57 results about "Levulinic acid" patented technology

The objective is to provide 5-aminolevulinic acid or its salts and a method for producing the same, which have fewer impurities and residual solvents and suppressed discoloration compared to conventional methods. The objective is to provide 5-aminolevulinic acid or its salts, wherein, based on peak area obtained by HPLC analysis, the ratio of the content of individual impurities to the content of 5-aminolevulinic acid or its salt is 0.0007 or less, and the sum of the ratios of the content of individual impurities to the content of 5-aminolevulinic acid or its salt is 0.0016 or less.

The application discloses a polyacid zeolite imidazolate framework loaded monatomic catalyst and a preparation method and application thereof, and belongs to the technical field of catalysts. The preparation method of the catalyst is as follows: (1) preparing a zeolite imidazolate framework material; (2) mixing the dried zeolite imidazolate framework material and a metal salt in a solvent and stirring; then adding a heteropoly acid, controlling the pH in the system to be 5-7, and performing a solvothermal reaction under the condition of 80-120 DEG C; after the reaction is completed, cooling and centrifugal separation are performed to obtain a precipitate; and (3) performing calcination treatment on the precipitate to obtain the polyacid zeolite imidazolate framework loaded monatomic catalyst. The polyacid zeolite imidazolate framework loaded monatomic catalyst prepared by the method has high catalytic activity, high selectivity and good cycle stability, and has a good application prospect in acetyl propionate esterification reaction.

The invention belongs to the technical field of metal surface treatment, and discloses a high-permeability and low-corrosion die-casting aluminum degreasing agent as well as a preparation method and application thereof. The die-casting aluminum degreasing agent comprises an active matter and water, the active matters comprise 6 to 10 percent of organic weak acid, 0.5 to 1.5 percent of chitosan oligosaccharide, 0.5 to 1.2 percent of tea polyphenol, 0.7 to 1.8 percent of curcumin, 4 to 6 percent of surfactant, 0.4 to 1.0 percent of cyclodextrin, 0.5 to 0.8 percent of low-foaming additive, 1.0 to 2.0 percent of buffering agent, 0.6 to 1.5 percent of corrosion inhibitor and 0.2 to 0.5 percent of lipase by taking the total mass of the die-casting aluminum degreasing agent as 100 percent; the organic weak acid comprises levulinic acid, lactic acid and acetoacetic acid; the corrosion inhibitor comprises polycarboxylate and hydroxy carboxylate. The die-casting aluminum degreasing agent has excellent removal capacity for common silicone oil / ester release agents on the surface of a die-casting aluminum alloy, is low in corrosivity and does not contain phosphorus or fluorine or other components prone to polluting water.

The present application relates to the field of metabolic engineering and microbial fermentation, and in particular to a recombinant shewanella producing 5-amino levulinic acid and its application. The present application discloses a new 5-amino levulinic acid producing strain, which is obtained by modularly modifying shewanella by synergistically expressing 5-amino levulinic acid production module genes (hemA, hemL and gltX) derived from shewanella, antioxidant module genes (katE, sodB) derived from escherichia coli, and introducing inhibition modules (the inhibition genes are hemB2 and sucA), so that the shewanella can efficiently produce 5-amino levulinic acid, and the yield of 5-amino levulinic acid can be increased by 134.0 times compared with the original strain.

Levulinic acid and formic acid are valuable chemical intermediaries present in byproducts of some biomass conversion processes. Described herein are commercially viable processes for extracting levulinic acid and formic acid at high recovery. Under the present approach, levulinic acid and formic acid may be extracted from an aqueous reactor product, such as an acidic brine (e.g., calcium chloride brine) feed from a biomass hydrolysis reaction. If present, mineral acid catalysts may be recovered. Embodiments use solvents such as, e.g., 2-methyl tetrahydrofuran, for extracting levulinic acid and formic acid from the aqueous solution.

