Bioactive bone-repairing cement material

Abstract

The invention relates to the technology of biological material in the field of biomedical engineering, specifically a preparation technology for bioactive bone-repairing cement material, which is suitable for medical application in the fields of orthopaedics department, thoracic surgery department and reconstructive surgery, such as artificial joint fixation, bone defect filling and implant restoration. The invention relates to a new material which is a combination of powder and liquid with bioactivity for bone repairing and is characterized in that the combination comprises a powder component including homopolymerization powder of methyl methacrylate or copolymerization powder of methyl methacrylate, and a sosoloid powder doped with strontium hydroxyapatite capable of being hardened and solidified to form solid substance with a certain mechanical intensity and synostosis activity when mixed with the liquid component. The main component of the liquid includes methyl methacrylate monomer, which can form bioactive bone-repairing cement when mixed with the powder component. Compared with the prior art, the material can further increase osteoconduction and osteoconduction activity of the combination, and accelerate healing of bone defect part; thus, the material is suitable for orthopaedics department and craniomaxillofacial plastic repair.

Description

[technical field]

[0001] The invention relates to biomaterial technology in the field of biomedical engineering, in particular to a preparation technology of bioactive bone repair cement material. [Background technique]

[0002] Traditional polymethylmethacrylate (PMMA) bone cement has been used in orthopedic clinics for fifty years as a bone filler and fixed prosthetic adhesive, although it has certain biocompatibility and high mechanical strength, but it cannot directly induce the growth of bone tissue, the interface bonding force between the host bone and the host bone is low, and it is easy to loosen, resulting in implant failure; and the excessively high heat accumulation temperature of PMMA bone cement when it is hardened is easy to cause damage to the surrounding tissues and Spinal cord injury, so the application of PMMA bone cement is limited, especially in spinal cord injury. Many studies have shown that in order to establish a strong chemical bond between the arti...