289 results about "High doses" patented technology

A method of planning radiation treatment for a patient includes identifying a region of interest of the patient to be treated with radiation and determining a simulated treatment plan for the region of interest based on a statistical analysis between one or more metrics of the identified region of interest and a previously determined predictive dynamics database that includes information regarding the one or more metrics for corresponding regions of interest for a population of patients. The method further includes characterizing the simulated treatment plan with a FLASH Index that compares an ideal FLASH radiation treatment plan to the simulated treatment plan.

The invention discloses a traditional Chinese medicine composition with the effects of benefiting qi, nourishing blood, invigorating the spleen and tonifying the kidney and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: cistanche, ginseng, American ginseng, astragalus membranaceus, medlar, rhizoma polygonati, oyster peptide, angelica sinensis, radix rehmanniae preparata, donkey-hide gelatin, fructus amomi, pericarpium citri reticulatae, hawthorn, folium cortex eucommiae, radix puerariae, liquorice and the like. The preparation method comprises the following steps: respectively crushing the medicinal materials, dissolving the colla corii asini, mixing, adding water, granulating and the like. The composition can be prepared into various dosage forms such as granules, capsules, tablets, oral liquid and the like. Experiments show that the traditional Chinese medicine composition can effectively improve the symptoms of deficiency of qi and blood (increasing erythrocyte count and hemoglobin content), weakness of spleen and stomach (increasing body weight and improving pepsin activity) and kidney deficiency (reducing creatinine and urea nitrogen content and improving SOD activity), and acute toxicity experiments show that the toxicity is slightly reversible under high dosage, and the safety is good under therapeutic dosage. The traditional Chinese medicine composition has potential application value in the aspect of preparing medicines for benefiting qi, nourishing blood, invigorating spleen and tonifying kidney.

The invention discloses a gravitational field model-based lattice space segmentation radiotherapy lattice point optimization method, and relates to the technical field of radiotherapy. According to the method, by combining a PET-CT functional image, a key region, especially a hypoxic region (functional target region), of a tumor is recognized more accurately, and the positions and the distances of lattice points are dynamically adjusted according to biological characteristics of the tumor; arrangement of lattice points is dynamically adjusted through a gravitational field model, it can be guaranteed that a high-dose area accurately covers a key area of a tumor, unnecessary side effects can be reduced to the maximum extent, the risk of tumor recurrence is reduced, the method can better adapt to functional heterogeneity of the tumor, personalized treatment is achieved, and the method has good application prospects. And the influence on normal tissues is reduced while the treatment accuracy is improved, a more reliable treatment scheme is provided for treatment of complex tumors, and accurate dose distribution aiming at different tumor biological characteristics is realized.

The invention discloses an ultra-high dose rate radiotherapy plan optimization system based on compensator modulation, and relates to the technical field of radiotherapy. A data acquisition module is used for acquiring medical image data of a patient and receiving a clinical target; the clinical target comprises a target region prescription dose, an organ-endangering limit and a minimum dose rate threshold value required for triggering and maintaining a FLASH effect; and the FLASH biological effect evaluation module is used for calculating FLASH biological effective dose distribution corresponding to the physical dose distribution through an embedded biological effect model based on the input physical dose distribution and dose rate distribution. According to the method, the physical dose is converted into the accurate FLASH biological effective dose through the improved linear quadratic model embedded with the FLASH correction factor, the target tumor killing effect is guaranteed, normal tissue protection is enhanced with the help of the tissue differentiation correction factor, the industrial pain point that the physical dose reaches the standard but the biological effect does not reach the expectation is effectively solved, and the application prospect is wide. And the treatment plan better meets the clinical curative effect and safety core requirements.

The present relates to device for ultra-high dose rate radiation treatment to a patient, comprising: —a radiation source for providing a radiation beam, and—a linear accelerator for accelerating said radiation beam until a predetermined energy, and—a beam delivery module for delivery the accelerated radiation beam. The device is arranged for generating an accelerated radiation beam having a predetermined energy between about 50 MeV and about 250 MeV, to deliver rate radiation dose of at least 10 Gy, during an overall time less than about 200 ms in order to generate a radiation field for treating a target volume of at least about 30 cm3, with said ultra-high dose rate radiation dose and / or a target volume located at least about 5 cm deep in the tissue of the patient with said ultra-high dose rate radiation dose.

