63results about How to "Sustained release" patented technology

The invention relates to a nicotine bag absorbed through oral mucosa and a preparation method of the nicotine bag. The nicotine bag comprises nicotine particles, at least one blasting bead containing liquid and a non-woven bag. The nicotine particles and the blasting beads are packaged in the non-woven fabric bags, and the number of the blasting beads contained in each non-woven fabric bag is 1-3. When the nicotine particles are dry particles, the particle size is 1-1000 microns, and the water content range is 1-10% (W / W); when the particles are wet particles, the particle size is 1-1000 microns, and the water content range is 5-15% (W / W); when the particles are oily particles, the particle size is 1-1000 microns, and the moisture content range is 1-10% (W / W); when the particles are pellets, the particle size is 30-2500 microns, and the water content range is 1%-10% (W / W). The nicotine bag capable of being absorbed through the oral mucosa can rapidly and continuously release nicotine and has a long shelf life.

The invention discloses a bone regeneration promoting drug-loaded skull implant with a bionic structure and a preparation method of the bone regeneration promoting drug-loaded skull implant, and belongs to the technical field of medical materials. The skull implant is prepared through a flat plate mold pressing technology and is of a bionic three-layer structure, the upper layer and the lower layer of the haft tube imitating structures and the middle layer of the bone trabecula imitating structure are prepared through the water-soluble core, a vascularization channel can be provided, and bone tissue climbing is promoted; a polydopamine-carboxymethyl chitosan coating is used for carrying out surface modification on a porous structure of the implant, hydroxyapatite in-situ forming and bone regeneration promoting medicine loading are achieved through an impregnation process, and the polydopamine coating can provide a hydration environment; hydroxyapatite in-situ forming increases biocompatibility on the premise of not influencing the mechanical properties of implants, in addition, hydroxyapatite degradation and drug release can jointly induce bone tissue regeneration, and skull repair is promoted.

The invention discloses construction and application of an oral gel drug delivery system based on a yeast microcapsule, and belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations, the drug delivery system is composed of budesonide nanoparticles, the yeast microcapsule and gel, budesonide nanoparticles are prepared from budesonide and a polylactic acid-glycolic acid copolymer through a water-in-oil emulsification evaporation technology, yeast cell wall microcapsules are formed after content of yeast powder is removed, and the budesonide-loaded yeast microcapsules are prepared from the yeast microcapsules and the budesonide nanoparticles through stirring, ultrasonic treatment and freeze drying methods. The yeast cell wall microcapsule without contents is used as a carrier, so that the medicine is protected from being degraded by gastric acid, and the intestinal immune response is regulated by targeting intestinal related lymphatic tissues (GALT). The gel prepared by combining pectin can prolong the residence time of the drug in the intestinal tract, realizes continuous release, reduces the whole-body side effect of budesonide, and improves the treatment efficiency.

The invention relates to the field of epilepsy, in particular to application of alprazolam gel particles in preparation of a medicine for treating the state of epilepsy. The invention provides application of alprazolam gel particles in preparation of a medicine for treating and / or preventing epileptic seizure of a subject, and is characterized in that the alprazolam gel particles are prepared by the following steps: S101, dropwise adding an alprazolam solution into a first solution to form an internal phase solution; s102, forming a preliminarily cured pre-crosslinked liquid drop; s103, forming cured particles; and S104, obtaining the alprazolam gel particles. The blood brain barrier transmittance of the alprazolam gel particles provided by the invention can reach 1.5-2 times that of the prior art, and the alprazolam gel particles are high in effect taking speed, have dual properties of quick release and continuous release, and are suitable for effective and timely treatment of epileptic seizure patients.

The invention discloses a gene engineering exosome and a slow release method and application thereof, the gene engineering exosome is derived from human adipose-derived stem cells, si-tgfbr2 is loaded in the gene engineering exosome, the si-tgfbr2 is specific siRNA aiming at a Tgfbr2 gene, and the gene engineering exosome can regulate and control proliferation of VSMCs, inhibit transformation of the VSMCs from a contraction phenotype to a synthetic phenotype when the VSMCs are stimulated, and inhibit the growth of the VSMCs. According to the present invention, the gene engineering exosome can be used to maintain the normal structure and the function of the blood vessel, and the sustained release effect of the content in the gene engineering exosome can be achieved by wrapping the gene engineering exosome in the PHA biodegradable material, such that the local treatment concentration can be easily stabilized, the drug administration frequency can be easily reduced, the lasting time of the treatment effect can be easily prolonged, and the treatment gene can be effectively delivered to the target cell; the treatment effect is improved; when being used for modifying a small-caliber artificial blood vessel, the small-caliber artificial blood vessel can be improved in biocompatibility and functionality, and can be prevented from being implanted into the blood vessel for remodeling unbenign hyperplasia stenosis; the invention not only provides a new thought and method for the treatment of vascular diseases, but also has important clinical application value and popularization prospect.

