27 results about "Host bone" patented technology

The invention discloses a chest wall defect three-dimensional reconstruction and personalized repair material design system, and relates to the technical field of intelligent medical aided design. Comprising a data acquisition module used for acquiring and preprocessing multi-modal data of the chest wall of a patient; the partition module is used for dividing the defect area into different functional partitions by coupling and analyzing stress and blood flow data and setting a threshold value; the dynamic optimization module is used for mapping the breathing time sequence to a three-dimensional space and dynamically correcting the partition boundary according to the stress change in the breathing cycle; the interface matching module is used for carrying out parameterization design on a host bone interface according to the bone mineral density data; and the optimization design module is used for carrying out topological structure and pore distribution dual optimization on the repair material based on the dynamic partition and the interface parameters, and finally, the output module generates design data capable of directly driving manufacturing. Precise matching of the repairing material and the physiological anatomical structure and the dynamic physiological function of the patient is achieved.

The invention relates to the technical field of biomedical material synthesis, in particular to a synthetic method of a bionic gradient mineralized collagen-polycaprolactone composite material, which comprises the following steps: a) activating the surface of PCL (polycaprolactone) through argon plasma to generate carboxyl groups with the density of more than or equal to 5 * 10 / cm; b) carrying out amination modification on nano-hydroxyapatite (nHA) by adopting APTES, wherein the surface potential of the modified nHA is greater than or equal to + 15 mV; c) covalently grafting aminated nHA to the surface of PCL through an amido bond under the conditions that the molar ratio of EDC / NHS is 1: 2 and the pH is 5.5 + / -0.2, and the grafting density is greater than or equal to 3 * 10 particles / mu m; the method has the beneficial effects that the gradient mineralization structure is subjected to bionic optimization: the concentration and the flow velocity (the inner / outer layer flow velocity ratio is 1: 3) of mineralization liquid are accurately controlled through a microfluidic gradient generator, linear gradual change (the gradient slope is 1.5 + / -0.3 wt% / 100 [mu] m, R is equal to 0.97) of the mineralization degree from 20-30 wt% of the inner layer to 50-60 wt% of the outer layer is realized, the mechanical gradient characteristics of the natural bone are simulated, the compression modulus is increased from 0.8 GPa of the inner layer to 3.2 GPa of the outer layer in a gradient manner, and the mechanical property of the natural bone is improved. The mechanical matching property of the material and the host bone is obviously improved.

The invention discloses a bone defect repair material suitability prediction method based on deep learning, and the method comprises the steps: carrying out the overlapping and uniform partitioning of a bone defect region and a host bone region in three-dimensional CT image data, carrying out the position coding and feature extraction of a plurality of sub-blocks through a three-dimensional visual Transform model of multi-scale position coding, and obtaining the anatomical and functional features; calculating a bone metabolism activity score and a systemic inflammation score based on blood detection data, and then constructing pathophysiological features; performing multi-round interaction on the anatomical and functional features, the pathophysiological features, the parameter data and the multidirectional multi-head cross attention layer, in each round, selecting one modal feature as a query vector, and selecting any modal feature in the rest modal features as a key vector and a value vector; and fusing the interaction features of each round, and determining the suitability score and the risk level of the bone repair material by combining the attention weight and the bone metabolism activity score in the multidirectional multi-head cross attention layer.

An acetabular bone defect filling block design method based on a force conduction path comprises the steps that a mechanical conduction target path is determined, specifically, the stress condition of a hip joint in a gait cycle is simulated on the basis of a three-dimensional model of a pelvis of a patient, a bone defect area Vdefect and a three-dimensional model of an implanted supporting bracket which are obtained in advance, and the mechanical conduction target path is determined; determining an expected force flow conduction path from the acetabular cup loading area to the host bone main bearing area; a filling space determining step: calculating a residual defect space Vremain formed after the support is implanted; a filling block main body generation step: taking the residual defect space Vremain as a design boundary, taking following of the expected force flow conduction path and realization of matching of the structural rigidity and the host bone as an optimization target, generating a filling block main body three-dimensional model with an internal support truss through a topological optimization algorithm, and steering a strong gluteus column by depending on an incomplete acetabular ring, and a fixed foundation which cannot be shaken is provided. An intelligent structure with the optimal mechanical property is generated by converting empirical shape matching into simulation driving generation type design.