A small animal imaging and radiotherapy (RT) irradiator device uses a circular array x-ray source to scan an anatomy of an animal, delivers conventional and ultra-high dose rate of radiation to the treatment target. The multipixel x-ray source includes a ring of focal spots capable of irradiating x-ray beams from around fifty beam angles. The x-ray beams are collimated with a collimator designed in treatment planning.

The present disclosure relates to the field of radiotherapy, in particular, methods of and apparatus for treating cancer using ultra-high dose rate radiotherapy (FLASH). The apparatus may comprise a device configured to administer to the subject no more than five fractions of proton ultra-high dose rate radiotherapy (FLASH), said fractions having a range of radiation from 1.5 Gy to 60 Gy, collectively. The device may be configured such that the treatment is sufficient to prevent further growth of the tumor for at least 10% longer than standard of care radiotherapy, induce at least 10% more tumor regression than standard of care radiotherapy and / or delay tumor regrowth by at least about 2 months longer than standard of care radiotherapy.

The invention relates to a low-pressure ionization chamber, a design method and a medical linear accelerator, and belongs to the technical field of radiotherapy dose monitoring, the low-pressure ionization chamber comprises a shell, a closed cavity is formed in the shell, a low-pressure environment lower than standard atmospheric pressure is formed in the closed cavity, and the ion recombination ratio of positive and negative charges is not larger than 0.01; according to the invention, the technical problem in the prior art that the monitoring result is inaccurate under the ultrahigh dose rate due to the influence of ion recombination on the penetration type air ionization chamber can be solved.

The invention discloses a coenzyme Q10-containing medicine for improving heart activity and a preparation method thereof, and particularly belongs to the technical field of biological medicines. The medicine comprises functional components and auxiliary materials, wherein the functional components comprise a cactus extract, a calligonum mongolicum extract, an astragalus membranaceus extract, a sea-buckthorn extract and coenzyme Q10; the hypoxia survival time and the load-bearing swimming time of mice can be remarkably prolonged through low, medium and high dose groups of the medicine for improving the heart vitality, the requirement of fatigue caused by high labor intensity for oxygen is further met by enhancing the immunity of the organism, supply of nutrient substances to the brain, the heart, the bones and the muscles of the organism is enhanced, and the effect of improving the heart vitality is achieved. The composition can regulate the activity of central nervous system, promote the normal operation of the body circulation system, relieve and eliminate fatigue and damage to the body caused by fatigue and chronic fatigue, and quickly recover physical strength.

The present invention relates to the technical field of medical imaging. Disclosed are a method, system and apparatus for oral cavity CBCT ultralow-dose imaging. The method comprises: collection of high-dose oral cavity CBCT image data, data splitting processing, data three-dimensional reconstruction processing, model training, image data inputting, image enhancement, and image data outputting; and the specific process involves: performing three-dimensional reconstruction processing on oral cavity CBCT two-dimensional projection data in an ultralow-dose mode of a patient, so as to obtain ultralow-dose oral cavity CBCT three-dimensional reconstruction image data, inputting same into an oral cavity CBCT ultralow-dose imaging image enhancement network model, and performing outputting to obtain high-quality oral cavity CBCT image data for a subsequent clinical diagnosis and treatment process. The present invention can significantly reduce a radiation dose for imaging and accelerate an imaging speed while ensuring the imaging quality, thereby improving the safety of oral cavity CBCT imaging, and having broad clinical application prospects.

The present disclosure provides systems and methods for dynamically visualizing the delivery of a device within a vessel by correlating at least one first extraluminal image with second extraluminal images. The extraluminal images may be correlated based on motion features, without the use of other sensors or timestamps. The first extraluminal image may be a high dose contrast x-ray angiogram ("XA") and the second extraluminal images may be low dose contrast XAs. The high dose contrast XA may be used to generate a vessel map. The low dose contrast XAs may be taken during the delivery of a device, such as a balloon, stent, probe, or the like. Correlating the high dose XA and low dose XA based on motion features allows for the vessel map to be overlaid on the low dose XA to provide the physician visualization of where the device is within the vessel tree in real time.

The invention provides an ultrahigh dose rate radiation method, which comprises the following steps: controlling a plurality of beam modules to be positioned at a plurality of target positions in a one-to-one correspondence manner so as to form different radiation angles relative to the same target part; and under the condition that a to-be-radiated area of a target object is located at the target part, the beam modules are controlled to alternately emit multiple radiation beams to the target part from the different radiation angles, and each radiation beam in the multiple radiation beams has an ultrahigh dose rate. The invention further provides an ultrahigh dose rate radiation device.

