945 results about "Spinal cord" patented technology

A neurophysiological magnetic stimulation (NMS) method includes obtaining motor thresholds over one or both motor strips adhered to the patient's head or the equivalent anatomic region for treatment of non-brain, nervous system disorders. The method further includes applying magnetic stimulation coils to a therapeutic target region of the patient's brain, brainstem, spinal cord, or peripheral nervous system and applying NMS in increasing amplitudes as tolerated over the course of treatment.

The invention belongs to the field of cerebral apoplexy rehabilitation training, and provides a cerebral apoplexy upper limb dynamic rehabilitation method and system based on vagus nerve electrical stimulation, the excitement degree of a cortical spinal cord pathway of a patient is measured and evaluated by using motor evoked potential to obtain a motor function evaluation result, and an initial rehabilitation training task is set according to the motor function evaluation result; the training motion intention of the patient is determined by monitoring the electroencephalogram signal and the electromyographic signal of the patient, and percutaneous ear vagus nerve electrical stimulation is triggered; after percutaneous ear vagus nerve electrical stimulation, performing rehabilitation training analysis on basic clinical characteristics and multi-modal signals of the patient to determine intermuscular coordination, brain region connectivity and brain muscle coupling of the patient; the training condition of the patient is evaluated according to the rehabilitation training analysis result, and parameters of percutaneous ear vagus nerve electrical stimulation and training tasks are adjusted based on the evaluation result for iterative rehabilitation training; and stopping iteration until the rehabilitation training analysis result of the patient reaches a preset standard, and completing rehabilitation training.

At least one electrical brain signal is received from a patient and is demultiplexed into an efferent motor intention signal and at least one afferent sensory signal (such as an afferent touch sense signal and / or an afferent proprioception signal). A demultiplexed afferent touch sense signal may be used to control a haptic device.

A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.

A device and algorithm for controlling an autonomic function in an individual. A controller device that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure. A control interface and algorithm for controlling an autonomic function in a subject. For instance, an algorithm that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure.

The invention discloses a bionic nanofiber-hydrogel composite biological scaffold as well as a preparation method and application thereof. The bionic nanofiber-hydrogel composite biological scaffold is a composite scaffold for simulating a gray-white matter partition structure of a spinal cord tissue, and comprises bionic nanofibers and a bionic hydrogel material, wherein the bionic nanofibers are arranged in an oriented manner and simulate a white matter ordered structure around the spinal cord, and the bionic hydrogel material is combined with the bionic nanofibers and simulates gray matter in the center of the spinal cord. According to the bionic nanofiber-hydrogel composite biological scaffold, the biological activity of loaded stem cells or adult cells can be improved, the problem that a large number of transplanted exogenous cells die due to unbalanced oxidative stress generated after tissue damage can be solved, and it is guaranteed that the transplanted cells reside in a damaged area and play a role; therefore, the spinal cord microenvironment is improved, proliferation and differentiation of endogenous neural stem cells are promoted, functional recovery after spinal cord injury is finally promoted, and great potential is achieved in spinal cord injury treatment.

The invention discloses a closed-loop noninvasive spinal cord electrical stimulation regulation and control method and system based on motion data, and the system is provided with a flexible electrode array patch which is attached to the skin surface of a to-be-tested human body; the sensing module is used for collecting electromyographic signals or acceleration signals of a user; the signals are processed, and characteristic values related to actions and motions are extracted; the closed-loop feedback module compares the characteristic value with a model set characteristic / threshold value, and judges whether to start stimulation site and stimulation parameter adjustment or not; automatically selecting an optimal electrode unit and a corresponding stimulation parameter based on a judgment result; the dynamic regulation and control module controls the optimal electrode unit to output stimulation current, and regulates the activity of corresponding spinal cord neurons; and continuously performing closed-loop adjustment on the electrode unit and the stimulation parameters according to the motion feedback data. According to the method and system, precise stimulation and closed-loop regulation and control based on the motion response of the patient are achieved, and the problems that stimulation target positioning depends on artificial experience, parameter adjustment is not timely, and individualized and closed-loop feedback capacity is lacked are solved.

