127 results about "Levulinic acid" patented technology

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

The invention belongs to the field of food fresh-keeping materials, and particularly relates to a deep-eutectic propolis extract and CS / DPE composite film, a preparation method thereof and application of the deep-eutectic propolis extract and CS / DPE composite film in fresh-keeping films. The preparation method of the deep-eutectic propolis extract comprises the following steps: propolis is subjected to extraction treatment by adopting a deep-eutectic mixed solution containing a deep-eutectic solvent and water, the deep-eutectic solvent is a mixture of betaine and levulinic acid, and the extraction condition is that the polyphenol content in the obtained extracting solution is 25 mg / g or above and the flavone content is 250 mg / g or above; the obtained extracting solution is the eutectic propolis extract. The preparation method of the food preservative film comprises the following steps: mixing a chitosan solution and the eutectic propolis extract, casting to form a film, standing, and drying to obtain the food preservative film. The eutectic propolis extract obtained by the method provided by the invention is rich in polyphenols and flavones, and the mechanical property of the chitosan-based preservative film can be improved and the preservation effect on foods can be prolonged when the eutectic propolis extract is added into the chitosan-based preservative film.

The present invention discloses a method for co-producing bio-aviation fuel from corncobs, which comprises the following steps: screening and pulverizing corncobs to control the particle size to be 10-15 mm; mixing the pulverized corncobs with furfural production wastewater containing acetic acid for hydrolysis reaction to generate a dilute furfural solution at 195-205 °C and 1.25-1.3 MPa; subjecting the solid residue after hydrolysis to alkali treatment to separate and obtain crude cellulose; subjecting the crude cellulose to acidolysis reaction by microwave heating in a solid acid catalyst and formic acid solution to generate a dilute levulinic acid solution; catalytically polymerizing the dilute furfural solution and the dilute levulinic acid solution under the action of a copper-based catalyst to generate a C10-C15 hydrocarbon mixture; generating a C10-C15 saturated hydrocarbon liquid mixture through oil-water separation and deoxygenation and hydrogenation reaction of a nickel-based catalyst; and finally through fractional distillation and activated carbon filtration; this method realizes the efficient co-production of furfural, cellulose and bio-aviation fuel from corncobs, and has the advantages of high raw material utilization rate, excellent catalytic efficiency, low energy consumption and environmental friendliness.

The invention discloses a catalyst for preparing alkyl levulinate from furfuryl alcohol as well as a preparation method and application of the catalyst. The preparation method of the catalyst comprises the following steps: (1) adding precursor salt of copper and aluminum oxide into deionized water, stirring at normal temperature, then adding 2-methylimidazole, stirring at normal temperature, and finally heating and stirring to obtain a mixed solution; (2) adding sodium carbonate into the mixed solution, heating and stirring, then filtering, washing filter residues with ionized water until the filter residues are neutral, and then drying to obtain a precursor; and (3) roasting the precursor to obtain the catalyst for preparing alkyl levulinate from furfuryl alcohol. The method for preparing the alkyl levulinate by catalyzing the hydrogenolysis of the furfuryl alcohol is mild in reaction condition, the alkyl levulinate is prepared by the hydrogenolysis of the furfuryl alcohol under the mild condition, and the yield of the alkyl levulinate is relatively high.

The invention belongs to the technical field of adsorption separation, and particularly relates to application of MOF-808 and / or HKUST-1 in separation of 5-hydroxymethylfurfural and impure-phase substances. According to the application, MOF-808 and / or HKUST-1 are / is used as an adsorbent, 5-hydroxymethylfurfural can be well separated from fructose, formic acid, levulinic acid and other impurities, especially HMF and LA can be separated, the selection factor reaches up to 43.8, the defect that efficient separation of the two substances is difficult to achieve in the prior art is overcome, the purity of the separated HMF is high, energy consumption is low during HMF separation, the flow rate is large, and the method is suitable for industrial production. The separation time is short.