The invention discloses a medicine for treating autism, application of the medicine for treating autism in preparation of a medicine for improving social competence damage of autism animals or people, and application of the medicine for treating autism in preparation of a medicine for improving anxiety behaviors of autism animals or people. When the high-dose vitamin D is used for intervening autism mice, the method has the advantages of being economical, convenient to take and good in effect, animal experiment evidence is provided for supplementing large-dose VD to intervene autism spectrum disorders in the early stage of clinical experiments, and a new thought is provided for early prevention and treatment of neurodevelopment disorders of clinical children.

The invention discloses a method for calculating a radiation dose rate based on pulse counting, which is used for filtering the influence of a large pulse generated under the condition of jitter or other interference in a dose rate calculation process on dose rate jitter calculation, and can effectively reduce the dose rate jitter caused by the interference. Meanwhile, pulse increase or decrease caused by normal rapid increase or decrease of radiation is responded in time, dose rate output is rapidly calculated, that is, when the radiation is rapidly increased or decreased, the dose rate change time is shortened, and therefore the current dose rate level is displayed more timely and stably; through the method provided by the invention, the calculation of the dose rate can effectively filter abnormal pulses and reduce fluctuations, and meanwhile, when the radiation intensity changes quickly, quick response can be realized, the timeliness of dose rate calculation can be improved, the stability and accuracy of dose rate output can be ensured, and reliable data support can be provided for safe operation in a nuclear radiation environment.

The present invention provides apparatuses comprising a plurality of junctions providing a Seebeck effect, configured as alternating hot and cold junctions. The apparatus can be configured such that the cold junctions exhibit a different thermal behavior than the hot junctions in response to incident radiation. The junctions can be connected in series, such that the sum of the Seebeck effect from the plurality of junctions provides a sensitive, inherently calibrated indication of heating of the apparatus responsive to incident radiation, and therefore of the radiation itself.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

Described is a device for radiotherapy treatment with a high dose rate of ionizing radiation, comprising an accelerating guide (11) of a medical radiofrequency accelerator, at least two simultaneously thermostated resonant cavities (10) and comprising a first pick-up (12), a second pick-up (12B) in at least two resonant cavities (10) and an optical system (20) of the beam.

The invention discloses an accurate X-ray radiation dose measurement system based on artificial intelligence, which comprises the following steps: acquiring CT image data of a patient and pulse irradiation parameters of radiotherapy equipment through terminal equipment, and calculating a patient specific anatomical structure dynamic influence factor set, a pulse waveform time domain characteristic factor and a tissue interface scattering correction factor; all the parameters are substituted into a dose measurement formula to obtain an accurate X-ray radiation dose value; through a deep fusion image recognition technology (such as a high-resolution anatomical structure, tissue density gradient and heterogeneous region distribution provided by CT / MRI), a secondary particle scattering effect of a junction region of a tumor and a normal tissue can be accurately represented; and dynamic anatomical information (such as respiratory movement and organ displacement) in the image is combined to correct the time characteristic (such as dynamic change under an instantaneous high dose rate) of the pulse radiation field in real time, so that the dose calculation accuracy of a fast algorithm in a complex scene is remarkably improved.

The invention discloses an application of a compound Isaridin E or a pharmaceutical salt thereof in preparation of anti-vascular calcification drugs and related diseases, and relates to the technical field of medical biology. A classical high phosphate induced smooth muscle cell calcification model and an in-vivo vascular calcification model induced by a high dose of vitamin D3 are adopted, and through an in-vitro cell experiment, an in-vitro experiment and an overall animal experiment, it is found that the compound Isaridin E has a remarkable improvement effect on vascular calcification caused by calcium and phosphorus metabolism disorder. The medicine has the effects of remarkably inhibiting vascular smooth muscle cell osteogenic differentiation induced by high phosphate and vitamin D3, inhibiting vascular calcification and remarkably reducing formation of calcium-phosphorus crystals on vascular walls. The invention develops a brand new medical application of the marine compound Isaridin E, and the marine compound Isaridin E can be used for research and development of drugs for treating vascular calcification and calcification-related diseases.

The invention provides a BNCT treatment plan generation method and device based on a barrier algorithm, a medium and a terminal. The method comprises the following steps: acquiring a plurality of irradiation fields; respectively calculating dose distribution per unit time of each irradiation field; taking the irradiation time combination of the plurality of irradiation fields as a generation target, and determining an evaluation index and a constraint condition of the generation target; obtaining the generation target of the minimum value of the evaluation index under the limitation of the constraint condition based on a barrier algorithm so as to obtain an optimal irradiation time combination of the plurality of irradiation fields; and determining the irradiation time of each irradiation field based on the optimal irradiation time combination so as to generate a BNCT treatment plan based on the irradiation time of all the irradiation fields and the corresponding unit time dose distribution. According to the method and the device, the BNCT treatment plan with relatively high dose uniformity can be generated, the damage to surrounding healthy tissues can be reduced while sufficient radiation dose is ensured to be received, and the safety of radiotherapy is effectively improved.

