16results about How to "Sustained release" patented technology

The application discloses a bacteriostatic and deodorizing zeolite cat litter and a preparation method thereof, and belongs to the technical field of zeolite cat litter preparation. The bacteriostatic and deodorizing zeolite cat litter is composed of the following components in parts by weight: 55-75 parts of modified zeolite, 3-6 parts of bacteriostatic gel, 2-5 parts of adhesive, and 1-3 parts of filler. The modified zeolite is prepared from sulfamic acid, N,N-dimethylformamide, lignocellulose and zeolite, and the bacteriostatic agent is prepared from four-arm polyethylene glycol, succinic anhydride, triethylamine, N-hydroxyl glutarimide, 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride and polylysine. The zeolite cat litter prepared by the method has excellent water absorption, antibacterial property and deodorizing property.

The utility model discloses a kind of semiconductor constant-temperature wine decanter, belong to wine decanter technical field, including wine storage shell, its inside is provided with wine storage heat preservation groove, wine storage heat preservation groove bottom is provided with temperature-guiding cold aluminium seat, the cold end of semiconductor refrigeration sheet is abutted in temperature-guiding cold aluminium seat, the hot end of semiconductor refrigeration sheet is abutted on radiating fin, radiating fin is connected in fan cover, fan cover is provided with radiating fan, wine storage shell bottom is provided with a plurality of first radiating holes, radiating fan is towards a plurality of first radiating holes, wine storage shell bottom is provided with support seat. The utility model utilizes semiconductor refrigeration sheet to combine wine storage heat preservation groove, ensure that internal temperature is constant and is not affected, this structure will wine bottle be placed in wine storage heat preservation groove, guarantee the constant temperature of wine in bottle, so that under constant-temperature environment, volatile speed of aroma molecule is relatively stable, can make grape wine continuously, stably release various aroma, improve drinking experience.

The invention discloses a granular gel-based living body material as well as a preparation method and application thereof. The particle gel-based living body material comprises hydrogel particles, sulfydryl-modified sulfate group-containing macromolecules and platelet-rich plasma dispersion liquid, and the particle gel-based living body material is of a cross-linked structure; photosynthetic oxygen production microorganisms are wrapped in the hydrogel particles. The hydrogel particles are prepared from branched macromolecules with double bonds and modified natural macromolecules through Michael addition polymerization, and the modified natural macromolecules are amino or sulfydryl modified natural macromolecules. The living body material is high in biological safety and stability, controllable release of the growth factors can be achieved, burst release and overhigh local concentration of the growth factors are prevented, and therefore the bioavailability of the growth factors is improved, and the lasting period of the growth factors is prolonged.

The invention relates to a controlled-release linalool emulsion based on a ternary system as well as a preparation method and application of the controlled-release linalool emulsion. The linalool emulsion is an oil-in-water Pickering emulsion composed of a water phase and an oil phase, the water phase comprises a ternary system composed of soybean protein isolate, pectin and hydroxypropyl methyl cellulose, and the oil phase is linalool essential oil. The preparation method comprises the following steps: respectively preparing soybean protein isolate, pectin and hydroxypropyl methyl cellulose solutions, and mixing to obtain a ternary composite water phase; and mixing the ternary composite water phase with the oil phase, and carrying out high-pressure homogenization treatment and ultrasonic treatment under a low-temperature condition to obtain the controlled-release linalool emulsion based on the ternary system. Compared with the prior art, the linalool essential oil emulsion embedding method solves the problem that linalool is easy to volatilize, and can be used in the fields of fruit and vegetable fresh keeping, tea fragrance maintaining and the like.

