53 results about "Synostosis" patented technology

This invention is directed to methods for treating conditions which present with low bone mass in a patient in need thereof using continuous combination therapy with a synergistically effective combination of an EP₄ receptor selective agonist or a pharmaceutically acceptable salt thereof, such as 5-(3-{2S-[3R-hydroxy-4-(3-trifluoromethyl-phenyl)-butyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid or a pharmaceutically acceptable salt thereof; and an estrogen or a pharmaceutically effective salt thereof, The present methods are useful for treating conditions that present with low bone mass including osteoporosis, osteotomy, osteoporotic fracture, childhood idiopathic bone loss, periodontitis and low bone mass and for enhancing bone healing following facial reconstruction, maxillary reconstruction or mandibular reconstruction, inducing vertebral synostosis, enhancing long bone extension, enhancing the healing rate of a bone graft or a long bone fracture or enhancing prosthetic ingrowth in a patient in need thereof.

The invention provides a method for preparing a bionic human bone biomaterial. The method comprises the steps of utilizing a direct laser selective sintering technique to prepare a human bone bionic micropore bracket, injecting a material with the function of inducing bone growth into the bionic micropore bracket, drying and curing the obtained product and obtaining the bionic human bone biomaterial. The method combines the advantages of metal biomaterials and non-metal biological ceramic materials (hydroxyapatite), and utilizes the direct laser selective sintering technique, a vacuum impregnation technique and the like to prepare a novel bionic human bone biological composite material. The material has the advantages of biomechanical properties similar to natural bones, good biocompatibility, capability of realizing the synostosis of implanted bones and human tissue after the material is implanted into human bodies, safety and reliability. The bionic human bone biomaterial prepared by the preparation method has ultimate tensile strength more than 300 MPa, elongation between 10 and 12 percent, tension-compression elastic modulus less than 50 GPa and good biocompatibility.

The invention relates to a surface treatment process of a bioactive metallic titanium implant having a multistage micro-pit structure, and the surface treatment process comprises the following steps: pretreatment, sandblasting treatment, acid etching treatment, sputtering treatment and glow discharge treatment; according to the surface treatment process, a multistage micro-pit three-dimensional structure having a bioactive tantalum coating is formed on the surface of the metallic titanium implant, so that the binding strength between the tantalum coating and the metallic titanium implant is very good, the tantalum coating is not easy to shed, shedding of the tantalum coating during or after an implantation process is avoided, the biological activity of the metal titanium implant can be improved, bone deposition of the surface of the metal titanium implant is accelerated, the tissue healing time is shortened, and through the formation of synostosis between the metal titanium implant and a surrounding bone tissue, the effect of improvement of the stability of the metal titanium implant can be achieved.

The invention provides a production method of a bone tissue engineering scaffold material artificial tooth root. The method includes the six steps of: preparing a steel model, preparing an initial green body of the artificial tooth root, processing pores, filling the pores with a PLLA/nHA composite, spray-coating the green body with a PGA/nHA composite coating, and performing surface degradation.In the invention, the initial green body of the artificial tooth root is prepared with a PEEK and HA crystal whisker composite material as a bone tissue engineering scaffold material, wherein at corresponding positions on the green body, pores are processed and are filled with the degradable PLLA/nHA active composite material; finally, the green body is spray-coated with the PGA/nHA bioactive coating and then surface degradation is carried out to produce the bone tissue engineering scaffold material artificial tooth root capable of improving synostosis function. The artificial tooth root can be combined with bone through self-repairing on bones with bone induction cells, so that the elasticity modulus of the tooth root is matched with alveolar bone better, and bone absorption of the alveolar bone is not liable to be caused. The artificial tooth root is greatly better than a common artificial tooth root.

The invention provides a double-metal prosthesis component. The double-metal prosthesis component comprises a metal synostosis layer (10), a wear-resistant metal layer (20) and a transition layer (30), wherein the wear-resistant metal layer (20) is arranged on one side of the metal synostosis layer (10), and the transition layer (30) is arranged between the metal synostosis layer (10) and the wear-resistant metal layer (20). The double-metal prosthesis component in the technical scheme is capable of solving the problem of poor metal prosthesis component replacement quality in the prior art effectively.