The invention provides an accelerator system adjustment method, an accelerator system, electronic equipment and a storage medium. The transmission characteristic data and the charge quantity data of the undeflected beam are obtained through the first beam position detector, and the form and the charge quantity of the undeflected beam are accurately adjusted in combination with a preset adjustment strategy, so that the stability of beam transmission is ensured. And after the form data of the first beam reaches a preset value, monitoring the deflected beam data by using a second beam position detector, and further accurately adjusting the accelerator system to ensure that the deflected beam conforms to the target transmission characteristics. According to the invention, the transmission state of the beam can be accurately controlled in real time, risks of vacuum box breakdown and the like caused by beam mismatch are avoided, the safety and the stability of the system are improved, the possibility of equipment damage is obviously reduced especially under the high-dose-rate transient beam, and the treatment effect and the continuity of Flash radiotherapy are guaranteed.

The application provides an application of a motion-induced sweat extract in preparation of a medicine for treating, relieving or preventing depression and / or anxiety, and belongs to the field of biological medicine. Specifically, sweat is induced by making a healthy subject perform aerobic exercise of a specific intensity (such as 60%-80% of maximum heart rate), the sweat is collected and eluted by physiological saline, centrifuged and filtered to obtain a biologically active sweat extract. The extract is analyzed by transcriptomics and reverse transcription method to predict the anti-depression potential, and it is proved by in-vivo animal experiments that the extract can significantly improve the anhedonia, behavioral despair and anxiety-like behavior of a depression model mouse, and the effect of a high dose is equivalent to that of a first-line drug fluoxetine. The preparation raw material provided by the application is natural and safe, the preparation process is simple and the cost is low, and a new, easy-to-promote alternative strategy is provided for the prevention and treatment of depression.

A method, system, and device for ultra-low-dose imaging of oral cone-beam computed tomography (CBCT) are provided. The method encompasses high-dose oral CBCT image data acquisition, data segmentation processing, three-dimensional (3D) reconstruction processing, model training, image data input, image enhancement, and image data output. Specifically, the process involves performing 3D reconstruction on 2D projection data of oral CBCT acquired in ultra-low-dose mode to obtain ultra-low-dose oral CBCT 3D reconstructed image data. This ultra-low-dose oral CBCT 3D reconstructed image data is then input into the oral CBCT ultra-low-dose imaging enhancement network model, from which high-quality oral CBCT image data is output for subsequent clinical diagnosis and treatment processes. This method significantly reduces the radiation dose of imaging while ensuring imaging quality, accelerates imaging speed, and enhances the safety of oral CBCT imaging, holding broad clinical application prospects.

The present invention provides a generation method for a surgical resection-type sufficient radiation therapy dose plan for a large hepatocellular carcinoma. Assuming the principles of liver segmentectomy or hemihepatectomy principles when surgical liver resection is used to resect a liver tumor, a radiation therapy plan is generated using a liver region volume remaining after the assumed surgical resection as a target. The method specifically comprises: step 1, obtaining an original medical image; step 2, identifying a target region, a maximal dose region, and a remaining liver region from the original medical image, and obtaining a region identification result; step 3, obtaining a remaining liver region volume, and determining whether the remaining liver region volume is within a preset range; if the remaining liver region volume is not within the preset range, ending; otherwise, executing step 4; step 4, performing radiation therapy plan design on the basis of the region identification result and the original medical image, and obtaining a radiation therapy plan result. The maximum value of the preset range is 700 ml, and the minimum value is 300 ml. The present method can automatically implement radiation therapy plan generation.

The present invention belongs to the technical field of medicine and food homologous compositions, and discloses a composition for enhancing exercise endurance and its applications. It is found that the composition has the following effects: (1) After 30 minutes of intervention with a high dose of the composition, exercise endurance can be significantly enhanced, and it can affect exercise endurance by regulating the levels of hormones such as testosterone and cortisol. (2) Intervention with the composition for 14 days can significantly prolong the swimming time to exhaustion under negative gravity in mice, reduce the accumulation of harmful metabolites, thereby increasing the body's energy metabolism and reducing the degree of fatigue of the body. (3) Intervention with a high dose of the composition for 28 days can significantly increase exercise endurance, and by increasing the muscle glycogen reserve and reducing the accumulation of harmful metabolites such as urea nitrogen and lactic acid, the effect of improving exercise endurance is achieved.