The application discloses a preparation method of water-soluble hydrogen-containing siloxane and application of the water-soluble hydrogen-containing siloxane in the field of cosmetics, and belongs to the technical field of cosmetic raw material preparation and application. The preparation method comprises the following steps: 1) preparation of a catalyst solution; 2) mixing of raw materials; 3) catalytic reaction; and 4) post-treatment and purification. In the application, water-soluble groups such as polyethylene glycol, polypropylene glycol and polyglycerol are used to modify siloxanes with Si-H bonds such as cyclosiloxane and polymethyl hydrogen siloxane, so as to prepare water-soluble hydrogen-containing siloxane. The water-soluble hydrogen-containing siloxane prepared in the application has excellent water solubility, good compatibility with a water phase system of cosmetics, can stably and continuously release hydrogen molecules in a water-based proton solvent, and the hydrogen molecules can effectively reduce high-activity free radicals in skin, reduce damage of the free radicals to skin cells, and realize antioxidant and anti-wrinkle effects. The product prepared in the application has high purity and good safety, raw materials are easy to obtain, the process is easy to industrialize, and the product can be widely applied to various water-based or water-oil compound cosmetics.

This invention discloses a hydrothermal method for preparing Bi₂MoO₆ / tourmaline functional composite materials, belonging to the field of functional materials technology. The preparation method of the Bi₂MoO₆ / tourmaline functional composite material of this invention is as follows: Molybdenum source and bismuth source are added to deionized water to prepare solution A and solution B, respectively; tourmaline powder is added to deionized water to prepare suspension C; solution B is added dropwise to solution A and stirred, then suspension C is added and stirred again to obtain mixture D; sodium hydroxide solution is added dropwise to mixture D to prepare mixture E; mixture E is transferred to a hydrothermal reactor, sealed for reaction, and cooled to obtain hydrothermal product F; hydrothermal product F is separated by suction filtration and washed to obtain wet filter cake G; wet filter cake G is dried to obtain solid H; solid H is ground to obtain the final product. The Bi₂MoO₆ / tourmaline functional composite material prepared by this invention has high negative oxygen ion generation efficiency and environmental adaptability, and can still maintain high-efficiency release capacity in low humidity or light-free environments.

This invention discloses a long-lasting antibacterial and mildew-resistant artificial leather, relating to the field of artificial leather preparation technology. It comprises a base fabric layer, a foaming layer, and a surface treatment layer sequentially composited. The foaming layer is prepared from the following raw materials in parts by weight: 100 parts polyvinyl chloride resin, 40-80 parts plasticizer, 2-8 parts stabilizer, 1-10 parts foaming agent, 0.5-8 parts antibacterial and mildew-resistant composite agent, and 1-10 parts additives. The antibacterial and mildew-resistant composite agent includes a supported inorganic antibacterial agent and an organic mildew-resistant agent. The supported inorganic antibacterial agent is one or more of silver-loaded zeolite, silver-loaded zirconium phosphate, nano-zinc oxide, and nano-copper oxide. This invention employs a dual-layer structure design where the foaming layer and surface treatment layer synergistically support the antibacterial and mildew-resistant composite agent, enabling the antibacterial active components to form a reservoir within the material and continuously exert their effects on the material surface, thereby significantly improving the long-lasting antibacterial and mildew-resistant performance of the artificial leather.

