185 results about "Nano hydroxyapatite" patented technology

The invention discloses a tooth repair composition containing mesoporous hydroxyapatite, a tooth repair product and a preparation method and application of the tooth repair composition and the tooth repair product. The tooth repair composition comprises nano-hydroxyapatite, fluoride and a chelating agent, the logarithm value logK of the stability constant K of the chelating agent to calcium ions is 1 < = logK < = 5, and K is measured in an aqueous solution with the temperature of 25 DEG C, the pH value of 7.0 and the ionic strength of 0.1 M; the nano-hydroxyapatite is prepared from nano-scale mesoporous hydroxyapatite, and the nano-hydroxyapatite contains nano-scale mesoporous hydroxyapatite. By adding the specific chelating agent, dynamic balance is formed in the tooth repairing composition, slow release protection can be formed on free calcium ions, the double inactivation effect possibly occurring when hydroxyapatite and fluoride exist at the same time is effectively avoided, the synergistic repairing effect of hydroxyapatite and fluoride is fully exerted, and the tooth repairing effect is improved. The use of fluorides can be greatly reduced, and safety and reliability are achieved.

The invention provides a composite hydrogel for infectious bone defect repair and a preparation method thereof, and belongs to the technical field of bone defect repair, the composite hydrogel comprises a three-dimensional porous network structure hydrogel and a bioactive unit, and the bioactive unit is loaded in the three-dimensional porous network structure hydrogel; the hydrogel with the three-dimensional porous network structure is prepared from photo-crosslinked methacrylated silk fibroin and nano-hydroxyapatite; the bioactive unit comprises a strontium metal organic framework loaded with curcumin. According to the invention, the photo-crosslinked methacrylated silk fibroin provides excellent biocompatibility; as an ion / drug dual carrier, the strontium metal organic framework can continuously release strontium ions and bidirectionally regulate bone metabolism (promoting osteogenesis and inhibiting osteoclast), and the porous structure of the strontium metal organic framework can efficiently load a hydrophobic drug curcumin (Cur). Curcumin has strong antibacterial and anti-inflammatory functions; the nano-hydroxyapatite can obviously enhance the mechanical strength of the hydrogel.

The invention discloses a humanized osteoporosis mouse model and a construction method thereof, and belongs to the technical field of biotechnology and animal models. The invention aims at the core defects of large species difference, insufficient humanization degree, low pathological simulation degree, unstable phenotype and the like of the existing osteoporosis model. The humanized osteoporosis mouse model is constructed through five core steps of experimental animal pretreatment, collagen-nano hydroxyapatite bionic scaffold preparation and cell pre-implantation, immune-bone metabolism double-derived system construction, progressive osteoporosis induction and model identification and verification. According to the method, double-person origination of immune and bone metabolism systems is realized for the first time, the colonization rate and survival time of human cells are greatly improved, the pathological process of clinical postmenopausal osteoporosis is accurately simulated, the phenotype of the model is stable and uniform, the reactivity matching degree with clinical drugs is high, and the method can be widely applied to research and development of anti-osteoporosis drugs and research of pathological mechanisms.

The invention belongs to the field of catalyst preparation, and particularly relates to a binder for catalyst forming and a preparation method and application thereof. The binder for forming the catalyst, provided by the invention, is prepared from the following raw materials in parts by weight: 0.5 to 2 parts of magnesium chloride, 1 to 2 parts of magnesium oxide, 0.5 to 2 parts of sodium carboxymethyl cellulose, 1 to 3 parts of ethylenediamine tetraacetic acid, 2 to 6 parts of nano-hydroxyapatite modified polyester, 1 to 3 parts of organic solvent and 10 to 35 parts of water. When the binder provided by the invention is applied to catalyst forming, on one hand, the problems that a conventional catalyst is poor in binding performance, and acid gas corrodes equipment and pollutes the environment in the roasting process can be solved; on the other hand, the surface acidity of the catalyst carrier can be reduced, a suitable reaction environment can be provided for some reactions needing to be carried out in an alkaline environment or reactions with acidic reactants and intermediates, and the selectivity and conversion rate of the reactions are improved.

