150 results about "Self emulsifying" patented technology

The invention relates to the technical field of carbon fiber sizing agents, in particular to a preparation method and application of a self-emulsifying cationic waterborne polyurethane emulsion sizing agent. The preparation method comprises the following steps: firstly, preparing the cationic waterborne polyurethane emulsion by adopting a self-emulsifying method, then mixing the cationic waterborne polyurethane emulsion with the lubricant, the surfactant and the coupling agent, adding distilled water, and stirring and diluting to prepare the sizing agent. According to the cationic waterborne polyurethane emulsion prepared by the method disclosed by the invention, the performance of the emulsion is improved, and the cationic waterborne polyurethane emulsion can be prepared by changing different synthesis raw materials, the ratio of the raw materials and the content of a solid intermediate and introducing a nano SiO2 structure. The emulsion has different hydrophilicity and lipophilicity, different particle sizes and different heat resistance degrees, is applied to fiber production with different requirements, and has the properties of improving the chemical bonding property and wettability of a resin and fiber interface, improving the tensile strength of fibers, enhancing the interlaminar shear strength of composite materials and the like.

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

A pharmaceutical formulation comprising a self-emulsifying drug delivery system comprising dydrogesterone or a pharmaceutically acceptable salt thereof, as well as methods of making and using the same.

The invention relates to a preparation method and application of a probiotic-drug co-delivery oral self-emulsifying agent, which can effectively solve the problems of preparation of the probiotic-drug co-delivery oral self-emulsifying agent and application of the probiotic-drug co-delivery oral self-emulsifying agent in drugs for treating atherosclerosis. Span80 and Cremophor RH40 are used as a compound emulsifier, PEG400 is used as a co-emulsifier, Res is used as a model drug, L.P resuspended by skim milk powder is used as an internal water phase, FA is used as a target head, a water-in-oil type targeted self-emulsifying preparation is constructed, after the water-in-oil type targeted self-emulsifying preparation is orally taken into an intestinal tract, the water-in-oil type targeted self-emulsifying preparation can be subjected to self-emulsifying phase inversion to form an oil-in-water type nano-emulsion, lactobacillus plantarum of the internal water phase is released and colonized in a gastrointestinal tract, different targets are co-delivered, synergistic interaction is achieved, and the water-in-oil type targeted self-emulsifying preparation is prepared. The preparation method is simple, production and preparation are easy, the biocompatibility is good, the medicine is an innovation in the aspect of medicine for treating atherosclerosis, and the economic and social benefits are remarkable.

An orally dissolvable or chewable tableted powder formulation is presented. The formulation includes one or more carrier systems including one or more liquid or solid self-emulsifying systems loaded with cannabinoids in an amount of at least 10% by weight of the tableted powder formulation. The one or more self-emulsifying systems includes: at least one or more surfactants, one or more lipids and one or more isolated or synthetic cannabinoids when self-emulsifying system is a liquid self-emulsifying system, and at least one or more surfactants, one or more waxes and one or more isolated or synthetic cannabinoids when self-emulsifying system is a solid self-emulsifying system. The formulation further includes one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation and one or more flavors. The one or more surfactants includes one or more surfactants having a chemical structure that includes a polyethylene glycol moiety.

The invention discloses a self-emulsifying adjuvant of a vaccine and a preparation method of the self-emulsifying adjuvant, and relates to the technical field of vaccine adjuvants. The adjuvant comprises an oil phase, an emulsifier and a freeze-drying protective agent, the oil phase comprises squalene and tocopherol, the emulsifier comprises polysorbate and a polyoxyethylene-polyoxypropylene block copolymer, and the freeze-drying protective agent comprises sugar and sugar alcohol. The preparation method comprises the following steps: emulsifying an oil phase and a water phase to form a nano-emulsion, and then freeze-drying to obtain freeze-dried powder. The adjuvant has the advantages of small particle size, uniform distribution, high stability, rapid reconstruction and the like, and can effectively maintain active components and improve the immune effect of vaccines.

The invention relates to the technical field of chemical oil displacement, and particularly discloses a self-emulsifying nano-composite modifying and flooding agent for an oil field and a preparation process of the self-emulsifying nano-composite modifying and flooding agent. The invention relates to a self-emulsifying nano composite modifying and flooding agent for an oil field. The self-emulsifying nano composite modifying and flooding agent is prepared from the following 100 parts by mass of raw materials: 3-5 parts of amphiphilic nano silicon dioxide, 1-2 parts of a zwitterionic surfactant, 0.5-1 part of a nonionic surfactant and the balance of water, the zwitterionic surfactant comprises hydroxyl sulfobetaine and imidazoline, and the zwitterionic surfactant comprises hydroxyl sulfobetaine and imidazoline; and the non-ionic surface active agent is an ethyoxyl-propoxyl block copolymer. The self-emulsifying nano-composite modifying and flooding agent prepared by the invention effectively realizes the balance of low interfacial tension and self-emulsifying efficiency.