The invention relates to a pathologically responsive nano-carrier as well as a preparation method and application thereof, belongs to the technical field of biological medicines, and aims to solve the problems that in the prior art, nano-particles are enriched in livers and kidneys in quantity, the risk of damaging organs and tissues exists, toxic and side effects on patients with spinal cord injury are large, the treatment effect is not obvious and the like. The carrier is a self-assembled nanoparticle which takes PLGA as a skeleton structure, is externally modified with hyaluronic acid and is connected with RVG29 through a diselenide bond. The carrier can load an active substance, such as curcumin, can be used for treating spinal cord injury, and can target spinal cord tissues through intravenous administration, penetrate a blood spinal cord barrier, target CD44 through HA at the early stage of injury, increase immune cell uptake and inhibit inflammatory infiltration and inflammatory cascade. In the late stage of injury, the nerve cell uptake is increased through RVG29 targeted acetylcholine receptor (nAchR), and nerve repair and regeneration are promoted.

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention provides an artificial intelligence spinal nerve regulation and control system and method based on a multi-modal physiology-nerve-experience closed loop, and relates to the technical field of medical instruments, the system comprises an implantable stimulation and sensing subsystem, a body surface and wearable sensing subsystem, a communication and time synchronization subsystem and a control processing unit, the implantable stimulation and sensing subsystem, the body surface / wearable sensing subsystem and the control processing unit are in communication connection in pairs through the communication and time synchronization subsystem. According to the method, the fundamental limitation that in the prior art, only dosage is maintained, and brain and subjective experience is ignored is broken through, and more stable, more efficient and more personalized accurate pain management is realized through multi-modal fusion and hierarchical cooperative control.

The invention relates to the technical field of biological materials, in particular to a hydrogel scaffold material for spinal cord injury repair as well as a preparation method and application of the hydrogel scaffold material. The hydrogel scaffold material AP39 (AP39-coated LIP) for spinal cord injury repair is prepared by combining the liposome-coated AP39 (AP39-coated LIP) serving as a drug with a GelMA hydrogel scaffold, and a scaffold is provided for injured spinal cords, so that axon regeneration of injured parts is guided, mitochondria of the injured parts is targeted to release H2S, neuronal injury is relieved, and the spinal cord injury repair effect is improved. Therefore, nerve regeneration and functional recovery after spinal cord injury are promoted.

The invention discloses a spinal cord injury analysis method and device based on deep learning. The method comprises the following steps: acquiring processed medical image information of a spinal cord part and spinal cord injury physiological information; performing space-time alignment on the medical image of the spinal cord part and the spinal cord injury physiological information so as to obtain an image sequence and an index time sequence after space-time alignment; establishing space-time diagram features according to the image sequence and the index time sequence; splicing the space-time diagram features, the medical image information of the spinal cord part and the physiological information of the spinal cord injury to generate joint features; generating a cross-modal fusion feature; acquiring a trained spinal cord injury analysis model; and inputting the cross-modal fusion features into the trained spinal cord injury analysis model to obtain an injury result. MRI images and physiological indexes are synchronously collected, the limitation of traditional single-mode analysis is broken through, and dual-dimension information of an anatomical structure and functional metabolism is provided for spinal cord injury assessment.

The invention provides a staged release type rigid-flexible composite nerve conduit as well as a preparation method and application thereof. A polymer fiber membrane with a double-layer nanofiber membrane structure is used as a tube wall, multi-section hydrogel comprising short-section hydrogel containing anti-inflammatory substances and long-section hydrogel containing growth factors is used as an inner core, and bioactive substance particles containing the growth factors are deposited on the inner wall of the polymer fiber membrane. The staged release type rigid-flexible composite nerve conduit is obtained. The composite nerve conduit provided by the invention is a rigid-flexible composite nerve conduit capable of controllably delivering anti-inflammatory substances and growth factors in time and space to meet the requirements of each stage of injury, and is combined with multiple induction signals such as a topological structure, chemotactic induction and the like to regulate and control the microenvironment of each stage after spinal cord injury and promote subsequent functional recovery.

Methods of treating a nerve injury are disclosed. The methods include administering to a target site of the nerve injury a thermally stable preparation having a purified amphiphilic peptide in an aqueous biocompatible solution, being configured to self-assemble into a hydrogel, and administering to the target site a buffer having an effective amount of an ionic salt and a biological buffering agent to form the hydrogel. The methods include administering to the target site a biological material suspension in an amount effective to treat the nerve injury. The methods include administering to the target site an anti-scarring agent in an amount effective to treat the nerve injury. The target site is associated with central nervous system tissue or peripheral nervous system tissue. The nerve injury includes spinal cord injury and peripheral nerve injury.

