637 results about "Spinal cord" patented technology

A neurophysiological magnetic stimulation (NMS) method includes obtaining motor thresholds over one or both motor strips adhered to the patient's head or the equivalent anatomic region for treatment of non-brain, nervous system disorders. The method further includes applying magnetic stimulation coils to a therapeutic target region of the patient's brain, brainstem, spinal cord, or peripheral nervous system and applying NMS in increasing amplitudes as tolerated over the course of treatment.

The invention belongs to the field of cerebral apoplexy rehabilitation training, and provides a cerebral apoplexy upper limb dynamic rehabilitation method and system based on vagus nerve electrical stimulation, the excitement degree of a cortical spinal cord pathway of a patient is measured and evaluated by using motor evoked potential to obtain a motor function evaluation result, and an initial rehabilitation training task is set according to the motor function evaluation result; the training motion intention of the patient is determined by monitoring the electroencephalogram signal and the electromyographic signal of the patient, and percutaneous ear vagus nerve electrical stimulation is triggered; after percutaneous ear vagus nerve electrical stimulation, performing rehabilitation training analysis on basic clinical characteristics and multi-modal signals of the patient to determine intermuscular coordination, brain region connectivity and brain muscle coupling of the patient; the training condition of the patient is evaluated according to the rehabilitation training analysis result, and parameters of percutaneous ear vagus nerve electrical stimulation and training tasks are adjusted based on the evaluation result for iterative rehabilitation training; and stopping iteration until the rehabilitation training analysis result of the patient reaches a preset standard, and completing rehabilitation training.

The invention discloses a bionic nanofiber-hydrogel composite biological scaffold as well as a preparation method and application thereof. The bionic nanofiber-hydrogel composite biological scaffold is a composite scaffold for simulating a gray-white matter partition structure of a spinal cord tissue, and comprises bionic nanofibers and a bionic hydrogel material, wherein the bionic nanofibers are arranged in an oriented manner and simulate a white matter ordered structure around the spinal cord, and the bionic hydrogel material is combined with the bionic nanofibers and simulates gray matter in the center of the spinal cord. According to the bionic nanofiber-hydrogel composite biological scaffold, the biological activity of loaded stem cells or adult cells can be improved, the problem that a large number of transplanted exogenous cells die due to unbalanced oxidative stress generated after tissue damage can be solved, and it is guaranteed that the transplanted cells reside in a damaged area and play a role; therefore, the spinal cord microenvironment is improved, proliferation and differentiation of endogenous neural stem cells are promoted, functional recovery after spinal cord injury is finally promoted, and great potential is achieved in spinal cord injury treatment.

The invention discloses a closed-loop noninvasive spinal cord electrical stimulation regulation and control method and system based on motion data, and the system is provided with a flexible electrode array patch which is attached to the skin surface of a to-be-tested human body; the sensing module is used for collecting electromyographic signals or acceleration signals of a user; the signals are processed, and characteristic values related to actions and motions are extracted; the closed-loop feedback module compares the characteristic value with a model set characteristic / threshold value, and judges whether to start stimulation site and stimulation parameter adjustment or not; automatically selecting an optimal electrode unit and a corresponding stimulation parameter based on a judgment result; the dynamic regulation and control module controls the optimal electrode unit to output stimulation current, and regulates the activity of corresponding spinal cord neurons; and continuously performing closed-loop adjustment on the electrode unit and the stimulation parameters according to the motion feedback data. According to the method and system, precise stimulation and closed-loop regulation and control based on the motion response of the patient are achieved, and the problems that stimulation target positioning depends on artificial experience, parameter adjustment is not timely, and individualized and closed-loop feedback capacity is lacked are solved.

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention provides an artificial intelligence spinal nerve regulation and control system and method based on a multi-modal physiology-nerve-experience closed loop, and relates to the technical field of medical instruments, the system comprises an implantable stimulation and sensing subsystem, a body surface and wearable sensing subsystem, a communication and time synchronization subsystem and a control processing unit, the implantable stimulation and sensing subsystem, the body surface / wearable sensing subsystem and the control processing unit are in communication connection in pairs through the communication and time synchronization subsystem. According to the method, the fundamental limitation that in the prior art, only dosage is maintained, and brain and subjective experience is ignored is broken through, and more stable, more efficient and more personalized accurate pain management is realized through multi-modal fusion and hierarchical cooperative control.

