968 results about "Self emulsifying" patented technology

Stable solutions of lipophilic drugs, such as cyclosporin, forming a polar lipid self-emulsifying drug delivery system. The solutions can include lipophilic drugs, such as cyclosporin, dissolved in a polar lipid, such as having a C₆-C₁₂ fatty acid monoglyceride content of at least about 50%, surfactants and triglycerides. The composition forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.

A self-emulsifying drug delivery system to improve dissolution, stability, and bioavailability of drug compounds of dronabinol or other cannabinoids. The drug compound(s) are dissolved in an oily medium (e.g. triglycerides and/or mixed glycerides and/or free fatty acids containing medium and/or long chain saturated, mono-unsaturated, and/or poly-unsaturated free fatty acids) together with at least one surfactant. The surfactant promotes self-emulsification, thereby promoting targeted chylomicron delivery and optimal bioavailability to a mammalian intestinal lumen. A dosage form can optionally include co-solvents, anti-oxidants, viscosity modifying agents, cytochrome P450 metabolic inhibitors, P-GP efflux inhibitors, and amphiphilic/non-amphiphilic solutes to induce semi-solid formation for targeted release rates.

The present invention provides an oral self micro-emulsifying pharmaceutical composition of a hydrophilic drug or a pharmaceutically acceptable salt thereof which, in addition to the hydrophilic drug, one or more solvents for solving the hydrophilic drug to form a drug-solvent solution and a surfactant system, further comprises one or more hydrophilic carrier which are compatible with said drug-solvent solution and the surfactant system. The oral self micro-emulsifying pharmaceutical composition of the invention exhibits comparative bioavailability to that of the hydrophilic drug through injection and is stable during storage. A method for preparing the oral self micro-emulsifying pharmaceutical composition is also provided.

The present invention provides novel dietary supplement compositions based on the use of a particular oil phase which comprises of Coenzyme Q10 and optionally other lipophilic dietary ingredients of low water solubility and a liquid mixture which comprises one or more emulsifiers, a fatty acid monoester formed between an short chain alcohol of C1 to C4 chain length and a saturated, or mono-unsaturated, or di-unsaturated (both conjugated and non-conjugated) fatty acid of C6 to C24 chain length, or medium chain mono-/di-esters, or the mixture of above. The composition is in a form of self-emulsifiable in the aqueous medium, for example, a simulated gastric fluid, which should provide a high oral bioavailability for the lipophilic dietary ingredients.

Methods and compositions are described whereby poorly water-soluble beneficial agents such as vitamins and co-factors are formulated into self-emulsifying formulas (SEF) and optionally sorbing the SEF into pores of porous solid particulates, or preparing supersaturated solutions (SSS) and sorbing the SSS into pores of porous solid particulates. These formulations are useful as dosage forms with oral availability.

A pharmaceutical composition comprising, in relation to 100% by weight of a total amount of a self-emulsifying composition, 70 to 90% by weight of eicosapentaenoic acid ethyl ester as a first medicinal component, 0.5 to 6% by weight of water, 1 to 29% by weight of polyoxyethylene sorbitan fatty acid ester (optionally further comprising polyoxyethylene castor oil) as an emulsifier, 1 to 25 parts by weight of lecithin in relation to 100 parts by weight of the eicosapentaenoic acid ethyl ester, and pitavastatin, rosuvastatin, or a salt thereof as a second medicinal component. The composition is excellent in any one of self-emulsifying property, dispersibility of the composition, emulsion stability, absorbability, and storage stability of the medicinal components and a preparation.

The invention relates to a preparation method of a terminated-type cation water-borne polyurethane color fixing agent, belonging to the field of organic adhesives. The terminated-type cation water-borne polyurethane color fixing agent with solid content of 20-40% of and transparent or translucent yellowish appearance can be prepared by the following steps of: (1) polyurethane prepolymer reaction, (2) terminated reaction, and (3) acid neutralization and ionization reactions. In the invention, partial terminating after prepolymerization is adopted, a small number of isocyanate groups is inactivated and a self-emulsifying method is adopted to synthesize the water-borne polyurethane color fixing agent; in the color fixing process, closed active groups are released through baking at high temperature and are carried out crosslinking reaction with hydroxyl and amino groups on textile fabrics and reactive dyes so that the color fastness to washing of the textile fabric is improved.

The present invention belongs to the field of chemical technology, and is especially one kind of conducting water soluble polyurethane paint containing carbon nanotube and its preparation process. The conducting paint is prepared through the first modifying carbon nanotube chemically for the surface to carry hydroxyl group, carboxyl group or amino group; the subsequent introducing to polyester polyol or isocyanate terminated polyurethane pre-polymer through chemical bonding and self-emulsifying to prepare water soluble polyurethane dispersoid containing carbon nanotube; and final adding deionized water and assistants through high speed stirring to obtain the conducting paint. The conducting paint can form coating with volume resistivity of 1x10<-5>-4x10<-4. ohm.cm, surface resistivity of 1x10<-1>-2x10<2> ohm, adhesion of 0 grade, shielding effectiveness of 70-85 dB, and long term stability, and has wide application.