The invention provides silicone wax capable of being self-emulsified into blue light emulsion and a preparation method of the silicone wax. The silicone wax has a general formula of (CH3) 3SiO [(CH3) 2SiO] a [(CH3) (C18-30H37-61) SiO] b [(CH3) (R) SiO] CSi (CH3) 3. The silicone wax capable of being self-emulsified into the blue-light emulsion is self-emulsified to serve as an additive to be applied to water-based paint or printing ink, can be independently used for improving the anti-sticking, wear-resistant and slip-increasing effects of a coating film, and can also be cooperatively used with other synthetic wax or vegetable wax to improve the anti-sticking, wear-resistant and slip-increasing effects of other wax, so that the anti-sticking, wear-resistant and slip-increasing effects of the other wax are improved. And the compounding compatibility and stability of the silicone wax with other waxes are superior to those of the traditional non-self-emulsifying silicone wax. The silicone wax provided by the invention can also be applied to cosmetic substrates, such as eye shadow cream, lipstick, cosmetics and the like, and has the effects of makeup protection, skin moistening, moisture preservation, shaping, lubrication and the like. The silicone wax disclosed by the invention can also be used as a raw material or an auxiliary agent in the application fields of a textile smoothing agent, an internal lubricant for plastic processing, a release agent for rubber and plastic and the like.

The invention discloses a self-emulsifying nervonic acid eye drop, which is prepared from the following raw material components in percentage by mass: 1 to 10 weight percent of nervonic acid, 30 to 60 weight percent of oil phase, 20 to 40 weight percent of surfactant and 10 to 20 weight percent of co-emulsifier, the oil phase is at least one of sunflower seed oil, squalane, olive oil and castor oil. According to the invention, the oil phase rich in unsaturated fatty acid is adopted, so that the eye cream has good solubility to nervonic acid, is mild and low-sensitive, can soften the cuticle of eyes and reduce the permeation resistance of nervonic acid, and is suitable for sensitive periocular skin. The prepared self-emulsifying nervonic acid eye drops overcome the defect that nervonic acid is almost insoluble in water, and compared with water-based eye drops, the self-emulsifying nervonic acid eye drops have the advantage that the drug loading capacity and the stability are obviously improved.

The invention discloses a traditional Chinese medicine self-emulsifying ointment, which takes water and / or ethanol as a solvent, and comprises 6-26 wt% of a solvent, 1-4 wt% of a traditional Chinese medicine extract and 70-90 wt% of an anhydrous plant-based semi-solid self-emulsifying matrix, and the anhydrous plant-based semi-solid self-emulsifying matrix comprises 30-45 wt% of anhydrous plant-based oil, 10-25 wt% of an emulsifier, 10-25 wt% of a co-emulsifier and 10-25 wt% of a thickener. According to the traditional Chinese medicine self-emulsifying ointment, the traditional Chinese medicine extract has good dispersity in the anhydrous plant-based semi-solid self-emulsifying matrix and does not have obvious crystals, the prepared traditional Chinese medicine self-emulsifying ointment is good in drug release performance, and the particle size is smaller than or equal to 150 microns. The invention further discloses a traditional Chinese medicine semi-solid spray which comprises the traditional Chinese medicine self-emulsifying ointment and a propellant, and the mass ratio of the traditional Chinese medicine self-emulsifying ointment to the propellant is (1-3): 1. The uniform and stable anhydrous semisolid antibiotic spray preparation is obtained by adjusting different proportions of the propellant and the traditional Chinese medicine self-emulsifying ointment.

A pharmaceutical formulation comprising a self-emulsifying drug delivery system comprising dydrogesterone or a pharmaceutically acceptable salt thereof, as well as methods of making and using the same.

