319 results about "Spinal cord" patented technology

The invention discloses a closed-loop noninvasive spinal cord electrical stimulation regulation and control method and system based on motion data, and the system is provided with a flexible electrode array patch which is attached to the skin surface of a to-be-tested human body; the sensing module is used for collecting electromyographic signals or acceleration signals of a user; the signals are processed, and characteristic values related to actions and motions are extracted; the closed-loop feedback module compares the characteristic value with a model set characteristic / threshold value, and judges whether to start stimulation site and stimulation parameter adjustment or not; automatically selecting an optimal electrode unit and a corresponding stimulation parameter based on a judgment result; the dynamic regulation and control module controls the optimal electrode unit to output stimulation current, and regulates the activity of corresponding spinal cord neurons; and continuously performing closed-loop adjustment on the electrode unit and the stimulation parameters according to the motion feedback data. According to the method and system, precise stimulation and closed-loop regulation and control based on the motion response of the patient are achieved, and the problems that stimulation target positioning depends on artificial experience, parameter adjustment is not timely, and individualized and closed-loop feedback capacity is lacked are solved.

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention discloses a spinal cord injury state evaluation system fusing pathological data and clinical characteristics, and the system comprises a multi-modal data synchronous collection module which is used for multi-modal original data flow; the damage feature collaborative extraction module is used for extracting structural damage features and functional damage features through a dual-channel deep learning network based on an attention mechanism, and calculating an association weight matrix; the individualized state quantitative evaluation module is used for generating damage state vectors based on weight matrix fusion features and outputting a comprehensive evaluation report through a pre-training model; and the self-adaptive rehabilitation strategy generation module is used for generating a personalized staged rehabilitation treatment scheme according to the comprehensive evaluation report and decomposing the personalized staged rehabilitation treatment scheme into an executable instruction sequence. The method has the following advantages and effects: accurate evaluation of the spinal cord injury state and accurate formulation of the rehabilitation strategy are realized by quantifying the personalized mapping relationship between the spinal cord structural injury and the body functional disorder.

The invention discloses application of a CXCL14 combined immune checkpoint inhibitor in treatment of spinal glioma. The immune checkpoint inhibitor is selected from a PD-1 inhibitor or a combination of the PD-1 inhibitor and a CTLA4 inhibitor. In-vivo and in-vitro experiments prove that the CXCL14 combined with the PD-1 inhibitor, the CXCL14 combined with the PD-1 inhibitor and the CTLA4 inhibitor can be used for remarkably inhibiting the growth of mutant spinal glioma and have a remarkable synergistic effect. The invention provides a new strategy for treatment of spinal glioma, and is widely applied clinically.

The invention provides a nerve regulation and control system and method for a spinal cord ventral epidural region, and the system employs a microprocessor to generate multiple paths of pulse width modulation signals, and drives a voltage-controlled current source after amplitude adjustment. Stimulation current with adjustable frequency, pulse width and amplitude is output to act on a spinal cord ventral nerve structure. Real-time monitoring of stimulation current of each channel is realized through combination of voltage sampling and a single-pole multi-throw analog switch, feedback information of a body position, myoelectricity, pressure and other multi-mode sensors is fused, a closed-loop control mechanism is constructed, and dynamic adjustment and individualized optimization of electrical stimulation parameters are realized. The system has the advantages of being more accurate in electrical stimulation positioning, more sensitive in response, more intelligent in control and the like, and is suitable for intelligent rehabilitation intervention in scenes of spinal cord injury, cerebral palsy, neurological dysfunction and the like.

The invention discloses a spinal cord electrical stimulation control method and system based on tremor detection. The method comprises the following steps: acquiring motion sensing data of a user; extracting tremor signal features of the user according to the motion sensing data and a preset feature extraction algorithm; determining an electrical stimulation parameter corresponding to the tremor signal feature according to a preset electrical stimulation parameter determination rule; according to the electrical stimulation parameters, generating an electrical stimulation control instruction corresponding to electrical stimulation equipment arranged in a spinal cord area of the user; the electrical stimulation control instruction is used for indicating current output of the electrical stimulation equipment. Therefore, accurate nerve intervention control in combination with tremor monitoring and spinal cord electrical stimulation can be realized, the physical therapy inhibition effect of electrical stimulation physical therapy measures on the tremor of the user is improved, and more efficient and accurate nerve regulation and control service is provided for the user.

