Nano calcium silicate-polyetheretherketone (PEEK) composite material and preparation method thereof
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A nano-calcium silicate and polyetheretherketone technology, which is applied in medical science, prosthesis, etc., can solve the problems of unsatisfactory mechanical strength, affecting polymer properties, and inability to host osseointegration. Biologically active, integrative-friendly effects
Active Publication Date: 2015-06-24
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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However, polymer materials also have obvious shortcomings: most of them are not ideal in mechanical strength when used alone; some polymers (such as PMMA) cannot be absorbed by themselves when used as bone fillers; the sterilization process ma
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Embodiment 1
[0029] (1) Materials and equipment required for the experiment
[0030] Material: PEEK powder (average particle size of 20μm, purchased from the UK Company); Ultra-high molecular weight polyethylene (UHMWPE) plates (molecular weight 2,000,000, purchased from Roechling Engineering Plastics, Germany); cell culture plates (Costar, Corning, USA); MC3T3-E1 cells (for this laboratory liquid nitrogen tank Stored cells); other reagents are commercially available analytical reagents.
[0052] The difference between this embodiment and Embodiment 1 is that in the preparation process of the nm-CS / PEEK composite material provided in this embodiment, the volume ratio of nano calcium silicate powder and PEEK powder is 15:85.
Embodiment 3
[0054] The difference between this embodiment and Embodiment 1 is that in the preparation process of the nm-CS / PEEK composite material provided in this embodiment, the volume ratio of nano calcium silicate powder and PEEK powder is 25:75.
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Abstract
The invention provides a nano calcium silicate-polyetheretherketone (PEEK) composite material which is composed of nano calcium silicate and PEEK in a volume ratio of (10-30):(70-90). The nano calcium silicate-PEEK composite material maintains the excellent biomechanical characteristics of the PEEK, and greatly enhances the biological activity of the PEEK. After being implanted into the body, the nano calcium silicate-PEEK composite material can be matched with peripheral normal bones in the mechanical aspect, can be well integrated with the host bone, promotes the adhesion, proliferation and osteogenesis differentiation of the bone source cells, can keep long-term stability, can be used in clinic as a spine interbody fusion device material and a joint prosthesis material, has active practical meanings, and can generate huge social and economic benefits.
Description
Technical field [0001] The invention relates to a polymer composite material, in particular to a nano calcium silicate-polyetheretherketone composite material and a preparation method thereof. Background technique [0002] In orthopedics, plastic surgery, oral and maxillofacial surgery and other fields, implants are the main means to repair and reconstruct damaged bone and joint structure and function. Currently commonly used implant materials in clinical practice include: metals, inorganic non-metals, polymers and composite materials. Metals (such as stainless steel, titanium and titanium alloys, cobalt-chromium-molybdenum alloys) have the advantages of high strength, friction resistance, and non-toxicity, and have been widely used in clinical practice. However, the strength and elastic modulus of metal materials are much higher than that of normal human bone tissue. After implantation in the body, the surrounding bone will be absorbed due to the stress shielding effect, which ...
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IPC IPC(8): C08L61/16C08K3/34A61L27/44
Inventor 汤亭亭马瑞魏杰邬迎阳
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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