The present invention relates to the field of organic synthesis and in particular to a process for the preparation of levulinic acid or a salt or levulinic acid ester thereof.

The application discloses a method for extracting flavones from scutellaria baicalensis georgi by using an ultrasonic-assisted deep eutectic solvent. The method selects a deep eutectic solvent (DES) such as choline chloride-levulinic acid as an extraction medium, and integrates a BBD-ANN-GA (response surface-artificial neural network-genetic algorithm) hybrid model to globally optimize the extraction process. Under the conditions of a material-liquid ratio of 78 g / g, a temperature of 58 DEG C and a time of 30 min, the yield of total flavones from scutellaria baicalensis georgi is 194.03 mg / g. The obtained extract has excellent antioxidant biological activity, and the DES solvent still maintains structural stability after being recycled for 5 times. It is proved by evaluation with ComplexGAPI and AGREEprep tools that the application has the advantages of high extraction efficiency, renewable solvent and low environmental impact, and provides a technical reference for intelligent and green development of traditional Chinese medicine resources.

This invention provides a high-temperature resistant core sampling sealing fluid, its preparation method, and its application. The high-temperature resistant core sampling sealing fluid comprises the following components in parts by weight: 65-85 parts of polyol ester, 6-20 parts of thickener, and 1-7 parts of sealant; wherein the polyol ester includes neopentyl glycol diacetylpropionate and / or pentaerythritol oleate. This invention prepares a high-temperature resistant core sampling sealing fluid with high Brinell viscosity and long fiber length by dissolving the thickener in a polyol ester containing a sealant. Furthermore, the preparation method of this sealing fluid is simple, cost-controllable, and conducive to large-scale application. The sealing fluid prepared by this invention has good film-forming properties, excellent sealing effect, low filtrate intrusion, and effectively protects the core from drilling fluid contamination. It is also biodegradable and environmentally friendly.

The disclosure relates to systems and methods for the production of levulinic acid, furfural, and formic acid from feedstock materials containing cellulose and hemicellulose. The levulinic acid, furfural, and formic acid can each be produced in relatively high yield simultaneously and in the same reactor vessel.

The application discloses a preparation method of a pyrrolidone derivative. Under the action of a non-precious bimetallic multifunctional catalyst, an acetylenic acid derivative shown in formula I is reacted with an amine, a nitro compound or a nitrile compound shown in formula II in a reaction solvent under the heating and stirring of hydrogen gas to prepare a pyrrolidone derivative shown in formula III, and a reaction formula is as follows: the non-precious bimetallic multifunctional catalyst is a nitrogen-doped carbon-based carrier NC derived from a metal-organic framework material ZIF-8 and an effective active ingredient embedded on the carrier NC; the effective active ingredient comprises two metals, one metal is Co, and the other metal is any one of Ni or Cu. The yield of the pyrrolidone derivative synthesized by the method can reach 77% to 100%. The method has the advantages of simple process, high selectivity of the target product, cleanness and environmental protection, small catalyst consumption, low cost, simple catalyst preparation, high catalytic stability and suitability for industrial production.

This invention discloses a method for extracting the effective components of Polygonum multiflorum based on a eutectic solvent system. The method involves dissolving Polygonum multiflorum powder in a eutectic solvent and then extracting it using ultrasound to obtain the effective components. The eutectic solvent includes hydrogen bond donor compounds and hydrogen bond acceptor compounds. The hydrogen bond donor compounds include one or more of xylitol, sorbitol, ethylene glycol, levulinic acid, DL-malic acid, urea, N,N'-dimethylurea, acetamide, glycerol, citric acid, oxalic acid, methylurea, or malonic acid. The hydrogen bond acceptor compounds include one or more of choline chloride, betaine, proline, levulinic acid, glycerol, citric acid, or ethylene glycol. This invention synthesizes various eutectic solvents and systematically investigates their extraction and transformation effects on the effective components of Polygonum multiflorum. These extraction solvents are green, biodegradable, and have great application prospects. They can effectively reduce hepatotoxic components in Polygonum multiflorum and improve the extraction efficiency of its effective components.