The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and / or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and / or tissue hydration, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.

The present invention relates to a system and method configured for analysing acoustic parameters of speech to detect, diagnose, predict and / or monitor progression of a condition, disorder, or disease, and more particularly, any of paediatric and adult neurological and central nervous system conditions including but not limited to low back pain, multiple sclerosis, stroke, seizures, Alzheimer's disease, Parkinson's disease, dementia, motor neuron disease, muscular atrophy, acquired brain injury, cancers involving neurological deficits, paediatric developmental conditions and rare genetic disorders such as spinal muscular atrophy. The system and method extracts a first formant data set from words spoken by an individual and uses these to classify the vowels in the words on a first computing device, such as a mobile smart phone equipped with a microphone into which an individual speaks. The system stores at least some of these frequencies for the vowel formants in a second formant data set as a recorded file and provides the second formant data set as input to acoustic metrics to generate score data from which an assessment is made to determine the articulation level of the vowels in the words spoken by the individual, allowing allow for detection, diagnosis, prediction and / or monitoring progression of the condition, disorder, or disease.

The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

Embodiments of the present application provide a whole brain and whole spinal cord automatic delineation method and device, electronic equipment and medium, the method comprises: acquiring a CT image, segmenting the CT image according to a first adaptive threshold to obtain a human body contour region of interest, segmenting the human body contour region of interest according to a second adaptive threshold to obtain a human body skeleton contour region of interest, performing inflation operation and corrosion operation on the human body skeleton contour region of interest to obtain a brain tissue region of interest, performing inflation translation superposition subtraction processing and corrosion operation on the human body skeleton contour region of interest to obtain a spinal cord target contour, and combining the brain tissue region of interest and the spinal cord target contour to obtain a whole brain and whole spinal cord region of interest. By using the method, the whole brain and whole spinal cord region of interest can be automatically, quickly and accurately delineated, which greatly helps image analysis, accurate treatment and reduction of the workload of clinicians for patients.

This invention relates to diselenylene-bridged mesoporous silica nanoparticles loaded with baicalin and their applications. The invention constructs a ROS-responsive, microglia-inspired Ba@Se-MSN&BV2 nanoplatform targeting the secondary phase of spinal cord injury. The BV2 cell membrane-mediated enrichment at the injury site, combined with the diselenylene-triggered, on-demand release of baicalin, enables targeted intervention in a highly oxidative and pro-inflammatory microenvironment. In vitro and in vivo studies show that Ba@Se-MSN&BV2 can alleviate oxidative stress and mitochondrial dysfunction, inhibit apoptosis, promote axonal and neuronal survival, and improve motor circuit function. This invention provides a new therapeutic target and research direction for neuroinflammatory injuries driven by redox homeostasis disruption, with significant clinical application prospects and social value.

The invention discloses a construction method of a conditional knock-down dynactin animal model of astrocytes and an application of the animal model of the conditional knock-down dynactin animal model of the astrocytes. According to the method, a Dctn1LoxP gene knock-in mouse is hybridized with an Aldh1l1-Cre / ERT2 transgenic mouse, a target genotype mouse is obtained through three rounds of breeding, 100mg / kg Tamoxifen is continuously injected into the intraperitoneal cavity of the 2-month-old mouse for 5 days, and specific knock-down of dynactin in brain and spinal astrocytes is realized, including knockout of p150Glue and reduction of DCTN4, p50 and Arp1alpha protein levels. The model has the advantages of being high in specificity, permanent in intervention aging and capable of covering multiple life stages, the defects of a traditional model are overcome, the model can be used for researching the influence of dynactin on astrocyte neurobiological functions, a reliable tool is provided for screening related targets of nervous system diseases, and the model has important application value.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a pH-responsive curcumin sustained-release microsphere hydrogel, a preparation method and application thereof in spinal cord injury repair materials. The preparation method is as follows: short fibers are prepared by pretreating and grinding discarded eggshell membranes; after sodium alginate is dissolved, the sodium alginate is blended with the eggshell membrane short fibers, curcumin is added, and stirring is uniformly performed to form a mixed solution; the mixed solution is injected into a calcium chloride solution by using a drip crosslinking method to form, and an eggshell membrane and sodium alginate curcumin microsphere hydrogel is obtained. The hydrogel has excellent water content, swelling performance, biocompatibility, blood compatibility and drug sustained-release function, and can be applied to spinal cord injury repair.