The invention relates to the technical field of cathode electrophoretic paint, and discloses an asymmetric double-blocked isocyanate curing agent as well as a preparation method and application thereof. Based on the reaction activity difference of primary carbon and secondary carbon NCO groups in isophorone diisocyanate molecules, a step-by-step asymmetric sealing strategy is adopted: in the first stage, a hydrophilic chain extender containing a tertiary amine structure is utilized to preferentially react with high-activity primary carbon NCO, and an internal catalytic center and a hydrophilic group are anchored in a molecular skeleton; and in the second stage, the active methylene compound and the bio-based long-chain phenol are used for carrying out hybrid dual-sealing on the residual secondary carbon NCO with relatively large steric hindrance. According to the preparation of the curing agent, the curing agent integrates internal catalysis, stepped curing and self-emulsifying functions, the deblocking energy barrier is effectively reduced, and 140-DEG C low-temperature curing or high-temperature high-performance curing can be realized under the tin-free catalysis condition.

The invention belongs to the technical field of fine chemical engineering and leather chemicals, and particularly relates to amide wax for self-emulsifying leather as well as a preparation method and application of the amide wax. The preparation method comprises the following steps: mixing a long-chain hydrophobic compound, an amino-containing compound and a metal catalyst, heating, and reacting to obtain a first reaction system; adding hydrophilic polyether and an organic acid catalyst into the first reaction system, heating and reacting to obtain a second reaction system; and vacuumizing the second reaction system to remove residual small molecules and low-boiling-point substances, and cooling to obtain the amide wax for the self-emulsifying leather. The self-emulsifying amide wax for leather has an amphiphilic structure, and can be self-dispersed in hot water to form a stable emulsion without adding an emulsifier. The finishing agent can be anchored with a metal cross-linking agent, endows leather with lasting smooth hand feeling, high fullness and excellent waterproofness, is suitable for finishing a top layer or a middle layer of the leather, and is convenient to apply and environment-friendly.

An orally dissolvable or chewable tableted powder formulation is presented. The formulation includes one or more carrier systems including one or more liquid or solid self-emulsifying systems loaded with cannabinoids in an amount of at least 10% by weight of the tableted powder formulation. The one or more self-emulsifying systems includes: at least one or more surfactants, one or more lipids and one or more isolated or synthetic cannabinoids when self-emulsifying system is a liquid self-emulsifying system, and at least one or more surfactants, one or more waxes and one or more isolated or synthetic cannabinoids when self-emulsifying system is a solid self-emulsifying system. The formulation further includes one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation and one or more flavors. The one or more surfactants includes one or more surfactants having a chemical structure that includes a polyethylene glycol moiety.

The invention discloses a cholic acid derivative as well as a preparation method and application thereof. The cholic acid derivative is prepared by the following steps: dissolving bile acid in vinyl ethyl ether, adding a catalyst, reacting at room temperature, removing acidic components and byproducts, filtering, evaporating and drying. Vinyl ethyl ether is used for modifying carboxyl side chains and hydroxyl groups of bile acid, so that the bile acid is endowed with higher hydrophobicity, and a structure with carboxyl and hydroxyl can be quickly recovered when the bile acid is in contact with water. The cholic acid derivative can spontaneously form a stable emulsion in a self-emulsifying drug delivery system, the solubility and bioavailability of drugs are improved, good biocompatibility is kept, and the cholic acid derivative is suitable for delivery of various drugs and has good application prospects. And the problems that the emulsifying time in the existing self-emulsifying system is relatively long, a toxic nonionic surfactant and a toxic cosolvent need to be used and the like are also solved.

The present invention provides a stable emulsion of a triterpenoid compound in a water-in-oil self-emulsifying type and a preparation method thereof. The emulsion uses the triterpenoid compound as an emulsifier. The preparation method includes the following steps: dispersing triterpenoid compound particles in a liquid edible vegetable oil under continuous stirring at a specific temperature to obtain a triterpenoid compound dispersion system; mixing the triterpenoid compound dispersion system obtained in step 1 with an aqueous phase in a certain proportion, and obtaining a stable W / O emulsion after treatment under specific homogenization conditions, and immediately storing it in a sealed manner. The present invention uses the triterpenoid compound as an emulsifier or a gelling agent to stabilize the emulsion or the high internal phase emulsion gel, and the obtained stable emulsion improves the bioavailability of the triterpenoid compound.

The application discloses a self-emulsifying high-wear-resistance vinyl carbon fiber sizing agent composition and a preparation method and application thereof. The application improves the wear resistance of the fiber by reducing the content of rigid groups such as benzene rings and double bonds, introduces hydrophilic groups such as amide bonds and ether bonds, adopts a self-emulsifying technical route, eliminates the weak boundary layer of the interface, and improves the interface performance of the fiber and the vinyl resin, so that the prepared self-emulsifying high-wear-resistance vinyl carbon fiber sizing agent composition has the advantages of self-emulsification, high wear resistance, seawater resistance, excellent carbon fiber composite material interface performance and outstanding smoke resistance, and has a wide application prospect in the preparation of carbon fiber composite materials suitable for marine environments.