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and / or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and / or have bone ingrowth surface features that create a strong bond with the bone.

The present dental implant, whether tapered or cylindrical, is cannulated, to allow placement over a slender post pre-embedded into the host bone. The post is a rigid, not a flexible, construct that can be placed accurately, as to position and angle, in the jawbone. With the post in the correct position, the implant is then installed directly over the temporarily anchored post, and after tightening of the implant by rotation the post is removed.

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and / or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and / or have bone ingrowth surface features that create a strong bond with the bone.

An anchor to be screwed into a hole with high primary stability and eventually even higher secondary stability. A right hand thread form winds with continuous turns along the body of the anchor. A trailing flank of the thread form is back-angled. The central region includes an array of flutes having left-hand helical twist. Each flute is composed of distinct flute segments. A condensing ramp is formed along the crest of the thread form between two circumferentially-adjacent flute segments. Each condensing ramp is pitched about 20° so as to apply a localized compressive strain to the interior surface of the host bone with a densifying action when the anchor is screwed into the prepared hole. The condensing ramps create induced stress and super-activated zones in the bone directly adjacent to healing chambers formed by the flute segments. The healing chambers draw bone to naturally encourage and promote healing.

The present application belongs to the technical field of surgical implant medical devices for foot and ankle, and discloses a preset angle ankle arthrodesis device with functions of promoting bone integration and resisting bacteria, which has a preset angle suitable for tibiodal joint, ranging from 3° to 7°. The device further comprises a three-dimensional porous bone implant body, a surface of the three-dimensional porous bone implant body in contact with host bone tissue is a porous titanium alloy, a plurality of convex anti-rotation ridges are arranged on the upper and lower end faces of the three-dimensional porous bone implant body, the three-dimensional porous bone implant body is fixed by occlusion with the host bone through the anti-rotation ridges, an in-situ growth film layer is grown on the surface of the three-dimensional porous bone implant body, and the in-situ growth film layer comprises functional substances and antibacterial substances. The present application effectively solves the technical problems of slow bone integration, high risk of infection, rotation instability and insufficient mechanical support in ankle arthrodesis, significantly improves the success rate of fusion and reduces postoperative complications.

The invention discloses a preparation method of a heterogeneous bone-microporous metal implant composite material, and belongs to the technical field of biology. The method comprises the following steps: implanting a microporous metal implant into a cancellous bone of a heterogenous animal, carrying out osseointegration connection on the microporous metal implant and the cancellous bone of the heterogenous animal after 12 weeks to form an interface interpenetrating structure, taking out the microporous metal implant, retaining a peripheral bone with the thickness of 1-10mm, and then sequentially carrying out gradient decalcification and complete decellularization treatment to obtain the porous metal implant of the heterogenous animal. The heterogeneous bone-microporous metal implant composite material with high bone induction activity, strong osseointegration and low immunogenicity is obtained; according to the invention, a metal implant material is converted into a bioactive implant composite material, and a heterogeneous interface of the metal implant and a transplanted bone is converted into a homogeneous interface of a host bone or a transplanted bone and a transplanted bone, so that the clinical problem that the interface osseointegration of the transplanted bone and the metal implant is poor is solved.

