67 results about "Blood pressure lowering drug" patented technology

The invention provides a method for detecting 31 common blood pressure-lowering and blood sugar-lowering drugs in blood by an ultra high performance liquid-mass spectrometry, and is characterized in that the method comprises the following steps: (1) confirmation of detected target compounds; (2) sample processing: processing a sample by an organic solvent protein-deposition method; (3) primary screening detection: carrying out primary screening detection by a multiple reaction monitoring (MRM) mode of the ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in different periods of time; (4) reexamining of the sample which is positive by the primary screening detection in the step (3): after treating and concentrating the sample which is positive by the screening detection, carrying out UPLC-MS/MS detection; and optionally, (5) reexamining of the sample which is positive by the reexamining detection in the step (4): reexamining by a high performance liquid chromatography-high resolution time-of-flight tandem mass spectrometry (HPLC-QTOF). According to a fact that the drugs have different retention time in the set detection conditions, a method for sectional detection is creatively completed. The required time for totally completing the detection of 31 drugs can be within 11 minutes.

The invention belongs to the technical field of medicine detection, and particularly relates to a method for detecting 43 types of medicines in blood by liquid chromatogram tandem mass spectrum. Aiming at the problem of lack of a method capable of simultaneously detecting seven types of common poisons, eleven types of antihypertensive drugs, eleven types of hypoglycemic agents and fourteen types of psychiatric drugs in the prior art, the invention provides the method. The method comprises the following steps of (a) performing protein precipitation on a to-be-detected sample with acetonitrile;and (b) detecting a selected drug by a multi-reaction monitoring (MRM) mode of high performance liquid chromatography-tandem mass spectrometry, and mass spectrum screening analysis is performed in a segmented way according to compound retention time and by two or three pairs of parent ions/daughter ions. By the method, the screening analysis of 43 types of drugs such as common antihypertensive drugs, common hypoglycemic agents, psychiatric drugs and poisons can be rapidly and accurately completed within 25 minutes in one time, the detection efficiency is high, and the method is good in sensitivity and is suitable for promotion and application.

The present invention relates to a medicine composite with imidazoline acceptor excitation activity, and preparation method of said medicine composite and its application. Said medicine composite contains the extracts of Chinese medicinal materials of prunella spike, gentian root, leonurus, white peony root and licorice. Said medicine composite can be used for preparing the medicines for curing heart failure, arrhythmia, dementia for curing heart failure, arrhythmia, dementia and reducing blood pressure, etc.

The present invention relates to a stable solid oral pharmaceutical multi-component composition comprising combination of blood pressure lowering drugs with lipid lowering agent/s and optionally a platelet aggregation inhibitor in a single dosage form. The blood pressure lowering agents are selected from β-adrenergic receptor blocking agent, ACE inhibitor and diuretic. The lipid lowering agent is selected from HMG Co-enzyme-A reductase inhibitor. The pharmaceutical composition made as per present invention a) overcomes any drug-drug interactions, b) exhibits pharmacokinetic and pharmacodynamic profile of individual therapeutic agent, c) has minimal side effects. The invention provides multi-component composition (MCC) to increase adherences to therapy. The MCC as per present invention provides compositions that maintain activity of all active ingredients without significant increase in adverse event profile. The present invention further relates to a method of preparing the said pharmaceutical composition.

The present invention is one kind of medicine composition containing active matter extracted from male agaric, and its preparation process and application in preparing anticancer medicine, immunity regulating medicine, hypotensor and hypoglycemic. The medicine composition includes active matter extracted from male agaric and pharmaceutically acceptable carrier, and the active matter is mixture of polysaccharide PT1 of molecular weight 11-15 KDa and proteoglycan PT2 of molecular weight 17-23 KDa in the weight ratio of 1 to 1.5-4.

The invention relates to a pharmaceutical composition containing azilsartan. The pharmaceutical composition particularly comprises azilsartan and at least one other antihypertensive medicine. The collaborative antihypertensive effect can be effectively played. The pharmaceutical composition for lowering blood pressure, which has a good antihypertensive effect, stable pressure reduction, and good tolerance, is provided.