The present application relates to the field of petroleum component separation, discloses a kind of composition, eutectic solvent and its preparation method and application, the method for extracting and separating aromatic hydrocarbon in petroleum fraction.A kind of composition, the composition includes 1-ethyl pyridine chloro salt and acetylenic acid;Wherein, the molar ratio of 1-ethyl pyridine chloro salt and acetylenic acid is 0.5-5:1.The eutectic solvent prepared by the specific composition disclosed in the present application is used to extract and separate aromatic hydrocarbon in petroleum fraction, and there is basically no solvent residue in the raffinate obtained, the subsequent aromatic hydrocarbon separation method is simple, the extraction effect is obviously improved;And compared with the existing commonly used extraction solvent, it has higher aromatic hydrocarbon selectivity.

The present invention relates to a transdermal absorption preparation that can maintain a blood concentration sufficient to exert the efficacy of tandospirone, and also shows good storage stability against heat, humidity, and light. According to the present invention, a transdermal absorption preparation containing tandospirone or a pharmaceutically acceptable salt thereof, and levulinic acid, which is superior in the skin permeability of tandospirone or a pharmaceutically acceptable salt thereof in the preparation, and shows good preservation stability against heat and light can be provided.

The application provides a kind of liposome nano-reactor loaded separation microneedle and its preparation method and application, belong to the field of biological medicine.The application uses phospholipid, cholesterol, tetramethoxysilane and 3-aminopropyl triethoxysilane as raw material, encapsulates cisplatin, 5-aminoacetylpropionic acid and catalase, and prepares liposome nano-reactor;With polyvinylpyrrolidone, citric acid, sodium bicarbonate and regenerated silk fibroin as raw material, the liposome nano-reactor is dispersed in microneedle body by pouring method, and a kind of microneedle that can be quickly separated is successfully prepared.The experimental research of the application proves that the separation microneedle has good biocompatibility and mechanical property, can effectively break through the stratum corneum, realize the efficient transdermal delivery of liposome nano-reactor.The liposome nano-reactor can be locally planted in deep tissue of tumor, continuously supply oxygen through enzymatic reaction, effectively improve the oxygen supply shortage of tumor photodynamic therapy, and has obvious advantages and broad prospects in the application of skin tumor photodynamic therapy.

This application relates to the field of aquatic product logistics technology, and more particularly to an additive for improving the survival rate of yellow catfish during long-distance transportation and its preparation method. An additive for improving the survival rate of yellow catfish during long-distance transportation comprises the following raw materials: 0.2-0.5 parts of microbial preparation, 2-3 parts of glucose, 0.5-1 parts of compound vitamins, 3-5 parts of pH adjuster, 0.2-0.4 parts of 5-aminolevulinic acid, 0.8-1.2 parts of traditional Chinese medicine extract, and 91-95 parts of deionized water. The additive of this application, through the synergistic effect of microbial preparation, 5-aminolevulinic acid, and traditional Chinese medicine extract, improves hypoxia, improves water quality, enhances the immunity and stress resistance of yellow catfish, significantly increases the survival rate of yellow catfish during long-distance transportation, effectively solves the problem of low survival rate of yellow catfish during long-distance transportation, and can be widely used in the logistics and distribution of yellow catfish.

