116 results about "Self emulsifying" patented technology

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

A pharmaceutical formulation comprising a self-emulsifying drug delivery system comprising dydrogesterone or a pharmaceutically acceptable salt thereof, as well as methods of making and using the same.

An orally dissolvable or chewable tableted powder formulation is presented. The formulation includes one or more carrier systems including one or more liquid or solid self-emulsifying systems loaded with cannabinoids in an amount of at least 10% by weight of the tableted powder formulation. The one or more self-emulsifying systems includes: at least one or more surfactants, one or more lipids and one or more isolated or synthetic cannabinoids when self-emulsifying system is a liquid self-emulsifying system, and at least one or more surfactants, one or more waxes and one or more isolated or synthetic cannabinoids when self-emulsifying system is a solid self-emulsifying system. The formulation further includes one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation and one or more flavors. The one or more surfactants includes one or more surfactants having a chemical structure that includes a polyethylene glycol moiety.

The invention discloses a self-emulsifying adjuvant of a vaccine and a preparation method of the self-emulsifying adjuvant, and relates to the technical field of vaccine adjuvants. The adjuvant comprises an oil phase, an emulsifier and a freeze-drying protective agent, the oil phase comprises squalene and tocopherol, the emulsifier comprises polysorbate and a polyoxyethylene-polyoxypropylene block copolymer, and the freeze-drying protective agent comprises sugar and sugar alcohol. The preparation method comprises the following steps: emulsifying an oil phase and a water phase to form a nano-emulsion, and then freeze-drying to obtain freeze-dried powder. The adjuvant has the advantages of small particle size, uniform distribution, high stability, rapid reconstruction and the like, and can effectively maintain active components and improve the immune effect of vaccines.

The invention relates to the technical field of chemical oil displacement, and particularly discloses a self-emulsifying nano-composite modifying and flooding agent for an oil field and a preparation process of the self-emulsifying nano-composite modifying and flooding agent. The invention relates to a self-emulsifying nano composite modifying and flooding agent for an oil field. The self-emulsifying nano composite modifying and flooding agent is prepared from the following 100 parts by mass of raw materials: 3-5 parts of amphiphilic nano silicon dioxide, 1-2 parts of a zwitterionic surfactant, 0.5-1 part of a nonionic surfactant and the balance of water, the zwitterionic surfactant comprises hydroxyl sulfobetaine and imidazoline, and the zwitterionic surfactant comprises hydroxyl sulfobetaine and imidazoline; and the non-ionic surface active agent is an ethyoxyl-propoxyl block copolymer. The self-emulsifying nano-composite modifying and flooding agent prepared by the invention effectively realizes the balance of low interfacial tension and self-emulsifying efficiency.

The invention provides silicone wax capable of being self-emulsified into blue light emulsion and a preparation method of the silicone wax. The silicone wax has a general formula of (CH3) 3SiO [(CH3) 2SiO] a [(CH3) (C18-30H37-61) SiO] b [(CH3) (R) SiO] CSi (CH3) 3. The silicone wax capable of being self-emulsified into the blue-light emulsion is self-emulsified to serve as an additive to be applied to water-based paint or printing ink, can be independently used for improving the anti-sticking, wear-resistant and slip-increasing effects of a coating film, and can also be cooperatively used with other synthetic wax or vegetable wax to improve the anti-sticking, wear-resistant and slip-increasing effects of other wax, so that the anti-sticking, wear-resistant and slip-increasing effects of the other wax are improved. And the compounding compatibility and stability of the silicone wax with other waxes are superior to those of the traditional non-self-emulsifying silicone wax. The silicone wax provided by the invention can also be applied to cosmetic substrates, such as eye shadow cream, lipstick, cosmetics and the like, and has the effects of makeup protection, skin moistening, moisture preservation, shaping, lubrication and the like. The silicone wax disclosed by the invention can also be used as a raw material or an auxiliary agent in the application fields of a textile smoothing agent, an internal lubricant for plastic processing, a release agent for rubber and plastic and the like.

The invention discloses a self-emulsifying nervonic acid eye drop, which is prepared from the following raw material components in percentage by mass: 1 to 10 weight percent of nervonic acid, 30 to 60 weight percent of oil phase, 20 to 40 weight percent of surfactant and 10 to 20 weight percent of co-emulsifier, the oil phase is at least one of sunflower seed oil, squalane, olive oil and castor oil. According to the invention, the oil phase rich in unsaturated fatty acid is adopted, so that the eye cream has good solubility to nervonic acid, is mild and low-sensitive, can soften the cuticle of eyes and reduce the permeation resistance of nervonic acid, and is suitable for sensitive periocular skin. The prepared self-emulsifying nervonic acid eye drops overcome the defect that nervonic acid is almost insoluble in water, and compared with water-based eye drops, the self-emulsifying nervonic acid eye drops have the advantage that the drug loading capacity and the stability are obviously improved.

