953 results about "Nano hydroxyapatite" patented technology

The invention discloses a method for removing heavy metal ions in sewage by nanometer hydroxylapatite, belonging to the technical field of heavy metal sewage treatment. The method comprises the following steps: adding nanometer grade hydroxylapatite powder in waste water containing heavy metal ions, wherein, the dosage of the hydroxylapatite powder is 6-8g / L; balancing the mixture for 12-48 hours at a temperature of 23-27 DEG C; and standing the mixture to remove the heavy metal ions in the waste water. The method uses the hydroxylapatite with relatively lower economic value to treat the heavy metal sewage, has high treatment efficiency, low treatment cost, strong field operability and small environment risk, and has heavy metal ion removal rate over 90 percent under conditions that concentration of Cd, Pb or Cu ions does not exceed 60mg / L.

The invention discloses an adsorption method for preparing hydroxyapatite pesticide and slow-release fertilizer compound, which comprises the following steps: soaking a nano hydroxyapatite carrier in phosphate buffer solution, then adding a starting material into the buffer solution and continuously stirring the mixture to form compound solution, finally centrifuging the compound solution to obtain sediment, and drying the sediment to obtain the compound. By using a porous structure of the nano hydroxyapatite self to embed medicaments into an internal grid of the carrier, the burst effect of the medicaments is avoided, the medicinal effect is long, the medicament residue is greatly reduced, and the medicaments are safer. A product obtained by using the nano hydroxyapatite as a pesticide and fertilizer carrier has the advantages of reliable quality, strong stability, safe use and low cost, greatly improves the medicament loading amount and adsorption amount, is easy for continuous production, and has good application prospect.

The invention relates to a kind of laminated gradient composite scaffold material based on the bionic structure and its preparation method. The said material has three or more layers of porous structure, comprising of hyaluronic acid, PLGA, PLA, collagen II and nano-hydroxyapatite (nano-HA) , beta- tricalcium phosphate ( beta-TCP). The upper layer is made by collagen II / hyaluronic acid or PLGA and PLA imitating the cartilage layer. With the counterfeit the calcified cartilage layer in the middle, it is one layer or multi- sublayer, made by nano-HA or beta-TCP with collagen II / hyaluronic acid or PLGA and PLA; the bottom is made of nano-HA or beta-TCP with collagen II or PLGA and PLA. From top to bottom, the content of inorganic material increases in its layers, about 0 to 60 mass percent of layers. The aperture of the scaffold material is 50 to 450 micron, with 70 to 93 percent porosity. The scaffold material made by this invention has an adjustable degradation rate, good mechanical and biocompatible properties, can adapt to culture with cartilage bone cells and compound with growth factor and small molecular or peptides, it can be used to repair cartilage simultaneously.

The invention relates to a method for preparing nano hydroxyapatite powder, belonging to the field of the biomedical material. The method for preparing the nano hydroxyapatite powder comprises the following steps: adding the organic polymer of polyethylene glycol to the initial reactants of calcium nitrate and diammonium phosphate solution to adjust and control the morphologies of the products of reaction; adding aqueous ammonia to adjust the pH values of the products of reaction, and making the aqueous ammonia react with the products of reaction at different water bath temperature to synthesize nano hydroxyapatite precipitate, wherein the agglomeration of the synthesized nano hydroxyapatite precipitate can be inhibited by the polyethylene glycol functioning as the dispersant; freezing and drying synthesized nano hydroxyapatite precipitate slurry to obtain dry nano hydroxyapatite powder which contains by-products of reaction and polyethylene glycol, and calcinating the dry nano hydroxyapatite powder at high temperature to remove the by-products of reaction and the polyethylene glycol which are contained in the dry nano hydroxyapatite powder to obtain the nano hydroxyapatite powder which is in the shape of the ball or the rod and in the particle size of 10-100 nm and has high yield and good dispersion. The method for preparing the nano hydroxyapatite powder is simple, needs short preparing period, causes no poison and pollution and is suitable for industrial production.

The invention relates to a fluorescent graft degradable block polyurethane, a bone repair material and a preparation method thereof. The polyurethane is formed by grafting a pharmaceutically acceptable fluorescent component into a structure formed by polymerizing a hard segment of aliphatic diisocyanate and a soft segment of a degradable polymer chain segment of a hydroxyl-terminated polymer or block copolymer. The bone repair material is composed of the polyurethane and nano hydroxyapatite powder. The polyurethane and corresponding bone repair material have favorable biocompatibility and degradability, have the fluorescent characteristic, can be used for performing tracing evaluation on the degradation process of the block polyurethane, analyzing the mechanism of degradation and inspecting the influence of the degradation rate on the mechanical properties of the material and the tissue regeneration and reconstruction process, and provide a new visual angle and means for evaluating the biosafety of the high-polymer degradable material. The preparation technique is simple, is easy to control and operate, and has favorable application prospects in the field of biomedicine.