The invention relates to the technical field of animal husbandry, and discloses a temperature-sensitive sustained-release gel for treating cow mastitis and a preparation method thereof.The temperature-sensitive sustained-release gel is prepared from, by mass, 15%-24% of a triblock copolymer PLGA-PEG-PLGA solution, 3-7 parts of eucommia ulmoides powder, 2-5 parts of nisin, 1-3 parts of a stabilizer, 1-3 parts of a pH regulator and the balance water. One-time perfusion can be completed under the condition of a small administration volume, a stable sustained-release drug library is formed in the local part of the mammary gland, and the drug is continuously and slowly released through the diffusion effect of the gel layer, so that a lasting inhibition effect is generated on pathogenic bacteria on the surface and in the mammary gland tissue. Due to the fact that the medicine mainly plays a role in the local part of the breast, the high local medicine concentration can be maintained in the breast tissue, diffusion of the medicine to the whole body tissue is reduced, and therefore the risk that the medicine has adverse effects on non-lesion organs or tissues is reduced.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a treprostinil soluble microcrystalline patch and a preparation method thereof. Existing treprostinil mainly depends on intravenous injection or subcutaneous injection, the administration mode needs to be operated by professional medical staff, pain is brought to a patient, and the problems of infection risk, inconvenience in long-term administration and the like exist. The invention provides a treprostinil soluble microcrystalline patch and a preparation method thereof. The patch is of a layered structure and comprises a backing layer, a microcrystal array layer, an adhesive layer and a protective layer, and the microcrystal array layer is composed of treprostinil, a biodegradable polymer matrix material and auxiliary materials. The preparation method comprises the following steps: dissolving the components in a solvent to form a microcrystal stock solution, injecting into a mold, curing microcrystals through vacuum drying, and laminating and assembling with each layer of material. The microcrystalline patch disclosed by the invention can penetrate through a skin cuticle painlessly and noninvasively, so that efficient and continuous transdermal administration of treprostinil is realized, and many defects of an existing administration mode of treprostinil are overcome.

The invention discloses a dexheptane structure prostacyclin-loaded nano transdermal patch and a preparation method, the dexheptane structure prostacyclin-loaded nano transdermal patch comprises 10-30 parts of dexheptane precursor liposome, 10-20 parts of a prostacyclin nano-structure lipid carrier and 50-70 parts of an acrylate pressure-sensitive adhesive, the dexheptane precursor liposome comprises 8-12 parts of dexheptane and 36-54 parts of hydrogenated soya bean lecithin, and the prostacyclin nano-structure lipid carrier comprises a prostacyclin nano-structure lipid carrier and an acrylate pressure-sensitive adhesive. The prostacyclin injection comprises the following components in parts by weight: 36-54 parts of mannitol, 80-240 parts of absolute ethyl alcohol, 150-450 parts of purified water, 0.150-0.200 part of prostacyclin, 80-150 parts of glyceryl monostearate, 20-50 parts of oleic acid, 10-30 parts of soybean lecithin and the balance of purified water, wherein the total amount of the prostacyclin injection, the glyceryl monostearate, the oleic acid, the soybean lecithin and the purified water is 1000 parts. According to the invention, the dextroheptane is used as a functional penetration enhancing component in transdermal drug delivery, the dextroheptane and the prostacyclin are synergistically integrated in the nano-lipid carrier, the transdermal penetration rate and the cumulative penetration amount of the prostacyclin are improved, the treatment effect is improved, and continuous and stable release of the prostacyclin is realized under the combined action of the nano-structure lipid carrier and the patch matrix.

The application discloses a coal gangue-based sandy soil modifier and application thereof, and belongs to the technical field of soil improvement. The modifier is composed of a basic component and a composite component, wherein the basic component is coal gangue, and the composite component is composed of straws and rotten leaves. The mass percentage of the basic component is 1-5%, and the mass ratio of the straws to the rotten leaves in the composite component is (1-4):(1-4). The modifier provided by the application can simultaneously, quickly and durably increase the contents of organic matter, total nitrogen and total phosphorus in sandy soil, significantly improve the problems of loose structure, poor water and fertilizer retention capacity and extreme nutrient deficiency of the sandy soil, and improve the soil fertility from an extremely low level to a high level, thereby effectively overcoming the problems of single effect, poor nutrient synergy, short duration and high cost of the existing modifier. The modifier is suitable for ecological restoration and fertility improvement of flowing sandy land, semi-fixed sandy land and sandy farmland.