The invention discloses a spinal cord injury state evaluation system fusing pathological data and clinical characteristics, and the system comprises a multi-modal data synchronous collection module which is used for multi-modal original data flow; the damage feature collaborative extraction module is used for extracting structural damage features and functional damage features through a dual-channel deep learning network based on an attention mechanism, and calculating an association weight matrix; the individualized state quantitative evaluation module is used for generating damage state vectors based on weight matrix fusion features and outputting a comprehensive evaluation report through a pre-training model; and the self-adaptive rehabilitation strategy generation module is used for generating a personalized staged rehabilitation treatment scheme according to the comprehensive evaluation report and decomposing the personalized staged rehabilitation treatment scheme into an executable instruction sequence. The method has the following advantages and effects: accurate evaluation of the spinal cord injury state and accurate formulation of the rehabilitation strategy are realized by quantifying the personalized mapping relationship between the spinal cord structural injury and the body functional disorder.

Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel processes for their synthesis and novel intermediates for use in their synthesis. Also provided is use of a compound for the prophylaxis, treatment, and control of aquaporin-mediated conditions. Aquaporin inhibitors, e.g., inhibitors of AQP4 and / or AQP2, may be of utility in the treatment or control of diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord), hyponatremia, and excess fluid retention, as well as diseases such as epilepsy, retinal ischemia and other diseases of the eye, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines.

The invention relates to the field of medical dynamic monitoring, in particular to a dynamic monitoring system for a spinal cord injury reconstruction process. Comprising an acquisition and fusion module, a dynamic modeling module, a function evaluation module and an adaptation control module. According to the system, nerve and muscle electrophysiological signals are collected through a wearable surface electrode and a flexible microelectrode array, timing sequence errors are corrected in combination with a calibration sample, and multi-modal signal fusion is achieved. And constructing a topological sequence and time sequence dependence structure, and extracting an incubation period, an activation gradient and response dispersion by adopting a time sequence convolutional network. And identifying function transition and abnormal compensation behaviors through a function evaluation module, and outputting a neural pathway response sequence diagram. And the sampling frequency, the feature weight and the evaluation period are dynamically adjusted based on a Bayesian optimization strategy, and self-adaptive optimization of the monitoring strategy is realized. Therefore, precise modeling and efficient tracking of the neural pathway function reconstruction process are realized.

The invention relates to the technical field of spinal cord injury repair, and discloses a multi-mode nerve regulation electric acupuncture control system for spinal cord injury repair, a patient evaluation module is used for establishing a personalized spinal cord injury model of a patient and evaluating the current nerve function state and rehabilitation potential of the patient to obtain a nerve function evaluation result; the parameter setting module is used for setting multi-modal stimulation parameters in electroacupuncture treatment; the signal processing module is used for collecting local field potential of a spinal cord injury area and electromyographic signals around the injury in real time, preprocessing the collected signals and extracting time-frequency characteristics of the signals. The evaluation module is used for inputting the time-frequency characteristics of the signals into an electro-acupuncture evaluation model, evaluating the neural pathway in real time through the electro-acupuncture evaluation model and outputting an evaluation result; the adjusting module is used for adjusting the frequency, waveform and current intensity parameters of the electroacupuncture needle based on the evaluation result and a Q-learning algorithm, searching an optimal electroacupuncture needle parameter combination and feeding back the optimal electroacupuncture needle parameter combination to the electroacupuncture needle; according to the invention, the pertinence and effectiveness of treatment are improved.

The invention discloses a multi-point electrode array system suitable for spinal cord time interference stimulation and a multi-target regulation and control method, the system comprises a flexible patch and a high-frequency stimulator, the flexible patch is provided with a plurality of electrode units distributed in a two-dimensional or three-dimensional matrix, the high-frequency stimulator is electrically connected with the electrode units, and the high-frequency stimulator is electrically connected with the flexible patch. A group of electrode channels are formed between the two electrode units, the high-frequency stimulator controls high-frequency current of each group of electrode channels, and a plurality of interference targets are constructed and formed among the plurality of groups of electrode channels at the same time. The flexible patch is attached to the spine to be detected, and the electrode units are located on the two sides of the spine; controlling high-frequency current of each electrode unit by using a high-frequency stimulator, and forming a plurality of groups of interfering electrode channels among the plurality of electrode units; subtracting the high-frequency current of the two interfered electrode channels to obtain a plurality of independent interference targets at the same time. The flexible patches are attached to the two sides of the spine to be detected, surgical treatment is not needed, and the treatment risk and cost are remarkably reduced.