The invention discloses a magnetic nano hydroxyapatite adsorbent, preparation and application thereof. Nano hydroxyapatite Ca10(PO4)6(OH)2 is used as a matrix of the adsorbent, and magnetic powder Fe3O3 is uniformly dispersed in the matrix, wherein the mass ratio of the nano hydroxyapatite to the magnetic powder Fe3O3 is (1.5-1):1. The preparation method comprises the following steps of: dissolving FeCl2 and FeCl3 with a mass ratio of (0.75-0.85):1 in deoxidized water; then adding an ammonia solution and uniformly stirring; simultaneously adding a Ca(NO3)2 solution and a (NH4)2HPO4 solution and uniformly stirring to obtain liliquoid; heating the liliquoid at the temperature of 90-100 DEG C; and then obtaining the magnetic nano hydroxyapatite adsorbent through cooling, separating, washing, drying and grinding. The magnetic nano hydroxyapatite adsorbent has large specific surface area, high adsorption efficiency, low cost and easy separation and can effectively remove heavy metal ions in waste water.

A process for preparing nano hydroxyapatite powder comprises the steps of, mixing Ca(NO3)-2-4H20 and NH4-2HPO-4 according to the mol ratio of Ca:P = 1.67-2.5:1, dissolving by charging distilled water, making the concentration of the Ca2++ ion to be 0.01-0.1 mol / L, charging aquadrate powder into the solution according the ratio of Ca(NO3)-2-4H2O : NH4-2HPO-4 = 1:5-12, conducting sound chemo synthesis through multiple frequency phonochemical generator, filtrating and washing the suspending liquid, placing the filtered material into vacuum drying oven for drying at the temperature of 80-100 deg. C, thus the nano hydroxyapatite powder can be obtained.

The invention relates to a medical polyurethane complex film and the preparation method thereof. The complex film is composed of fatty group polyurethane and nanometer hydroxylapatite, wherein the content of the anometer hydroxylapatite is 20-50 wt percent. The fatty group polyurethane is polymerized by at least one of fatty group vulcabond and polyether or polyester polyol, wherein the mol ratio of the fatty group vulcabond-NCO and -OH in the polyol is 1.5-3 to 1. The film belongs to a thermoplasticity elastic film, has favorable elasticity and easy moulding, can load microspheres containing medicine or active components such as biological nutrilit and the like and structures distributed with through holes, thereby having favorable biological performance, and the film does not contain aromatic components but contains ester groups and / or hydrophilic ether groups which can be hydrolyzed or biologically degraded; the hydrophile and hydrophobic nature balance and the degradation of the film can be changed through adjusting the proportion, and the film can be applied to the medical health field of bone tissue guiding regeneration film and medicine slow-released film, and the like.

The invention discloses a method for preparation of a bone hydroxyapatite-imitating bone repair material, nano hydroxyapatite ceramic powder and NH4HCO3 powder are mixed proportionally, after mixing, the powder is loaded into a gradient mold for mechanical pressing into a block pressed blank, the block pressed blank is put into a discharge plasma sintering furnace, heated to 950 DEG C and 1050 DEG C in the heating rate of 100 DEG / min, and then kept warm for 10-20min, and after demoulding, a nano scale bone gradient-imitating porous hydroxyapatite bone repair material is obtained. The nano scale bone gradient-imitating porous hydroxyapatite bone repair material is prepared by the method comprises outer and inner two layers, the porosity is 34% to 80%, and the pore scale is controllable in the range of 100-500mum, and the nano scale bone gradient-imitating porous hydroxyapatite bone repair material has the advantages of fine grain size, composition purity, no residual pore former, controllable mechanical properties and degradation rate and the like, and can be used as a good artificial bone tissue repair material.

The invention discloses a preparation method of porous microspheres composite with hydroxyapatite microspheres being capable of carrying drugs and bone cement, which belongs to the technical field of biological material preparation. The method comprises the following steps: the preparation of nano hydroxyapatite powders; the preparation of Alpha- tricalcium phosphate powders; the preparation of the hydroxyapatite microspheres; and the preparation of the porous microspheres composite with the hydroxyapatite microspheres and the bone cement. The method has the advantages that: the porosity of the porous microspheres composite with the hydroxyapatite microspheres and the bone cement, and the size of the microspheres can be easily controlled; the composite of the drugs can be carried out by the preparation process of the bone cement stuff, the drug-carrying rate is large and controllable; and the composite porous microspheres can be served as drug carriers or stents with integration of bone restoration and cure.