The invention discloses a spinal cord injury analysis method and device based on deep learning. The method comprises the following steps: acquiring processed medical image information of a spinal cord part and spinal cord injury physiological information; performing space-time alignment on the medical image of the spinal cord part and the spinal cord injury physiological information so as to obtain an image sequence and an index time sequence after space-time alignment; establishing space-time diagram features according to the image sequence and the index time sequence; splicing the space-time diagram features, the medical image information of the spinal cord part and the physiological information of the spinal cord injury to generate joint features; generating a cross-modal fusion feature; acquiring a trained spinal cord injury analysis model; and inputting the cross-modal fusion features into the trained spinal cord injury analysis model to obtain an injury result. MRI images and physiological indexes are synchronously collected, the limitation of traditional single-mode analysis is broken through, and dual-dimension information of an anatomical structure and functional metabolism is provided for spinal cord injury assessment.

The invention discloses a spinal cord injury state evaluation system fusing pathological data and clinical characteristics, and the system comprises a multi-modal data synchronous collection module which is used for multi-modal original data flow; the damage feature collaborative extraction module is used for extracting structural damage features and functional damage features through a dual-channel deep learning network based on an attention mechanism, and calculating an association weight matrix; the individualized state quantitative evaluation module is used for generating damage state vectors based on weight matrix fusion features and outputting a comprehensive evaluation report through a pre-training model; and the self-adaptive rehabilitation strategy generation module is used for generating a personalized staged rehabilitation treatment scheme according to the comprehensive evaluation report and decomposing the personalized staged rehabilitation treatment scheme into an executable instruction sequence. The method has the following advantages and effects: accurate evaluation of the spinal cord injury state and accurate formulation of the rehabilitation strategy are realized by quantifying the personalized mapping relationship between the spinal cord structural injury and the body functional disorder.

The invention relates to the field of medical dynamic monitoring, in particular to a dynamic monitoring system for a spinal cord injury reconstruction process. Comprising an acquisition and fusion module, a dynamic modeling module, a function evaluation module and an adaptation control module. According to the system, nerve and muscle electrophysiological signals are collected through a wearable surface electrode and a flexible microelectrode array, timing sequence errors are corrected in combination with a calibration sample, and multi-modal signal fusion is achieved. And constructing a topological sequence and time sequence dependence structure, and extracting an incubation period, an activation gradient and response dispersion by adopting a time sequence convolutional network. And identifying function transition and abnormal compensation behaviors through a function evaluation module, and outputting a neural pathway response sequence diagram. And the sampling frequency, the feature weight and the evaluation period are dynamically adjusted based on a Bayesian optimization strategy, and self-adaptive optimization of the monitoring strategy is realized. Therefore, precise modeling and efficient tracking of the neural pathway function reconstruction process are realized.

The invention relates to the technical field of spinal cord injury repair, and discloses a multi-mode nerve regulation electric acupuncture control system for spinal cord injury repair, a patient evaluation module is used for establishing a personalized spinal cord injury model of a patient and evaluating the current nerve function state and rehabilitation potential of the patient to obtain a nerve function evaluation result; the parameter setting module is used for setting multi-modal stimulation parameters in electroacupuncture treatment; the signal processing module is used for collecting local field potential of a spinal cord injury area and electromyographic signals around the injury in real time, preprocessing the collected signals and extracting time-frequency characteristics of the signals. The evaluation module is used for inputting the time-frequency characteristics of the signals into an electro-acupuncture evaluation model, evaluating the neural pathway in real time through the electro-acupuncture evaluation model and outputting an evaluation result; the adjusting module is used for adjusting the frequency, waveform and current intensity parameters of the electroacupuncture needle based on the evaluation result and a Q-learning algorithm, searching an optimal electroacupuncture needle parameter combination and feeding back the optimal electroacupuncture needle parameter combination to the electroacupuncture needle; according to the invention, the pertinence and effectiveness of treatment are improved.