The objective is to provide 5-aminolevulinic acid or its salts and a method for producing the same, which have fewer impurities and residual solvents and suppressed discoloration compared to conventional methods. The objective is to provide 5-aminolevulinic acid or its salts, wherein, based on peak area obtained by HPLC analysis, the ratio of the content of individual impurities to the content of 5-aminolevulinic acid or its salt is 0.0007 or less, and the sum of the ratios of the content of individual impurities to the content of 5-aminolevulinic acid or its salt is 0.0016 or less.

The invention relates to the technical field of chemical substance preparation, and particularly discloses preparation equipment and a preparation method of 5-aminolevulinate, the preparation equipment comprises a preparation table, and further comprises a feeding unit arranged on the preparation table; the screening unit is arranged below the feeding unit; through the arrangement of the feeding bin, crushing of raw materials can be achieved, meanwhile, the raw materials can be screened during crushing, secondary screening is conducted through the screening bin below after screening, meanwhile, through the arrangement of the first driving unit and the moving unit, the screening bin can be driven to move while feeding is conducted, and in the back-and-forth moving process, the screening efficiency is improved. The feeding bin and the screening bin are impacted by the moving strips to generate vibration, so that the screening efficiency of the feeding bin and the screening bin is improved, raw materials clamped on the screening holes and the screening plate can be vibrated off through impact, the raw materials can be cleaned without shutdown, the caked raw materials can be crushed in the impact process, and the screening efficiency is improved. And therefore, subsequent screening work is facilitated.

The invention discloses a method for synthesizing a pyrrolidone compound by reductive amination of biomass-based levulinic acid and derivatives thereof, which comprises the following steps: taking a stainless steel high-temperature reaction kettle as a reaction container, respectively adding 0.5-20 mmol of biomass-based levulinic acid or derivatives thereof, 10-200 mg of catalyst and 0.1-1 mL of ammonia water into 5-10 mL of solvent, and sealing the reaction container, the mass concentration of the ammonia water is 28%; the method comprises the following steps: introducing hydrogen into a stainless steel high-temperature reaction kettle, pressurizing to 0.1-5 MPa, reacting at 40-120 DEG C for 0.1-8 hours, putting the reaction kettle into water, cooling to room temperature, deflating, additionally adding 0.5-5 mmol of toluene as an internal standard, and carrying out solid-liquid separation by using a needle type organic filter to obtain the target product 5-methyl-N-methyl-2-pyrrolidone. The method has the advantages of simple reaction system, mild conditions, no pollution to the environment, high efficiency, energy saving, low cost, few byproducts, high yield and high selectivity, and can realize green closed loop from raw materials to products.

The invention relates to a solvent composition comprising at least one specific levulinic acid ester as a first solvent and at least one specific amide ester as a second solvent. The invention also relates to the use of the solvent composition for producing agrochemical formulations and to the agrochemical formulations themselves.

The present invention discloses a biochar-supported aluminum-zirconium dual acid type solid acid catalyst and a preparation method and application thereof, belonging to the technical field of heterogeneous solid acid catalysts. 3 ) 3 and CO 4 Zr is used as raw material, and a full solid phase method strategy of mechanical activation treatment combined with high temperature calcination is adopted to construct a biochar-loaded aluminum-zirconium double acid type solid acid catalyst. The catalyst is a double acid type solid acid catalyst of green economy, stable performance and directional catalysis, and the acid content thereof is about 3.6 μmol / g, and the Lewis acid content is about 47.7 μmol / g. The preparation method of the catalyst of the present invention is simple to operate, the raw materials are easy to obtain, the conditions are simple and mild, and the production cost is low. The catalyst of the present invention is applied to catalyze cellulose to prepare levulinic acid, the conversion rate of cellulose can reach 97.5%, and the yield of levulinic acid can reach 67.5%, which has a good application prospect for efficiently converting cellulose to prepare levulinic acid, and has important research significance for effectively promoting the high value utilization of cellulose resources.