The invention discloses a preparation method of a growth factor gradient bionic scaffold for tendon-bone interface regeneration and repair, and belongs to the technical field of biomedical materials. The composite scaffold is constructed by adopting a coaxial electrospinning and self-assembly technology, and is compounded by a core-shell oriented nanofiber layer and a non-oriented nanofiber layer through a gelatin adhesive to respectively simulate tendon phase and bone phase structures of a tendon-bone interface; a shell layer of the tendon-phase-simulated core-shell oriented nanofiber is a PCL layer containing CTGF, a core layer of the tendon-phase-simulated core-shell oriented nanofiber is a PVA layer containing TGF-beta1, and a bone-phase-simulated non-oriented nanofiber layer is a PCL / Gel co-spun layer containing BMP-2 polylactic acid microspheres and nano-hydroxyapatite. The scaffold can realize secondary controlled release of early-stage release of CTGF, slow release of TGF-beta1 in the middle and later periods and continuous release of BMP-2, and cooperates with a fiber orientation structure to induce graded differentiation of mesenchymal stem cells and promote integrated repair of a tendon-bone interface gradient structure, so that the problems of poor healing of a tendon-bone interface and high repeated fracture rate in a traditional repair method are solved, and the scaffold has good application prospects. The important application value is realized in the field of tendon-bone injury treatment in sports medicine.

The invention relates to a composite carbon source and application thereof in sewage denitrification nitrogen removal, and belongs to the technical field of sewage treatment.The composite carbon source is obtained by forming a gel network through polyvinyl alcohol and sodium alginate, then crosslinking the gel network with calcium ions in calcium chloride to form a three-dimensional framework, and wrapping modified composite powder and polylactic acid in the three-dimensional framework. The three-dimensional skeleton can provide certain mechanical strength, so that the internal carbon source can resist water flow scouring, the porous structure can also enable the internal carbon source to be slowly released, more pores are formed after Na-montmorillonite and iron-carbon powder are compounded, the loading rate of flaky nano-hydroxyapatite on the montmorillonite intercalated iron-carbon powder is further improved, and the adsorption capacity of the montmorillonite intercalated iron-carbon powder is improved. Hydroxyl groups in the flaky nano-hydroxyapatite can form hydrogen bonds with Na-montmorillonite and hydroxyl groups on a three-dimensional skeleton, the interface bonding force is improved, the mechanical strength of the composite carbon source is further improved, polylactic acid serves as a slow-release carbon source and is gradually hydrolyzed under the action of microorganisms, and the release period of the composite carbon source under continuous impact of high-speed water flow is prolonged.

The invention discloses antibacterial and antiskid PU leather and a preparation method and application thereof, and belongs to the technical field of PU leather.The preparation method comprises the steps that a ZIF-8 / g-CNcomposite photocatalyst is obtained through an in-situ growth method, silver-doped nano-hydroxyapatite is prepared through an ion replacement method, the ZIF-8 / g-CNcomposite photocatalyst and the silver-doped nano-hydroxyapatite are compounded through liquid phase adsorption, and the antibacterial and antiskid PU leather is obtained. The preparation method comprises the following steps: preparing composite antibacterial powder, uniformly dispersing the composite powder into acrylamide, Arabic gum and polyethylene glycol methyl ether methacrylate serving as monomers, initiating polymerization to form composite coating slurry, performing oxygen plasma activation on PU leather, blade-coating the composite coating slurry, and curing to obtain the antibacterial antiskid PU leather. The material integrates the functions of self-cleaning, antibiosis, skid resistance and wear resistance.

