel by means of a conduit, and two ends of the conduit are respectively an inlet end and an outlet end of blood, the inlet end being in communication with an umbilical artery of a fetus, and the outlet end being in communication with an umbilical vein of the fetus by means of an oxygenator; a controller, which is in communication connection with both a first air pouch assembly and a second air pouch assembly; and a heart acquisition unit, which is arranged on the outer surface of an artificial uterus and is in communication connection with the controller. The present invention has advantages, such as being capable of generating a pulsating blood flow, adapting to the high heart rate of a fetus, not affecting a cardiac afterload balance of the fetus, and preventing umbilical vascular intubation spasm.

The invention provides a medicinal preparation as well as a preparation method and application thereof, and belongs to the technical field of medicines. Comprising acetazolamide or acetazolamide derivatives and a pH regulator in a mass ratio of (10-15): (2-6). According to the invention, the acetazolamide or the acetazolamide derivative and the pH regulator are selected to prepare the pharmaceutical preparation, so that the pharmaceutical preparation can be used for preoperative cerebrovascular reserve capacity detection of a patient to be subjected to cerebral blood circulation and reconstruction, and can also be used for completing cerebrovascular reserve capacity detection of the patient after cerebral blood circulation and reconstruction; cerebral hemodynamics changes of a patient in a resting state before medication and a load state after medication are detected through a medical imaging means, a cerebrovascular reserve power evaluation standard is established according to the change degree, preoperative or non-operative indications are formulated according to the evaluation standard, postoperative success and failure and a recovery state of the patient are evaluated, and a cerebral vascular reserve power evaluation result is obtained. And a basis is provided for further treatment scheme design.

The utility model discloses a hemodynamics testing device of a heart and kidney auxiliary blood pump. The hemodynamics testing device comprises a circulation loop formed by sequentially connecting a ventricle simulator, an aorta model, an after-load simulator, an ultraviolet sterilization device and a liquid storage cavity. The switching tool is connected with the aorta model, and a blood pump to be tested penetrates through the switching tool and is arranged near a renal artery branch of the aorta model; each branch of the aorta model converges to the post-load simulator through an auxiliary pipeline, the post-load simulator is connected with the ultraviolet sterilization device, the ultraviolet sterilization device is connected with the liquid storage cavity, the liquid storage cavity is connected with the ventricular simulator, and the ventricular simulator is connected with the aorta model to form a complete circulation loop; wherein the post-load simulator may simultaneously adjust compliance and peripheral resistance in the circulation loop. Based on the real aorta structure of the human body, the working performance of the blood pump in the body of a patient can be evaluated, and the hemodynamic characteristics of the blood pump in the human body environment can be mastered more effectively and more accurately.

An epicardial implant system prevents right heart failure following left ventricular assist device (LVAD) implantation through dual-mechanism support of the right ventricular free wall and tricuspid valve annulus. The device comprises a biocompatible independent adjustment mechanisms for ventricular wall constraint and annular geometry optimization. The invention simultaneously treats both ventricular dilation and annular valve dysfunction through separate adjustable elements. Epicardial placement eliminates atriotomy requirements while providing real-time hemodynamic optimization. Atraumatic anchoring permits repositioning without tissue damage. Preclinical validation confirms six-minute implantation with independent component efficacy under afterload conditions. The ventricular component prevents dilation while the annular component reduces regurgitation, validating dual-mechanism necessity. The prophylactic approach addresses mechanical disruption causing right heart failure in 40% of LVAD recipients. Applications extend beyond LVAD to coronary bypass, and valvular corrections. Biodegradable embodiments accommodate pediatric cardiac growth. The system provides the first dedicated prophylactic intervention for post-surgical right heart failure across multiple cardiac procedures.

The invention discloses an external counterpulsation positive and negative pressure air path system which comprises a bearing body and an air path system, the air path system comprises an air compressor, a positive pressure tank (safety valve), a negative pressure tank (gulp valve), an electromagnetic valve and a connecting pipe fitting, one end of the air compressor is connected with the positive pressure tank through the connecting pipe fitting, and the other end of the air compressor is connected with the negative pressure tank through the connecting pipe fitting; the positive pressure tank and the negative pressure tank are respectively connected with the electromagnetic valve through connecting pipe fittings, the electromagnetic valve is divided into three pipelines, the three pipelines are communicated and connected with an air channel pipeline formed by the bearing body through the connecting pipe fittings, and finally the three pipelines are externally connected with an air bag of a terminal. The external counterpulsation device related to the design is additionally provided with a negative pressure gas path system, positive pressure is used during inflation, negative pressure is used for assisting in pumping and exhausting gas in a gas bag during the end of diastole and exhausting, so that the gas bag is quickly exhausted, and due to the fact that exhausting is more sufficient, elastic potential energy stored in the blood vessel wall is instantly converted into kinetic energy, and the gas path closed loop is formed. And the blood vessel wall is driven to rapidly rebound to try to recover to the original shape and diameter when the blood vessel wall is not pressed, so that the heart ejection accommodating capability of the artery lumen can be further improved, the end diastolic pressure is reduced, the systolic pressure is obviously reduced, the heart post-load is obviously reduced, and the counterpulsation effect is better.