The invention discloses application of a cell surface adhesion molecule CD22 as a target spot in preparation of drugs for treating spinal cord injury related diseases. The change of gene expression in the glial scar formation process is represented by space transcriptome sequencing, and the specific expression of CD22 in the glial scar region is up-regulated. According to single cell sequencing, in-situ hybridization and immunohistochemistry, specific high expression CD22 of part of microglial cells in a glial scar area is found. CD22 is knocked out through a genetic means, and it is found that formation of glial scars after spinal cord injury is remarkably reduced through inhibition of CD22. Behavioral detection finds that the error rate of irregular horizontal ladders is remarkably reduced by inhibiting CD22, and fine movement recovery of hind limbs of mice after spinal cord injury is promoted. The siRNA specifically targeting CD22 is injected into the sheath, so that the expression of microglial cells CD22 is inhibited, the error rate of irregular horizontal ladders of hind limbs can be reduced, and the recovery of the fine movement function of the hind limbs of the mouse after spinal cord injury is promoted. The invention provides a new possibility for development of drugs for spinal cord injury and treatment of spinal cord injury.

The invention discloses a preparation method of a targeting system based on bio-orthogonal chemistry, the targeting system comprises gel GelMA-DBCO modified with a targeting receptor DBCO and nanoparticles NV-N3 modified with a targeting ligand azide group, the preparation method comprises the following steps: respectively dissolving GelMA and DBCO-NHS, mixing, adding triethylamine, and stirring at room temperature for reaction to obtain GelMA-DBCO; the preparation method comprises the following steps: adding GelMA-DBCO into a solution containing a photoinitiator, and carrying out ultraviolet crosslinking to obtain GelMA-DBCO gel; the preparation method comprises the following steps: adding Ac4ManNAz into a culture medium of MSC to obtain mesenchymal stem cells MSC with N3 modified on the surface, digesting and collecting cells, and extruding the MSC by using a liposome extruder to pass through a filter membrane to obtain nano-particles with azido modified on the surface; and purifying by centrifuging, and resuspending to obtain the NV-N3. The invention also provides application of the targeting system in preparation of products for treating spinal cord injury. The targeting system provided by the invention has strong specificity and stability, good biocompatibility and biodegradability, and effectively improves the targeting ability of the nanoparticles in a spinal cord injury area.

High frequency stimulation for treating sensory and / or motor deficits in patients with spinal cord injuries and / or peripheral polyneuropathy, and associated systems and methods. A representative method includes addressing the patient's somatosensory dysfunction and / or motor dysfunction, resulting from neuropathy and / or spinal cord injury, by directing an electrical therapy signal to the patient's spinal cord region, the therapy signal having a frequency in a frequency range from 1.5 kHz to 100 KHz.

The invention discloses a progressive dynamic pressure gradient bladder function regulation and control system and method, and aims to solve the problems of high infection rate, bladder injury risk, complicated operation, lack of dynamic pressure regulation and control and the like in the existing bladder management technology. According to the system, the urinary bladder internal pressure, the urine flow rate and the residual urine volume are monitored in real time through the urodynamic monitor, and the pressure gradient is dynamically adjusted according to the health condition of a patient. Progressive pressure training is adopted in the system, the bladder function is gradually enhanced, meanwhile, an emergency adjustment strategy is introduced, and the safety of a patient is ensured. In addition, the system also integrates machine learning and reinforcement learning algorithms, and realizes personalized treatment according to the treatment history and real-time feedback optimization adjustment strategy of the patient. The system has the advantages of precise regulation and control, personalized treatment, improvement of the comfort level of the patient and the like, and the bladder rehabilitation effect of the spinal cord injury patient is remarkably improved.

The invention discloses preparation and application of dual-network hydrogel. The dual-network hydrogel comprises the following components: (Z1) a spinal cord acellular matrix network DSM formed by self-assembly of a spinal cord acellular matrix dSECM; and (Z2) a metal-polyphenol network MPN formed by coordination of metal ions and polyphenols; wherein the DSM and the MPN are cross-linked through hydrogen bonds to jointly form a double-network structure. DSM provides a microenvironment suitable for cell survival and growth for the dual-network hydrogel and induces stem cells to differentiate into neurons, and MPN provides the dual-network hydrogel with biological effects of inhibiting inflammation and accumulation of reactive oxygen species (ROS). The dual-network hydrogel has the advantages of the two components, the active component neurotrophic factor and the inhibitor loaded on the dual-network hydrogel can regulate and control immune response after SCI, improve neuroinflammation microenvironment and promote nerve repair, and a new strategy is provided for in-situ tissue repair of SCI.