The invention provides a drug-loaded sophorolipid microsphere, a preparation method thereof and application of the drug-loaded sophorolipid microsphere in preparation of a bionic cartilage scaffold. The preparation method of the drug-loaded sophorolipid microspheres comprises the following steps: (1) preparing a drug-containing sophorolipid solution; (2) preparing multiple emulsion; and (3) adding a horse radish peroxidase solution into the multiple emulsion for reaction to obtain the drug-loaded sophorolipid microspheres. The bionic cartilage scaffold sequentially comprises a bone layer, a transition layer and a cartilage layer from bottom to top, the bone layer is a cross-linked compound of nano-hydroxyapatite and drug-loaded sophorolipid microspheres; the transition layer is a physical mixture of nano-hydroxyapatite and drug-loaded sophorolipid microspheres; the cartilage layer is drug-loaded sophorolipid microspheres. The drug-loaded sophorolipid microspheres disclosed by the invention have good biocompatibility, excellent biocompatibility and good mechanical properties. The bionic cartilage scaffold utilizes the characteristics of the nHA and the drug-loaded sophorolipid microspheres to form a unique network structure, so that material failure caused by mechanical mismatching is avoided.

The invention provides a high-strength fire-resistant cable and a preparation method thereof, and belongs to the technical field of cables, and the preparation method of the high-strength fire-resistant cable comprises the following steps: reacting nano-hydroxyapatite with 10-(2-methacryloyloxy) monodecyl phosphate in ethanol, and drying to obtain modified hydroxyapatite; ethylene-vinyl acetate copolymer, magnesium hydroxide, zinc borate, zinc stannate, polyethylene wax, vinyltrimethoxysilane, 2-hydroxy-2-methyl propiophenone and modified hydroxyapatite are mixed, melt-extruded and illuminated at constant temperature, and a sheath layer is obtained; mixing tetraethoxysilane, ethanol, dibutyltin dilaurate, fumed silica, phlogopite paper and glass fibers, heating and aging, and cutting to obtain a fireproof layer; the insulating layer, the fireproof layer and the sheath layer are sequentially coated on the conductor to prepare the high-strength fireproof cable, and the cable prepared by the invention has good mechanical property, electrical insulating property and fireproof property.

This invention relates to the field of biomedical technology, specifically to a biomimetic piezoelectric scaffold for promoting bone repair, its preparation method, and its applications. The biomimetic piezoelectric scaffold provided by this invention is produced by electrospinning PLLA into oriented nanofibers, and then modifying the fiber surface with nano-hydroxyapatite. To enhance the adhesion of hydroxyapatite to the fiber surface, a polydopamine layer is modified between the two as a connecting layer, ultimately resulting in a biomimetic piezoelectric scaffold with high porosity, good osteointegration, and osteogenic promoting effects. This scaffold exhibits good bone regeneration promoting effects in in vitro MSC recruitment, osteogenic differentiation experiments, and repair of skull bone defects in rats.

The invention relates to a high-breathability and high-fitness in-vitro fixing device with a shape memory function and a preparation method of the high-breathability and high-fitness in-vitro fixing device, and relates to the field of biomedical materials, the high-breathability and high-fitness in-vitro fixing device comprises the following components in parts by mass: 40-45 parts of polycaprolactone, 40-45 parts of polylactic acid, 4-6 parts of a compatilizer, 0.5-1.5 parts of a cross-linking agent, 8-12 parts of nano-hydroxyapatite, 10-20 parts of biocompatible polyurethane and 0.1-0.3 part of a coloring agent. The preparation method comprises the following steps: mixing the raw materials, carrying out melt blending, and carrying out extrusion granulation to obtain composite particles; the composite particles are subjected to melt-blowing spinning, and non-woven cloth is obtained; and carrying out hot press molding on the non-woven fabric, shaping and cooling to obtain the high-breathability and high-fitness in-vitro fixing device with the shape memory function. The in-vitro fixing device prepared by the invention has a silk net structure, has good air permeability, a shape memory function and fitness, and has good mechanical properties and antibacterial properties.

