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222 results about "Hydrophilic-lipophilic balance" patented technology

The hydrophilic-lipophilic balance of a surfactant is a measure of the degree to which it is hydrophilic or lipophilic, determined by calculating values for the different regions of the molecule, as described by Griffin in 1949 and 1954. Other methods have been suggested, notably in 1957 by Davies.

Vaccine formulations

The present invention provides for a novel oil-in-water (O / W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified or weakly purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group comprising an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof. In one embodiment, the present invention provides for an injectable oil-in-water (O / W) emulsion comprising: (1) an aqueous solution containing an immunogen, said immunogen selected from the group comprising an inactivated Mycoplasma hyopneumoniae bacterium, an inactivated porcine circovirus type 2 (PCV-2) virus or combinations thereof; (2) a mineral oil; (3) a non-ionic lipophilic surfactant; and (4) a non-ionic hydrophilic surfactant having a low HLB value which comprises ethoxylated fatty acid diesters of sorbitan (generally having HLB value between 11 and 13). In another preferred embodiment, the present invention provides for an injectable oil-in-water (O / W) emulsion comprising: (1) an aqueous solution containing an immunogen; (2) a non-ionic hydrophilic surfactant having a high hydrophilic-lipophilic balance (HLB) value greater than 13 and less than 40, in particular HLB≧13.5, and preferably HLB≧14; (3) a mineral oil; (4) a non-ionic lipophilic surfactant; and (5) a non-ionic hydrophilic surfactant having a low HLB value (HLB value of about 9 to about 13).
Owner:MERIAL INC

Barrier film

A barrier composition which is injection mouldable and able to be made into a transparent film or incorporated (by co-extrusion and/or lamination) into multi-layer film products, the composition on dry basis: a) from 45 to 90% by weight of a starch and/or a modified starch selected from starches modified by reaction with a hydroxyl alkyl group, an acetate or a dicarboxylic acid anhydride or a grafting polymer; b) from 4 to 12% by weight of a water soluble polymer selected from polyvinyl alcohol, polyvinylacetate, and copolymers of ethylene and vinylalcohol which have a melting point compatible with the molten state of the starch components c) from 5 to 45% by weight of a non-crystallising mixture of sorbitol and at least one other plasticizer selected from glycerol, maltitol, xylitol, mannitol, glycerol trioleate, epoxidised linseed or soybean oil, tributyl citrate, acetyl tri-ethyl citrate, glyceryl triacetate, 2,2,4-trimethyl-1,3-pentanediol diisobutyrate; polyethylene oxide or polyethylene glycol; d) from 0.3 to 2.5 % by weight of a C12-22 fatty acid or salt; e) from 0.25% to 3% of an emulsifier system having a hydrophilic lipophilic balance value between 2 and 10. The barrier film may be co-injection moulded with polyethylene terephthalate (PET) or polylactic acid (PLA) for blow moulding into beverage bottles, with polyethylene (PE) or polypropylene (PP) or biodegradable polymers for high gas-barrier containers or closures, or may be co-extruded with polyethylene, polypropylene or polylactic acid for thin film packaging applications or for blow-moulded containers.
Owner:PLANTIC TECH

Barrier film

A barrier composition which is injection mouldable and able to be made into a transparent film or incorporated (by co-extrusion and / or lamination) into multi-layer film products, the composition on dry basis: a) from 45 to 90% by weight of a starch and / or a modified starch selected from starches modified by reaction with a hydroxyl alkyl group, an acetate or a dicarboxylic acid anhydride or a grafting polymer; b) from 4 to 12% by weight of a water soluble polymer selected from polyvinyl alcohol, polyvinylacetate, and copolymers of ethylene and vinylalcohol which have a melting point compatible with the molten state of the starch components c) from 5 to 45% by weight of a non-crystallising mixture of sorbitol and at least one other plasticizer selected from glycerol, maltitol, xylitol, mannitol, glycerol trioleate, epoxidised linseed or soybean oil, tributyl citrate, acetyl tri-ethyl citrate, glyceryl triacetate, 2,2,4-trimethyl-1,3-pentanediol diisobutyrate; polyethylene oxide or polyethylene glycol; d) from 0.3 to 2.5% by weight of a C12-22 fatty acid or salt; e) from 0.25% to 3% of an emulsifier system having a hydrophilic lipophilic balance value between 2 and 10. The barrier film may be co-injection moulded with polyethylene terephthalate (PET) or polylactic acid (PLA) for blow moulding into beverage bottles, with polyethylene (PE) or polypropylene (PP) or biodegradable polymers for high gas-barrier containers or closures, or may be co-extruded with polyethylene, polypropylene or polylactic acid for thin film packaging applications or for blow-moulded containers.
Owner:PLANTIC TECH