The invention discloses a preparation method for synthesizing 2, 5-furandimethanol (BHMF) from biomass saccharides through a one-pot method based on a water-phase catalysis system, and belongs to the technical field of chemical synthesis. According to the method, in a single water phase reaction system, efficient catalytic conversion is realized through two key steps of integrating biomass sugar dehydration to generate 5-hydroxymethylfurfural (HMF) and biologically reducing HMF to convert into BHMF. Wherein in the dehydration reaction stage, an acid catalyst is adopted, and a polyethylene glycol additive is introduced, so that the yield of HMF is remarkably increased, the generation of by-products levulinic acid and formic acid is effectively inhibited, and the toxic influence of the by-products on thalli in the subsequent reduction stage is reduced; meanwhile, due to the excellent biocompatibility, the inhibition effect on the thallus activity in the whole-cell catalytic reduction process is avoided. The innovative design ensures the continuity and system compatibility of the whole catalytic process, and realizes an efficient and stable catalytic conversion process.

The invention provides a wild jujube pulp polyphenol extraction process based on a deep eutectic solvent. The deep eutectic solvent (DES) technology is adopted to optimize the extraction process of the wild jujube pulp polyphenol, and the antioxidant activity of the extracted wild jujube pulp polyphenol is evaluated. According to the method, five different eutectic solvents are prepared and screened, and choline chloride / levulinic acid (ChCl / LA) is determined as the optimal solvent of wild jujube pulp polyphenol. Through single factor and orthogonal experiment optimization, the optimal extraction conditions of the wild jujube pulp polyphenol are determined as follows: the water content is 10%, the extraction time is 40 min, the extraction temperature is 60 DEG C, the material-liquid ratio is 1: 30 g / mL, and the polyphenol yield can reach 10.5 mg / g and is increased by 1.6 times compared with that before optimization. The method provides a technical path for green and efficient extraction and high-valued utilization of wild jujube pulp polyphenol, and provides reference for deep application of DES in plant resources.

The present invention relates to a method for preparing 2-methyltetrahydrofuran using a mixture of compounds derived from lignocellulosic biomass, a catalyst used therefor, and a method for preparing the catalyst. According to the present invention, 2-methyltetrahydrofuran can be prepared in high yield from a mixed lignocellulosic biomass-derived compound by performing a hydrogenation dehydration reaction using a furfural compound and a levulinic acid compound as reactants, and the effect can be maximized through optimization of the composition and reaction conditions of the reactants. In addition, the selectivity of 2-MTHF can be further improved by using a catalyst in which nickel and copper, which are non-noble metal-based materials, are supported on an acid support in the reaction.

The application discloses a polyacid zeolite imidazolate framework loaded monatomic catalyst and a preparation method and application thereof, and belongs to the technical field of catalysts. The preparation method of the catalyst is as follows: (1) preparing a zeolite imidazolate framework material; (2) mixing the dried zeolite imidazolate framework material and a metal salt in a solvent and stirring; then adding a heteropoly acid, controlling the pH in the system to be 5-7, and performing a solvothermal reaction under the condition of 80-120 DEG C; after the reaction is completed, cooling and centrifugal separation are performed to obtain a precipitate; and (3) performing calcination treatment on the precipitate to obtain the polyacid zeolite imidazolate framework loaded monatomic catalyst. The polyacid zeolite imidazolate framework loaded monatomic catalyst prepared by the method has high catalytic activity, high selectivity and good cycle stability, and has a good application prospect in acetyl propionate esterification reaction.