The invention discloses a traditional Chinese medicine composition with an effect of lowering blood pressure, which is prepared from the following raw materials in parts by weight: 20-25 parts of radix astragali, 15-20 of radix scutellariae, 10-15 parts of sanchi flowers, 10-15 parts of Rubiaceae Borreria stricta, 8-12 parts of loranthus parasiticus, 14-18 parts of folium apocyni veneti, 16-22 parts of sunflower disc, 10-15 parts of uncaria, 11-16 parts of puerarin, 15-20 parts of wild chrysanthemum flowers, 10-15 parts of semen cassiae, 5-10 parts of bitter vines, 8-12 parts of eucommia barks, 10-15 parts of pubescent pepper herbs, 5-10 parts of harlequin glorybower leaves, 10-15 parts of corn stigma, 5-10 parts of sophora flowers, 8-12 parts of tea tree roots, and 10-15 parts of grape skins. The traditional Chinese medicine composition disclosed by the invention is prepared from various medicinal materials, and plays the synergistic effect of the medicinal materials, so that the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, dredging blood vessels, removing heat to cool blood, calming liver wind, and nourishing yin and activating blood; the traditional Chinese medicine composition has a good blood pressure lowering effect, and is exact in anti-hypertension efficacy, rapid in effect taking, efficient and durable, and has no side effect and no adverse reaction, therefore, the traditional Chinese medicine composition is an ideal, safe and reliable blood-pressure lowering medicament.

The invention provides a blood pressure reducing medicated wine which comprises 100g of raw cortex eucommiae, 100g of herba taxilli, 100g of radix scutellariae, 100g of flos lonicerae, 5g of ricepaperplant pith, 50g of Chinese angelica, 1g of safflower, 60g of fructus lycii, 60g of arillus longan, 1,000g of mulberry and 1,000ml of 50% ethanol. The invention aims at providing a blood pressure reducing medicated wine which prevents the rise of blood pressure without needing a medicine or diet control while reducing the blood pressure, and middle-aged and elderly people are not forced to cut out wine to reduce blood pressure.

The invention discloses a herb tea for lowering blood pressure. The herb tea comprises the following active pharmaceutical ingredients in the mass ratio: 15-20 of folium mori, 14-18 of salvia miltiorrhiza, 9-12 of herba portulacae, 8-12 of fructus crataegi, 3-7 of folium ginkgo and 8-15 of catsia tora linn. The herb tea is prepared by selecting, cleaning, drying and grinding the active pharmaceutical ingredients, and evenly mixing in the mass ratio so as to obtain the mixed medicinal powder; bagging by using a conventional preparing method. A method for taking the herb tea is as follows: the herb tea is brewed in warm water to be taken and is taken three times a day, and one bag of the herb tea is taken each time, is brewed in 200ml of warm water to be taken and is repeatedly brewed to form tea for being drunk. The herb tea for lowering blood pressure is prepared from natural traditional Chinese medicinal materials, can lower the blood pressure and relieves the hypertension symptom; the herb tea for lowering blood pressure has an obvious effect and can prevent hypertension; and the herb tea for lowering blood pressure is suitable for people suffering from hypertension.

The invention belongs to the traditional Chinese medicine field, and relates to corynoxeine and an application of an isomer of the corynoxeine in preparing medicines. In the invention, the results of animal experiments prove that the corynoxeine and the isomer thereof have the effects of expanding vessels and lowering blood pressure, and can be used for preparing the medicines for expanding the vessels and lowering the blood pressure; the corynoxeine and isocorynoxeine have the effects of expanding the vessels, lowering heart afterload, lightening heart burden and decreasing myocardial oxygen consumption, and can be used for preparing anti-angina pectoris medicines; the corynoxeine has the effects of negative myodynamia, directly decreasing the myocardial oxygen consumption, and doubly lowering the myocardial oxygen consumption; the corynoxeine and the isocorynoxeine have the effects of improving the ventricular muscle excited threshold and lowering the ventricular muscle contraction frequency, can be used for treating ventricular tachycardia, and can be used as a quality identification uncaria and tagged molecules of the ffective parts of the corynoxeine and the isocorynoxeine.

The invention relates to the field of food, in particular to blood pressure lowering drink. The blood pressure lowering drink is prepared from the following raw materials in parts by weight: 15-20 parts of sea buckthorn juice, 5-10 parts of celery juice, 15-20 parts of fresh ginger juice, 15-20 parts of garlic juice, 15-20 parts of lemon juice, 10-15 parts of apple vinegar and 10-15 parts of honey. The blood pressure lowering drink provided by the invention can partially replace a blood pressure lowering drug, so that damage of chemicals on body of a patient is avoided.

The invention discloses an ACE inhibitory peptide P2 with an amino acid sequence of WFRDGQELR, and further discloses an application of the ACE inhibitory peptide P2 in drugs or functional foods for assisting in lowering blood pressure and a preparation method of the ACE inhibitory peptide P2. The obtained ACE inhibitory peptide P2 is extracted from puffer fish skin, has strong capacity of bindingwith ACE enzyme and high activity, can be effectively used in antihypertensive drugs or functional foods to assist in lowering blood pressure, and has the advantages of high specificity and small toxic and side effects.