The invention relates to the technical field of concrete admixtures, in particular to an emulsion type polycarboxylate superplasticizer and a preparation method thereof. The water reducing agent is formed by polymerizing a modified polyether monomer and a self-reaction type emulsifying monomer through free radical copolymerization under the action of an initiator and a chain transfer agent, the self-reaction type emulsifying monomer combination is composed of A-type monomers, B-type monomers and C-type monomers, or composed of A-type monomers, B-type monomers and D-type monomers, or composed of A-type monomers, C-type monomers and D-type monomers. The water reducing agent does not need to be added with an emulsifier, only the self-reaction type emulsifying monomer needs to be introduced into a reaction system, and the self-emulsifying capacity and high reaction activity of the self-reaction type emulsifying monomer are utilized, so that the air entraining capacity of the polycarboxylic acid water reducing agent in concrete can be improved, the viscosity of the concrete is reduced, and the dispersity of the concrete is improved, and field construction is facilitated; meanwhile, it is guaranteed that the concrete has a good machine discharging state, the problems of bleeding, segregation and bottom grabbing do not occur, the concrete does not have the stone exposure phenomenon, and the wrapping performance is good.

The invention relates to the technical field of high polymer materials, in particular to hydrophilic ice-feeling silicone oil. The invention provides an organic silicon copolymer named as hydrophilic ice-feeling silicone oil, and aims to overcome the limitation of hydrophilic performance, ice-feeling hand feeling, chemical stability and self-emulsifying ability of the existing hydrophilic ice-feeling silicone oil in a complex application environment, especially under harsh conditions of high salinity, strong acid and alkali or long-term use / washing and the like. The organosilicon copolymer is characterized in that the organosilicon copolymer is constructed by synergistically grafting a polyether chain segment and a sulfobetaine zwitterionic chain segment to an epoxy functionalized polydimethylsiloxane main chain; the epoxy functionalized polydimethylsiloxane is prepared from epoxy functionalized polydimethylsiloxane, terminal aminated polyether and a terminal aminated sulphobetaine derivative through a ring-opening addition reaction. Through the scheme, the fabric can be endowed with excellent soft and smooth hand feeling and obvious ice feeling effect, and the lasting stability of hydrophilic performance, excellent chemical stability and self-emulsifying ability can be maintained under the harsh conditions of high salinity, strong acid and alkali or long-term use / washing and the like.

The present disclosure provides cannabinoid formulations, more particularly pharmaceutical formulations which are highly-loaded with cannabinoids. The formulations are suitable for self-emulsifying into emulsions that are characterized by a stable mono-modal narrow droplet size distribution, and suitable for administration to subjects in need of cannabinoids administration for treatment of various conditions.

The application belongs to the technical field of bio-based packaging materials, and particularly relates to a novel double-layer composite film and application thereof. The novel double-layer composite film comprises the following steps: reacting palmitic anhydride and carboxymethyl cellulose to obtain carboxymethyl cellulose palmitate; adding a pH-sensitive natural dye indicator to obtain carboxymethyl cellulose palmitate nanoemulsion containing a pH-sensitive substance; then loading a natural polymer material to prepare a film material; finally adding the film material to the carboxymethyl cellulose palmitate to prepare a composite film, thereby obtaining the novel double-layer composite film. The double-layer composite film can be self-emulsified without adding a surfactant, and has the ability to load functional indicator (pH-sensitive color indicator) substances; meanwhile, the barrier performance of the film material, such as a chitosan film, to water vapor and oxygen is improved, and the double-layer composite film has a very promising application in food or fruit preservation. The method provided by the application is not only green in raw materials, but also uses a flow casting method, which can be applied to industrial production and has a good application prospect.

This invention relates to a fully synthetic aluminum alloy cutting fluid. By weight, the fully synthetic aluminum alloy cutting fluid comprises the following components: a) 5-15 parts of organic acid; b) 10-20 parts of organic alcohol amine; c) 2-11 parts of self-emulsifying ester; d) 0.2-5 parts of corrosion inhibitor; e) 0-3 parts of bactericide; f) 0-0.1 parts of defoamer; h) 52-82 parts of water; wherein the self-emulsifying ester is a reaction product of a second organic acid, a polyol, and a polyether, and the molar ratio of the second organic acid, the polyol, and the polyether is 1:(0.6-1):(0.6-1). The cutting fluid of this invention, through the rational combination of its components and the addition of a specific self-emulsifying ester, can effectively improve the lubricity of water-based cutting fluids while maintaining excellent low-foaming properties. This invention also relates to a method for preparing the fully synthetic aluminum alloy cutting fluid and its applications.