The invention belongs to the technical field of metal surface treatment, and discloses a high-permeability and low-corrosion die-casting aluminum degreasing agent as well as a preparation method and application thereof. The die-casting aluminum degreasing agent comprises an active matter and water, the active matters comprise 6 to 10 percent of organic weak acid, 0.5 to 1.5 percent of chitosan oligosaccharide, 0.5 to 1.2 percent of tea polyphenol, 0.7 to 1.8 percent of curcumin, 4 to 6 percent of surfactant, 0.4 to 1.0 percent of cyclodextrin, 0.5 to 0.8 percent of low-foaming additive, 1.0 to 2.0 percent of buffering agent, 0.6 to 1.5 percent of corrosion inhibitor and 0.2 to 0.5 percent of lipase by taking the total mass of the die-casting aluminum degreasing agent as 100 percent; the organic weak acid comprises levulinic acid, lactic acid and acetoacetic acid; the corrosion inhibitor comprises polycarboxylate and hydroxy carboxylate. The die-casting aluminum degreasing agent has excellent removal capacity for common silicone oil / ester release agents on the surface of a die-casting aluminum alloy, is low in corrosivity and does not contain phosphorus or fluorine or other components prone to polluting water.

The invention provides a separation microneedle of a loaded lipidosome nanoreactor as well as a preparation method and application of the separation microneedle, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: by taking phospholipid, cholesterol, tetramethoxysilane and 3-aminopropyltriethoxysilane as raw materials, entrapping cis-platinum, 5-aminolevulinic acid and catalase to prepare a liposome nano-reactor; polyvinylpyrrolidone, citric acid, sodium bicarbonate and regenerated silk cellulose are used as raw materials, a liposome nano reactor is dispersed in a microneedle body through a pouring method, and the microneedle capable of being rapidly separated is successfully prepared. Experimental research proves that the separation microneedle has good biocompatibility and mechanical properties, can effectively break through cuticle and realizes efficient transdermal delivery of a liposome nanoreactor. The liposome nanoreactor can be locally planted in deep tumor tissues, continuously supplies oxygen through enzymatic reaction, effectively improves the difficulty of insufficient oxygen supply in tumor photodynamic therapy, and has obvious advantages and wide prospects in the aspects of skin tumor photodynamic therapy application and the like.

The present application relates to the field of metabolic engineering and microbial fermentation, and in particular to a recombinant shewanella producing 5-amino levulinic acid and its application. The present application discloses a new 5-amino levulinic acid producing strain, which is obtained by modularly modifying shewanella by synergistically expressing 5-amino levulinic acid production module genes (hemA, hemL and gltX) derived from shewanella, antioxidant module genes (katE, sodB) derived from escherichia coli, and introducing inhibition modules (the inhibition genes are hemB2 and sucA), so that the shewanella can efficiently produce 5-amino levulinic acid, and the yield of 5-amino levulinic acid can be increased by 134.0 times compared with the original strain.

Levulinic acid and formic acid are valuable chemical intermediaries present in byproducts of some biomass conversion processes. Described herein are commercially viable processes for extracting levulinic acid and formic acid at high recovery. Under the present approach, levulinic acid and formic acid may be extracted from an aqueous reactor product, such as an acidic brine (e.g., calcium chloride brine) feed from a biomass hydrolysis reaction. If present, mineral acid catalysts may be recovered. Embodiments use solvents such as, e.g., 2-methyl tetrahydrofuran, for extracting levulinic acid and formic acid from the aqueous solution.

The invention belongs to the technical field of carbon nanosphere preparation, and particularly relates to a monodisperse core-shell structure adjustable carbon nanosphere and a preparation method thereof. According to the preparation method, a reaction kettle and a high-pressure feeding pump are combined, glucose hydrothermal carbonization (HTC) is utilized, the hydrothermal carbon nanospheres with excellent dispersity are obtained, accurate control over the form and structural characteristics of the carbon nanospheres can be achieved by adjusting feeding kinetics, reaction time and the concentration of formic acid (FA) and levulinic acid (LA), and the preparation method is suitable for industrial production. This is because FA can promote core formation by accelerating dehydration and condensation reactions, and LA can promote shell growth by aldol condensation and crosslinking. Compared with the traditional HTC method, the preparation method disclosed by the invention does not use any catalyst and template, fully utilizes the inherent advantages of HTC, such as low energy consumption requirement and biomass compatibility, and can be used for preparing the monodisperse CNS with the core-shell structure and the polydispersity index of 0.008.