The preparation method of porous collagen composite nano hydroxyapatite artificial bone includes the following steps: firstly preparing nano hydroxyapatite, then preparing collagen solution, adding collagen solution into the hydroxyapatite powder body, finally mixing them and making them into pasty material, freeze-drying so as to obtain the invented porous collagen composite nano hydroxyapatite artificial bone.

The invention discloses a nano hydroxyapatite / chitose / gelatine composite porous bone tissue engineering cradle material and the preparing method. The material comprises chitose and gelatine with their mass ratio being 3:7-7:3 and the nano hydroxyapatite of 40-80nm deposited on the porous cradle material formed by chitose and gelatine. Preparing the porous cradle material with pore diameter 100-300 ª–m and factor of porosity greater than 90% by using phase separation technique, then immersing it in the Tris buffer solution of Ca(NO3)2 for 10-12 hours, washing with deionized water three times and then immersing it in the Tris buffer solution of Na3PO4 for 10-12 hours, regulating pH value between 11 to 13, washing with deionized water three times and freezing for drying, then getting the nano hydroxyapatite / chitose / gelatine composite porous material by recycling the steps above several times, the size diameter of the hydroxyapatite is about 50nm, the material prepared in this invention possesses good mechanical property and biological compatibility.

The invention relates to tissue engineering materials and particularly discloses a nanometer hydroxyapatite / natural polymer composite, a preparation method and an application thereof. The preparation method includes the steps of putting the natural polymer composite into the mixed solution of alcohol, water and urea and adding monosodium phosphate solution and calcium chloride solution to conduct sealing reaction and obtain the composite, wherein the volume ratio of the alcohol and the water in the mixed solution is 2-6:1, the concentration of urea in the mixed solution is 1-3g / 100ml. The method is quick and effective, the conditions of the reaction system are mild, the reaction method and the reaction system are easy to operate and control, the cost is low and investment of high energy source is saved. The composite obtained by the method has a thicker mineralization layer and therefore higher tensile and compressive strength and also can be applied to the field of the tissue engineering materials requiring high mechanical strength, for example the manufacture of bone tissue engineering materials.

The invention discloses a method for preparing nano hydroxyapatite / polylactic acid composite microspheres, which uses nano hydroxyapatite (n-HA) and polylactic acid (PLA) as raw materials and adopts an ultrasonic blending composite process and an emulsification-solvent evaporation method to prepare the microspheres of a nano hydroxyapatite / polylactic acid composite material. The preparation method comprises the following steps: nano-crystallizing hydroxyapatite, proportionally preparing complex liquid, performing ultrasonic dissolving and blending, emulsifying the mixture into small liquid drops, reducing pressure to volatilize a solvent, performing refrigeration and filtration, performing washing, and performing freeze-drying to obtain the composite microspheres. Compared with like products, the composite microspheres have the characteristics that the method has simple and easy operation, the size of the microspheres is easy to control, and the prepared microspheres have large surface holes and specific area, and good mechanical property. The prepared nano hydroxyapatite / polylactic acid composite microspheres are mainly applied to microsphere bonding type brackets in bone tissue engineering and cell micro-carriers in cell engineering, and can be applied to conveying medicaments and bioactive molecules.

A process for synthesizing nano-class hydroxy apatite includes such steps as dissolving the organic compound containing carboxy, hydroxy and sulfonyl in the aqueous solution of Ca(NO3)2*4H2O at 40-100 deg.C, proportionally dripping H3PO4, regulating pH=10 or more, reaction for at least 4 hr, reaction at 40-200 deg.C for at least 8 hr, filter, washing and drying.

The invention relates to a process for preparing nano hydroxyapatite / polyamide series biological medical composite material by using polyamides component and nano hydroxyapatite as raw material, wherein the weight ration of polyamides / nano hydroxyapatite is 8 / 2-2 / 8, through the steps of, dissolving polyamides into methanol solution, mixing nano hydroxyapatite into nano hydroxyapatite slurry consisting polyethylene glycol and water or methanol solution containing water, mixing the two for recombination while stirring, water sedimentation of the obtained product, washing with hot-water and anhydrous alcohol respectively.