The invention discloses a novel process for producing a high-quality liquid fertilizer by using an acetylisovaleryltylosin tartrate finished product liquid, and relates to the technical field of fertilizer preparation, and the novel process comprises the following specific steps: step 1, firstly, weighing polyoxyethylene sorbitan fatty acid ester, ethylenediamine tetraacetic acid disodium salt, cellulase and protease, and uniformly stirring; the preparation method has the advantages that the polylactic acid-glycolic acid copolymer serving as a functional high-molecular polymer has good biocompatibility and controlled release performance, and when a solution prepared from the polylactic acid-glycolic acid copolymer is emulsified and mixed with an alginate oligosaccharide solution, a uniform emulsion-like active synergistic carrier solution is formed; the emulsifying and mixing process enables the effective components in the two solutions to be fully and uniformly combined together to form a stable microsphere and micelle structure, so that the continuous and slow release of the acetylisovaleryltylosin tartrate and the synergistic plant growth regulatory factors thereof in the growth cycle of crops can be ensured, the fertilizer effect of the acetylisovaleryltylosin tartrate and the synergistic plant growth regulatory factors thereof can be fully exerted, and the crop quality is improved. Therefore, the problem that the fertilizer efficiency is not obvious in the prior art is effectively solved.

The invention discloses a selenium-rich foliar fertilizer and a preparation method thereof. The selenium-rich foliar fertilizer comprises the following raw materials in parts by weight: 0.01-0.1 part of a selenium compound, 1-5 parts of a carrier and an auxiliary agent, 0.05-0.3 part of a trace element additive, 10-20 parts of an organic material, 0.1-1 part of a seaweed extract, 0.1-2 parts of a microbial preparation, 0.01-0.1 part of a plant growth regulator, 1-2 parts of silicate and 1-2 parts of montmorillonite. The selenium-rich foliar fertilizer has the advantages of antibiosis and insect pest prevention, and solves the problems that in the preparation process of existing selenium-rich foliar fertilizers, natural materials are inconvenient to use for antibiosis and insect pest resistance, chemical pesticides possibly need to be additionally used for controlling insect pests, the production cost is increased, and chemical pesticide residues are possibly caused; the food safety and the environmental health are influenced.

The invention relates to the technical field of medical instruments, in particular to an intravascular stent. According to the specific technical scheme, the intravascular stent comprises a stent skeleton, after the stent skeleton is subjected to surface treatment, at least one layer of film covering section is arranged outside the stent skeleton, and medicine release sections are arranged at the two ends of the stent skeleton. The problems that in the drug release process of an existing stent, the drug release rate is uneven, biocompatibility is poor, and thrombus and restenosis are caused by a metal stent are solved.

The invention provides an anti-HPV (human papillomavirus) temperature-sensitive gel as well as a preparation method and application thereof. The invention provides the anti-HPV temperature-sensitive gel as well as the preparation method and application thereof. The gel consists of a natural active extract, a temperature-sensitive polymer, a cross-linking agent and a stabilizer, wherein the natural active extract comprises a mixture of a sophora flavescens extract, an artemisia annua extract and a mushroom extract in a specific mass ratio. These extracts are obtained by specific extraction processes to ensure their antiviral activity. The thermo-sensitive polymer is a mixture of poly (N-isopropylacrylamide) and hydroxypropyl methyl cellulose, and the cross-linking agent and the stabilizer are used for enhancing the performance of the gel. The preparation method of the gel comprises the following steps: preparing a natural active extract emulsion, preparing a wall material solution, emulsifying and microencapsulating, so as to finally form the gel with temperature sensitivity. The gel has specific rheological properties at body temperature, can be used for treating HPV infection, and provides a new local treatment method.