The invention relates to a self-emulsifying polyurethanes epoxy sizing agent for carbon fibers and a preparation method thereof. The sizing agent comprises the following components in part by weight: 10 to 15 parts of self-emulsifying polyurethanes epoxy emulsion, 0.2 to 0.3 part of aid, and 84.7 to 89.8 parts of deionized water. The method for preparing the sizing agent comprises the following steps of: (1) preparing hydrophilic polyurethane prepolymer of the self-emulsifying polyurethanes epoxy emulsion; (2) preparing a prepolymer of which the end group is an epoxy group; (3) adding 6 to 20 parts of neutralizer into the prepolymer of which the end group is an epoxy group for neutralization, pouring the neutralized solution into water for dispersing, and removing the solvent through reduced pressure distillation to obtain the self-emulsifying polyurethanes epoxy emulsion; and (4) adding the aid and the deionized water into the polyurethanes epoxy emulsion in the ratio, and uniformly mixing to obtain the self-emulsifying polyurethanes epoxy sizing agent for the carbon fibers. The self-emulsifying polyurethanes epoxy sizing agent for the carbon fibers and the preparation method thereof have reasonable design. The sizing agent can improve the mechanical property of carbon fiber composite materials, and has excellent dilution stability.

Self-emulsifying drug delivery systems are provided to improve dissolution, stability, and bioavailability of drug compounds of dronabinol or other cannabinoids. The drug compound(s) are dissolved in an oily medium (e.g. triglycerides and/or mixed glycerides and/or free fatty acids containing medium and/or long chain saturated, mono-unsaturated, and/or poly-unsaturated free fatty acids) together with at least one surfactant. The surfactant promotes self-emulsification, thereby promoting targeted chylomicron/lipoprotein delivery and optimal bioavailability through the mammalian intestinal tract. A dosage form can optionally include co-solvents, anti-oxidants, viscosity modifying agents, cytochrome P450 metabolic inhibitors, P-GP efflux inhibitors, and amphiphilic/non-amphiphilic solutes to induce semi-solid formation for targeted release rates.

The invention provides a novel method for preparing a latent nonionic self-emulsifying epoxy curing agent. The method comprises the following steps of: reacting long alkyl chain fatty amine with diglycidyl ether to prepare an addition product of which the middle part is connected with a long hydrophobic side chain and two ends are provided with epoxy groups; and reacting polyamine with a carbonyl compound to prepare an imine compound which contains secondary amine, and sealing the end to prepare the latent nonionic self-emulsifying epoxy curing agent. Under water environment, the imine structure in the curing agent hydrolyzes hydrophilic amino, and the curing agent contains the long hydrophobic alkyl chain, so the curing agent has the functions of emulsifying and curing an epoxy resin. The curing agent can be used for water-based epoxy emulsion coatings, water-based epoxy resin modified emulsified asphalt and cement and the like, and has excellent adhesion performance of ketimine on a wet surface. Due to the introduction of hydrophobic chains, the stability of the imine curing agent is improved in the water environment, and the performance of the curing agent in the aspect of wet surface or underwater adhesion can also be improved.

A water-based pigment dispersion in which a pigment is dispersed with a water soluble or self-emulsifying thermoplastic resin containing carboxylic group, characterized in that the ratio of the pigment to the thermoplastic resin containing the carboxylic group (pigment/thermoplastic resin containing carboxylic group (weight ratio of effective solid matter)) is 10/10 to 10/1, the thermoplastic resin containing the carboxylic group is cross-linked with a cross-linking agent after the pigment is dispersed with the thermoplastic resin, and the ratio of the cross-linking agent to the thermoplastic resin containing the carboxylic group (cross-linking agent/thermoplastic resin containing carboxylic group (weight ratio of effective solid matter)) is 1/100 to 50/100; a process for preparing the same; and a water-based ink containing the same. The water-based pigment dispersion shows excellent light resistance, water resistance, alkali resistance, solvent resistance and stability during the passage of time at the same time.

The invention belongs to the technical field of chemical industry, and particularly relates to an organosilicon-modified aqueous polyurethane-acrylate composite coating agent and a preparation method thereof. The method comprises the following steps of: performing hydroxyl condensation reaction by using hydroxyl-terminated silicone oil and polyoxyethylene ether to prepare polyoxyethylene ether-containing hydroxyl silicone oil resin; introducing the polyoxyethylene ether-containing hydroxyl silicone oil resin into isocyanate-terminated polyurethane prepolymer by using a chemical bonding method; preparing organosilicon-modified aqueous polyurethane-acrylate dispersion through a self-emulsification method; and finally preparing the organosilicon-modified aqueous polyurethane-acrylate composite coating agent. According to the method, the problems of poor compatibility among the three components, i. e., organosilicon, polyurethane and acrylate and poor mechanical property of an aqueous composite coating layer of the organosilicon-modified aqueous polyurethane-acrylate composite coating agent are solved well. The preparation method provided by the invention has the advantages of simple process, convenience, high product quality, high input-output ratio and the like. The coating agent has high compatibility and superior mechanical property and is a new-generation environmentally-friendly high-performance chemical product.