A pharmaceutical formulation comprising a self-emulsifying drug delivery system comprising dydrogesterone or a pharmaceutically acceptable salt thereof, as well as methods of making and using the same.

The invention relates to the technical field of cathode electrophoretic paint, and discloses an asymmetric double-blocked isocyanate curing agent as well as a preparation method and application thereof. Based on the reaction activity difference of primary carbon and secondary carbon NCO groups in isophorone diisocyanate molecules, a step-by-step asymmetric sealing strategy is adopted: in the first stage, a hydrophilic chain extender containing a tertiary amine structure is utilized to preferentially react with high-activity primary carbon NCO, and an internal catalytic center and a hydrophilic group are anchored in a molecular skeleton; and in the second stage, the active methylene compound and the bio-based long-chain phenol are used for carrying out hybrid dual-sealing on the residual secondary carbon NCO with relatively large steric hindrance. According to the preparation of the curing agent, the curing agent integrates internal catalysis, stepped curing and self-emulsifying functions, the deblocking energy barrier is effectively reduced, and 140-DEG C low-temperature curing or high-temperature high-performance curing can be realized under the tin-free catalysis condition.

The invention belongs to the technical field of fine chemical engineering and leather chemicals, and particularly relates to amide wax for self-emulsifying leather as well as a preparation method and application of the amide wax. The preparation method comprises the following steps: mixing a long-chain hydrophobic compound, an amino-containing compound and a metal catalyst, heating, and reacting to obtain a first reaction system; adding hydrophilic polyether and an organic acid catalyst into the first reaction system, heating and reacting to obtain a second reaction system; and vacuumizing the second reaction system to remove residual small molecules and low-boiling-point substances, and cooling to obtain the amide wax for the self-emulsifying leather. The self-emulsifying amide wax for leather has an amphiphilic structure, and can be self-dispersed in hot water to form a stable emulsion without adding an emulsifier. The finishing agent can be anchored with a metal cross-linking agent, endows leather with lasting smooth hand feeling, high fullness and excellent waterproofness, is suitable for finishing a top layer or a middle layer of the leather, and is convenient to apply and environment-friendly.

An orally dissolvable or chewable tableted powder formulation is presented. The formulation includes one or more carrier systems including one or more liquid or solid self-emulsifying systems loaded with cannabinoids in an amount of at least 10% by weight of the tableted powder formulation. The one or more self-emulsifying systems includes: at least one or more surfactants, one or more lipids and one or more isolated or synthetic cannabinoids when self-emulsifying system is a liquid self-emulsifying system, and at least one or more surfactants, one or more waxes and one or more isolated or synthetic cannabinoids when self-emulsifying system is a solid self-emulsifying system. The formulation further includes one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation and one or more flavors. The one or more surfactants includes one or more surfactants having a chemical structure that includes a polyethylene glycol moiety.

The application discloses a self-emulsifying high-wear-resistance vinyl carbon fiber sizing agent composition and a preparation method and application thereof. The application improves the wear resistance of the fiber by reducing the content of rigid groups such as benzene rings and double bonds, introduces hydrophilic groups such as amide bonds and ether bonds, adopts a self-emulsifying technical route, eliminates the weak boundary layer of the interface, and improves the interface performance of the fiber and the vinyl resin, so that the prepared self-emulsifying high-wear-resistance vinyl carbon fiber sizing agent composition has the advantages of self-emulsification, high wear resistance, seawater resistance, excellent carbon fiber composite material interface performance and outstanding smoke resistance, and has a wide application prospect in the preparation of carbon fiber composite materials suitable for marine environments.

The invention relates to the technical field of concrete admixtures, in particular to an emulsion type polycarboxylate superplasticizer and a preparation method thereof. The water reducing agent is formed by polymerizing a modified polyether monomer and a self-reaction type emulsifying monomer through free radical copolymerization under the action of an initiator and a chain transfer agent, the self-reaction type emulsifying monomer combination is composed of A-type monomers, B-type monomers and C-type monomers, or composed of A-type monomers, B-type monomers and D-type monomers, or composed of A-type monomers, C-type monomers and D-type monomers. The water reducing agent does not need to be added with an emulsifier, only the self-reaction type emulsifying monomer needs to be introduced into a reaction system, and the self-emulsifying capacity and high reaction activity of the self-reaction type emulsifying monomer are utilized, so that the air entraining capacity of the polycarboxylic acid water reducing agent in concrete can be improved, the viscosity of the concrete is reduced, and the dispersity of the concrete is improved, and field construction is facilitated; meanwhile, it is guaranteed that the concrete has a good machine discharging state, the problems of bleeding, segregation and bottom grabbing do not occur, the concrete does not have the stone exposure phenomenon, and the wrapping performance is good.