The solar water purification evaporator comprises a dome-shaped solar evaporator, a sewage area (4), a water purification area (5), a condensation water collection area (1), a moisture absorption water collection area (2) and a photo-thermal evaporation area (3) are arranged in the dome-shaped solar evaporator, and a water conveying pump and a pump body power supply system are arranged outside the dome-shaped solar evaporator; the photo-thermal evaporation area comprises a blue-green algae biomass charcoal photo-thermal evaporation ball group arranged in the sewage area; the moisture absorption and water collection area comprises a porous supporting plate (21) and a patterned moisture absorption system (22), wherein the porous supporting plate (21) and the patterned moisture absorption system (22) are arranged on a water separation plate (32) in a sewage area and a clean water area in the dome-type solar evaporator, and the patterned moisture absorption system adopts polyacrylic acid (PAA) hydrogel (221) compounded by embedded lithium chloride (LiCl) and calcium chloride (CaCl2) and polytetrafluoroethylene (PTFE) gel (222) in an alternating mode. The condensation water collecting area comprises a condensation water collecting system arranged in the dome-type solar evaporator and mainly comprises a radiation condensation coating (12), and a condensation coating area is a radiation condensation coating composed of polydimethylsiloxane (PDMS) and silicon dioxide (SiO2). Compared with a traditional evaporator, the novel evaporator integrating evaporation, condensation and moisture absorption is provided, the water purification rate of a common evaporator is increased, and the evaporator can be used for agricultural irrigation and other aspects.

The application discloses a bacteriostatic and deodorizing zeolite cat litter and a preparation method thereof, and belongs to the technical field of zeolite cat litter preparation. The bacteriostatic and deodorizing zeolite cat litter is composed of the following components in parts by weight: 55-75 parts of modified zeolite, 3-6 parts of bacteriostatic gel, 2-5 parts of adhesive, and 1-3 parts of filler. The modified zeolite is prepared from sulfamic acid, N,N-dimethylformamide, lignocellulose and zeolite, and the bacteriostatic agent is prepared from four-arm polyethylene glycol, succinic anhydride, triethylamine, N-hydroxyl glutarimide, 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride and polylysine. The zeolite cat litter prepared by the method has excellent water absorption, antibacterial property and deodorizing property.

The utility model discloses a kind of semiconductor constant-temperature wine decanter, belong to wine decanter technical field, including wine storage shell, its inside is provided with wine storage heat preservation groove, wine storage heat preservation groove bottom is provided with temperature-guiding cold aluminium seat, the cold end of semiconductor refrigeration sheet is abutted in temperature-guiding cold aluminium seat, the hot end of semiconductor refrigeration sheet is abutted on radiating fin, radiating fin is connected in fan cover, fan cover is provided with radiating fan, wine storage shell bottom is provided with a plurality of first radiating holes, radiating fan is towards a plurality of first radiating holes, wine storage shell bottom is provided with support seat. The utility model utilizes semiconductor refrigeration sheet to combine wine storage heat preservation groove, ensure that internal temperature is constant and is not affected, this structure will wine bottle be placed in wine storage heat preservation groove, guarantee the constant temperature of wine in bottle, so that under constant-temperature environment, volatile speed of aroma molecule is relatively stable, can make grape wine continuously, stably release various aroma, improve drinking experience.

The present invention discloses a sensitizing film for radioactive stents and a preparation method thereof, aiming to overcome the existing radiotherapy stents' great damage to normal tissues and the shortcomings of traditional sensitizing drug coating materials. The sensitizing film for radioactive stents includes a first film layer and a second film layer, wherein the first film layer is a polyurethane support layer, and the second film layer contains a radiosensitizing drug component; the platinum radiosensitizing drug is oxidized to a tetravalent platinum drug, a polyarginine targeting group is introduced for modification, and then PLGA50:50 with a molecular weight of 5k is used for modification; the first film layer composed of polyurethane and the second film layer composed of PLGA75:25 with a molecular weight of 100k and containing a radiosensitizing drug component are prepared by electrospinning technology. The sensitizing film for radioactive stents of the present invention has the advantages of high targeting, low toxicity and side effects, high efficiency sensitization, good support, sustained release, and simple and efficient preparation process, providing a new, safe and effective treatment method for the field of intracavitary tumor radiotherapy.