The invention relates to the field of functional feed, in particular to application of 5-aminolevulinic acid in preparation of products for preventing and treating ascites symptoms of broiler chickens, the products further contain bacillus coagulans BC001, and the preservation number of the bacillus coagulans BC001 is CGMCC No.26470. The invention further relates to application of the 5-aminolevulinic acid in preparation of the products for preventing and treating ascites symptoms of the broiler chickens. The addition amount of the 5-aminolevulinic acid or the pharmaceutically acceptable salt of the 5-aminolevulinic acid in the product is 5-1000g per ton of feed according to the addition amount of the 5-aminolevulinic acid in the feed; the product contains vitamin C and sodium selenite. It is found for the first time that 5-ALA has a remarkable effect on reducing the occurrence rate of broiler ascites syndrome, and the remarkable effect can be achieved by preferably adding 50 g of 5-ALA per ton of feed. 5-aminolevulinic acid, VC and sodium selenite synergistically act, so that the effect of preventing and treating the ascites syndrome of the broilers is better, and the morbidity and mortality of the ascites syndrome of the broilers can be remarkably reduced through synergism.

The invention belongs to the technical field of food chemistry and biological catalysis, and particularly relates to an enzymolysis reaction additive in low-sugar food and a preparation method of the enzymolysis reaction additive. According to the additive, tea polyphenol subjected to glycosylation-amidation synergistic modification and gluconic acid-acetamide are used as main components, sodium lactobionate, levulinic acid, 1-ethyl-3-methylimidazolium acetate, sodium citrate, polyethylene glycol-400 and ascorbic acid are used as auxiliary components, and through a synergistic modification and small molecule stabilization strategy, the tea polyphenol-gluconic acid-ascorbic acid composite additive is prepared. The hydrophilicity, the stability and the interaction capability with enzyme molecules of the tea polyphenol are improved. The prepared additive can significantly improve the reaction rate and thermal stability of amylase and protease in a low-sugar system, and improve the dispersity and uniformity of the system. The method has the advantages of scientific and reasonable formula, mild reaction conditions, high stability, excellent food compatibility and the like, and can be widely applied to the field of enzymatic processing of low-sugar foods, sugar substitutes and functional foods.

The present application belongs to the technical field of synthetic biology and microbial metabolic engineering, and particularly relates to a high-yield 5-amino levulinic acid (ALA) strain, a screening method and application thereof. The present application discloses that 5-amino levulinic acid (ALA) causes higher levels of oxidative stress in a dose-dependent manner, and the oxidative stress caused by ALA reduces the intracellular cAMP level of Escherichia coli. Based on this, the present application constructs cAMP response promoters with different kinetic ranges, and establishes a high-throughput screening system of ALA high-yield strains on the basis. The present application uses the system to screen enzyme high-yield mutants in two ALA production pathways (C4 pathway and C5 pathway) through fluorescence-activated cell sorting (FACS), and successfully screens excellent mutant strains of ALA production pathway enzymes, and therefore has good practical application value.

The invention relates to cosmetic and dermatological preparations comprising a combination of levulinic acid and anisic acid. The preparations according to the invention are particularly suitable for application to the skin. These preparations exhibit selective antibacterial action on the skin, specifically targeting anaerobic bacteria of the skin flora, while having little or no bactericidal action against aerobic bacteria. The compositions according to the invention are therefore suitable for cosmetic skin care as well as for the dermatological treatment of certain skin conditions, such as acne.

The invention belongs to the technical field of catalytic chemistry and biomass conversion, and particularly relates to a method for preparing alkyl levulinate by catalyzing furfuryl alcohol through a molecular sieve. The method comprises the following steps: in an inert atmosphere, taking furfuryl alcohol as a raw material, taking an alcohol / water mixed solution as a solvent, adopting a specific catalyst, and carrying out alcoholysis reaction on furfuryl alcohol at a certain reaction temperature and reaction pressure to prepare alkyl levulinate by a one-pot method. The problems that in the prior art, a route for preparing alkyl levulinate from levulinic acid is high in cost and furfuryl alcohol conversion selectivity is low are solved, a high-activity and high-selectivity environment-friendly catalytic system is developed, the conversion rate of furfuryl alcohol in the whole reaction can reach 100%, the yield of alkyl levulinate can reach 85%, and the method is suitable for industrial production. And a very attractive technical route is provided for green, efficient and sustainable production of alkyl levulinate.

