The invention relates to an artificial bone with a porous laminated structure and passages, which belongs to the technical field of biomedical materials. The artificial bone is alternately laminated and formed by compact layers and porous layers which are made of calcium phosphate base biological ceramic materials, and in addition, passages for conveying cells and body fluid are arranged in the direction which forms a set angle with the laminated layers. The preparation method comprises the following step: mixing powder such as hydroxylapatite, beta-tricalcium phosphate and the like through using deionized water as medium to be prepared into pulp. A three-dimensional gel laminated forming system is adopted for preparing ceramic blanks formed by the compact layers, the porous layers and the passages, and then the ceramic blanks are sintered at a high temperature for preparing the artificial bone. The invention has the characteristics that the artificial bone has high mechanical strength, has the porous structure with the effects of osteoplast adhesion, propagation, growth and vascularization, can be used as the artificial bone, can also be used as a bone tissue engineering support frame, and has wide application prospects in clinics in the orthopedics department.