15 results about "Self emulsifying" patented technology

This invention relates to a drug delivery composition, a self-emulsifying composition thereof and a method for producing the same for oral administration to enhance the normalisation of fatty liver. More particularly, the self-emulsifying composition comprises a non-ionic surfactant, a co-surfactant, vegetable oil and active ingredients comprising phospholipids, tocotrienols and tocopherols. The composition aforementioned works synergistically to provide an effectively delivered micronutrients and vitamins to the liver and also facilitate hepatic regeneration thereof.

The application belongs to the technical field of bio-based packaging materials, and particularly relates to a novel double-layer composite film and application thereof. The novel double-layer composite film comprises the following steps: reacting palmitic anhydride and carboxymethyl cellulose to obtain carboxymethyl cellulose palmitate; adding a pH-sensitive natural dye indicator to obtain carboxymethyl cellulose palmitate nanoemulsion containing a pH-sensitive substance; then loading a natural polymer material to prepare a film material; finally adding the film material to the carboxymethyl cellulose palmitate to prepare a composite film, thereby obtaining the novel double-layer composite film. The double-layer composite film can be self-emulsified without adding a surfactant, and has the ability to load functional indicator (pH-sensitive color indicator) substances; meanwhile, the barrier performance of the film material, such as a chitosan film, to water vapor and oxygen is improved, and the double-layer composite film has a very promising application in food or fruit preservation. The method provided by the application is not only green in raw materials, but also uses a flow casting method, which can be applied to industrial production and has a good application prospect.

This invention relates to a fully synthetic aluminum alloy cutting fluid. By weight, the fully synthetic aluminum alloy cutting fluid comprises the following components: a) 5-15 parts of organic acid; b) 10-20 parts of organic alcohol amine; c) 2-11 parts of self-emulsifying ester; d) 0.2-5 parts of corrosion inhibitor; e) 0-3 parts of bactericide; f) 0-0.1 parts of defoamer; h) 52-82 parts of water; wherein the self-emulsifying ester is a reaction product of a second organic acid, a polyol, and a polyether, and the molar ratio of the second organic acid, the polyol, and the polyether is 1:(0.6-1):(0.6-1). The cutting fluid of this invention, through the rational combination of its components and the addition of a specific self-emulsifying ester, can effectively improve the lubricity of water-based cutting fluids while maintaining excellent low-foaming properties. This invention also relates to a method for preparing the fully synthetic aluminum alloy cutting fluid and its applications.

Disclosed are a self-emulsifying composition of a coenzyme Q10 with high bioavailability, and a method and device for preparing the same. The composition includes the following components in percentage by weight: 5-35% of a coenzyme Q10, 1-50% of an oil phase, 10-60% of a surfactant, 1-10% of a cosurfactant, 0-7% of an antioxidant, and 0.5-2% of pyrroloquinoline quinone disodium salt. The coenzyme Q10 medicinal liquid obtained can be kept in a clear and transparent solution state at room temperature, can be stably dispersed in water and self-emulsified to a transparent emulsion, significantly improves the bioavailability of the coenzyme Q10 by more than 4 times, and can be filled in capsules or softgels to swallow. The method disclosed by the disclosure includes two steps: material grinding and vacuum self-emulsifying. The method is concise in step and easy to control. Moreover, the device is simple in structure and low in cost.

Orally administered pharmaceutical compositions comprising incretin or its analogues or derivatives are presented, which allow for prolonged glycemic control. The formulations presented herein incorporate a self-emulsifying drug delivery system (SEDDS). Advantageously, such formulations provide protection in the upper gastrointestinal tract from proteolytic conditions while allowing for efficient drug release and absorption in the lower gastrointestinal tract.