The invention relates to the technology of biological material in the field of biomedical engineering, specifically a preparation technology for bioactive bone-repairing cement material, which is suitable for medical application in the fields of orthopaedics department, thoracic surgery department and reconstructive surgery, such as artificial joint fixation, bone defect filling and implant restoration. The invention relates to a new material which is a combination of powder and liquid with bioactivity for bone repairing and is characterized in that the combination comprises a powder component including homopolymerization powder of methyl methacrylate or copolymerization powder of methyl methacrylate, and a sosoloid powder doped with strontium hydroxyapatite capable of being hardened and solidified to form solid substance with a certain mechanical intensity and synostosis activity when mixed with the liquid component. The main component of the liquid includes methyl methacrylate monomer, which can form bioactive bone-repairing cement when mixed with the powder component. Compared with the prior art, the material can further increase osteoconduction and osteoconduction activity of the combination, and accelerate healing of bone defect part; thus, the material is suitable for orthopaedics department and craniomaxillofacial plastic repair.

The invention provides a bimetal prosthesis part. The bimetal prosthesis part comprises a synostosis metal layer (10), a metal wear-resistant layer (20) arranged on one side of the synostosis metal layer (10), and a transition layer (30) arranged between the synostosis metal layer (10) and the metal wear-resistant layer (20). According to the technical scheme, the problem that in the prior art, a metal prosthesis part is not good in replacement quality can be effectively solved.

The invention relates to a dental implant, in particular to a dental implant implantation method which comprises the following steps of S1, rubbing an oral cavity model of a patient; S2, preparing a hole in an alveolar bone, and implanting an artificial implant; S3, waiting for synostosis; S4, installing a healing abutment to enable the implant to penetrates through a gingiva, and waiting for formation of soft tissues; S5, preparing a locator according to the oral cavity model of the patient; S6, after formation of the soft tissues, dismantling the healing abutment, putting the locator and a permanent abutment at the implantation part of the patient after the locator and a permanent abutment are matched to enable the locator to be matched with teeth and the gingivae on the two sides of theimplantation part, and installing an abutment fixing bolt from an installation hole to fix the permanent abutment on the implant; and S7, wearing a dental crown on the permanent abutment. By adoptingthe dental implant implantation method provided by the invention, the locator is adopted to assist location when the permanent abutment is installed, and the effect of accurately locating and installing the position of the permanent abutment is achieved.

The invention relates to a self-stabilization artificial vertebral body which is used for being inserted to replace resected or deleted parasitic vertebral body sections. The self-stabilization artificial vertebral body comprises a vertebral body main body and vertebral body fixing screws. An integration surface of the vertebral body main body and a vertebral body is a microcellular structure which is beneficial to ingrowth of bone cells. In an operation, the vertebral body main body with the suitable height is installed into the position with a damaged parasitic vertebral body section taken out and the vertebral body main body is fixed with an adjacent upper main healthy vertebral body and an adjacent lower main healthy vertebral body through the vertebral body fixing screws by penetrating through vertebral body fixing screw holes. The self-stabilization artificial vertebral body has the advantages of being good in instance stability after the operation and good in synostosis to effectively resist to subsidence, enabling the height of the replaced vertebral body to be continuously kept and being free of incisure after the operation and simple and reliable in operation.

The present invention relates to a synostosis artificial tooth, in particular to a synostosis artificial tooth which can enlarge the bone contact quantity and strengthens the structure intensity inside an Osseo-Integrated Dental Implant with a high ground abrasive belt. The synostosis artificial tooth of the present invention has the abrasive belt as follows: the abrasive belt is placed between the position at one third of the total length from the upper part of the fang to the fang and the position at two third of the total length, the abrasive belt is ground with the surface roughness within 0.5 micron along the circle direction, and the abrasive belt has the width between 0.5mm and 1.0mm under the occasion that the length of the fang is less than 8mm; the abrasive belt has the width between 0.5mm and 1.2mm under the occasion that the length of the fang is between 9mm and 12mm; the abrasive belt has the width between 0.5mm and 1.5mm under the occasion that the length of the fang is more than 13mm. The synostosis artificial tooth of the present invention is characterized by also comprising a thread- shaped embossment which is protrudent from the abrasive belt and has the same surface roughness as the abrasive belt.