This invention provides a modified BoNT / A for treating facial wrinkles, wherein the modified BoNT / A is administered via intramuscular injection at multiple sites on an individual's face, wherein the modified BoNT / A is administered at a unit dose of greater than 1754 pg or greater than 8000 pg per site, wherein the multiple sites are selected from: up to two sites on the corrugator supercilii muscle and one site on the depressor supercilii muscle for treating glabellar lines; up to five sites on the frontalis muscle for treating forehead wrinkles; and up to three sites on the orbicularis oculi muscle for treating lateral canthal wrinkles, wherein the total dose of modified BoNT / A administered during treatment is up to 264,000 pg (and optionally greater than 88,000 pg), and wherein the modified BoNT / A comprises a BoNT / A light chain and a translocation domain (H N The structure domain), and the BoNT / B receptor binding domain (H C (structural domain).

The invention discloses an insecticidal aerosol composition and a preparation method thereof, and belongs to the technical field of pesticides, a natural plant extract and a low-dose chemically synthesized insecticide are subjected to a synergistic effect, the natural plant extract has certain insecticidal activity, and when the natural plant extract and the chemically synthesized insecticide act together, the insecticidal activity of the natural plant extract is greatly improved. On the premise of ensuring effective insect killing, the dosage of the chemically synthesized insecticide is reduced, the toxic residual quantity is reduced, and toxic substances in contact with a user in the using process are reduced, so that the health risks such as respiratory tract stimulation and skin allergy are reduced, and the body health of the user can be more effectively protected; when a traditional aerosol is used in a high-dose mode, residual toxic substances can be attached to the surface of an indoor article for a long time and enter a human body through ways such as contact and breathing, the risk is greatly reduced by optimizing component combination, and a healthier and safer use environment is provided for a user.

This invention provides a drug-coated balloon catheter, its preparation method, and its application, relating to the field of medical device technology. The drug-coated balloon catheter includes a balloon catheter and a drug coating disposed on the surface of the balloon catheter; the drug coating includes an active drug and an excipient; the active drug is a flavonoid. The drug-coated balloon catheter utilizes flavonoids, which combine the advantages of low toxicity and high water solubility. While reducing the toxic side effects of the drug coating, it achieves rapid release and efficient absorption of the drug. Furthermore, through a dual mechanism of anti-proliferation and anti-inflammation, it effectively solves the problems of potential toxic side effects, limited transport efficiency, and limited functionality that may exist in existing products at high dose densities.

One or more new indicators are introduced in the process of processing the plan. More specifically, correction factors / metrics referred to herein as key / repair ratio indices are introduced, and / or spatially periodic correction factors / metrics referred to herein as key equal dose values are introduced. By using these indicators, the expected savings of the dose spatial distribution may be better considered in the processing mode, including general spatially segmented radiation therapy (SFRT) and particularly SFRT with ultra-high dose rates. The targets may be covered by extended Bragg peaks according to a treatment plan strategy to optimize and / or homogenize target levels of dose distribution, but still can benefit from SFRT saving effects at healthy tissue levels. Transport techniques include a dynamic focusing technique and a magnetic bundle steering technique. Increasing the dose rate can maximize the peak valley dose distribution of SFRT despite movement of the patient.

The present invention provides a pharmaceutical composition for preventing and treating avian white crown disease, belonging to the technical field of chicken breeding. The pharmaceutical composition of the present invention is prepared by mixing 10 to 30 parts of Morin hydrate, 5 to 20 parts of artemisinic acid, 5 to 20 parts of quinic acid, and 5 to 20 parts of ginsenoside total saponin sulfate derivatives. It can effectively improve the phenomena of a sharp drop in egg production rate, an increase in soft-shell eggs, and an increase in mortality rate of sick laying hens in cages, so that the egg production rate, egg quality, and lean meat content can be restored to normal levels; enhance the disease resistance of poultry, reduce stress reactions caused by factors such as drastic changes in temperature and microbial invasion, and improve the immunity of animal bodies; the dosage is small and the curative effect is significant. The high-dose oral liquid of the pharmaceutical composition prepared by the present application was used to feed sick chickens, and the effective rate of treatment reached 100%, and the cure rate reached 94.00%.