Invention relates to polyaxial spinal screws for correcting and stabilizing a spinal cord by open and minimally invasive technique. The polyaxial spinal screw comprises a screw shaft (10), a coupling (20), a sleeve (30) and a set screw (50). The coupling (20) has a proximal end (202) and a distal end (203). The coupling (20) comprises a spherical cut (21) sized to receive the screw shaft (10). The coupling (20) further comprises two slots (26) for receiving a stabilizing rod (40). The coupling (20) comprises an inner thread (24) where the set screw (50) is threaded. The sleeve (30) has a proximal end (302) closer to the proximal end (202) of the coupling (20) and a distal end (303). The sleeve (30) comprises at least two slots (32) for receiving a stabilizing rod (40) and at least two recesses (33) for fixation of the polyaxial spinal screw by auxiliary tools.

The invention belongs to the technical field of biological medicine, and particularly relates to a single-domain antibody VHH-L1 targeting LINGO-1 protein, and the amino acid sequence of the single-domain antibody VHH-L1 is shown as SEQ ID NO: 1. The single-domain antibody has nanomole-level high affinity and excellent specificity, can effectively block the interaction between LINGO-1 and ligands thereof, and remarkably promotes differentiation and myelination of oligodendroglia cells. The invention further provides a neural stem cell subjected to genetic engineering modification, and the neural stem cell can stably and continuously secrete the single-domain antibody VHH-L1. In a spinal cord injury animal model, the engineered stem cell shows an excellent treatment effect, can significantly promote motor function recovery, axon regeneration and myelin sheath repair, and effectively inhibits glial scar formation. The double advantages of cell therapy and long-acting protein delivery are fused, and a brand new efficient treatment strategy is provided for demyelination diseases such as multiple sclerosis and spinal cord injury.

The invention relates to the field of biomedical ultrasonic imaging, and discloses a pulse wave detection method and system based on ultrafast Doppler imaging, and the method comprises the steps: firstly obtaining a dynamic power Doppler image of the blood flow of a biological tissue; performing spectral analysis on the Doppler signal of each pixel point in the image to obtain a function that the frequency spectrum changes along with time; and on the basis, calculating a blood flow speed time sequence, an impedance index and a pulsation index of each pixel point, and finally obtaining an impedance index distribution diagram and a pulsation index distribution diagram of the whole blood vessel network. According to the method, ultrafast imaging and spectral analysis technologies are ingeniously combined, the structure and the function of the vascular network can be comprehensively evaluated, a new technical means is provided for hemodynamic research and disease diagnosis of organs such as spinal cords, hearts and brains, and the method has a wide application prospect.

The invention discloses a spinal cord electrical stimulation physiotherapy device based on a multi-polarity time domain interference electric field, and the device comprises a control module which is used for receiving physiotherapy demand parameters inputted by a user, and outputting a control instruction according to the physiotherapy demand parameters; the at least two electrode groups are connected to the control module, are arranged at the epidermal tissue of the user and are used for outputting at least two interference fields with the same envelope phase according to the control instruction; time-domain interference occurs between the interference fields to produce focused stimulation in the spinal cord region of the user. Therefore, according to the invention, high-focus stimulation treatment on the spinal cord area can be realized based on the time domain interference among the multiple interference fields, so that the accuracy and the treatment effect of spinal cord electrical stimulation treatment are improved.

The invention relates to medicine, and more particularly to a novel method for the control of stepping movements in patients with traumatic injuries or diseases of the spinal cord and / or the brain using transcutaneous electrical stimulation, which includes continuously stimulating the spinal cord at the level of the C5-C6, T11-T12 and L1-L2 vertebrae and simultaneously creating a synergistic effect to control foot movement by means of spatial-temporal stimulation of the flexor and extensor muscles of the lower leg in the corresponding phases of the gait cycle. This combined spinal and muscular stimulation enables a coordinated, complete gait, in which the patient is able to control the stepping movements, including controlling foot movements.