The invention relates to the field of ecological restoration, and discloses a rock slope ecological restoration planting hole construction technology which comprises the following steps that a planting hole is drilled in a selected position on a rock slope, the planting hole is composed of an upper regular cylindrical forming hole section and a lower breaking section, and the inner wall of the planting hole is coated with a water-absorbing moisturizing coating; modularized planting cups are placed in the planting holes, each planting cup comprises a vegetation area and a nutrition storage area, the vegetation areas are used for placing plant seeds or saplings, and the nutrition storage areas are used for providing nutrition support; the crushing section is used for crushing rocks through mechanical equipment to form an irregular crack structure. By means of the reasonably designed planting hole structure, the water-absorbing moisturizing coating and the modularized planting cups, the survival rate, the water retention capacity and long-term nutrition supply of vegetation are effectively improved, the method is suitable for various environments, efficient and sustainable recovery of slope ecology is achieved, and meanwhile the construction and maintenance cost is reduced.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition and a traditional Chinese medicine glasses frame. 10 to 20 parts of rhizoma acori graminei; 10 to 20 parts of polygala tenuifolia; 20 to 30 parts of menthol; 5-10 parts of clove; 10 to 15 parts of borneol; 10 to 20 parts of Chinese angelica; 10 to 20 parts of radix astragali seu hedysari; 5-10 parts of cassia oil; 10 to 20 parts of poria cocos; the traditional Chinese medicine composition fully embodies the compatibility principle of monarch, minister, assistant and guide. Ligusticum wallichii is used as monarch for promoting blood circulation to remove blood stasis; the rhizoma acori graminei and the polygala tenuifolia are used as minister Menthol, clove and borneol are used as assistants to enhance the drug effect; angelica sinensis and astragalus membranaceus are used as guide drugs to tonify qi and nourish blood. The combination not only can improve local symptoms, but also can regulate body functions on the whole, and embodies the thought of overall view and treatment based on syndrome differentiation of traditional Chinese medicine.

The invention discloses an attached auricular point treatment patch and a preparation method thereof, and particularly relates to the technical field of medical devices, the attached auricular point treatment patch comprises a core medicine layer, a protective isolation layer and a fixing layer, the core medicine layer is covered with the protective isolation layer, and the fixing layer is attached to the other side of the protective isolation layer; the core medicine layer is prepared from the following raw materials in parts by weight: 5 to 20 parts of radix angelicae sinensis, 5 to 15 parts of radix achyranthis bidentatae, 3 to 10 parts of rhizoma gastrodiae, 3 to 8 parts of rhizoma atractylodis macrocephalae, 1 to 5 parts of radix ginseng, 2 to 6 parts of rhizoma chuanxiong, 0.5 to 3 parts of nano folium ginkgo extract, 0.5 to 2 parts of radix astragali seu hedysari extract, a viscous matrix accounting for 5 to 20 percent of the total weight and a penetration enhancer accounting for 1 to 5 percent of the total weight; and the protective isolation layer is made of a medical grade polyethylene or polypropylene film with the thickness of 0.01-0.06 mm. The auricular point treatment patch can stably and continuously release medicine and effectively permeate into auricular points to achieve a good treatment effect, meanwhile, the solubility and bioavailability of the medicine are remarkably improved, the treatment effect is enhanced, and the comfort level and the fitting degree are good.

The invention discloses a selenium-iron co-doped hydroxyapatite reinforced polylactic acid scaffold and a preparation method thereof, and the preparation method comprises the following steps: co-doping SeO3 < 2-> and Fe < 3 + > into HAP through a co-precipitation method to obtain SF-HAP powder; sF-HAP and PLLA are dispersed in ethyl alcohol, and PLLA / SF-HAP composite powder is obtained through stirring, centrifuging, drying and the like; the PLLA / SF-HAP biological scaffold is prepared through an additive manufacturing technology, in order to endow the PLLA / HAP bone scaffold with an anti-tumor function, Fe is doped into HAP, a Fenton reaction can be promoted in an osteosarcoma environment so that ROS can be generated to kill tumor cells, but overexpressed GSH existing in the tumor cells can consume the ROS to weaken the anti-tumor effect, and doping of Se and Fe can reduce the crystallinity of HAP crystals, so that the anti-tumor effect is improved. The SeO3 < 2-> and the Fe < 3 + > are added into the tumor cells, so that the sustained release of functional ions is facilitated, meanwhile, the consumption of the SeO3 < 2-> and the Fe < 3 + > on the over-expressed GSH and H2O2 in the tumor cells can effectively destroy the redox balance in the tumor cells, and the death of the tumor cells is promoted.

