Corynoxeine and application of isomer thereof in preparing medicines

Abstract

The invention belongs to the traditional Chinese medicine field, and relates to corynoxeine and an application of an isomer of the corynoxeine in preparing medicines. In the invention, the results of animal experiments prove that the corynoxeine and the isomer thereof have the effects of expanding vessels and lowering blood pressure, and can be used for preparing the medicines for expanding the vessels and lowering the blood pressure; the corynoxeine and isocorynoxeine have the effects of expanding the vessels, lowering heart afterload, lightening heart burden and decreasing myocardial oxygen consumption, and can be used for preparing anti-angina pectoris medicines; the corynoxeine has the effects of negative myodynamia, directly decreasing the myocardial oxygen consumption, and doubly lowering the myocardial oxygen consumption; the corynoxeine and the isocorynoxeine have the effects of improving the ventricular muscle excited threshold and lowering the ventricular muscle contraction frequency, can be used for treating ventricular tachycardia, and can be used as a quality identification uncaria and tagged molecules of the ffective parts of the corynoxeine and the isocorynoxeine.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to the active ingredient of the traditional Chinese medicine Uncaria and its new application, in particular to the application of dehydrorhynchophylline and its isomer (isodehydrorhynchophylline) in the preparation of medicines, especially the preparation of dehydrorhynchophylline Use in blood pressure drugs, vasodilators, anti-anginal drugs or anti-ventricular arrhythmia drugs. Background technique [0002] Hypertension is a major disease that threatens human health. Its harmfulness lies in the damage of target organs caused by long-term hypertension, which is the root cause of disability and death of hypertensive patients. Studies have shown that target organ damage often involves important organs such as the heart and kidneys, and its mechanism includes multiple independent pathways. Hyperplasia of vascular smooth muscle cells induced by hypertension, diabetes, etc.; i...

AI Technical Summary

Problems solved by technology

2. The diastolic function of the arterioles in the target organ is disordered, which leads to abnormal contraction of the arterioles supplying blood to the organ, which reduces the blood flow of the organ and causes ischemic damage to the target organ

4. The primary disease causes oxidative stress, which releases a large amount of oxygen free radicals in the body and causes damage to target organs

So far, there have been no reports on the vasodilator, antihypertensive, and cardiac effects of the active ingredient of Uncaria: dehydrorhynchophylline (corynoxeine) and its isomers (isocorynoxeine, isocorynoxeine)

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