The invention discloses a nonionic self-emulsifying waterborne epoxy curing agent and a preparation method thereof. The curing agent is prepared from the following raw materials in percentage by weight: 8-30% of basic amine, 5-25% of epoxy-terminated polyether, 7-25% of polyether amine, 5-10% of epoxy resin, 5-15% of a mono-epoxy compound, 0.5-3% of a silane coupling agent and 30-60% of water. The preparation method comprises the following steps: (1) conducting chain extension and partial blocking on basic amine to obtain a pre-polymer A; (2) conducting partial blocking on polyether amine to obtain a pre-polymer B; (3) combining the pre-polymer A and the pre-polymer B with the chain segment of epoxy resin, and carrying out blocking to obtain the curing agent. The curing agent can be cured with liquid epoxy resin or an epoxy resin dispersion for film forming, and the obtained film is excellent in flexibility, adhesive force, impact resistance and chemical reagent resistance; the curing agent is synthesized at relatively low temperature, and no solvent or catalyst needs to be added, so that safety and environmental protection are ensured, and the controllability is strong.

The invention belongs to the technical field of chemical engineering, and discloses polyether modified organic silicone oil that adopts a comb structure shown in formula (1) and a preparation method and application as a defoamer, and overcomes the service restrictions of conventional organic silicone defoamers. The preparation method comprises the following steps: compounds such as short polyols polydimethyl siloxane or polymethyl phenyl siloxane in which end groups are hydrogen, allyl alcohol polyether, aliphatic esters or alkanes amides that contain end alkenyl are selected as raw materials to synthesize the polyether modified organic silicone oil. According to the invention, as a defoamer, the polyether modified organic silicone oil has good characteristics of self-emulsifying property, self-dispersing property, steady emulsifying property, good defoaming and foam inhibiting performance, high temperature resistance, and acid and alkali resistance.

The invention relates to an epoxy hardener, in particular to a non-ionic self-emulsifying aqueous epoxy hardener. The hardener is prepared according to the following steps: adopting hydrophobic alkylamine and hydrophilic diglycidol ether with low molecular weight for reaction so as to obtain a diepoxy compound which has epoxy groups at two ends and a middle nitrogen atom linked with a long hydrophobic alkyl side chain; and adopting alicyclic amine for reaction for purpose of sealing the ends or respectively using the alicyclic amine and hydrophilic amine to seal the two ends, and finally obtaining the amino-terminated non-ionic self-emulsifying aqueous epoxy hardener similar to the structure of surfactant. The hardener can be further mixed with deionized water so that a light-yellow aqueous epoxy resin hardener with 50-60 percent of solids content can be obtained. The hardener has good self-emulsifying effect, is well compatible with epoxy resin and has high stability and good flexibility and surface activating function. The hardener can be widely applied in materials such as aqueous epoxy resin paint, epoxy resin binding agent, aqueous epoxy grouting materials, and the like.

N-[1S,2S]-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-trifluoromethyl]pyridine-2-yl}oxy}propanamide (Compound I) has surprisingly improved solubility and bioavailability in a lipophilic vehicle comprising a pharmaceutically acceptable digestible oil, a surfactant, or a cosolvent, or a mixture of any two or more thereof. In one embodiment of the present invention are self-emulsifying or self-microemulsifying composition comprising 1) Compound I; 2) a surfactant having an HLB of 1 to 8; and 3) a surfactant having an HLB of over 8 to 20; and optionally, 4) a digestible oil and/or cosolvent and/or antioxidant or preservative.

The invention relates to a hydroxylated polyurethane water dispersoid for a waterborne soft-feel coating and a preparation method thereof. The hydroxylated polyurethane water dispersoid is the water dispersoid formed by the following steps of: taking the raw materials in parts by weight: 15 to 20 parts of polycarbonate diols, 15 to 25 parts of elastic 4-butanediol, 1 to 5 parts of pentaerythritol, 2 to 5 parts of hydroxylated dimethylolpropionic acid or dihydroxymethyl butyric acid, 10 to 20 parts of fatty group or alicyclic group isocyanates monomers and 0.1 to 1.0 part of catalysts and solvents; carrying out heating polymerization to obtain hydroxylated urethane resin; and then neutralizing a water dispersoid formed after salt forming, self emulsifying and the solvent removing, wherein the coating-4 viscosity change of the coating stored for 6 months is smaller than 5 percent. After the hydroxylated polyurethane water dispersoid prepared by the method is prepared into a double-ingredient waterborne soft-feel coating, better balance is obtained between the coating film soft feel and the coating film resistance on alcohol and contaminants, and the effect of the hydroxylated polyurethane water dispersoid is proved.