The application relates to the field of makeup, and specifically discloses a water-based self-emulsifying water mist lipstick and a preparation method thereof. The self-emulsifying water mist lipstick comprises the following raw materials in percentage by weight: 10-50% of polydimethylsiloxane / vinyl polydimethylsiloxane crosslinking polymer, 10-30% of cyclopentasiloxane, 5-30% of lauryl PEG / PPG-18 / 18 polymethylsiloxane, 1.1-12% of a humectant, 5-10% of polydimethylsiloxane, 0.1-0.5% of aminomethylpropanol, 10-50% of water, 0.1-0.5% of a thickening agent, 0.1-1% of emollient oil, 0.1-1% of a preservative, 0.02-0.4% of a water-soluble pigment, 0.1-2% of salicylic acid and 0.1-2% of an active liquid. The obtained lipstick has good self-emulsifying performance, good color development effect, good makeup duration, no staining and discoloration, high product moisturizing degree, can effectively moisturize the lips and reduce the appearance of lip wrinkles.

The present application belongs to the technical field of epoxy primer, and particularly relates to a water-based epoxy zinc-rich primer, a preparation method and application thereof. The water-based epoxy zinc-rich primer is prepared by using non-continuous point-like silica modified composite zinc powder as a cathodic protection functional filler, using modified epoxy resin as a film-forming base material, and combining with a modified aminoethyl piperazine curing agent, and has long-term cathodic protection performance and excellent hydrolysis resistance. The composite zinc powder is constructed by spherical and flaky zinc powder to form a continuous conductive network and a physical anti-settling structure. A point-like passivation layer formed by mild activation of glycolic acid and targeted adsorption of acidic silica sol can close the high active sites of zinc powder while ensuring electron conduction. The modified epoxy resin has self-emulsifying dispersibility and zinc powder coordination stability. The curing agent realizes water-based adaptation and storage stability through epoxy addition and reversible capping. After construction and unsealing, the curing agent can form a dense cross-linked paint film with the epoxy resin, thereby improving the long-term corrosion protection service performance of the primer.

The invention relates to a medicine formed by means of SEDDS from lipid-based nano drug carrier systems containing nadolol as the active substance and intended for use in the treatment of hypertension, and to the production method of this product. By means of the nano formulation in question, a medicine is obtained that has high bioavailability and medicine compliance values and is also more accessible.

A method for preparing a self-emulsifying hybrid polyisocyanate crosslinking agent, belonging to the field of waterborne polyurethane composite system preparation, includes the following steps: S1, reacting an aliphatic-alicyclic hybrid diisocyanate mixture A with a polyalkylene ether alcohol, followed by silane modification to obtain a dispersible active reaction product; S2, using the dispersible active reaction product obtained in step S1 with an aliphatic-alicyclic hybrid polyisocyanate B, conducting a precisely temperature-controlled urethane esterification reaction under the action of a novel composite urethane esterification catalyst, achieving a balance between product structure and performance by regulating the conversion rate of urethane groups, and obtaining a self-emulsifying hybrid polyisocyanate crosslinking agent after catalyst deactivation, anti-aging modification, and hydrophilic modification with phosphate esters. The crosslinking agent of this invention is suitable for waterborne coatings, adhesives, and sealing material systems, significantly improving the weather resistance, chemical resistance, and mechanical strength of the system, while also possessing low-temperature curing characteristics.

The application belongs to the technical field of metal processing fluid, and discloses a low-carbon biodegradable metal processing fluid, which comprises the following components in percentage by mass: 4-6% of isopropyl alcohol amine, 1-3% of nano silicon corrosion inhibitor, 2-5% of ternary carboxylic acid rust inhibitor, 0.5-2.5% of benzotriazole, 5-10% of 182 self-emulsifying ester, 4-6% of castor oil acid, 40-60% of DOTP, 4-8% of gelberol, 2-4% of ether carboxylic acid complexing agent, 2-5% of cashew phenol polyoxyethylene ether 5EO, 4-8% of cashew phenol polyoxyethylene ether 2EO, 0.4-0.6% of potassium hydroxide, and the balance of water. The low-carbon biodegradable metal processing fluid does not contain harmful substances, has excellent environmental protection performance, has good lubricity, and can be applied to the processing of metals such as copper, aluminum and its alloys, magnesium and its alloys, and has a good application prospect.