The present application relates to the technical field of composite biological coating. Specifically, the present application relates to a hydrophobic composite layer on a medical degradable magnesium alloy substrate and a preparation method thereof. In the preparation method, firstly, a porous ceramic oxide layer is formed on the magnesium alloy substrate through micro-arc oxidation treatment, so as to reduce the corrosion rate of the magnesium alloy; then, a strontium-doped hydroxyapatite layer is prepared on the surface of the micro-arc oxidation layer using a chemical deposition method, so as to improve the biocompatibility of the magnesium alloy; finally, the magnesium alloy subjected to the micro-arc oxidation and chemical deposition treatment is immersed and pulled once or more times in a polylactic acid solution containing nano-hydroxyapatite, so as to form a hydrophobic polymer layer. The hydrophobic composite layer prepared by the present application improves the corrosion resistance and biocompatibility of the magnesium alloy at the same time. The present application also relates to a magnesium alloy implant product comprising the hydrophobic composite layer.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

The invention provides a mussel bionic composite adhesive and a preparation method thereof, and belongs to the technical field of high-performance adhesives. The composite material is prepared from 88 parts by mass of premixed mother liquor, 3-6 parts by mass of a silane coupling agent KH-560 and 4-8 parts by mass of nano-hydroxyapatite, 3, 4-dihydroxy phenyl methacrylamide is taken as an adhesion function core of the premixed mother liquor, is cooperated with 2-ethylhexyl acrylate and isobornyl methacrylate, and is compounded with a specific composite photoinitiator, an antioxidant 1010 and an ultraviolet absorbent 328. The preparation method comprises the following steps: preparing premixed mother liquor under the dark condition of 30 DEG C, primarily dispersing the premixed mother liquor, the silane coupling agent and the nano-hydroxyapatite under normal pressure, and performing vacuum stirring, dispersing and degassing under-0.05 to-0.08 MPa. The adhesive has excellent adhesion to inorganic base materials such as hydroxyapatite and natural stone, has compressive strength of more than or equal to 22MPa and high elongation at break of 35-55%, has outstanding weather resistance and stable performance after long-term ultraviolet aging, and is suitable for the fields of medical bone repair material fixation, stone adhesion, high-end composite material forming and the like.

The invention provides a wound dressing for wound hemorrhage. The wound dressing is prepared from the following components in parts by mass: 20 to 25 parts of cationic cassava starch, 10 to 13 parts of polyethylene glycol, 1.2 to 1.8 parts of xanthan gum, 0.1 to 0.2 part of cannabidiol, 6 to 8 parts of tannic acid modified chitosan, 1.8 to 2.5 parts of a polydopamine solution with the concentration of 5mg / mL and 1 to 1.5 parts of nano-hydroxyapatite. The wound dressing has an instant hemostatic effect and a long-acting tissue regeneration induction capability.

The invention provides a full-biodegradable multifunctional agricultural mulching film material and a manufacturing method, and relates to the technical field of material processing, the full-biodegradable multifunctional agricultural mulching film material comprises a mulching film material, the mulching film material comprises a core biodegradable base material, a multifunctional modification auxiliary agent, an environmental response type slow release functional component and a multi-scale enhancement system, according to the invention, polycaprolactone and a starch grafted copolymer are compounded in a core biodegradable base material, and a multi-scale enhancement system (modified cellulose nanocrystals and nano-hydroxyapatite) and a high-shear directional mixing process are combined, so that the biodegradable material is prepared; and a three-dimensional nano support network structure in the membrane is realized. According to the structure, the tensile strength and the elongation at break of the film are effectively improved, the film can still keep integrity under the conditions of long-period covering and agricultural machinery operation, flexibility and toughness are both considered, and the problems that a traditional biodegradable mulching film is prone to breakage and poor in durability are solved.

The application relates to the technical field of medical suture materials, and particularly discloses a non-absorbable suture with tissue self-adaptive performance, which comprises a core layer, a transition layer and an outer layer; the core layer and the transition layer are fixed through hot melt adhesion, and the outer layer is coated on the surface of the transition layer through electrostatic spinning; the core layer is a polyether ether ketone fiber with a diameter of 50-100 mu m and a tensile modulus of greater than or equal to 3 Gpa; the transition layer is a nickel-titanium alloy wire braided net with a thickness of 40-60 mu m, and the wire diameter of the nickel-titanium alloy wire is 20-30 mu m; and the outer layer is a poly-lactic acid-glycolic acid copolymer coating layer containing nano-hydroxyapatite with a thickness of 30-50 mu m; and the application further provides a preparation method of the non-absorbable suture. The non-absorbable suture has the advantages of tissue self-adaptive performance, persistent mechanical support and bioactivity, can effectively avoid tissue cutting, abrasion and suture loosening, and can reduce the incidence of postoperative complications such as inflammation and pain.