The invention relates to the technical field of high polymer materials, in particular to hydrophilic ice-feeling silicone oil. The invention provides an organic silicon copolymer named as hydrophilic ice-feeling silicone oil, and aims to overcome the limitation of hydrophilic performance, ice-feeling hand feeling, chemical stability and self-emulsifying ability of the existing hydrophilic ice-feeling silicone oil in a complex application environment, especially under harsh conditions of high salinity, strong acid and alkali or long-term use / washing and the like. The organosilicon copolymer is characterized in that the organosilicon copolymer is constructed by synergistically grafting a polyether chain segment and a sulfobetaine zwitterionic chain segment to an epoxy functionalized polydimethylsiloxane main chain; the epoxy functionalized polydimethylsiloxane is prepared from epoxy functionalized polydimethylsiloxane, terminal aminated polyether and a terminal aminated sulphobetaine derivative through a ring-opening addition reaction. Through the scheme, the fabric can be endowed with excellent soft and smooth hand feeling and obvious ice feeling effect, and the lasting stability of hydrophilic performance, excellent chemical stability and self-emulsifying ability can be maintained under the harsh conditions of high salinity, strong acid and alkali or long-term use / washing and the like.

The present disclosure provides cannabinoid formulations, more particularly pharmaceutical formulations which are highly-loaded with cannabinoids. The formulations are suitable for self-emulsifying into emulsions that are characterized by a stable mono-modal narrow droplet size distribution, and suitable for administration to subjects in need of cannabinoids administration for treatment of various conditions.

The application belongs to the technical field of bio-based packaging materials, and particularly relates to a novel double-layer composite film and application thereof. The novel double-layer composite film comprises the following steps: reacting palmitic anhydride and carboxymethyl cellulose to obtain carboxymethyl cellulose palmitate; adding a pH-sensitive natural dye indicator to obtain carboxymethyl cellulose palmitate nanoemulsion containing a pH-sensitive substance; then loading a natural polymer material to prepare a film material; finally adding the film material to the carboxymethyl cellulose palmitate to prepare a composite film, thereby obtaining the novel double-layer composite film. The double-layer composite film can be self-emulsified without adding a surfactant, and has the ability to load functional indicator (pH-sensitive color indicator) substances; meanwhile, the barrier performance of the film material, such as a chitosan film, to water vapor and oxygen is improved, and the double-layer composite film has a very promising application in food or fruit preservation. The method provided by the application is not only green in raw materials, but also uses a flow casting method, which can be applied to industrial production and has a good application prospect.

This invention relates to a fully synthetic aluminum alloy cutting fluid. By weight, the fully synthetic aluminum alloy cutting fluid comprises the following components: a) 5-15 parts of organic acid; b) 10-20 parts of organic alcohol amine; c) 2-11 parts of self-emulsifying ester; d) 0.2-5 parts of corrosion inhibitor; e) 0-3 parts of bactericide; f) 0-0.1 parts of defoamer; h) 52-82 parts of water; wherein the self-emulsifying ester is a reaction product of a second organic acid, a polyol, and a polyether, and the molar ratio of the second organic acid, the polyol, and the polyether is 1:(0.6-1):(0.6-1). The cutting fluid of this invention, through the rational combination of its components and the addition of a specific self-emulsifying ester, can effectively improve the lubricity of water-based cutting fluids while maintaining excellent low-foaming properties. This invention also relates to a method for preparing the fully synthetic aluminum alloy cutting fluid and its applications.

The invention discloses a Cinnamomum longepaniculatum essential oil self-microemulsion drug delivery system and a preparation method thereof, the system comprises an oil phase, an emulsifier and a co-emulsifier, the oil phase is Cinnamomum longepaniculatum essential oil; the system is mutually soluble with water in any proportion to form a transparent micro-blue microemulsion. The preparation method of the Cinnamomum longepaniculatum essential oil self-microemulsion drug delivery system adopts 30 emulsifiers and 8 co-emulsifiers, and comprises the following steps: step 1, preliminary screening of the emulsifiers; step 1.1, carrying out compatibility evaluation; step 1.2, carrying out self-emulsification evaluation; step 2, screening of a co-emulsifier; step 2.1, carrying out compatibility evaluation; step 2.2, carrying out self-emulsification evaluation; and step 3, Km value screening. The Cinnamomum longepaniculatum essential oil self-microemulsion drug delivery system provided by the invention has good stability.