The application provides an aortic dissection rupture sealing device, which comprises a body having a hollow flow channel extending along the axial direction of the body, the hollow flow channel penetrating the rupture for conducting the true lumen of the aorta and the branch blood vessel, and the body being used for connecting a stent located in the branch blood vessel; and an anchoring part arranged on the body and surrounding the hollow flow channel, and anchored to the surrounding intima at the rupture, so as to prevent the fluid from conducting between the true lumen and the false lumen formed at the rupture. By using the above scheme, the rupture sealing effect can be improved, the continuous expansion of the false lumen caused by the incomplete rupture sealing and the residual liquid leakage can be avoided, and the blood supply stability of the branch blood vessel can be ensured, so that the blood supply demand of the internal organs, the spinal cord and the like supplied by the branch blood vessel can be met.

The utility model discloses a portable dual-purpose cervical vertebra repairing and correcting pillow which comprises a pillow body filled with flowable filler. The pillow-shaped adjusting piece is arranged in the middle of the pillow body and used for adjusting the shape of the pillow body so that the pillow body can be converted between a conventional square pillow shape and a correction shape, wherein the middle of the correction shape is columnar, and the two sides of the correction shape are oval-like supporting structures higher than the columnar shape. In the correcting state, the cervical vertebra of a patient can be clamped and fixed to the columnar part, and the ellipse-like supporting structure is used for supporting the gap of the rear pillow part of the patient, the gap from the neck to the scapula part and the two sides of the head, so that the correcting pillow body can help the hemiplegia and spinal cord injury patient to fix the head and can also well fit the physiological curvature of the cervical vertebra; neck discomfort symptoms of people with neck and shoulder discomfort are relieved; when the pillow body is in the shape of a conventional square pillow, the conventional use requirements of a user can be met.

The invention provides a detection method and system for determining a spinal cord injury degree and an injury part, and relates to the technical field of spinal cord injury detection. User data can be collected in real time through the wearable sensor, real-time monitoring of the physical condition of the user is achieved, time sequence data are collected by setting the fixed interval time, the illness state change of the user can be tracked for a long time, the illness state development trend can be found in time, and a doctor can adjust a treatment scheme according to the illness state change. Besides, the basic framework model and the analysis framework model are trained and optimized by utilizing case information with known results, so that the models can learn a large amount of diagnosis knowledge and experience, interference of data volume and noise can be reduced by a hierarchical analysis processing mode of the basic framework model and the analysis framework model, and the diagnosis efficiency and accuracy of the models are improved.

The application provides an aortic dissection rupture sealing device, which comprises an anchoring part, a hollow flow channel, and an intima around the rupture, so as to prevent the fluid communication between the true lumen of the aorta and the false lumen formed at the rupture; a stent, which is adjustably coupled to the anchoring part, has a connecting end and a free end, and at least the free end of the stent is located in a branch blood vessel; and the stent has a hollow structure in communication with the hollow flow channel and is supported in the branch blood vessel to communicate the true lumen and the branch blood vessel. The above scheme can avoid the continuous expansion of the false lumen caused by the incomplete sealing of the rupture and residual shunt, and at the same time, the blood supply of the blood vessel channel is retained to ensure the stability of the blood supply of the branch blood vessel, which is beneficial to meet the blood supply demand of the internal organs, spinal cord and the like supplied by the branch blood vessel.