The application discloses a kind of bone defect repair material adaptability prediction methods based on deep learning, the bone defect region and host bone region in three-dimensional CT image data are overlapped and evenly divided, and the three-dimensional visual Transformer model of multi-scale position coding is used to carry out position coding and feature extraction to multiple sub-blocks, to obtain anatomical and functional characteristics;Pathophysiological characteristics are constructed after calculating bone metabolic activity score and systemic inflammation score based on blood test data;Anatomical and functional characteristics, pathophysiological characteristics, parameter data and multi-direction multi-head cross attention layer are interacted in multiple rounds, in each round, select a modal feature as a query vector, select any modal feature in the remaining modal feature as a key vector and a value vector;The interactive features of each round are fused, and the adaptability score and risk level of bone repair material are determined by combining the attention weight in the multi-direction multi-head cross attention layer and the bone metabolic activity score.

The invention relates to the technical field of medical instruments, in particular to an L-shaped side wing reinforcing block for reconstruction around acetabulum based on a gluteus column structure, which comprises a reinforcing block area configured in a bone defect area at the top of the acetabulum so as to bridge a host bone gluteus column area and an acetabular cup; the side wing area simulates the anatomic form of the gluteal muscle column area of the outer wall bone surface in the direction of the gluteal muscle column of the ilium of the natural acetabulum in a bionic mode and comprises a first arc-shaped surface attached to the bone surface of the gluteal muscle column area of the ilium; the bottom of the first arc-shaped surface of the side wing area is fixedly connected with one surface, which is arranged on the outer side of the acetabulum top bone defect area, of the reinforcing block area, and the side wing area is fixed on an iliac gluteal muscle column through matching of a first mounting piece and a first fixing piece; wherein the arc-shaped surface, close to the side wing area, in the lower end surface of the reinforcing block area abuts against the acetabular cup, and an abutting force facing the circle center area of the acetabular cup is applied to the acetabular cup; the lower end face of the reinforcing block area is fixedly connected with the upper end face of the acetabular cup through a second fixing piece.

The invention provides a split type acetabulum filling cushion block driving-in tool, and belongs to the technical field of medical instruments. Performing main body mold testing; the tooth structure is fixedly connected to one side end of the main body test mold; the notch is formed in the lower end of the main body test mold; the acetabular cup prosthesis test mold is positioned in the notch; the striking head is positioned in the acetabular cup prosthesis test mold; the main body test mold adopts an L-shaped design and is preliminarily fixed through the sliding nail holes, so that fine adjustment can be performed in an operation to reach an optimal position, and accurate placement of the acetabulum filling cushion block is ensured. Due to the design that the tooth peak of the tooth structure is gradually thinned from the root to the head, the tooth structure can be embedded into the acetabular fossa of the host bone more smoothly, the operation difficulty is reduced, and the stability is improved.

According to the preparation method of the PEEK-based tantalum coating skull restoration, the tantalum coating is prepared through data modeling, fused deposition modeling 3D printing and magnetron sputtering, the preparation process is simplified, and the production efficiency and the product consistency are improved. Medical-grade PEEK serves as a substrate, a micro-nano structure is formed on the surface through laser pretreatment, an ultrathin tantalum coating (the thickness is smaller than or equal to 1 micrometer) is deposited through magnetron sputtering, the matching degree of the appearance of the prosthesis and the anatomical appearance of a skull defect area reaches + / -1 mm, and the proximity error between the elasticity modulus of a bone contact area and a host bone is smaller than or equal to + / -10%.

This invention discloses a composite cranial repair bioprobe based on a 3D frame structure, comprising a 3D frame and biological patch units. The 3D frame includes an edge retention device and an internal main frame, each with a support platform. Each support platform houses the biological patch unit, which comprises a porous layer, a biomimetic layer, and a reinforcing layer arranged sequentially from the outside in. The porous layer has a porous structure with pores, the biomimetic layer is a biomimetic structure mimicking the trabeculae of the skull, and the reinforcing layer is a solid structure. The 3D frame portion of the composite cranial repair bioprobe provided by this invention sufficiently ensures the mechanical strength of the repair. The design of individual biological patch units, while meeting certain mechanical strength requirements, also ensures the integration of soft tissue and the ingrowth of host bone, guaranteeing the long-term stability of the repair.