A device for spinal correction includes a stabilizer assembly including a hinge including a first rod-bearing leaf; a second rod-bearing leaf rotatably coupled to the first rod-bearing leaf to provide coronal or sagittal freedom of movement, or both, of the stabilizer assembly; a locking mechanism to lock the first and second rod-bearing leaves at a desired angle; a first stabilizing rod coupled to the first rod-bearing leaf; a second stabilizing rod coupled to the second rod-bearing leaf; and a plurality of monoaxial or polyaxial links, wherein each monoaxial or polyaxial link is movably coupled to the first or second stabilizing rod and is movably couplable to a first spinal rod or a second spinal rod fixed to the spine; wherein the stabilizer assembly is couplable to the first or second spinal rod to stabilize the spine to prevent compression, distraction, or translation of the spinal cord during a spinal correction.

The invention discloses a magnesium-containing nanoparticle modified biological scaffold composite material as well as a preparation method and application thereof. The magnesium-containing nano particle modified biological scaffold composite material comprises a biological scaffold material and magnesium-containing nano particles modified on the biological scaffold material, the magnesium-containing nano particles comprise nano magnesium oxide particles and / or nano magnesium oxide-polyphenol compound particles, the nano magnesium oxide-polyphenol compound particles are of a shell-core structure, and the shell-core structure is of a hollow structure. Comprising magnesium oxide serving as a core and a polyphenol compound shell layer coating the surface of the magnesium oxide. The magnesium-containing nanoparticle-modified biological scaffold composite material provided by the invention can prolong the degradation and release of magnesium ions, promote improvement of microenvironment problems such as inflammation and active oxygen outbreak after spinal cord injury, regulate and control oxidative stress and inflammatory response, promote nerve regeneration and motor function recovery, and improve the survival rate of spinal cord injury. The problem that nanoparticles stop in a spinal cord injury area is effectively solved, and support is provided for migration, growth and differentiation of endogenous neural stem cells.

Disclosed herein are embodiments of a system and embodiments of a method for stabilizing spinal vertebrae through a skin incision. In some embodiments, the system or method can include a first screw having a first screw head, a second screw having a second screw head, and / or a third screw having a third screw head, a first tower having a distal portion, a proximal portion, and a bend between the distal portion and the proximal portion, a second tower having a distal portion, a proximal portion, and a bend between the distal portion and the proximal portion, a third tower having a distal portion and a proximal portion, the third tower configured to be removably coupled with the third screw at a distal end of the third tower, and a rod insertion device configured to rotatably advance a connection element to at least the first and second towers.

Variable amplitude signals for neurological therapy, and associated systems and methods are disclosed. A representative method includes activating automatic delivery of an electrical therapy signal to a patient's spinal cord region at a frequency in a frequency range between 1.5 kHz and 100 kHz, via at least one signal delivery contact carried by an implanted signal delivery device. The delivery can include repeatedly and automatically delivering the electrical therapy signal at each of multiple therapy signal amplitudes to the at least one signal delivery contact, without the therapy signal generating paresthesia in the patient. The foregoing process can be used as a screening tool to screen responders from non-responders in the context of a non-paresthesia-generating therapy, and / or can be used during long-term treatment, for example, for chronic pain.

Aspects of the disclosure relate to compositions and methods for treating spinal muscular atrophy (SMA). The disclosure is based, in part, on isolated nucleic acids and vectors (e.g., viral vectors, such as rAAV vectors) encoding SMN1. In some embodiments, the expression of SMN 1 is driven by a native SMN 1 promoter or a variant thereof. In some embodiments, isolated nucleic acids and vectors of the disclosure have reduced toxicity and / or increased transgene expression relative to previously described SMN-encoding vectors.

Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with increased transduction enrichment in the central nervous system, brain, and / or spinal cord. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. The rAAV capsid and capsid proteins described herein comprise a sequence that bind to the TEK receptor tyrosine kinase (TEK) protein and / or tissue factor pathway inhibitor (TFPI) protein to facilitate crossing the blood-brain barrier. Gene therapy using the rAAVs is described. Also described are methods of treating brain-, spinal-, and central nervous system-related diseases and conditions.