Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for prolonging antihypertensive effect time

A technology of drug effect time and blood pressure lowering, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of mild effect and long effective blood pressure reduction time, and achieve the effect of prolonging drug effect time

Inactive Publication Date: 2017-08-04
JIANGSU UNIV
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with captopril, soybean antihypertensive peptide reduces systolic blood pressure less than captopril, but has mild effect and effective antihypertensive duration for a long time. , 2009)
[0006] Captopril and soybean antihypertensive peptides have their own advantages and disadvantages in terms of blood pressure lowering effects, but there is no report on the use of antihypertensive peptides and captopril to prolong the antihypertensive effect of captopril.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] One-time gavage test: Take captopril and soybean antihypertensive peptide and mix it at a mass ratio of 8:2 (mass ratio), and use normal saline as a solvent to prepare a captopril-soybean antihypertensive peptide mixed solution at 15 mg / mL. Rats were intragastrically administered at a dose of 30 mg / kg·bw. After intragastric administration, the systolic blood pressure of the rats was measured every 1 hour, and the average value was taken for three consecutive measurements. The effective time to lower blood pressure was 7.46±0.38 h. Compared with the control 1 captopril group, the efficacy time was extended by 0.68 h, and compared with the control 2 soybean hypotensive peptide group, the efficacy time was extended by 0.30 h.

Embodiment 2

[0035] One-time gavage test: Take captopril and soybean antihypertensive peptide and mix it at a mass ratio of 7:3 (mass ratio), and use normal saline as a solvent to prepare a captopril-soyhypertensive peptide mixed solution at 15 mg / mL. Rats were intragastrically administered at a dose of 30 mg / kg·bw. After intragastric administration, the systolic blood pressure of the rats was measured every 1 hour, and the average value was taken for three consecutive measurements. The effective time to lower blood pressure was 7.88±0.28 h. Compared with the control 1 captopril group, the efficacy time was extended by 1.10 h, and compared with the control 2 soybean hypotensive peptide group, the efficacy time was extended by 0.72 h.

Embodiment 3

[0037] One-time gavage test: Take captopril and soybean antihypertensive peptide and mix it at a mass ratio of 6:4 (mass ratio), and use normal saline as a solvent to prepare a captopril-soybean antihypertensive peptide mixed solution at 15 mg / mL. Rats were intragastrically administered at a dose of 30 mg / kg·bw. After intragastric administration, the systolic blood pressure of the rats was measured every 1 hour, and the average value was taken for three consecutive measurements. The effective time to lower blood pressure was 7.93±0.36 h. Compared with the control 1 captopril group, the efficacy time was extended by 1.15 h, and compared with the control 2 soybean hypotensive peptide group, the efficacy time was extended by 0.77 h.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for prolonging antihypertensive effect time of captopril and belongs to the field of antihypertensive drugs. Captopril and soybean antihypertensive peptides are mixed at a certain ratio and then are used. According to the method, the purpose of guaranteeing the antihypertensive effect of the captopril while prolonging the antihypertensive effect time is achieved and the defects of violent effect and short effect time of captopril are overcome. The method has the advantages of mild effect and longer antihypertensive effect time.

Description

Technical field [0001] The invention belongs to the field of blood pressure lowering drugs, and specifically relates to a method for prolonging the effect time of captopril for lowering blood pressure. Background technique [0002] Hypertension is a high-risk chronic disease with elevated arterial blood pressure as the main manifestation. It has a high incidence at all ages and ranks first in the cause of death. According to the survey data of the World Health Organization (WHO), about one-third of adults in the world suffer from hypertension, which accounts for 12.8% of all deaths worldwide. Among them, Angiotensin I-converting enzyme (ACE, EC 3.4.15.1) plays a key role in the blood pressure regulation system. Human blood pressure is mainly regulated by two antagonistic systems, the renin-angiotensin system and the kinin-kallikrein system. Renin converts angiotensinogen into angiotensin I, and angiotensin converting enzyme (ACE) converts angiotensin I into angiotensin II. Ang...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/01A61P9/12A61K31/401
CPCA61K31/401A61K38/011A61K2300/00
Inventor 王禹程马海乐李云亮杨雪黄姗芬陆峰赵丽霞魏康
Owner JIANGSU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com