The invention discloses a self-adaptive supporting assembly and a spinal cord injury patient body position transferring device and method, and belongs to the field of medical auxiliary equipment. The problems that in the body position transferring process of an existing wheelchair, dynamic height collapse is generated when the gravity center laterally moves due to elastic deformation of tires, and the wheelchair and a bed body are separated due to the fact that rigid lateral locking is lacked are solved. According to the technical scheme, the wheelchair bed is characterized by comprising a bed body and a wheelchair, a bottom plate with rollers (the rotating direction is perpendicular to driving wheels) is arranged at the bottom of the wheelchair, a motor drives a threaded rod mechanism to push the bottom plate to move downwards, the driving wheels of the wheelchair are jacked up and suspended, and flexible tire supporting is converted into rigid mechanical supporting. The wheelchair and the bed body are mechanically interlocked through the movable armrests in cooperation with a positioning frame and a positioning groove at the bottom of the bed body. The device eliminates elastic settlement during load transfer, ensures absolute stability of a transfer plane, and enables a patient with spinal cord injury to safely and independently complete'zero-clearance 'translation in cooperation with a body position adjusting mechanism.

The invention provides a spinal cord war wound animal model preparation device, which belongs to the technical field of war wound model preparation, and comprises a three-dimensional positioning platform and a shock wave and elastic sheet generator, the three-dimensional positioning platform comprises a bottom plate, a plurality of moving units and at least four groups of telescopic positioning assemblies; the telescopic positioning assembly is erected on the moving unit through the height adjusting assembly. The shock wave and shrapnel generator comprises an operation table erected on a moving unit; the piston cylinder is vertically and fixedly arranged on the operation table; the lifting assembly is arranged on the operation table, a piston rod is slidably arranged in a piston barrel, and a pulse igniter is arranged; the top of the universal pipe communicates with the lower end of the piston cylinder; the tail end of the universal pipe is detachably connected with an elastic piece pipe. And elastic sheets with different shapes are preset in the elastic sheet tube. The manufacturing device can form multiple types of spinal cord battle trauma animal models.

This invention relates to the field of biomedical materials technology, specifically disclosing a hydrogel material for spinal cord nerve repair containing magnetic nanospheres and its preparation method. The hydrogel material provided by this invention is a photocurable hydrogel formulated using chitosan, dimethylaminoethyl methacrylate, methacryloyloxyethyltrimethylammonium chloride, and magnetic iron oxide nanospheres. Compared with traditional spinal cord nerve repair materials, the hydrogel material provided by this invention has good biocompatibility, is safe and non-toxic, and has a simple and easy preparation method. Photocuring is performed when the hydrogel is injected into the spinal cord injury site, while a magnetic field is simultaneously applied to the injury site. This causes the magnetic nanospheres to rotate according to the magnetic field, forming a series of magnetic channels. As the hydrogel gradually solidifies, the magnetic channels are permanently retained. During the spinal cord nerve repair process, the magnetic channels guide nerve growth, preventing incorrect nerve connections and ensuring the effectiveness of nerve repair.

The invention discloses application of TPN171H, an active fragment thereof or a derivative thereof in preparation of a medicine for treating spinal cord injury. The TPN171H shows an excellent treatment effect in spinal cord injury treatment, the levels of apoptosis factors BAX and Caspase-3 cleaved can be remarkably reduced, the level of Bcl-2 is improved, the content of a neuron marker MAP-2 is also remarkably increased, and the number of Tunel bodies and the cavitation-like structure are remarkably reduced. The intervention of the TPN171H also can reduce MNSS, and prompts that the TPN171H has the functions of promoting the spinal cord movement and coordination of the rat with spinal cord injury and improving the sensory system of the rat with spinal cord injury.

Disclosed are devices, systems, methods and kits for delivering active agents to the spinal cord.

An experimental platform for implantable brain-computer interface of limited movement, comprising: a cooperative control module, which extracts the brain neuron signals of a limited rat through a microelectrode, pre-processes and extracts features of the neuron signals, analyzes and processes the movement information contained therein, converts the movement information into appropriate control instructions, and delivers the control instructions from Raspberry Pi to Arduino to control the corresponding actions of a machine rat made by the limited rat, so as to realize the movement control and sensing feedback between the limited rat and the machine rat; and an external control module, which is installed on the machine rat, and is used for carrying out epidural spinal cord electrical stimulation on the limited rat with partial movement function after incomplete spinal cord injury and combining with external equipment for rehabilitation training. The application can analyze and record the neuron signals of specific regions when the limited rat performs actions, which is helpful for in-depth analysis of the neuron activity characteristics and regulation mechanism of the limited rat.