The invention provides preparation and application of a PKM2 enzyme response polypeptide hydrogel capable of simultaneously delivering PTX and GDC0919. The first purpose of the invention is to provide a polypeptide molecule Nap-T, and the Nap-T is a Nap-FFF fragment and an amino acid fragment as shown in SEQ ID NO.1 which are sequentially connected from an N terminal to a C terminal. The invention also provides a PKM2 enzyme response polypeptide hydrogel capable of simultaneously delivering PTX and GDC0919. The PKM2 enzyme response polypeptide hydrogel comprises the polypeptide molecule Nap-T, a chemotherapeutic drug and an IDO inhibitor. The polypeptide molecule Nap-T is self-assembled into hydrogel and wraps a chemotherapeutic drug and an IDO inhibitor. On the basis that PTX and GDC0919 are wrapped by the polypeptide hydrogel, the curative effect of PTX in NSCLC treatment can be improved, and the IDO-mediated immunosuppression effect is overcome. Based on a peptide sequence of a PKM2 phosphorylation substrate on the polypeptide molecule Nap-T, the hydrogel has PKM2 enzyme responsiveness and is gradually degraded under high-level PKM2 enzyme activity in tumor tissues, accurate and continuous release of drugs is achieved, and the treatment experience and life quality of patients are improved.

The present invention relates to a composite material for preventing peritoneal dialysis catheter outlet infection and a preparation method and application thereof, and belongs to the technical field of clinical medicine. The method firstly adds hydroxyapatite to a tannic acid aqueous solution, reacts under centrifugal conditions, adds the TA / HAP NPs nanoparticles obtained by the reaction to a cupric chloride dihydrate aqueous solution, reacts under centrifugal conditions, and obtains Cu 2+ / TA / HAP composites; then Cu 2+ The Cu / TA / HAP composite material was added into chitosan acetic acid aqueous solution and ultrasonically dispersed to obtain Cu 2+ / TA / HAP / CS composite material EPD solution. The composite material of the present invention has good antibacterial performance, good cell compatibility and low cytotoxicity; the antibacterial coating prepared by using the composite material of the present invention has a stable fixing effect and is not easy to wear and fall off. At the same time, chitosan can play a role in the tissue repair process, promote tissue growth, and is easy to promote and apply.

The invention discloses dinotefuran water dispersible granules and a preparation process thereof, and relates to the technical field of medicament production, and the dinotefuran water dispersible granules comprise dinotefuran raw medicine, a dispersing agent, a wetting agent, an auxiliary agent, a cosolvent, a synergist, a binder, a water-based carrier and a filler in a weight ratio of (10-50): (10-20): (1-3): (2-5): (5-10): (1-3): (2-5): (10-30): (1-3). The preparation method of the binder comprises the following steps: reacting hydroxyethyl cellulose with lauryl sodium sulfate at 60-80 DEG C for 2-4 hours to obtain a grafted product; and carrying out a cross-linking reaction on the grafted product and a calcium citrate complex at 60-90 DEG C for 1-3 h, cooling the reaction product to room temperature, and successively carrying out filtration and centrifugation treatment to obtain the binder. The stability and dispersity of the medicament are greatly improved, and the efficacy of the medicament is improved.

The invention discloses a mineral-based material capable of slowly releasing calcium and alkali, a preparation method of the mineral-based material and application of the mineral-based material in rice cadmium reduction, and belongs to the technical field of heavy metal polluted farmland soil remediation. The preparation method comprises the following steps: mixing metakaolin and a strong alkali solution to react I, removing supernatant after the reaction is completed, adding a calcium salt solution, oscillating to react II, and drying to obtain the mineral-based material capable of slowly releasing calcium and alkali. Calcium ions and basic ions are gradually dissolved and continuously released, the pH value and the structure of soil are improved, favorable conditions are created for plant growth, and the long-term effect of cadmium reduction is kept.

The invention belongs to the technical field of biological medicines, and particularly relates to an ovary-targeting drug carrier as well as a preparation method and application thereof. Specifically, the invention provides a targeted ovarian drug carrier ZIF-8-GH-ZP3, so as to realize targeted treatment of POI and targeted ovarian release of growth hormone to improve the treatment effect and reduce the adverse reaction of the growth hormone. According to the design of the drug carrier, a zeolite imidazole skeleton (ZIF-8) and a zona pellucida antibody (ZP3Ab) are adopted, growth hormones can be released in a targeted mode according to follicles developed at different levels in an ovary, targeted therapy of primary ovarian insufficiency is finally achieved based on the dual functions of targeting and promoting development of dominant follicles of the growth hormones, and the drug carrier has good practical application value.