The present disclosure describes a modular bone implant device, which is artificial bone material for repairing bone defects, comprising a plurality of assembled filling units, each filling unit having a hole and an interlocking mechanism for mutual assembly, after the plurality of filling units are assembled by the interlocking mechanism, each hole forms an internal passage through the bone implant device in at least one direction, the filling units are made of degradable biological material, and the elastic modulus of the filling units is always not less than the elastic modulus of the host bone during the repair period, and the ratio of the two decreases over time. Thus, a modular bone implant device with good structural stiffness, flexible assembly and degradation absorption can be provided.

The application relates to the technical field of medical prostheses, and discloses a porous metal pad block for extension fixation and used for acetabular severe bone defect reconstruction, which is used in cooperation with an acetabular cup and comprises a supporting plate, the bottom surface of the supporting plate is used for receiving the acetabular cup; a supporting wing, one end of the supporting wing is fixed to one end of the supporting plate, the supporting wing is arranged at an included angle between the supporting plate, the side of the supporting wing away from the supporting plate is used for being attached to the remaining host bone of the acetabulum, and a fixing part for arranging a fixing piece is arranged on the supporting wing, wherein the fixing piece is used for being fixed with the remaining host bone of the acetabulum; and a tooth structure, the tooth structure is arranged at the bottom of the side of the supporting wing away from the supporting plate and comprises at least two strip-shaped teeth arranged in a comb shape, one end of each strip-shaped tooth is fixed to the side of the supporting wing away from the supporting plate, and the other end is suspended. The application has the effects of reconstructing excellent acetabular stability, restoring the original physiological function of a patient, reducing the economic burden of the patient, and reducing the waiting period of the patient.

The application discloses a kind of biomimetic biological mineralization osteogenesis hydrophilic bioactive ceramic coating material, which includes HA / BaTiO3 composite layer in the material.The application also discloses its preparation method, which is prepared by using wideband laser cladding method.The application introduces BaTiO3 into traditional bioactive ceramic coating material to form HA / BaTiO3 composite layer, in-situ constructs bioelectric microenvironment to make hydrophilic bioactive ceramic coating, realizes the effective combination of electric stimulation and artificial joint coating, uses the electrostatic interaction between piezoelectric charge and inorganic salt ions in body fluid to adsorb calcium and phosphorus inorganic salt to coating surface, creates osteogenesis environment for life body osteogenesis, improves the hydrophilic performance of coating surface, promotes the inorganic salt and water molecules in body fluid environment to infiltrate on material surface, enhances bioactivity and accelerates bone integration, so as to be beneficial to promote the rapid establishment of joint prosthesis and host bone interface bone integration.

The invention relates to the field of medical repair, in particular to an acetabular bone defect repair system which comprises a moldable complex module made of a flowable composite material formed by mixing porous metal particles and bone cement according to a predetermined volume mixing ratio, and the moldable complex module is configured to be positioned in an acetabular bone defect area after being implanted, the bionic support frame module is used for providing mechanical support for the moldable complex module and the acetabular cup prosthesis; the inclusive cushion film can also be included; the bionic supporting frame module provides initial mechanical stability and has a space structure allowing the flowable composite material to permeate and be solidified, so that the bionic supporting frame module and the flowable composite material form a mechanically-interlocked integrated bearing structure. The inclusive cushion film is laid in the acetabular bone defect area, and a filling space is defined by the inclusive cushion film and the host bone. According to the acetabular cup prosthesis, the technical effects of anatomical matching and long-term biological integration of the irregular bone defect surface and the acetabular cup prosthesis are achieved.