Disclosed are a self-emulsifying composition of a coenzyme Q10 with high bioavailability, and a method and device for preparing the same. The composition includes the following components in percentage by weight: 5-35% of a coenzyme Q10, 1-50% of an oil phase, 10-60% of a surfactant, 1-10% of a cosurfactant, 0-7% of an antioxidant, and 0.5-2% of pyrroloquinoline quinone disodium salt. The coenzyme Q10 medicinal liquid obtained can be kept in a clear and transparent solution state at room temperature, can be stably dispersed in water and self-emulsified to a transparent emulsion, significantly improves the bioavailability of the coenzyme Q10 by more than 4 times, and can be filled in capsules or softgels to swallow. The method disclosed by the disclosure includes two steps: material grinding and vacuum self-emulsifying. The method is concise in step and easy to control. Moreover, the device is simple in structure and low in cost.

Provided is a pharmaceutical composition comprising a sulfonamide derivative represented by the following formula (1), a pharmaceutically acceptable salt thereof, or an active metabolite thereof, and having improved absorbability when orally administered. Disclosed is a self-emulsifying composition comprising: a sulfonamide derivative represented by the following formula (1), a pharmaceutically acceptable salt thereof, or an active metabolite thereof; and at least two solubilizers.

Orally administered pharmaceutical compositions comprising incretin or its analogues or derivatives are presented, which allow for prolonged glycemic control. The formulations presented herein incorporate a self-emulsifying drug delivery system (SEDDS). Advantageously, such formulations provide protection in the upper gastrointestinal tract from proteolytic conditions while allowing for efficient drug release and absorption in the lower gastrointestinal tract.

The subject of the invention is a new system in the form of an instant self-emulsifying powder, their preparation process as well as the application of this oily system associated with one or a mixture of cyclodextrins for the instant formation of a solid spherical system of effervescent or non-self-emulsifying granule or pellet types (Spontaneous Powder Self Emulsifying Drug Delivery Systems (SP-SEDDS®)). And for the encapsulation of a substance of therapeutic interest. Applications to the encapsulation of one or more substances of interest, in particular therapeutic or preventive, nutritional, and usable in pharmacy, veterinary, nutrition or agri-food by oral route.

The invention discloses a self-emulsifying bio-based polyester stabilized multi-class bio-based polymer water-based emulsion as well as a preparation method and application thereof, and belongs to the technical field of bio-based high polymer materials and water-based resin. According to the preparation method disclosed by the invention, a dual-interface synergistic stabilization mechanism is constructed by adopting the self-emulsifying bio-based polyester containing furandicarboxylic acid and the rosin-based component, so that efficient emulsification and interface compatibility of various hydrophobic bio-based film-forming polymers such as polyhydroxyalkanoate and polylactic acid are realized. The emulsion prepared by the invention has excellent storage stability and machining adaptability, maintains extremely high bio-based content and extremely low volatile organic compound residue while remarkably improving the water resistance, oil resistance and gas barrier property of a paper-based coating, and completely meets the safety standard of food contact-grade materials. According to the preparation process, the microstructure of dispersed phase particles is accurately regulated and controlled through phase inversion and high-pressure homogenization, and an ideal green coating solution is provided for high-performance environment-friendly paper-based packaging.

The invention belongs to the field of cancer medicine preparations, and discloses a polycyclic compound oral preparation and a preparation method thereof. The polycyclic compound oral preparation contains a polycyclic compound as shown in a formula I, polyethylene glycol, propylene glycol monooctoate and polyoxyethylene (40) hydrogenated castor oil, wherein the concentration of the polycyclic compound as shown in the formula I is 0.1-80 mg / mL. According to the polycyclic compound oral preparation disclosed by the invention, the solubility of the polycyclic compound shown in the formula I in an aqueous solution is improved, the preparation can obtain a self-emulsifying particle size smaller than 100nm in the aqueous solution, and meanwhile, the polycyclic compound oral preparation has good stability, dissolution rate, oral bioavailability, body tolerance or safety of auxiliary materials, low cost, easiness in production and storage resistance, # imgabs0 #