The invention provides a mugwort charcoal hot patch prepared by adopting a low-temperature slow baking process, and relates to the technical field of heating physiotherapy products. The mugwort charcoal hot patch prepared through the low-temperature slow baking process comprises a breathable inner layer, a mugwort charcoal functional layer, a heating layer and a protective outer layer, the breathable inner layer is made of full-bio-based degradable non-woven fabric, the mugwort charcoal functional layer is close to the breathable inner layer, the core component is mugwort charcoal subjected to composite modification treatment through the low-temperature slow baking process, and the protective outer layer is made of non-woven fabric. The mugwort charcoal functional layer can continuously and stably release active ingredients under the heat action of the heating layer. The mugwort charcoal is prepared by combining a low-temperature slow baking process with composite modification treatment, active ingredients in mugwort can be fully reserved, the mugwort charcoal and the mugwort leaf extract are synergistic at a heating temperature, trace ingredients with soothing, blood activating and aromatic effects can be continuously and stably released, far infrared rays radiated by the infrared emission ceramic powder are combined with thermal therapy, and the health care effect is achieved. And the physiotherapy effect is obviously improved.

The present invention provides methods for preventing, inhibiting or treating a surgical site infection associated with a surgical operation comprising the step of applying to the surgical site a biocompatible, biodegradable substrate being impregnated and / or having its surface coated fully or partially with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the surgical site.

The invention relates to the technical field of improved breeding of animal husbandry, and particularly discloses an improved NK cell culture medium and a preparation method thereof. The improved NK cell culture medium comprises a basic culture medium, a supplement and a composite sustained-release body. All the components are mixed according to a specific proportion, and the requirements of NK cell proliferation and function maintenance are met. Wherein the inner layer of the composite sustained-release body takes trehalose and human recombinant serum albumin as protective agents to wrap the interleukin, and the outer layer of the composite sustained-release body is an acrylate prepolymer photocuring polymer containing a photoinitiator, so that the continuous and stable release of the interleukin is realized. Through component optimization and slow release system design, the NK cell culture efficiency and activity are effectively improved, and the method is suitable for NK cell multiplication culture.

This invention belongs to the field of medical patch technology. It discloses a reusable patch comprising, from bottom to top, a non-woven fabric layer, a PU film adhesive layer, a core, a leak-proof pad, a cover cotton, and a release film. The outer surface of the PU film is coated with a composite adhesive layer for durable adhesion. The core, made of a special matrix, traditional Chinese medicine powder, oil, and excipients, is adhered to the center of the PU film through this composite adhesive layer. A leak-proof pad, preferably with an annular leak-proof ring, is provided between the core and the PU film to effectively prevent side leakage of the core components. The cover cotton covers the core to absorb trace amounts of exudate. This invention, through the synergistic design of the silicone gel composite adhesive layer and the leak-proof structure, ensures good sustained-release of the medication and comfortable application while enabling the patch to be repeatedly peeled and reapplied. This solves the problems of traditional single-use patches being prone to leakage and contamination, making it economical, practical, and providing a superior user experience.

The invention discloses a novel package for hydrolytic sponge and a preparation method thereof. The package comprises a carrier bone needle, the component of the carrier bone needle is silicon dioxide, the carrier bone needle is of a porous structure, the pore diameter range is 10-500 nm, and the porosity is not lower than 70%; the wrapping layer covers the outer surface of the bone needle, is synthesized by a biodegradable polymer and is added with a sebum response type plasticizer; by adopting a high-pressure pre-landfill process, liquid nutritional ingredients can be forcibly pressed into the deep positions of micro-pores of the silicon dioxide bone needle, meanwhile, by optimizing the material and the thickness of a wrapping layer, accurate regulation and control of active ingredient release kinetics are achieved, a continuous release window from several hours to more than ten hours can be provided, and the preparation process is simple and convenient. Therefore, long-acting nourishing on the skin is realized, the shortages of instant effect and non-lasting effect of traditional cosmetics are overcome, the high loading rate and deep filling far beyond those of a conventional adsorption method are realized, and the problems that active ingredients are easy to fall off and are released too fast due to the fact that the active ingredients are only attached to the surface of a carrier are solved.