Coenzyme Q10 self-emulsifying composition, preparation method and application thereof

A self-emulsification and composition technology, applied in the field of medicine, can solve problems such as affecting the efficacy and safety of drugs, coenzyme Q10 is insoluble in water, and cannot avoid first-pass effect, etc., so as to enhance human immunity and increase skin penetration. effect on the protection of fragile skin

Inactive Publication Date: 2009-12-09
苏州国纳生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes how certain substances like caffeine have antihypertensive properties that help reduce blood pressure without causing damage on your heart's own vasculature. These chemical agents also work better when taken together during exercise activities compared to just one single agent alone. They make them easier to store up overnight at room temperature while still being able to release their benefits quickly through various methods including mixing different types of oil solutions containing these compounds.

Problems solved by technology

This patents discuss various technical solutions involving enzymatic activity called coenzymer transferase (CNT) involved in regulating biology processes like energy production, blood clotting, inflammation, weather resistance, gene expression modulation, signal transduction pathways, growth factor release, protein synthesis, carboxyside transport systems, iron regulators, prosthetic functions associated with these therapies, and potential uses in medicine. These technologies aim to provide stable formulations of cozotransferrin complex(CCQ).

Method used

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  • Coenzyme Q10 self-emulsifying composition, preparation method and application thereof
  • Coenzyme Q10 self-emulsifying composition, preparation method and application thereof
  • Coenzyme Q10 self-emulsifying composition, preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1, the preparation of coenzyme Q10 self-emulsifying composition

[0033] prescription:

[0034] Coenzyme Q10 0.5g

[0035] Lecithin 10g

[0036] Caprylic / Capric Triglycerides 5g

[0037] Tween 80 35g

[0038] Glycerin 33g

[0039] Propylene glycol 16.5g

[0040]

[0041] Made into 100g

[0042] Preparation method:

[0043] Stir Coenzyme Q10, Lecithin, Caprylic / Capric Triglyceride, Tween 80, Glycerin, and Propylene Glycol in a water bath at 50-55°C according to the prescription amount (protected from light and N2), mix well, and filter to obtain Coenzyme Q10 self-emulsifying composition. The composition is emulsified with an aqueous phase medium (physiological saline) to obtain coenzyme Q10 nanoemulsion. Under the condition of 25±0.1° C., the particle size of the nanoemulsion was measured with a ZetaPALS laser dynamic light scattering instrument (Brookhaven Instrument Company, USA), and the effective par...

Embodiment 2

[0044] Embodiment 2, the preparation of coenzyme Q10 self-emulsifying composition

[0045] prescription:

[0046] Coenzyme Q10 5g

[0047] 53MCT 20g

[0048] Caprylic Capric Triglyceride 10g

[0049] HS15 40g

[0050] Glycerin 15g

[0051] Propylene glycol 10g

[0052]

[0053] Made into 100g

[0054] Preparation method:

[0055] Stir coenzyme Q10, 53MCT (Phospholipid company, Germany), caprylic / capric triglyceride, HS15 (BASF company, Germany), glycerin, and propylene glycol in a water bath at 50-55°C according to the formula amount (protected from light and protected by N2) , mix evenly, and filter to obtain the coenzyme Q10 self-emulsifying composition. The composition was emulsified with an aqueous medium, and its effective particle size was detected to be 15.5 nm.

Embodiment 3

[0056] Embodiment 3, the preparation of coenzyme Q10 self-emulsifying composition

[0057] prescription:

[0058] Coenzyme Q10 5g

[0059] 53MCT 25g

[0060] Caprylic Capric Triglyceride 15g

[0061] Tween 20 25g

[0062] Glycerin 20g

[0063] Propylene glycol 10g

[0064]

[0065] Made into 100g

[0066] Preparation method:

[0067] Stir coenzyme Q10, 53MCT (Phospholipid company, Germany), caprylic / capric triglyceride, Tween 20, glycerin, and propylene glycol in a water bath at 50-55°C (protected from light, with N2 protection), and mix evenly according to the formula amount. Filter to obtain the coenzyme Q10 self-emulsifying composition. The composition was emulsified with an aqueous medium, and its effective particle size was detected to be 24.0 nm.

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Abstract

The invention discloses a coenzyme Q10 self-emulsifying composition, a preparation method and the application thereof. The composition comprises the components with the mass parts: 0.5-20 parts of coenzyme Q10, more than 0 parts and less than or equal to 30 parts of medium chain fatty acid triglycercide, 0.5-50 parts of phospholipid, 5-50 parts of surface active agent and 10-60 parts of latent solvent; wherein the surface active agent has the hydrophile-lipophile balance value being more than 10, and the latent solvent is alcohol having 1-3 carbon atoms in a carbon chain. The components are heated at the temperature of 50-55 DEG C and stirred to be evenly mixed, so that the coenzyme Q10 self-emulsifying composition can be obtained; the whole preparation process requires to be kept in dark place. The coenzyme Q10 self-emulsifying composition can be fully self-emulsified to form nano-emulsion with the grain diameter of below 200nm in aqueous medium, so that the problem of insolubility of the coenzyme Q10 can be solved; meanwhile, the bioavailability and the stability of the coenzyme Q10 are obviously improved, so that the coenzyme Q10 self-emulsifying composition can be used for the drugs, health-care foods and cosmetic additive which take the coenzyme Q10 as active ingredient.

Description

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Claims

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Application Information

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Owner 苏州国纳生物技术有限公司
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