The invention discloses a multi-point electrode array system suitable for spinal cord time interference stimulation and a multi-target regulation and control method, the system comprises a flexible patch and a high-frequency stimulator, the flexible patch is provided with a plurality of electrode units distributed in a two-dimensional or three-dimensional matrix, the high-frequency stimulator is electrically connected with the electrode units, and the high-frequency stimulator is electrically connected with the flexible patch. A group of electrode channels are formed between the two electrode units, the high-frequency stimulator controls high-frequency current of each group of electrode channels, and a plurality of interference targets are constructed and formed among the plurality of groups of electrode channels at the same time. The flexible patch is attached to the spine to be detected, and the electrode units are located on the two sides of the spine; controlling high-frequency current of each electrode unit by using a high-frequency stimulator, and forming a plurality of groups of interfering electrode channels among the plurality of electrode units; subtracting the high-frequency current of the two interfered electrode channels to obtain a plurality of independent interference targets at the same time. The flexible patches are attached to the two sides of the spine to be detected, surgical treatment is not needed, and the treatment risk and cost are remarkably reduced.

The invention discloses application of a cell surface adhesion molecule CD22 as a target spot in preparation of drugs for treating spinal cord injury related diseases. The change of gene expression in the glial scar formation process is represented by space transcriptome sequencing, and the specific expression of CD22 in the glial scar region is up-regulated. According to single cell sequencing, in-situ hybridization and immunohistochemistry, specific high expression CD22 of part of microglial cells in a glial scar area is found. CD22 is knocked out through a genetic means, and it is found that formation of glial scars after spinal cord injury is remarkably reduced through inhibition of CD22. Behavioral detection finds that the error rate of irregular horizontal ladders is remarkably reduced by inhibiting CD22, and fine movement recovery of hind limbs of mice after spinal cord injury is promoted. The siRNA specifically targeting CD22 is injected into the sheath, so that the expression of microglial cells CD22 is inhibited, the error rate of irregular horizontal ladders of hind limbs can be reduced, and the recovery of the fine movement function of the hind limbs of the mouse after spinal cord injury is promoted. The invention provides a new possibility for development of drugs for spinal cord injury and treatment of spinal cord injury.

The invention discloses a progressive dynamic pressure gradient bladder function regulation and control system and method, and aims to solve the problems of high infection rate, bladder injury risk, complicated operation, lack of dynamic pressure regulation and control and the like in the existing bladder management technology. According to the system, the urinary bladder internal pressure, the urine flow rate and the residual urine volume are monitored in real time through the urodynamic monitor, and the pressure gradient is dynamically adjusted according to the health condition of a patient. Progressive pressure training is adopted in the system, the bladder function is gradually enhanced, meanwhile, an emergency adjustment strategy is introduced, and the safety of a patient is ensured. In addition, the system also integrates machine learning and reinforcement learning algorithms, and realizes personalized treatment according to the treatment history and real-time feedback optimization adjustment strategy of the patient. The system has the advantages of precise regulation and control, personalized treatment, improvement of the comfort level of the patient and the like, and the bladder rehabilitation effect of the spinal cord injury patient is remarkably improved.

The invention discloses preparation and application of dual-network hydrogel. The dual-network hydrogel comprises the following components: (Z1) a spinal cord acellular matrix network DSM formed by self-assembly of a spinal cord acellular matrix dSECM; and (Z2) a metal-polyphenol network MPN formed by coordination of metal ions and polyphenols; wherein the DSM and the MPN are cross-linked through hydrogen bonds to jointly form a double-network structure. DSM provides a microenvironment suitable for cell survival and growth for the dual-network hydrogel and induces stem cells to differentiate into neurons, and MPN provides the dual-network hydrogel with biological effects of inhibiting inflammation and accumulation of reactive oxygen species (ROS). The dual-network hydrogel has the advantages of the two components, the active component neurotrophic factor and the inhibitor loaded on the dual-network hydrogel can regulate and control immune response after SCI, improve neuroinflammation microenvironment and promote nerve repair, and a new strategy is provided for in-situ tissue repair of SCI.

A device for spinal correction includes a stabilizer assembly including a hinge including a first rod-bearing leaf; a second rod-bearing leaf rotatably coupled to the first rod-bearing leaf to provide coronal or sagittal freedom of movement, or both, of the stabilizer assembly; a locking mechanism to lock the first and second rod-bearing leaves at a desired angle; a first stabilizing rod coupled to the first rod-bearing leaf; a second stabilizing rod coupled to the second rod-bearing leaf; and a plurality of monoaxial or polyaxial links, wherein each monoaxial or polyaxial link is movably coupled to the first or second stabilizing rod and is movably couplable to a first spinal rod or a second spinal rod fixed to the spine; wherein the stabilizer assembly is couplable to the first or second spinal rod to stabilize the spine to prevent compression, distraction, or translation of the spinal cord during a spinal correction.