The invention provides a cleaning solution for a semiconductor chip after chemical mechanical polishing, and a preparation method and application thereof, the cleaning solution for the semiconductor chip after chemical mechanical polishing comprises the following components by mass: 5-20 parts of a strong base; 5-30 parts of a weak base; 0.5-3 parts of a cellulose derivative; 0.5 to 2 parts of a chitin derivative; and 70-95 parts of ultrapure water. The cellulose derivative is one or more of 2, 5-furandicarboxylic acid, levulinic acid and 5-aminolevulinic acid. The chitin derivative is one or more of chitosan oligosaccharide, carboxymethyl chitosan, N-acetyl glucose, glucosamine and carboxymethyl glucosamine. According to the cleaning solution for the semiconductor chip after chemical mechanical polishing, CuO generated on the surface of copper after CMP can be effectively removed, a monomolecular adsorption layer is generated on the surface of Cu, and reoxidation of the surface of Cu is effectively inhibited within waiting time, so that Vbd is prevented from being reduced, and the reliability of a gate oxide layer of an MOS (Metal Oxide Semiconductor) device is improved.

The present invention discloses a method and application for reducing the content of levulinic acid in caramel. The method for reducing the content of levulinic acid in caramel provided by the present invention comprises the following steps: S1, making a syrup having a pH of 7 to 8 undergo a caramelization reaction in a reducing atmosphere, reacting to a chroma of 12000-17000EBC, and obtaining a preliminary caramel; S2, adjusting the pH of the preliminary caramel to 8 to 9, performing a secondary caramelization reaction in a reducing atmosphere, reacting to a pH of 5 to 7, and obtaining a caramel. The present invention is carried out by two caramelization reactions under alkaline conditions, so that levulinic acid is produced later and in less amount; meanwhile, the reaction is carried out in a reducing atmosphere, and levulinic acid can be deacetylated to generate ethanol and sodium propionate, thereby further reducing the content of levulinic acid in caramel, and ensuring that the caramel has good product quality, such as good red index and salt tolerance.

The present invention relates to the field of organic synthesis and in particular to a process for the preparation of levulinic acid or a salt or levulinic acid ester thereof.

A composition comprising a solubiliser, at least one preservative, at least one liquid emollient and at least one antimicrobial agent, wherein the composition comprises thymol and carvacrol. The antimicrobial agent may comprise essential oils, active ingredients derived from essential oils or synthetic equivalents thereof and, optionally, additional antimicrobial compounds. The composition may comprise thymol, carvacrol, levulinic acid and lauric acid. The composition may be used for intra-anal douching and may be used to reduce the risk of the transmission of sexually transmitted diseases (STDs) and / or sexually transmitted infections (STIs). The composition may be essentially free of water and may be provided as a single unit dosage formulation. Alternatively, the composition may further comprise water and may be provided as a single unit dosage or multi-dosage formulation. Methods of making the composition that is essentially free of water and the composition further comprising water are also disclosed.

The present invention relates to the technical field of the preparation of silicone rubber materials, and particularly relates to a ketonized halloysite nanotube and its preparation method and application. The preparation method includes: dissolving levulinic acid in N,N'-dimethylformamide, and then adding an acidic reagent to adjust the pH to 2.5-3.5 to obtain a mixed solution; adding halloysite nanotubes to the mixed solution, and under acidic conditions, carrying out an esterification reaction between levulinic acid and halloysite nanotubes to obtain ketonized halloysite nanotubes; then using the ketonized halloysite nanotubes to prepare a ketonized halloysite nanotube silicone rubber composite material, and the composite material is made of the following raw materials in parts by weight: 100 parts of a silicone rubber matrix, 30-80 parts of a reinforcing agent, 2-4 parts of a vulcanizing agent, and 10-80 parts of ketonized halloysite nanotubes. The present invention not only overcomes the problem that halloysite nanotubes are difficult to be uniformly dispersed in the silicone rubber matrix, but also significantly improves the flame retardancy and mechanical properties of the silicone rubber.