The present application relates to wastewater treatment technical field, specifically to a kind of threonine waste liquid processing technology, first add dicyandiamide-formaldehyde resin quaternary ammonium salt and nano hydroxyapatite composite modifier, adjust pH to complete chelation flocculation.Secondly, through light-enzyme synergistic degradation, electrochemical-ozone combined oxidation treatment, then use microbial electrofermentation system to convert threonine into short-chain fatty acid, finally through nanofiltration-RO membrane concentration, combined with vacuum cooling and melt crystallization recycle high-purity threonine and ammonium sulfate, realize pollutant removal and resource recovery.The present application is through multiple technology cooperation, efficiently removes COD, ammonia nitrogen and other pollutants in threonine waste liquid, simultaneously improves threonine recovery rate, product purity is high, compared with traditional process, with environmental protection and economic value, strong adaptability.

The invention relates to the technical field of reverse osmosis membranes, in particular to a reverse osmosis membrane as well as a preparation method and application thereof. The reverse osmosis membrane comprises a polysulfone supporting layer; the aromatic polyamide separation layer is formed on the surface of the polysulfone supporting layer and is formed through an interfacial polymerization reaction of m-phenylenediamine and trimesoyl chloride; the surface of the aromatic polyamide separation layer is coated with the composite modified layer, and the composite modified layer comprises modified nano-hydroxyapatite, a zwitterionic polymer, an antioxidant, nano-silica and a quaternary ammonium salt functionalized silane coupling agent. The reverse osmosis membrane structure improves the hydrophilicity and the surface charge characteristic of the membrane, and enhances the pollution resistance, the antibacterial property and the separation performance of the membrane. The aromatic polyamide separation layer formed through interfacial polymerization has desalting capacity, and the composite modification layer improves the interception efficiency of colloidal particles and has good cleaning regeneration capacity and long-term operation stability.

This invention relates to the field of biomaterial preparation technology, and in particular to a morphology-controllable mesoporous hydroxyapatite nanosphere, its preparation method, and its applications. The preparation method includes: S1, mixing an aqueous solution of pyridoxal phosphate with an aqueous solution of calcium chloride, adjusting the pH of the mixed solution to 7-11 to obtain a precursor solution; S2, placing the precursor solution in a microwave reactor for reaction to obtain mesoporous hydroxyapatite nanospheres. The preparation method provided by this invention is simple, the reaction conditions are easily controlled, and it is highly safe and reliable. It enables precise control of the morphology and particle size of the hydroxyapatite microspheres, and the prepared product exhibits excellent biocompatibility and structural regularity. It has good industrial application prospects in the field of biomedical implants such as bone tissue repair and is suitable for large-scale production.

The invention relates to the technical field of orthopedic repair materials, in particular to a polycaprolactone and nano-hydroxyapatite composite bone repair implant and a preparation method thereof.The preparation method comprises the steps that PCL-PLA serves as a shell material, citric acid serves as a core material, and n-HA degradation accelerator microcapsules are prepared; the preparation method comprises the following steps: weighing the following raw materials in parts by mass: n-HA, PCL, CNW, PEG and n-HA degradation accelerator microcapsules; the implant prepared through the preparation method is excellent in mechanical property, has the performance of replacing an existing steel plate and an existing steel nail and is applied to bone repair, compared with natural degradation, the degradation rate is increased by 2.1 times, the degradation period of n-HA can be greatly shortened through the n-HA degradation accelerator micro-capsules, the situation that the difference between the degradation periods of PCL and n-HA is large is avoided, and the degradation efficiency of the implant is greatly improved. After the later-stage PCL degradation and implant material mechanical failure, the n-HA has a large number of residual particles, and bone remodeling is affected.