The invention discloses a granular gel-based living body material as well as a preparation method and application thereof. The particle gel-based living body material comprises hydrogel particles, sulfydryl-modified sulfate group-containing macromolecules and platelet-rich plasma dispersion liquid, and the particle gel-based living body material is of a cross-linked structure; photosynthetic oxygen production microorganisms are wrapped in the hydrogel particles. The hydrogel particles are prepared from branched macromolecules with double bonds and modified natural macromolecules through Michael addition polymerization, and the modified natural macromolecules are amino or sulfydryl modified natural macromolecules. The living body material is high in biological safety and stability, controllable release of the growth factors can be achieved, burst release and overhigh local concentration of the growth factors are prevented, and therefore the bioavailability of the growth factors is improved, and the lasting period of the growth factors is prolonged.

The invention relates to a controlled-release linalool emulsion based on a ternary system as well as a preparation method and application of the controlled-release linalool emulsion. The linalool emulsion is an oil-in-water Pickering emulsion composed of a water phase and an oil phase, the water phase comprises a ternary system composed of soybean protein isolate, pectin and hydroxypropyl methyl cellulose, and the oil phase is linalool essential oil. The preparation method comprises the following steps: respectively preparing soybean protein isolate, pectin and hydroxypropyl methyl cellulose solutions, and mixing to obtain a ternary composite water phase; and mixing the ternary composite water phase with the oil phase, and carrying out high-pressure homogenization treatment and ultrasonic treatment under a low-temperature condition to obtain the controlled-release linalool emulsion based on the ternary system. Compared with the prior art, the linalool essential oil emulsion embedding method solves the problem that linalool is easy to volatilize, and can be used in the fields of fruit and vegetable fresh keeping, tea fragrance maintaining and the like.

The application discloses a preparation method of water-soluble hydrogen-containing siloxane and application of the water-soluble hydrogen-containing siloxane in the field of cosmetics, and belongs to the technical field of cosmetic raw material preparation and application. The preparation method comprises the following steps: 1) preparation of a catalyst solution; 2) mixing of raw materials; 3) catalytic reaction; and 4) post-treatment and purification. In the application, water-soluble groups such as polyethylene glycol, polypropylene glycol and polyglycerol are used to modify siloxanes with Si-H bonds such as cyclosiloxane and polymethyl hydrogen siloxane, so as to prepare water-soluble hydrogen-containing siloxane. The water-soluble hydrogen-containing siloxane prepared in the application has excellent water solubility, good compatibility with a water phase system of cosmetics, can stably and continuously release hydrogen molecules in a water-based proton solvent, and the hydrogen molecules can effectively reduce high-activity free radicals in skin, reduce damage of the free radicals to skin cells, and realize antioxidant and anti-wrinkle effects. The product prepared in the application has high purity and good safety, raw materials are easy to obtain, the process is easy to industrialize, and the product can be widely applied to various water-based or water-oil compound cosmetics.

This invention discloses a hydrothermal method for preparing Bi₂MoO₆ / tourmaline functional composite materials, belonging to the field of functional materials technology. The preparation method of the Bi₂MoO₆ / tourmaline functional composite material of this invention is as follows: Molybdenum source and bismuth source are added to deionized water to prepare solution A and solution B, respectively; tourmaline powder is added to deionized water to prepare suspension C; solution B is added dropwise to solution A and stirred, then suspension C is added and stirred again to obtain mixture D; sodium hydroxide solution is added dropwise to mixture D to prepare mixture E; mixture E is transferred to a hydrothermal reactor, sealed for reaction, and cooled to obtain hydrothermal product F; hydrothermal product F is separated by suction filtration and washed to obtain wet filter cake G; wet filter cake G is dried to obtain solid H; solid H is ground to obtain the final product. The Bi₂MoO₆ / tourmaline functional composite material prepared by this invention has high negative oxygen ion generation efficiency and environmental adaptability, and can still maintain high-efficiency release capacity in low humidity or light-free environments.