Preparation of double-long-chain non-ionic oil-removing surfactant and applications

The invention relates to a preparation of a double-long-chain non-ionic oil-removing surfactant and applications, belonging to colloid and interface chemistry fields. In the invention, by reacting fatty alcohol with chloropropylene oxide and ethylene oxide, a novel non-ionic surfactant-double-long-chain alkyl glyceryl ether ethoxy compound is prepared. The surfactant has excellent chemical stability, acid and alkali resistance and inorganic electrolyte, wherein the hydrophile lipophile balance can be regulated by controlling alkyl chain length of the raw material fatty alcohol and ethylene oxide number of added on each molecule. The surfactant has big saturation adsorption quantity on a water/air and oil/water interface, thereby high efficiency reducing a tensile force of a crude oil/water interface. The surfactant can be matched to other surfactants, wherein a mol fraction of the surfactant is 0.1-0.5, and a total mass fraction of the surfactant is in a range of 0.05-0.5%, under an oil reservoir temperature 45 DEG C, the interface tension force of Daqing crude oil/stratum water is reduced to 10-3mN/m order of magnitude, without addition of any acid salt, basic salt, neutral electrolyte and cosurfactant. Therefore, the surfactant is suitable for being used as an alkali-free oil displacement agent.
Owner:JIANGNAN UNIV

Coenzyme Q10 self-emulsifying composition, preparation method and application thereof

The invention discloses a coenzyme Q10 self-emulsifying composition, a preparation method and the application thereof. The composition comprises the components with the mass parts: 0.5-20 parts of coenzyme Q10, more than 0 parts and less than or equal to 30 parts of medium chain fatty acid triglycercide, 0.5-50 parts of phospholipid, 5-50 parts of surface active agent and 10-60 parts of latent solvent; wherein the surface active agent has the hydrophile-lipophile balance value being more than 10, and the latent solvent is alcohol having 1-3 carbon atoms in a carbon chain. The components are heated at the temperature of 50-55 DEG C and stirred to be evenly mixed, so that the coenzyme Q10 self-emulsifying composition can be obtained; the whole preparation process requires to be kept in dark place. The coenzyme Q10 self-emulsifying composition can be fully self-emulsified to form nano-emulsion with the grain diameter of below 200nm in aqueous medium, so that the problem of insolubility of the coenzyme Q10 can be solved; meanwhile, the bioavailability and the stability of the coenzyme Q10 are obviously improved, so that the coenzyme Q10 self-emulsifying composition can be used for the drugs, health-care foods and cosmetic additive which take the coenzyme Q10 as active ingredient.
Owner:苏州国纳生物技术有限公司

Detection method for simultaneously measuring residue of nitroimidazoles drugs in royal jelly

The invention relates to a method for measuring the residue of nitroimidazoles drugs in royal jelly, in particular to a method for measuring the residue of nitroimidazoles drugs, such as 1-(2-hydroxyethyl)-2-hydroxy-methyl-5-nitroimidazol (MNZOH), 2-methyl-5-nitroimidazole, 2-hydroxymethyl-1-methyl-5-nitroimidazole (DMZOH / HMMNI), metronidazole (MNZ), dimetridazole (DMZ), ronidazole (RNZ), 5-chloro-1-methyl-4-nitroimidazole, 5-nitrobenzimidazole, 2-(2'-hydroxyisopropyl)-1-methyl-5-nitroimidazol (IPZOH), 2-isopropyl-1-methyl-5-nitroimidazol (Ipronidazole, IPZ) and the like, in the royal jelly by the liquid chromatography-mass spectrometry / mass spectrometer (LC-MS / MS). The method comprises the following steps: precipitating protein by methanol; extracting; further carrying out the purification using HLB (hydrophilic-lipophilic balance) and C18 solid-phase extraction (SPE) columns; and measuring the residue by LC-MS / MS. The invention has the characteristics of high specificity, high sensitivity and accurate results, and allows for the measurement of both the nitroimidazoles original drugs and the metabolites thereof; the lower limit of detection (10 mug / kg) in the method meets the existing requirements for the residue of nitroimidazoles drugs in the royal jelly at home and aboard; the recovery rate ranges from 70.7% to 105.0%; and the relative standard deviation (RSD) is lower than 12.7%.
Owner:THE INSPECTION & QUARANTINE TECH CENT ZHEJIANG ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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