The invention discloses a Cinnamomum longepaniculatum essential oil self-microemulsion drug delivery system and a preparation method thereof, the system comprises an oil phase, an emulsifier and a co-emulsifier, the oil phase is Cinnamomum longepaniculatum essential oil; the system is mutually soluble with water in any proportion to form a transparent micro-blue microemulsion. The preparation method of the Cinnamomum longepaniculatum essential oil self-microemulsion drug delivery system adopts 30 emulsifiers and 8 co-emulsifiers, and comprises the following steps: step 1, preliminary screening of the emulsifiers; step 1.1, carrying out compatibility evaluation; step 1.2, carrying out self-emulsification evaluation; step 2, screening of a co-emulsifier; step 2.1, carrying out compatibility evaluation; step 2.2, carrying out self-emulsification evaluation; and step 3, Km value screening. The Cinnamomum longepaniculatum essential oil self-microemulsion drug delivery system provided by the invention has good stability.

Disclosed are a self-emulsifying composition of a coenzyme Q10 with high bioavailability, and a method and device for preparing the same. The composition includes the following components in percentage by weight: 5-35% of a coenzyme Q10, 1-50% of an oil phase, 10-60% of a surfactant, 1-10% of a cosurfactant, 0-7% of an antioxidant, and 0.5-2% of pyrroloquinoline quinone disodium salt. The coenzyme Q10 medicinal liquid obtained can be kept in a clear and transparent solution state at room temperature, can be stably dispersed in water and self-emulsified to a transparent emulsion, significantly improves the bioavailability of the coenzyme Q10 by more than 4 times, and can be filled in capsules or softgels to swallow. The method disclosed by the disclosure includes two steps: material grinding and vacuum self-emulsifying. The method is concise in step and easy to control. Moreover, the device is simple in structure and low in cost.

Provided is a pharmaceutical composition comprising a sulfonamide derivative represented by the following formula (1), a pharmaceutically acceptable salt thereof, or an active metabolite thereof, and having improved absorbability when orally administered. Disclosed is a self-emulsifying composition comprising: a sulfonamide derivative represented by the following formula (1), a pharmaceutically acceptable salt thereof, or an active metabolite thereof; and at least two solubilizers.

Orally administered pharmaceutical compositions comprising incretin or its analogues or derivatives are presented, which allow for prolonged glycemic control. The formulations presented herein incorporate a self-emulsifying drug delivery system (SEDDS). Advantageously, such formulations provide protection in the upper gastrointestinal tract from proteolytic conditions while allowing for efficient drug release and absorption in the lower gastrointestinal tract.

The subject of the invention is a new system in the form of an instant self-emulsifying powder, their preparation process as well as the application of this oily system associated with one or a mixture of cyclodextrins for the instant formation of a solid spherical system of effervescent or non-self-emulsifying granule or pellet types (Spontaneous Powder Self Emulsifying Drug Delivery Systems (SP-SEDDS®)). And for the encapsulation of a substance of therapeutic interest. Applications to the encapsulation of one or more substances of interest, in particular therapeutic or preventive, nutritional, and usable in pharmacy, veterinary, nutrition or agri-food by oral route.

The invention discloses a self-emulsifying bio-based polyester stabilized multi-class bio-based polymer water-based emulsion as well as a preparation method and application thereof, and belongs to the technical field of bio-based high polymer materials and water-based resin. According to the preparation method disclosed by the invention, a dual-interface synergistic stabilization mechanism is constructed by adopting the self-emulsifying bio-based polyester containing furandicarboxylic acid and the rosin-based component, so that efficient emulsification and interface compatibility of various hydrophobic bio-based film-forming polymers such as polyhydroxyalkanoate and polylactic acid are realized. The emulsion prepared by the invention has excellent storage stability and machining adaptability, maintains extremely high bio-based content and extremely low volatile organic compound residue while remarkably improving the water resistance, oil resistance and gas barrier property of a paper-based coating, and completely meets the safety standard of food contact-grade materials. According to the preparation process, the microstructure of dispersed phase particles is accurately regulated and controlled through phase inversion and high-pressure homogenization, and an ideal green coating solution is provided for high-performance environment-friendly paper-based packaging.