The invention provides a method for detecting a drug capable of reducing blood sugar and blood pressure by high-performance liquid chromatography-high resolution time of flight tandem mass spectrometry. The method comprises the following steps of (1) identifying a to-be-detected target compound; (2) pre-treating a sample: treating the sample by using an organic solvent precipitation protein method; (3) detecting by using the high-performance liquid chromatography-high resolution time of flight tandem mass spectrometry (HPLC-QTOF) and screening and analyzing according to a retention time, accurate molecular weight and isotopic peak abundance; (4) re-checking the positive samples detected by the step (3); and/or (5) re-detecting by using HPLC-QTOF and identifying according to the retention time and the accurate molecular weight. According to different retention times of each drug in detection conditions set by the method, the method that carries out detection in section is finished originally. The method can finish the detection of 31 drugs within 20 minutes. Detection accuracy of the method can reach 95%, preferably, over 99%.

The invention belongs to the technical field of deep processing of agricultural and sideline products and particularly relates to sesame polypeptide. The polypeptide is composed of nine amino acids, and the sequence of the amino acids is Ser-Tyr-Pro-Thr-Glu-Cys-Arg-Met-Arg. The sesame polypeptide can be artificially synthesized through a chemical solid phase synthesis method, or can also be obtained through enzymolysis of sesame protein, separation and purification. According to the sesame polypeptide, by measuring the DPPH removal ability, the BTS removal ability and the ACE inhibiting ability, it is found that the polypeptide has strong oxidation resisting and strong blood pressure reducing activity, can serve as a functional activity ingredient to be used for preparing drugs, healthcareproducts, food, nutrient enhancers, animal feed and cosmetics daily use chemical supplies and other fields, and has wide market prospects.

The invention belongs to the field of medicines and particularly relates to medicinal liquor capable of recuing blood pressure and a preparation method thereof. In the invention, fresh artemisia apiacea and radix rehmanniae are placed into a reaction kettle for reaction and are subjected to a concentrating process with peony roots in a rotary evaporator so that a sufficient action among the fresh artemisia apiacea, the radix rehmanniae and the peony roots is achieved. Finally a mixing process is carried out with other components so that a blood pressure reducing function is greatly improved. In addition, the medicinal liquor is quick in curative effects and enables a patient to feel a significant improvement just after 3-4 days. The medicinal liquor is good in mouthfeel, is portable and is convenient to drink. All of the components in the medicinal liquor are Chinese herbal medicines so that the medicinal liquor is free of toxic and side effects and can be widely applied in people in different stages. Raw materials of the medicinal liquor are easy to obtain. The medicinal liquor is easy to prepare, is low in production cost, is wide in effects, is high in safety and is significant in benefit.

The invention relates to the field of medicines and particularly relates to a composition assisting in lowering blood pressure. The composition consists of the following components in parts by weight: 200-500 parts of nattokinase, 50-150 parts of red kojic rice powder, 100-300 parts of gamma-aminobutyric acid, 100-300 parts of taurine, 100-300 parts of ascorbic acid, 250-750 parts of haematococcus pluvialis, 100-3000 parts of blueberry powder, 0-3000 parts of whey protein powder, 10-300 parts of dietary fiber and 0.01-0.1 part of xanthophyll. The invention also provides a preparation method and application of the composition. In the composition provided by the invention, all components are medicinal and edible matters without toxic or side effects, and various adverse effects of existing antihypertensive drugs are avoided; and the composition is convenient to take, and the blood pressure is lowered at a cell level.

The invention belongs to the field of biological pharmacy and in particular relates to polypeptide with the function of lowering blood pressure and application thereof. The invention aims to solve the technical problem of providing new blood pressure lowering polypeptide. The technical scheme for solving the technical problem is as follows: the polypeptide with the function of lowering blood pressure is provided. The polypeptide with the function of lowering blood pressure is (1) the polypeptide with the amino acid sequence in the SEQ ID No.3 or (2) the polypeptide with the same or similar function after one or more amino acids are replaced, deleted or added on the basis of the amino acid sequence in the SEQ ID No.3. In vivo and in vitro experiments prove that the polypeptide has good function of lowering blood pressure, can be prepared into blood pressure lowering drugs and provides a new effective selection for the blood pressure lowering field.

The invention relates to an edible electrolyte-balancing salt. The electrolyte-balancing salt is prepared by mixing the following components in parts by weight (mass): 23-70 parts of food-grade sodiumchloride, 25-67 parts of food-grade potassium chloride and 5-15 parts of food-grade magnesium sulfate. In order to meet the intake demand of salt in daily diet for people, the invention provides theelectrolyte-balancing mixed salt which comprises the food-grade sodium chloride, the food-grade potassium chloride and the food-grade magnesium sulfate, so that the mixed salt achieves the effects ofmaintaining electrolyte balance, reducing blood pressure and reducing the incidence rate of various complications caused by hypertension and/or electrolyte balance disorder for normal adults, people with insufficient food intake and salt-sensitive hypertension patients. The electrolyte-balancing salt achieves the effects of reducing the hypertension morbidity, reducing the disability rate, reducing the death rate, reducing the social cost, reducing the medical insurance expenditure cost, improving the patient compliance, reducing the side effects of antihypertensive drugs and the occurrence rate of adverse reactions are, and has practical significance and social significance.