The present invention is one kind of nanometer hollow spherical granular hydroxyapatite and its preparation process. The nanometer hollow spherical granular hydroxyapatite has diameter of 130-170 nm, wall thickness of 40-50 nm, crystalline hydroxyapatite content of 40-60 % and amorphous calcium phosphate for the rest. The preparation process includes the following steps: dropping calcium salt solution slowly into solution containing phosphate radical and CTAB as template agent at certain temperature and in ultrasonic condition, dropping ammonia water solution to regulating the solution pH value to 9-10 and obtain milk white suspension, filtering, washing and low temperature vacuum drying. The nanometer hollow spherical granular hydroxyapatite has simple preparation process, light weight, great specific surface area and important application foreground in medicine release controlling carrier, medicated tissue engineering rack, etc.

The porous bnoe prosthesis with good biological compatibility and biological activity is formed from nano hydroxyapatite and polyamide component with weight ratio of 1 / 1-0.3, and has mutual through pores whose pore size is 1-300 micrometers, and its total porosity is 30-70%. Its preparation method includes the following steps: according to the described ratio mixing fine hydroxyapatite powder and polyamide fine powder, then mixing them with ethyl alcohol solution containing calcium chloride to make solidifiation, and using water to dissolve the above-mentioned obtained material to remove water solubility component from solidified material and form porous structure in the bone prosthesis material.

A slowly-releasing artificial nerve canal for repairing nerve is prepared through dissolving the bio absorptive polylactic acid in organic solvent adding hydroxy apatite nanoparticles and freeze-dried nerve growth factor (NGF) powder, ultrasonic dispersing and volatilizing solvent to obtain milliporous canal.

The present invention relates to electrochemical deposition process of preparing nanometer ordered hydroxyapatite coating on the surface of medical metal material. Cathode electrochemical deposition onto surface of Ti or Ti alloy is performed with electrodeposition solution containing Ca ion of 1E(-4) to 1E(-3) mol / L and LH2PO4 ion of 0.5E(-4) to 1E(-3) mol / L and in voltage of 1-20 V and current of 0.1-10 mA / sq cm. By means of controlling the electrochemical deposition parameters for forming nanometer hydroxyapatite coating, nanometer hydroxyapatite crystal particles may have different aggregate forms to form different secondary microscopic structures, blossom cluster shaped, upstanding or microspore. The form controllable nanometer hydroxyapatite material is biological material with different topologic structure and homogeneous chemical property, and is expected to have raised biocompatibility and bioactivity in clinical application.

A porous scaffold material for tissue engineering is the composition of a polylactic acid type polymer, such as poly-L-lactic acid (PLLA), poly-D, L-lactic acid (PDLLA) and poly-L-lactic acid / hydroxyacetic acid copolymer (PLGA), and a modified nano-class hydroxyapatite (NHA). It is prepared by the thermal phase separation technique.

A composite chitosan / nano-hydroxyapatite microsphere-based material used for bone-grafting and delivery of therapeutic agents. The composite material may be produced using co-precipitation methods. The composite material may be used to form scaffolds with significantly greater surface area and surface roughness than scaffolds composed of only chitosan. Composite scaffolds exhibit less swelling and greater toughness and flexibility than scaffolds fabricated by other techniques. Composite scaffolds also exhibit greater osteoblast proliferation. Composite scaffolds also may contain therapeutic agents or medicaments, and may be lyophilized.

The invention relates to a preparation method of a magnesium alloy / hydroxyapatite composite, which comprises the steps of firstly preparing nano hydroxyapatite powder by a sol-gel process, and then uniformly mixing the magnesium powder with the nano hydroxyapatite powder; putting the mixture into a mould and performing cold pressing; putting the cold-pressing formed sample into a vacuum heat treatment furnace for sintering to obtain the magnesium alloy / hydroxyapatite composite. Compared with the prior art, in the method provided by the invention, the magnesium alloy is used as a metal matrix, the hydroxyapatite with the same chemical composition as the human skeleton and having low solubility in the human body environment is used as a reinforcing body, and the method aims at preparing a magnesium alloy / calcium phosphate composite biomedical material by use of a powder metallurgical process; the material is mainly applied to clinical medicine as a degradable endosteal fixing material, a porous bone repair material, a dental implantation material, an oral repair material, a cardiovascular stent and the like, and has broad prospects in terms of bone tissue defect repair.

A nano hydroxyphosphorite / alumina bioceramics is prepared through physically depositing hydroxyphosphorite, preparing precursor by template technique, stirring while heating to obtain nano-class precursor by calcium hydroxide suspension and phosphoric acid, ultrasonic treating to obtain suspension, and immersing alumina in it to obtain product.