The invention discloses a spine prosthesis based on 3D printing and a making method thereof. The spine prosthesis comprises supporting frames, hollowed-out structures and fixing parts; each supportingframe is of a cavity-type main body stress structure formed by multiple transverse beams and longitudinal beams, each transverse beam comprises an upper bearing beam, a lower bearing beam and a middle transverse beam body, the upper bearing beams and the lower bearing beams are matched with the centrum surfaces in contact with the upper bearing beams and the lower bearing beams in dissection shape respectively, multiple longitudinal beams are distributed between the upper bearing beams and the lower bearing beams, and the middle transverse beam bodies are connected among the longitudinal beams; the hollowed-out structures are non-main-stress parts distributed among the supporting frames. According to the spine prosthesis, the upper and lower bearing beams are required to be designed in reference to the dissection shapes of the adjacent upper and lower centrum surfaces and completely attached to each other during installation, conical fixing spine structures are evenly distributed, theholding force is reinforced, and accordingly fixing is more stable; the main body structure is a waisted structure and is beneficial to effective conduction of a load and stress diffusion. The cavitydesign and opening design are adopted for the interior of the supporting frame, the supporting frame is used for containing the bone tissue, and synostosis of the upper and lower centrums is promoted.

The invention provides an implantable toe joint prosthesis. The implantable toe joint prosthesis comprises a metatarsal bone marrow needle, a metatarsal bone base station, a metatarsal joint head, a cushion block, a toe bone base station and a toe bone marrow needle which are sequentially arranged from top to bottom, wherein the metatarsal bone marrow needle and the metatarsal bone base station are integrally formed, the metatarsal bone marrow needle is vertically arranged, the metatarsal bone base station is obliquely arranged, and an obtuse angle is formed between the axis of the metatarsal bone marrow needle and the axis of the metatarsal bone station; and the metatarsal bone base station is connected with the metatarsal joint head in a conical fit mode, the metatarsal joint head is connected with the toe bone base station through a gasket, the toe bone base station and the toe bone marrow needle are integrally formed, and the axis of the toe bone base station and the axis of the toe bone marrow needle are collinear. The implantable toe joint prosthesis has the advantages that bone ingrowth is facilitated, the synostosis rate is increased, the weight is reduced, and fixation of the interior of a medullary cavity is facilitated.

A regulation-control orthosis for coronal plane deformity of an ankle is formed by a bone fixing support, steel needle fixing clamps connected onto the bone fixing support and steel needles clamped in the steel needle fixing clamps; the bone fixing support comprises a far end hole ring, a near end hole full ring arranged at the middle or middle upper section of a tibia, at least two fast extending lengthening rods connected between the far end hole ring and the near end hole full ring, a hole ring connecting rod provided with threads and connected between the far end hole ring and the near end hole full ring, and an arc hole ring adjustably connected to the hole ring connecting rod by an up-and-down adjusting nut and arranged at the middle lower section of the tibia. The regulation-control orthosis coronal plane deformity of the ankle is special for treating the strephexopodia or strephenopodia deformity of the ankle caused by synostosis, can perform traction, resetting, fixing and deformity correcting on fracture or deformity of the ankle in introversion and extroversion spaces, and is suitable for the traction, fixing and correcting on the coronal place of the ankle.

The invention discloses a mucoperiosteal type implant, which comprises a pure titanium casing matched with the skeleton face of a covered synostosis oral cavity. The longitudinal section of the casing in the extending direction is saddle-shaped, and a gap between the longitudinal section of the casing and covered bones can be filled with materials favorable to guiding of skeletal regeneration. A plurality of papillary concave portions and convex portions are respectively arranged on the edge of the casing, the concave portions and the convex portions are arranged at intervals, and the edge form is apt to enable mucoperiosteal tissue to be implanted and filled. At least two fixing holes and fixing screws matched with the fixing holes are arranged on the casing, the material of the fixing bolts is pure titanium, and the design of the casing with a rough inner surface and a smooth outer surface is favorable to osseointegration and protection of soft tissue. A connecting structure connected with false teeth or artificial crowns to be repaired is arranged outside the sellar crest portion of the casing to be in mechanical connection or cementation with the false teeth or the artificial crowns so as to improve repairing effects.

The invention discloses a fluorapatite coating which is prepared by ion coated gel preparation, shielding layer gel preparation and biomineralization process. The fluorapatite coating has higher bioactivity, biocompatibility and synostosis capability, and effectively overcomes the defects of the existing implanted materials.