The invention discloses sclera shell slurry suitable for ceramic photocuring 3D printing and a preparation method of the sclera shell slurry, and relates to the technical field of biomedical materials and additive manufacturing, and the sclera shell slurry comprises 2.0%-5.0% wt of methacrylated gelatin, 70%-90% wt of nano-hydroxyapatite, 10%-25% wt of a photosensitive resin solution, 1%-3% wt of a composite photoinitiator and 1%-5% wt of a composite dispersion stabilizer. The high-solid-content slurry and the optimized sintering process disclosed by the invention ensure that the final ceramic product has enough mechanical strength similar to that of human bones, scar contracture can be effectively resisted, and a long-term stable physical barrier is provided. And the process is stable, the forming precision is high, high fluidity and low viscosity of the slurry are guaranteed through unique powder grading and a dispersion stable system, the photocuring printing process is smooth, the forming structure resolution ratio is high, and defects are few. The whole set of process has clear parameters and good reproducibility.

The invention relates to the technical field of wastewater treatment materials, in particular to a preparation method of a nano-hydroxyapatite-based composite material, which comprises the following steps: selecting high-density polyethylene as a continuous phase matrix material and nano-hydroxyapatite as a functional filler, adding a silane coupling agent as an interface modifier, and carrying out hydrophilic modification through a hydrophilic agent to obtain the nano-hydroxyapatite-based composite material. The composite material is obtained through nano-hydroxyapatite pretreatment, melt blending, physical foaming and molding processing. The composite material is applied to an MBBR (Moving Bed Biofilm Reactor) for wastewater treatment; the compressive strength of the obtained composite material is greater than or equal to 15 MPa, and the annual wear rate lt Meanwhile, the microporous structure of the nano-hydroxyapatite provides a large number of active sites for microorganism attachment, the biological membrane quantity of the system can reach 35 g / L, the ammonia nitrogen removal rate is increased by 30-50% compared with the prior art, and the phosphorus adsorption capacity reaches 8-10 mg / g.

The application relates to the technical field of forestry seedling raising and ecological restoration, and discloses a root guiding type full-biodegradable tree planting bag based on hybrid material modification and application, the tree planting bag is an integrally injection molded structure, the inner wall is provided with vertical root guiding edges, and the bottom is provided with a cross-shaped easy-to-crack line; the tree planting bag is longitudinally divided into an upper structure area and a lower degradation promoting area. The upper part is composed of PBAT / PLA and hybrid materials and has high strength and weather resistance; the lower part is composed of PBAT / PPC, hybrid materials and plant fibers and has moisture absorption and rapid degradation characteristics. The hybrid material is a composite in which nano-hydroxyapatite grows in situ on the surface of attapulgite. Through the synergy of the longitudinal gradient material and the physical root guiding structure, long-term shape retention during seedling raising and rapid disintegration of the bottom after planting are realized, the problems of seedling taproot and degradation lag are solved, the degradation products can adjust the pH value of the rhizosphere soil and provide phosphorus and calcium nutrition, and the afforestation survival rate is improved.

This invention belongs to the field of heavy metal pollution remediation technology, and relates to the preparation and application of a cadmium passivating agent for weakly alkaline soil. The weakly alkaline soil cadmium passivating agent mainly comprises the following components by weight: 30-50 parts of a mineral complex, 40-60 parts of a bioactive component, and 5-15 parts of an auxiliary stabilizer. The mineral complex includes natural sepiolite, calcium-based bentonite, and a polyether-polyester diblock copolymer; the bioactive component includes microbial agents, phosphorus-modified biochar, lecithin, and phosphatidylserine; and the auxiliary stabilizer includes nano-hydroxyapatite and a chitosan-grafted polyaspartic acid complex. This weakly alkaline soil cadmium passivating agent exhibits excellent remediation effects on cadmium in contaminated soil, effectively preventing or reducing the entry of cadmium and other heavy metals into the food chain, and has significant market potential.