The invention relates to a preparation process of nano-hydroxyapatite / silk fibroin composite material, which comprises choosing CaC1 2-C 2 H5 OH-H2O ternary system with molar ratio of 1:2:8 as solution, adding silk fibroin fiber which has fully been degelatinized according to the proportion that mass fraction is 3-14.68 (w / w) under the temperature of 75+-5 DEG C, dissolving 0.5h to obtain silk fibroin solution whose mass fraction is 3-14.68 (w / w), adding diammonium phosphate in silk fibroin solution according to the molar ration that calcium: phosphorus=10:6 under the condition of uniform stirring, finishing the dripping within 2-5h, then continuing compound reaction for 2-3h, wherein the temperature in former 2-4h is 30-60 DEG C, and the temperature of the latter 2-4h is 60-100 DEG C in the whole 4-8h reaction process, paying attention to the change of pH value of reaction system, regulating the pH value to 9-12 with ammonial solution which is diluted, and obtaining the composite material through filtering, fully repeatedly scouring and filtering after finished reaction.

The invention discloses chitosan-hydroxylapatite in-situ loaded icariin composite microspheres and a preparation method thereof. The preparation method is characterized in that a micro-capsule forming device is adopted, chitosan is used as an organic substrate, and soluble calcium salt and soluble phosphate are used as precursors of inorganic phase nanometer hydroxylapatite; the in-situ crystal induction effects of hydroxyl radicals and amino radicals in the chitosan on the hydroxylapatite are used for adjusting and controlling the in-site heterogeneous nucleation crystallization of an inorganic mineral on the organic substrate; and meanwhile, a traditional Chinese medicine, namely icariin which has the effect of promoting proliferation and differentiation on osteoblast is compounded, and the chitosan-hydroxylapatite in-situ loaded icariin composite microspheres are prepared through in-situ simulation. The chitosan-hydroxylapatite in-situ loaded icariin composite microspheres are bone filling materials, have good biocompatibility and biodegradability and are expected to serve as repair materials for bone tissue defects to be widely applied in clinic; the preparation processes are simple and easy; and the method is mild.

The invention relates to a method for preparing combined supporting frame of nanometer hydroxyapatite and silk fibroin-chitosan, belonging to field of tissue organizing technology. It is to solve problems of damage of biological activity of material by introduced organic dissolvent, small porous size and low porous rate inside material, bad porous connectivity and unfavorable for reproduction of bone cell in current preparation method. The material in this invention comprises inorganic and organic material, inorganic material is nanometer hydroxyapatite, and organic material is silk fibroin and chitosan. The ratio by weight between inorganic and organic material is 50-70:30-50, the ratio between silk fibroin and chitosan by weight is 1:1-2.The said supporting frame is prepared by freezing and drying method. The cell frame porous rate is 75%-90%, the pore size is 150-500 um, and compression strength is 0.85-1.85 Mpa.

The invention discloses a making method of sequent hydroxy phosphorite polycrystalline powder and calcium phosphate, which comprises the following steps: mixing 30% 0. 00167mol calcium nitrate per ml water and 15-60% 0. 0033-0. 0667g sodium dodecylbenzene sulfonate per ml alcohol; placing the mixed solution in the flask with reflux device; adding the composite solution with 30% ammonium monohydric phosphate at 0. 01mol phosphor / ml water solution and 15-60% alcohol and the composite solution with 20% sodium hydroxide solution at 0. 05-0. 1g sodium per ml water and 10-40% alcohol; heating to the refluxing temperature at 88-92 deg. c to do hydrothermal reaction at 4-14h; centrifuging; separating; drying the white sediment under 60-80 deg. c; obtaining the product with good crystallizing degree, high-sequent (spatial symmetry) nanometer layered polycrystalline structure; simplifying the method and reducing the cost.

The invention relates to a method of adsorbing a lead-copper-zinc mixed solution with a charcoal-hydroxyapatite nanocomposite material. Rice straw is adopted as a carbonized raw material to carry nano-hydroxyapatite and is used for adsorbing the lead-copper-zinc mixed solution. Compared with the prior art, the method of adsorbing the lead-copper-zinc mixed solution with the charcoal-hydroxyapatite nanocomposite material has the advantages that the charcoal-hydroxyapatite nanocomposite material used for adsorbing the heavy metal lead-copper-zinc mixed solution is prepared by adopting nano-hydroxyapatite as a center material and conducting hypoxia high temperature carbonization on the rice straw; after a phosphonio charcoal material is thrown into the lead-copper-zinc mixed solution, lead-copper-zinc is adsorbed by charcoal, the phosphonio charcoal material is stable in performance, nano-hydroxyapatite powder bodies wrapped with charcoal are released slowly, long-term effectiveness can be maintained, meanwhile phosphorus release amount is not large, and thus water body eutrophication cannot be caused.