The invention belongs to the field of oral cavity rehabilitation, and discloses an oral cavity implant stiffener and a digital processing method thereof. The oral cavity implant stiffener comprises aconnecting rod and at least two positioning structural members, wherein the positioning structural members and implanting positions are in corresponding arrangement; each of the positioning structuralmembers is provided with a positioning part, and the running direction of each of the positioning parts is the same as that of the corresponding implanting position; the connecting rod is connected between every two positioning structural members; and the connecting rod and the positioning structural members are made from a rigid material. Compared with steel wires, the oral cavity implant stiffener is higher in rigidity, the force is easier and uniformly transferred to various implants, the entire dispersing action of jaw force is improved, and initial stage synostosis and long-term stability of the implants are facilitated. According to implant pattern digital design, the time cost and the work difficulty can be greatly reduced, a technician does not need special tuning, and the reworkpercentage does not exist almost. Because of the mechanical property and the force conduction advantages, immediate rehabilitation can be realized for more implant cases, and indication is extended.

The invention discloses a porous dental implant internally combined with biodegradable magnesium alloy and a manufacturing method of the porous dental implant. The dental implant comprises a main bodyand an embedded body, wherein the main body is composed of a bone grafting section and a transgingival section, and the side wall of the bone grafting section is provided with a thread; the embeddedbody is a cylinder prepared from a biodegradable magnesium alloy material, and the surface of the embedded body is provided with an external thread. An internal threaded hole allowing the embedded body to be screwed in is formed in the bottom end of the bone grafting section, a plurality of permeating holes are formed in the bone grafting section, one end of each permeating hole is communicated with the internal threaded hole, and the other end of each permeating hole is communicated with the side wall of the bone grafting section. By means of the dental implant, under the condition that the porosity of the dental implant is ensured, the mechanical property and strength of the dental implant are ensured. The magnesium alloy is mechanically connected with the dental implant body through threads, the operation is simple, and connection is stable and reliable. After implantation, the magnesium alloy is automatically degraded, meanwhile, bone cells are induced to grow into the dental implant, and finally, synostosis is achieved. In the magnesium alloy degradation process, the mechanical property of the dental implant can meet work requirements all the time.

The invention provides a distal radioulnar joint reduction fixation plate, and belongs to the field of internal fixation instruments for clinical medicine orthopedic operations. The distal radioulnar joint reduction fixation plate comprises an ulna hook and a radius fixing portion, wherein the ulna hook surrounds the periphery of an ulna and is used for hooking the ulna, the radius fixing portion is used for fixing a radius, and the ulna hook and the radius fixing portion are positioned at two ends of the distal radioulnar joint reduction fixation plate respectively. The distal radioulnar joint reduction fixation plate is fixed onto the radius through the radius fixing portion, the ulna is hooked by the ulna hook, reduction effects can be enhanced, the shortcoming of loosening caused by suture is overcome, reduction of the movement range of a distal radioulnar joint and complications of synostosis caused by ulna and radius steel needle fixation are avoided, reduction can be reliable by the aid of the distal radioulnar joint reduction fixation plate, rotation of the distal radioulnar joint is limited, natural healing of a distal radioulnar joint ligament or/and a joint capsule is facilitated, surgical effects are improved, and the complications are decreased.

The invention discloses a combined-type soft tissue horizontal dental implant which comprises a base of the dental implant, an implant root and a fixing screw which connects the base with the implant root. An outer thread is arranged at the implant root, and the surfaces of dental sides of one or more sides of the outer thread are rough surfaces. By means of the combined-type soft tissue horizontal dental implant, 'synostosis' between the dental implant root and the surrounding bone tissue is more facilitated, and meanwhile the phenomenon of spin of the implant under the action of external force can be hindered.

The invention relates to a method for preparing a biological active coating layer on the surface of zirconia convenient for synostosis. The method comprises the following steps: (1) carrying out magnesium ion implantation after sequentially putting and washing zirconia test pieces, wherein the implantation voltage is 10 to 20 keV, and the magnesium ion concentration is 2 to 3*10<15> ion/cm<2>; (2)carrying out arginine-glycine-aspartic acid tripeptide complex connection on the surface of the zirconia test pieces after the magnesium ion implantation. The test pieces prepared through zirconia for preparing the biological active coating layer are beneficial for adhesion, extension and proliferation of osteoblast, and meanwhile, tissue mineralization can be promoted.

Provided is a dental implant fixture with 3 or more ridged portions having mutually different pitches to distribute load uniformly across osseous tissue. The pitches of the ridged portions (200) progressively decrease in one direction. The ridged portions (200) include a larger ridged portion (220) that contacts spongy bone with low bone density, and a smaller ridged portion (240) that contacts cortical bone with high bone density. The smaller ridged portion (240) is provided with 2 or more threaded regions with respectively different pitches. With this configuration, bone decay and bone damage can be prevented, and synostosis can be improved.