Bioactive bone-repairing cement material

A biologically active and bone repair technology, applied in medical science, prosthesis, etc., can solve problems affecting infant development, nervous system damage, etc.

Inactive Publication Date: 2009-09-16
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

However, according to the latest information, bisphenol A, one of the raw materials of Bis-GMA, is similar to estrogen, which can trig...

Method used

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Embodiment Construction

[0007] The polymethyl methacrylate homopolymer or copolymer in the powder component is suspended and polymerized with a single monomer or a mixed monomer at a water bath temperature of about 80°C. Strontium-doped hydroxyapatite solid solution material (Ca 5-n Sr n (PO 4 ) 3 OH) is prepared by a solution reaction method, that is, in Sr(OH) 2 and Ca(OH) 2 The suspension was continuously dripped with dilute H 3 PO 4 , synthesized by controlling the pH reaction. In the reaction starting material, the mole ratio of Sr to Ca is in the range of 5:95-50:50. The reactants are calcined at a temperature of 700°C to 1000°C. This temperature can not only maintain the biological activity of the strontium-doped hydroxyapatite solid solution powder, but also better form the apatite phase crystal structure. The particle size of the strontium-doped hydroxyapatite solid solution powder is selected to be about 60 mesh or larger than 60 mesh. The mixing ratio of the above two parts of pow...

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Abstract

The invention relates to the technology of biological material in the field of biomedical engineering, specifically a preparation technology for bioactive bone-repairing cement material, which is suitable for medical application in the fields of orthopaedics department, thoracic surgery department and reconstructive surgery, such as artificial joint fixation, bone defect filling and implant restoration. The invention relates to a new material which is a combination of powder and liquid with bioactivity for bone repairing and is characterized in that the combination comprises a powder component including homopolymerization powder of methyl methacrylate or copolymerization powder of methyl methacrylate, and a sosoloid powder doped with strontium hydroxyapatite capable of being hardened and solidified to form solid substance with a certain mechanical intensity and synostosis activity when mixed with the liquid component. The main component of the liquid includes methyl methacrylate monomer, which can form bioactive bone-repairing cement when mixed with the powder component. Compared with the prior art, the material can further increase osteoconduction and osteoconduction activity of the combination, and accelerate healing of bone defect part; thus, the material is suitable for orthopaedics department and craniomaxillofacial plastic repair.

Description

[technical field] [0001] The invention relates to biomaterial technology in the field of biomedical engineering, in particular to a preparation technology of bioactive bone repair cement material. [Background technique] [0002] Traditional polymethylmethacrylate (PMMA) bone cement has been used in orthopedic clinics for fifty years as a bone filler and fixed prosthetic adhesive, although it has certain biocompatibility and high mechanical strength, but it cannot directly induce the growth of bone tissue, the interface bonding force between the host bone and the host bone is low, and it is easy to loosen, resulting in implant failure; and the excessively high heat accumulation temperature of PMMA bone cement when it is hardened is easy to cause damage to the surrounding tissues and Spinal cord injury, so the application of PMMA bone cement is limited, especially in spinal cord injury. Many studies have shown that in order to establish a strong chemical bond between the arti...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/12A61L27/16
Inventor 陈德敏
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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