The invention relates to a needle solution for a double-drug-loading self-emulsifying drug release system and a preparation method thereof.The needle solution is obtained by mixing an SE solution and a water phase, and the SE solution is prepared from an oil phase solution obtained by dissolving a water-insoluble drug 1 in an oil ester organic solvent and a hydrotropy solution, the hydrotropy solution is a mixed solution of an emulsifier and a co-emulsifier; the water phase is an aqueous solution obtained by dissolving a water-soluble medicine 2 into water, and HA, Dex or Chs are added into the aqueous solution. The invention also relates to a drug-loaded soluble microneedle obtained from the needle solution, and also provides an application of the double drug-loaded soluble microneedle in preparation of drugs for treating gouty arthritis. The double-drug-loading microneedle prepared by the invention can obviously improve the corrosion speed in the skin and quickly release the drug, can play a role in promoting the drug permeation after being combined with the ultrasonic action, and can play a role in controlled release by controlling the demulsification release of the drug by utilizing the mechanical action of the ultrasonic.

This invention provides a method for enhanced geological sequestration of carbon dioxide through self-emulsification. The method includes: establishing an injection well in a seafloor sedimentary layer; injecting a penicillin-based chemical agent and CO2 into the seafloor sedimentary layer through the injection well; the CO2 carrying the penicillin-based chemical agent and seawater fluid flowing within the sediments of the seafloor sedimentary layer, whereby the CO2 undergoes self-emulsification to form a water-in-water CO2 microemulsion; under the impetus of injection pressure and buoyancy, the mixed fluid containing the water-in-water CO2 microemulsion displaces pore seawater and diffuses within the seafloor sedimentary layer, achieving geological sequestration of carbon dioxide. This method, by injecting the penicillin-based chemical agent and CO2 into the target layer, enables the CO2 to undergo self-emulsification within the target seafloor layer, transforming the pore fluid into a water-in-water CO2 microemulsion with good dispersibility and stability, thereby improving displacement capacity and sweep range.

The invention relates to the technical field of nursing materials, in particular to preparation and application of hydrophilic PU bamboo charcoal dead sea salt self-cleaning bath sponge which is prepared by mixing and foaming a component A and a component B at a high speed. The material A is a water-based emulsified material and comprises the following components in parts by weight: 55-75 parts of water, 1-3 parts of a pore opening agent, 10-15 parts of a surfactant, 0.2-0.5 part of aloe essence, 5-8 parts of glycerol, 6-10 parts of a self-emulsifying agent, 6-8 parts of dead sea salt, 4-7 parts of bamboo charcoal powder and 0.1-0.3 part of nano silver ions; and the material B is hydrophilic polyurethane. A component A and a component B are mixed at a high speed according to a certain proportion through a double-component polyurethane foaming machine, foaming and drying are conducted, the surface of a product is smooth, the interior of the product is of a honeycomb structure, and rich foam can be released when the product is cleaned; the product has the characteristics that the product has a bath cleaning function, the bamboo charcoal / dead sea salt improves the skin surface, the product is easy to degrade after being abandoned, and the nano silver ions serving as the antibacterial agent are efficient and durable.

The application relates to the field of daily chemical personal care, in particular to a hydrophilic modified organic silicone elastomer with moisturizing performance and a preparation method thereof, which comprises the following components: a polysiloxane containing at least three Si-H units in the molecule; a divinyl-terminated polysiloxane; a hyaluronic acid-modified monovinyl polysiloxane; a polyethylene glycol-modified vinyl polysiloxane; a carrier fluid; and a platinum metal catalyst for silicon hydrogen addition. The organic silicone elastomer is hydrophilically modified by introducing hyaluronic acid fragments and polyethylene glycol segments, the moisturizing performance of the organic silicone elastomer is improved, the organic silicone elastomer can effectively enhance the moisturizing feeling of skin in cosmetic application, and dryness and tightness are reduced. The modified elastomer has good self-emulsifying properties, can easily form a stable gel system in a water-based or water-containing formula, simplifies the emulsification process, and improves the applicability and stability of the formula.

The invention relates to the technical field of functional modification of epoxy resin, in particular to self-emulsifying waterborne epoxy resin, emulsion and a preparation method. In the self-emulsifying water-borne epoxy resin provided by the invention, a hydrophilic polylysine chain segment with antibacterial ability is grafted into a hydrophilic polyethylene glycol chain segment, then an amino group is obtained on a side chain of the polylysine chain segment, and then the amino group is further reacted with an aldehyde acid compound, so that the amino group is connected with an aldehyde group, and the self-emulsifying water-borne epoxy resin is obtained. And finally, grafting the epoxy resin polymer to the carboxyl to obtain the self-emulsified water-borne epoxy resin. The emulsion has good emulsion stability and antibacterial ability.