This invention provides a 5-aminolevulinic acid producing strain, its construction method, and its application. Based on the existing strain JAL9, it involves knocking out… pflB、ldhA、poxB、adhE、ackA、dppA Genes, upregulated eamA、grxA、sodB The transcriptional level of the katE gene was downregulated. pfkB Gene transcription level, heterologous expression hemA ST Genes and xfp The gene, along with a high-copy plasmid PETC4, expresses genes from... Rhodobacter capsulatus of hemA RC Genes, ultimately through hemB Introducing an ASV degradation tag at the gene terminus enhances the degradation of HemB protein, effectively improving the synthesis efficiency of 5-aminolevulinic acid. This method has good industrial application value when applied to the fermentation production of 5-aminolevulinic acid.

The present invention provides an emulsified hair cosmetic composition that offers excellent manageability of hair during application and after heat treatment, as well as excellent manageability and persistence of hair after heat treatment. [Solution] The emulsified hair cosmetic composition of the present invention contains levulinic acid (component A), a cationic surfactant (component B), an aliphatic alcohol having 8 to 24 carbon atoms (component C), a silicone compound (component D), and water (component E).

Provided are methods for producing levulinic acid from hemp hurds. In some embodiments, the methods include dissolving hemp hurds in an ionic liquid medium to produce a cellulose-rich product; hydrolyzing cellulose present in the cellulose-rich product to produce a glucose-rich product; dehydrating glucose present in the glucose-rich product, and / or fructose resulting from isomerization of the glucose, to produce 5-hydroxymethyl furfural (HMF); and hydrolyzing the HMF to levulinic acid. Also provided are methods for producing levulinic acid from sugar sources generally, which can include providing a sugar source, wherein the sugar source is a hydrolysis product produced by hydrolyzing a cellulose-rich product generated from hemp hurds and / or a cellulase digestion product of softwood pre-treated with phosphoric acid (H3PO4) or another acid; dehydrating the glucose present in the sugar source, and / or fructose resulting from isomerization of glucose present in the sugar source, to produce 5-hydroxymethyl furfural (HMF); and hydrolyzing the HMF to produce levulinic acid.

The utility model discloses an instrument for accurately detecting the content of 5-aminolevulinic acid, which relates to the technical field of chemical detection and comprises a pretreatment tank, a treatment cavity is formed in the pretreatment tank, a rotating rod is arranged in the treatment cavity, a plurality of filter screen frames are uniformly and fixedly connected to the periphery of the rotating rod, and the filter screen frames are fixedly mounted at the bottom end of the rotating rod; fixing rods are fixedly connected to the two sides of the treatment cavity, and bristles are fixedly connected to the ends, close to each other, of the two fixing rods. According to the utility model, through the cooperation of the components, the outer wall of the filter screen frame is brushed by the bristles in the rotary filtering process of the filter screen frame, so that the bristles can remove impurities on the filter screen frame in time, the filter screen frame is prevented from being blocked by the impurities, the detection result deviation caused by impurity interference is avoided, and the detection accuracy is improved; due to the fact that the outer wall of the filter screen frame is cleaned in the rotating process of the filter screen frame, the automatic cleaning effect is achieved, manual intervention is reduced, and the labor intensity and the working risk of workers are reduced.

The invention discloses a method for preparing isopropyl levulinate through catalytic conversion of furfural. The catalyst 1 is prepared by a coprecipitation method. The method comprises the following steps: by taking biomass furfural as a raw material and isopropanol as a solvent, carrying out closed reaction for 2-12 hours at 110-160 DEG C under the N2 pressure of 1 MPa at the stirring speed of 800 rpm, and then cooling to room temperature, thereby obtaining isopropyl levulinate. Under optimal conditions, the conversion rate of furfural is 100%, and the yield of isopropyl levulinate is 86.80%; the catalyst is simple in preparation method and low in cost, and the catalytic system is green and efficient and has a wide application prospect.