The application discloses a method for extracting flavones from scutellaria baicalensis georgi by using an ultrasonic-assisted deep eutectic solvent. The method selects a deep eutectic solvent (DES) such as choline chloride-levulinic acid as an extraction medium, and integrates a BBD-ANN-GA (response surface-artificial neural network-genetic algorithm) hybrid model to globally optimize the extraction process. Under the conditions of a material-liquid ratio of 78 g / g, a temperature of 58 DEG C and a time of 30 min, the yield of total flavones from scutellaria baicalensis georgi is 194.03 mg / g. The obtained extract has excellent antioxidant biological activity, and the DES solvent still maintains structural stability after being recycled for 5 times. It is proved by evaluation with ComplexGAPI and AGREEprep tools that the application has the advantages of high extraction efficiency, renewable solvent and low environmental impact, and provides a technical reference for intelligent and green development of traditional Chinese medicine resources.

This invention provides a high-temperature resistant core sampling sealing fluid, its preparation method, and its application. The high-temperature resistant core sampling sealing fluid comprises the following components in parts by weight: 65-85 parts of polyol ester, 6-20 parts of thickener, and 1-7 parts of sealant; wherein the polyol ester includes neopentyl glycol diacetylpropionate and / or pentaerythritol oleate. This invention prepares a high-temperature resistant core sampling sealing fluid with high Brinell viscosity and long fiber length by dissolving the thickener in a polyol ester containing a sealant. Furthermore, the preparation method of this sealing fluid is simple, cost-controllable, and conducive to large-scale application. The sealing fluid prepared by this invention has good film-forming properties, excellent sealing effect, low filtrate intrusion, and effectively protects the core from drilling fluid contamination. It is also biodegradable and environmentally friendly.

The disclosure relates to systems and methods for the production of levulinic acid, furfural, and formic acid from feedstock materials containing cellulose and hemicellulose. The levulinic acid, furfural, and formic acid can each be produced in relatively high yield simultaneously and in the same reactor vessel.

The application discloses a preparation method of a pyrrolidone derivative. Under the action of a non-precious bimetallic multifunctional catalyst, an acetylenic acid derivative shown in formula I is reacted with an amine, a nitro compound or a nitrile compound shown in formula II in a reaction solvent under the heating and stirring of hydrogen gas to prepare a pyrrolidone derivative shown in formula III, and a reaction formula is as follows: the non-precious bimetallic multifunctional catalyst is a nitrogen-doped carbon-based carrier NC derived from a metal-organic framework material ZIF-8 and an effective active ingredient embedded on the carrier NC; the effective active ingredient comprises two metals, one metal is Co, and the other metal is any one of Ni or Cu. The yield of the pyrrolidone derivative synthesized by the method can reach 77% to 100%. The method has the advantages of simple process, high selectivity of the target product, cleanness and environmental protection, small catalyst consumption, low cost, simple catalyst preparation, high catalytic stability and suitability for industrial production.

The invention relates to a solvent composition comprising at least one specific levulinic acid ester as a first solvent and at least one specific amide as a second solvent. The invention also relates to the use of the solvent composition for producing agrochemical formulations and to the agrochemical formulations themselves.

Article side polymers useful in the packaging of transdermal patches are disclosed. These films do not absorb skin permeation enhancers that are contained in transdermal patches including keto acids such as levulinic acid or sulfoxides such as an alkyl sulfoxide, e.g., dimethyl sulfoxide. Using such polymeric film, multilayer pouch constructions can be manufactured which include other polymeric layers, such as aluminum foil for moisture and oxygen barrier properties, polyester for tear resistance and paper layers for optimal printing and design.