The invention discloses a sensitization film for a radioactive stent and a preparation method of the sensitization film, and aims to overcome the defects that an existing radiotherapy stent causes great damage to normal tissues and a traditional sensitization drug coating material is insufficient. The sensitization film for the radioactive stent comprises a first film layer and a second film layer, the first film layer is a polyurethane supporting layer, and the second film layer contains radiosensitization medicine components; the preparation method comprises the following steps: oxidizing a platinum radiosensitization drug into a tetravalent platinum drug, introducing a polyarginine targeting group for modification, and then modifying by using PLGA 50: 50 with the molecular weight of 5k; a first film layer composed of polyurethane and a second film layer which is composed of PLGA 75: 25 with the molecular weight of 100 k and contains radiosensitization medicine components are prepared through the electrostatic spinning technology. The sensibilization film for the radioactive stent has the advantages of high targeting property, low toxic and side effects, high sensibilization efficiency, good supporting property, continuous slow release, simple and efficient preparation process and the like, and a novel, safe and effective treatment means is provided for the field of radiotherapy of tumors in a cavity.

The invention discloses a traditional Chinese medicine preparation for intestinal diseases, and belongs to the technical field of traditional Chinese medicine, and the traditional Chinese medicine preparation for intestinal diseases comprises the following raw materials in parts by weight: 25-35 parts of angelica sinensis-paeonia lactiflora powder prescription extract, 10-15 parts of lactose oligosaccharide nano-microspheres, and 15-22 parts of sodium alginate capsule shells containing angelica sinensis-paeonia lactiflora powder prescription dregs, the Chinese angelica and Chinese herbaceous peony powder prescription comprises six medicinal materials of Chinese angelica, Chinese herbaceous peony, poria cocos, rhizoma alismatis, bighead atractylodes rhizome and ligusticum wallichii. According to the finally prepared traditional Chinese medicine preparation for intestinal diseases, the traditional Chinese medicine angelica sinensis and paeonia lactiflora powder is successfully converted into an efficient oral preparation simulating enema administration, the medicine can be prevented from being damaged by the stomach, the active ingredients of the angelica sinensis and paeonia lactiflora powder are accurately delivered to the colon part for targeted release, the whole body effect is reduced, the colon medicine concentration is increased, and the intestinal diseases are treated. Therefore, the administration dosage is reduced, the compliance of a patient is improved, and the bioavailability of the medicine and the treatment effect on ulcerative colitis are improved.

This invention discloses a long-lasting antibacterial and mildew-resistant artificial leather, relating to the field of artificial leather preparation technology. It comprises a base fabric layer, a foaming layer, and a surface treatment layer sequentially composited. The foaming layer is prepared from the following raw materials in parts by weight: 100 parts polyvinyl chloride resin, 40-80 parts plasticizer, 2-8 parts stabilizer, 1-10 parts foaming agent, 0.5-8 parts antibacterial and mildew-resistant composite agent, and 1-10 parts additives. The antibacterial and mildew-resistant composite agent includes a supported inorganic antibacterial agent and an organic mildew-resistant agent. The supported inorganic antibacterial agent is one or more of silver-loaded zeolite, silver-loaded zirconium phosphate, nano-zinc oxide, and nano-copper oxide. This invention employs a dual-layer structure design where the foaming layer and surface treatment layer synergistically support the antibacterial and mildew-resistant composite agent, enabling the antibacterial active components to form a reservoir within the material and continuously exert their effects on the material surface, thereby significantly improving the long-lasting antibacterial and mildew-resistant performance of the artificial leather.

The invention relates to a progesterone composition, progesterone foam gel and a preparation method thereof. The invention finds that choline carbenoic acid can effectively improve the solubility of progesterone in water. According to the progesterone foam gel, progesterone is dissolved in an aqueous solution containing choline carbenoic acid, then the progesterone foam gel, poloxamer and a propellant are prepared into the progesterone foam gel, the progesterone content in the progesterone foam gel is high, the progesterone foam gel can fully cover vaginal mucosa after administration, the contact area between a drug and vaginal tissue is increased, and the progesterone foam gel has temperature response gelling performance and pH response gelling performance at the same time; after vaginal administration, the gel can be quickly converted from foam to gel and is adhered to vaginal mucosa, and the gel is good in self-healing performance and can resist a vaginal discharge mechanism, so that relatively good adhesion and continuous action at a medication part are realized. Meanwhile, the progesterone foam gel can promote permeation and absorption of progesterone through vaginal mucosa, enrichment of progesterone in the uterus after vaginal administration is remarkably improved, and side effects of the whole body are avoided.