The invention provides a hip joint thighbone prosthesis, and relates to the technical field of artificial joint prostheses, the hip joint thighbone prosthesis comprises a thighbone prosthesis main body, a plurality of anti-rotation keels are arranged on the inner surface of a spherical joint part, the plurality of anti-rotation keels are arranged along the circumferential direction of a connecting part, and the spherical joint part is connected with the thighbone prosthesis main body. The multiple anti-rotation keels divide the inner surface of the spherical joint part into multiple outer areas, and the pore diameters of the porous structures of the adjacent outer areas are different. According to the hip joint femoral prosthesis provided by the invention, the plurality of anti-rotation keels are arranged on the inner surface of the spherical joint part of the femoral prosthesis main body, and the anti-rotation keels can effectively improve the anti-rotation effect of the hip joint femoral prosthesis; the anti-rotation keel enables the inner surface to form a plurality of outer areas, and the pore diameters of the porous structures of the adjacent outer areas are different, that is, each outer area corresponds to different bone density areas of the femoral head, so that the problem of prosthesis looseness caused by biomechanical mismatching of the prosthesis and the host bone is solved.

The application provides a bone filling net bag with a double-material filling structure, which comprises an inner layer net bag and an outer layer net bag wrapped outside the inner layer net bag; a first filling cavity is formed in the inner layer net bag, and the first filling cavity is used for filling polymethyl methacrylate bone cement; an annular gap between the inner layer net bag and the outer layer net bag forms a second filling cavity, and the second filling cavity is used for filling artificial bone material; a connecting pipe is arranged on the outer surface of the inner layer net bag, the connecting pipe is connected with the first filling cavity and the second filling cavity, and is used for guiding the polymethyl methacrylate bone cement to enter the second filling cavity from the first filling cavity. The synergistic design of the structure and the material enables the implanted body to form a gradient composite interface of 'bone cement-artificial bone-host bone' in microcosm, realizes the unity of immediate stability and long-term fusion in macrocosm, and reduces the risk of postoperative implant loosening and re-fracture.

The present application belongs to the technical field of surgical implant medical devices for foot and ankle, and discloses an antibacterial ankle arthrodesis intramedullary nail, which comprises an intramedullary nail body made of three-dimensional porous bone implant material, the intramedullary nail body is a full porous structure or a mixed structure of porous and solid structure, the surface in contact with the host bone tissue is a porous titanium or a porous titanium alloy, the porosity of the intramedullary nail body is 40-90%, and the pore size is 200-1500 microns; and the antibacterial ankle arthrodesis intramedullary nail further comprises an in-situ growth film layer grown in-situ on the surface of the intramedullary nail body, the in-situ growth film layer comprises functional substances and antibacterial substances, and the antibacterial substances comprise any one or more of zinc ions, copper ions or silver ions. The zinc, copper and silver ions in the in-situ growth film layer have a broad-spectrum antibacterial effect, especially a significant inhibitory effect on common pathogenic bacteria in orthopedics such as Staphylococcus aureus and Escherichia coli, and the antibacterial rate can reach 60%-99.8% through experimental verification, thereby effectively reducing the risk of postoperative infection and improving the antibacterial performance.

The application relates to the technical field of medical devices, and discloses an absorbable door opening maintainer for cervical vertebra canal plasty, wherein the maintainer body is integrally formed by using high-strength absorbable material, a hollow bone ingrowth matrix is arranged in the maintainer body in the axial direction, the maintainer body comprises a spiral coupler structure and a zero-cut trace cable structure, and the spiral coupler structure and the zero-cut trace cable structure are both hollow structures. In the application, the whole maintainer is made of high-strength absorbable material, is matched with absorbable sutures of the same type, the degradation periods of the two are mutually adapted, the degradation process is synchronized with the bone growth period, secondary surgery for removal is not needed, secondary damage to bone and soft tissues is avoided, the multi-dimensional bone ingrowth channel is beneficial to the migration, proliferation and angiogenesis of bone cells, biological fusion between the maintainer and the host bone is promoted, and the bone repair process is accelerated.