The application discloses a self-emulsifying bio-based polyester stabilized multi-class bio-based polymer aqueous emulsion and a preparation method and application thereof, and belongs to the technical field of bio-based polymer materials and aqueous resins. The application realizes efficient emulsification and interfacial compatibility of various hydrophobic bio-based film-forming polymers such as polyhydroxyaliphatic acid ester and polylactic acid by adopting a self-emulsifying bio-based polyester containing furan dicarboxylic acid and a rosin-based component to construct a double-interface synergistic stabilization mechanism. The emulsion prepared by the application has excellent storage stability and mechanical processing adaptability, significantly improves the water resistance, oil resistance and gas barrier performance of paper-based coatings, maintains a very high bio-based content and a very low volatile organic compound residue, and fully meets the safety standards of food contact grade materials. The preparation process precisely regulates the microstructure of the dispersed phase particles through phase inversion and high-pressure homogenization, and provides an ideal green coating solution for high-performance environment-friendly paper-based packaging.

The present invention relates to a method for improving the UV blocking efficiency and a cosmetic manufacturing use, which uses a composition comprising a combination of (a) a polymer having self-emulsifying ability and (b) a polyol having an IOB value of 5.0 or less, wherein the above composition includes an aqueous phase portion and an oily phase portion, (a) the polymer having self-emulsifying ability and (b) the polyol having an IOB value of 5.0 or less are contained in the above aqueous phase portion, a UV blocking agent is contained in the above oily phase portion, wherein the above composition does not contain an oily phase thickening agent, the viscosity of the above oily phase portion is 1,000 cps or less. Generally, the UV blocking efficiency of a UV blocking agent decreases due to heat, but according to the present invention, a remarkable effect of improving the UV blocking efficiency of a UV blocking agent by heat can be obtained.

This invention belongs to the field of bio-based polymer materials technology, specifically relating to a self-emulsifying palm oil-based waterborne polyurethane, its preparation method, and its application. The waterborne polyurethane is prepared by using palm oil as a raw material to prepare a carboxyl-grafted palm oil-based diol, which is then subjected to a condensation reaction with diisocyanate and 1,6-naphthol to synthesize a linear polyurethane oligomer. This oligomer is then emulsified and dispersed in deionized water under the action of triethylamine to obtain a self-emulsifying palm oil-based waterborne polyurethane emulsion. This emulsion can be coated onto steel surfaces to prepare environmentally friendly metal coatings, featuring environmentally friendly raw material sources and a preparation process that requires no additional emulsifiers. The resulting waterborne polyurethane emulsion exhibits excellent properties of high solids content and low viscosity, and the material possesses excellent mechanical and anti-corrosion properties, including good adhesion, flexibility, impact resistance, and excellent water and salt spray resistance.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a self-emulsifying nanometer preparation of tofacitinib and a preparation method thereof. The tofacitinib free base is mixed with diethylene glycol monoethyl ether, and is dissolved by heating and oscillation; then polyoxyethylene 40 hydrogenated castor oil and glyceryl monocaprylate are added, and are uniformly stirred to obtain a drug-containing SEDDS solution; the SEDDS solution is added dropwise into magnesium aluminosilicate to obtain a SEDDS solidified powder. The method significantly improves the solubility and stability of the tofacitinib free base, simplifies the production process, improves the bioavailability and safety of the drug, provides various preparation forms, and meets the medication needs of different patients.

The application discloses a high-stability peach gum polysaccharide nanoemulsion loaded with hydrophobic functional molecules and a preparation method thereof, and relates to the field of natural polymer materials and nanotechnology. The peach gum polysaccharide is chemically modified by thioctic acid, the balance of hydrophilicity and hydrophobicity in the molecular structure is effectively regulated, and thus the peach gum polysaccharide is endowed with excellent self-emulsifying capacity. A plurality of hydrophobic functional components can be efficiently loaded without additional addition of synthetic emulsifiers, the obtained nanoemulsion system is uniform and stable, and has good biocompatibility and slow-release performance. The emulsification and active component loading process are integrated in one step, the process flow is simplified, the loss of active components in multi-step operation is effectively avoided, the preparation efficiency and practicability are significantly improved, and a new way is provided for efficient and safe delivery of natural functional components.