The invention relates to a blood pressure lowering health tea. The formula of the health tea comprises the following components by weight: 1-3 parts of buckwheat, 1-3 parts of red dates, 0.01-0.05 part of ganoderma lucidum polysaccharide, 1-3 parts of pumpkin flower, 1-2 parts of Angelica sinensis, 0.5-1.5 parts of Eucommia ulmoides, 1-2 parts of corn stigma, and 0.5-2 parts of black sesame. According to the invention, all the components have obvious synergistic effect, can improve the body immunity and reach an effective blood pressure lowering effect, and has no toxic or side effect. The health tea provided by the invention has the efficacy of lowering blood pressure and lipid, clearing liver and improving eyesight, nourishing blood and tranquilizing mind, invigorating stomach and tonifying qi, etc., can achieve good effect, also has simple preparation process, can be drank individually and also can be used together with blood pressure lowering drugs cooperatively, and can reduce the side effects of drugs.

The invention discloses a blood pressure reducing medicine pillow and belongs to the technical field of traditional Chinese medicine. The pillow is prepared from the raw materials of 50-150 g of selfheal, 50-150 g of radix clematidis, 50-150 g of cassia twigs, 50-150 g of salviae miltiorrhizae, 50-150 g of cornus, 50-150 g of salviae miltiorrhizae, 50-150 g of dandelions, 50-150 g of flos carthami,50-150 g of saposhnicovia divaricata, 150-250 g of radix rehmanniae preparata, 150-250 g of folium mori, 250-350 g of pericarpium citri reticulatae and 350-450 g of chrysanthemums. According to the medicine pillow, after the medicine is combined, the medicine has a synergistic effect. Medicine property in a pillow interior is volatilized; sensation spreading is promoted; the medicine has direct effects on the skin, the mucous membrane, the five sense organs and the nine orifices and permeates into blood vessels. The pillow has the effects of qi benefiting, blood activating, yin-yang balancing, blood stasis dispersing, heat clearing and channel dredging.

The invention discloses a method for prolonging antihypertensive effect time of captopril and belongs to the field of antihypertensive drugs. Captopril and soybean antihypertensive peptides are mixed at a certain ratio and then are used. According to the method, the purpose of guaranteeing the antihypertensive effect of the captopril while prolonging the antihypertensive effect time is achieved and the defects of violent effect and short effect time of captopril are overcome. The method has the advantages of mild effect and longer antihypertensive effect time.

The invention relates to the field of medicines, and in particular relates to a blood-pressure-lowering medicine for treating hypertension. The blood-pressure-lowering medicine is characterized by being prepared from the following raw materials in parts by weight: 20-30 parts of tuber fleeceflower root, 15-25 parts of hawthorn fruit, 10-20 parts of danshen root, 7-9 parts of panax notoginseng, 7-9 parts of peppermint, 6-8 parts of eucommia bark, 3-5 parts of green tea leaves, 3-5 parts of nacre, 1-3 parts of Chinese taxillus twig and 1-3 parts of Chinese wolfberry. The blood-pressure-lowering medicine disclosed by the invention is mild and durable in action; by virtue of clinical application, the blood-pressure-lowering medicine has the functions of lowering blood pressure, reducing blood fat and promoting peaceful sleeping; and patients can feel comfortable in a blood pressure control process, and the blood-pressure-lowering medicine especially has significant curative effects on hypertension.

The invention discloses tealeaf polypeptide having ACE inhibitory activity and application thereof, and belongs to the technical field of bio-medicines. An amino acid sequence of the tealeaf polypeptide is Ile-Gln-Asp-Lys-Glu-Gly-Ile-Pro-Pro-Asp-Gln-Gln-Arg. ACE inhibitory peptide is obtained through separating the tealeaf polypeptide from striped red tealeaves; the study on enzyme kinetics determines that the tealeaf polypeptide has stronger ACE inhibitory activity, Lineweaver-Burk plot is drawn to define action ways; polypeptide is uncompetitive inhibition, and the inhibition type is very seldom seen in food source ACE inhibitory peptide, and is a good material which develops and researches multi-target point hypotensor medicines, and the tealeaf polypeptide can be used as an important component of a medicine or a health care product for treating and/or preventing hypertension diseases and cardiovascular diseases; therefore, the tealeaf polypeptide has a good development value and an application prospect on development and research of cardiovascular medicines.