The invention relates to the technical field of environmental engineering and water body remediation, in particular to a river and lake sediment covering material capable of cooperatively controlling phosphorus and fluorine and a method and application thereof. The covering material provided by the invention comprises a base material, an active component and a binder, the matrix material adopts modified clay, is of a porous net structure, and provides stable physical support and adsorption basis; nano-hydroxyapatite and ferric oxide are added into the active component, are dispersed in pores of the matrix and are respectively used for efficiently adsorbing phosphorus and fluorine; the binder is an environment-friendly polymer binder and wraps the surfaces of the matrix and the active component to form a continuous bonding layer, so that the mechanical strength and durability of the material are enhanced. According to the covering material provided by the invention, through specific adsorption of the nano-hydroxyapatite to phosphorus and efficient adsorption of the iron oxide to fluorine, release of phosphorus and fluorine in sediments can be inhibited at the same time, and the problems that a common covering material in the prior art is single in function, low in adsorption capacity and poor in stability are solved.

The invention discloses a medical-grade PEEK composite material for 3D printing and a preparation method of the medical-grade PEEK composite material, relates to the technical field of 3D printing, and solves the problem of low biological activity of an existing PEEK material. The medical-grade PEEK composite material is prepared from the following raw materials in parts by weight: 80-95 parts of a polyether-ether-ketone matrix, 5-15 parts of a bioactive filler, 0.5-5 parts of an interface modifier and 0.1-3 parts of a heat conduction and nucleation enhancer, the bioactive filler comprises nano-hydroxyapatite and bioactive glass in a weight ratio of (1-5): (5-1). The natural bone environment can be effectively simulated, the biological activity of the composite material is improved, and cell adhesion and proliferation are promoted, so that the cell proliferation rate is increased, and the antibacterial effect and the mechanical property of the composite material can be effectively improved.

The invention discloses a silverweed cinquefoil root flowering fertilizer composite formula and application thereof, and relates to the technical field of compound fertilizers, the silverweed cinquefoil root flowering fertilizer composite formula comprises, by weight, 15-25 parts of a nano carrier, 28-44 parts of an organic raw material, 7-15 parts of an inorganic raw material, 8-12 parts of biological bacteria, 0.2-0.3 part of a biological regulator, and 6-11 parts of a trace element composition; wherein the nano carrier is prepared from 12 to 20 parts of nano diatomite and 3 to 5 parts of nano hydroxyapatite; the nano diatomite is obtained by sequentially stirring a 2mol / L NaOH solution at the temperature of 60 DEG C for 2 hours, adjusting the pH value to 6.0 by a 1mol / L HCl solution and drying at the temperature of 105 DEG C; the specific surface area of the nano diatomite is greater than or equal to 85 m < 2 > / g The application has the effects of meeting the nutrient and physiological requirements in the key flowering period of the potentilla anserine and improving the flowering rate and the fruit setting rate of the potentilla anserine through nano-carrier modification and functional component optimization.

This invention discloses an acid-resistant sealing grouting material suitable for the treatment of acidic mine water inrush, its preparation method, and its application. It belongs to the technical field of mine groundwater pollution prevention and control and mine water hazard management. The acid-resistant sealing grouting material, by weight, comprises: 8-12 parts nano-hydroxyapatite, 1.5-3 parts sodium alginate, 5-8 parts porous adsorbent material, 100 parts cement, 25-35 parts water glass, 3-5 parts quicklime, 0.5-1.0 parts retarder, and 50-65 parts water. The acid-resistant sealing grouting material of this invention can immobilize iron and manganese, exhibits strong acid resistance and good pressure resistance, and is suitable for grouting materials used in sealing goaf areas and fissures in closed mines.

A fully dissolvable anticaries remineralization toothpaste for children and a preparation method thereof. The toothpaste has a three-layer composite structure: a dissolvable backing protective layer, an anticaries remineralization active layer, and a pH responsive layer. All components are food grade or pharmaceutical excipient grade, and completely dissolve within 10-30 minutes in the oral environment, without the need to remove after use. The active layer contains a "fluoride-nano hydroxyapatite-xylitol" ternary synergistic system, which can inhibit demineralization, promote remineralization, and inhibit cariogenic bacteria. The active layer also contains pH-responsive food colorants, which visually indicate the end of use through color changes. Formulas are designed for children aged 3-6 and 6-12, respectively, and the toothpaste can be cut along the preset line to fit different arch sizes. The invention solves the problems of poor use compliance, high risk of swallowing, and short residence time of active ingredients in existing children's anticaries products, and achieves safe, effective, and fun oral care for children.