The application discloses a manufacturing method of a porous implant, and relates to the technical field of medical devices, and comprises the following steps: obtaining a bone implant model; performing uniform porous treatment on a porous structure region in the bone implant model which is in contact with host bone and is adapted to the performance of the host bone; determining a non-uniform porous structure region in the bone implant model according to a uniform porous implant geometric model, and importing preset material performance parameters into the non-uniform porous structure region to perform optimization calculation; when stress distribution results of the non-uniform porous structure region meet preset constraint conditions, reconstructing a non-uniform porous implant geometric model according to distribution results of the material performance parameters in the non-uniform porous structure region and a mapping relationship database, and finally performing 3D printing processing on all geometric models to obtain the porous implant. The porous implant obtained by the application has high bearing safety, can further promote effective stress stimulation of bone ingrowth, and has a long service life.

The present application relates to a kind of knee joint prosthesis and its manufacturing method, wherein the knee joint prosthesis includes tibial platform prosthesis, tibial platform prosthesis has osteotomy fitting area;Osteotomy fitting area includes integration area, anchoring area and transition zone;Integration area is positionally corresponding with host cancellous bone area, for inducing bone tissue growth to realize long-term biological fixation;Anchoring area is positionally corresponding with host sclerotic bone area or cortical bone area, realizes immediate fixation by mechanical interlocking;Transition zone is located between integration area and anchoring area, and the porosity of transition zone gradually decreases along the direction of integration area to anchoring area, and structural rigidity gradually increases along the direction of integration area to anchoring area, its beneficial effect is, the active adaptation of prosthesis and host bone bed non-uniform biological characteristics is realized, immediate mechanical stability and long-term biological integration effect are obtained under the premise of not needing permanent screw auxiliary fixation, the risk of prosthesis loosening is reduced, and the clinical service life of prosthesis is effectively prolonged.

The invention discloses a preparation method and application of a titanium cage with the surface coated with an Si-CaP coating, the surface of the titanium cage is coated with the Si-CaP coating with pores and baohuoside-at-fucoidin, the surface of the titanium cage is sprayed with the Si-CaP coating, the Si-CaP coating is of a porous microstructure, the roughness and porosity of a natural bone matrix are simulated, and the titanium cage has the advantages that the porosity of the titanium cage is improved; a vital three-dimensional space environment is provided for migration, adhesion, spreading and growth of osteoblasts and vascular endothelial cells, that is, the porous structure of the Si-CaP coating provides a physical basis for adhesion of the osteoblasts and precursor cells of the osteoblasts, while baohuoside-1 in the baohuoside-at-fucoidin is a bioactive small molecule, so that the baohuoside-1 in the baohuoside-at-fucoidin is a biologically active small molecule. Through slow release of dunaliella salina polysaccharide with certain biological activity, and through the synergistic effect of the biological activity of baohuoside-1 and fucoidin thereof and the Si-CaP coating, the time required for forming biological fixation between the titanium cage and the host bone can be remarkably shortened, and the early stability is effectively improved.

The application discloses a preparation method of a xenogeneic bone-microporous metal implant composite material, and belongs to the technical field of biology; the microporous metal implant is implanted into cancellous bone of a xenogeneic animal, and after 12 weeks, the microporous metal implant is connected with the cancellous bone of the xenogeneic animal through bone integration, forming an interfacial interpenetrating structure; the microporous metal implant is taken out, 1mm-10mm thickness of surrounding bone is reserved, and then gradient decalcification and complete decellularization treatment are sequentially performed, so that the xenogeneic bone-microporous metal implant composite material with high bone induction activity, strong bone integration and low immunogenicity is obtained; the metal implant material is changed into a bioactive implant composite material, and the heterogeneous interface between the metal implant and the grafted bone is changed into a homogeneous interface between the host bone or the grafted bone and the grafted bone, so that the clinical problem of poor bone integration of the grafted bone and the metal implant is solved.