The invention discloses a synthetic method of 5-aminolevulinic acid and derivatives thereof, 5-aminolevulinic acid and derivatives thereof and application, and relates to the technical field of chemical synthesis, and the synthetic method comprises the following steps: mixing monoalkyl succinate, an inert solvent and an activating reagent, and carrying out acylation activating reaction to obtain a first intermediate; mixing the first intermediate, nitromethane, an alkaline agent, a molecular sieve and an organic solvent, and carrying out nitro condensation reaction to obtain a second intermediate; and mixing the second intermediate, a solvent and a catalyst, and carrying out catalytic hydrogenation reaction to obtain the 5-aminolevulinic acid and the derivative thereof. By adopting the steps, only three-step reaction is needed from the initial raw material to the target product, the reaction conditions are mild and efficient, the 5-aminolevulinic acid and the derivative thereof prepared by the process are white solids, the chemical purity of the 5-aminolevulinic acid and the derivative thereof can reach more than 96.0% and the yield can reach more than 70% through HPLC (High Performance Liquid Chromatography) analysis, and the requirements of industrial large-scale production are completely met.

A process to obtain a halogenated methyl furfural from a high purity cellulose source, said process comprising the steps of: - providing a reaction vessel; - providing said high purity cellulose source into said reaction vessel, wherein said high purity cellulose source has a content of hemicellulose of less than 15 %, preferably less than 10 % and more preferably less than 5 %, and a Kappa number of less than 10, more preferably less than 5, and even more preferably, less than 2; - mixing said high purity cellulose source to a concentrated acid and an organic solvent at a reaction temperature ranging from 50 to 200 °C for a period of time sufficient to convert at least 75 % of the high purity cellulose source into said halogenated methyl furfural; - separating a resulting organic phase from an aqueous phase, wherein the organic phase comprises said halogenated methyl furfural and where the concentrated acid is comprised in said aqueous phase; - optionally, evaporating said organic solvent to yield said halogenated methyl furfural; and wherein said process yields less than 2.5 % of levulinic acid as a side product.

This invention relates to the field of preservation materials technology, specifically to a method for preparing and applying a long-chain glycerol levulinic acid carboxylic acid derivative. The specific technical solution is as follows: a method for preparing a long-chain glycerol levulinic acid carboxylic acid derivative involves reacting the long-chain glycerol levulinic acid derivative with levulinic acid under heating in the presence of a catalyst. The reaction is carried out under vacuum, with a vacuum degree of 0.07–0.1 MPa, a reaction temperature of 80–150°C, and a reaction time of 1–5 hours. This invention solves the problem that existing glycerol monolaurate is difficult to use as a functional additive for PLA or PBAT.

The invention discloses a method for determining organic acids in main stream smoke of cigarettes, which is used for determining 16 organic acids in the main stream smoke of the cigarettes. The 16 organic acids are respectively crotonic acid, tiglic acid, trans-2-methyl-crotonic acid, levulinic acid, benzoic acid, furoic acid, lauric acid, tetradecanoic acid, cinnamic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, nonadecanoic acid, linolenic acid and arachidic acid; the method comprises the following steps: capturing flue gas, oscillating and extracting, preparing a standard solution, preparing a solution to be detected, qualitatively analyzing and quantitatively analyzing. By adopting the method, the 16 organic acids in the mainstream smoke of the cigarette can be accurately determined.

The present invention relates to a procedure for the conversion of γ-ketoacids, such as levulinic acid, to γ‑lactones in the presence of a Ni-based catalyst and isopropanol as hydrogen source and solvent via photothermal process using UV to NIR light as energy source (such as solar and laser). This is a sustainable, economically and environmentally viable procedure that has demonstrated nearly complete conversion in less than 2h under moderate conditions.