The invention discloses a magnesium-containing nanoparticle modified biological scaffold composite material as well as a preparation method and application thereof. The magnesium-containing nano particle modified biological scaffold composite material comprises a biological scaffold material and magnesium-containing nano particles modified on the biological scaffold material, the magnesium-containing nano particles comprise nano magnesium oxide particles and / or nano magnesium oxide-polyphenol compound particles, the nano magnesium oxide-polyphenol compound particles are of a shell-core structure, and the shell-core structure is of a hollow structure. Comprising magnesium oxide serving as a core and a polyphenol compound shell layer coating the surface of the magnesium oxide. The magnesium-containing nanoparticle-modified biological scaffold composite material provided by the invention can prolong the degradation and release of magnesium ions, promote improvement of microenvironment problems such as inflammation and active oxygen outbreak after spinal cord injury, regulate and control oxidative stress and inflammatory response, promote nerve regeneration and motor function recovery, and improve the survival rate of spinal cord injury. The problem that nanoparticles stop in a spinal cord injury area is effectively solved, and support is provided for migration, growth and differentiation of endogenous neural stem cells.

Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with increased transduction enrichment in the central nervous system, brain, and / or spinal cord. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. The rAAV capsid and capsid proteins described herein comprise a sequence that bind to the TEK receptor tyrosine kinase (TEK) protein and / or tissue factor pathway inhibitor (TFPI) protein to facilitate crossing the blood-brain barrier. Gene therapy using the rAAVs is described. Also described are methods of treating brain-, spinal-, and central nervous system-related diseases and conditions.

The invention discloses application of a CXCL14 combined immune checkpoint inhibitor in treatment of spinal glioma. The immune checkpoint inhibitor is selected from a PD-1 inhibitor or a combination of the PD-1 inhibitor and a CTLA4 inhibitor. In-vivo and in-vitro experiments prove that the CXCL14 combined with the PD-1 inhibitor, the CXCL14 combined with the PD-1 inhibitor and the CTLA4 inhibitor can be used for remarkably inhibiting the growth of mutant spinal glioma and have a remarkable synergistic effect. The invention provides a new strategy for treatment of spinal glioma, and is widely applied clinically.

The invention provides application of ACT001 in preparation of a medicine for treating spinal cord injury, and relates to the technical field of biomedicine. The parthenolide structure-improved compound ACT001 disclosed by the invention, as a novel neuroprotective drug, has a remarkable effect, and can be used for practically relieving inflammatory response after spinal cord injury, inhibiting formation of glial scars after injury and protecting neurons so as to promote functional recovery. The medicine can improve the lower limb function recovery of the SCI patient, improve the life quality of the patient, and bring a brand new treatment choice for acute and chronic spinal cord injury patients.

The present invention discloses an FES cycling control method, system, electronic device, and computer program product, relating to the technical field of rehabilitation training methods. The FES cycling control method combines a flywheel, an electromagnetic clutch, and a bicycle crank to provide an FES cycling control method for the quadriceps femoris of patients with spinal cord injury. This method addresses technical difficulties in FES-based fixed cycling rehabilitation exercises, such as the limited torque of electrically stimulated muscles, the difficulty of precise control of muscles as nonlinear elements, and the tendency for long-term continuous electrical stimulation to induce muscle fatigue. The practical effects of FES-based fixed cycling rehabilitation exercises still need to be improved. Compared with traditional electrical stimulation treatment methods, the present invention effectively reduces the intensity of electrical stimulation, improves energy utilization, and achieves energy-saving effects while ensuring rehabilitation needs.

The invention provides a nerve regulation and control system and method for a spinal cord ventral epidural region, and the system employs a microprocessor to generate multiple paths of pulse width modulation signals, and drives a voltage-controlled current source after amplitude adjustment. Stimulation current with adjustable frequency, pulse width and amplitude is output to act on a spinal cord ventral nerve structure. Real-time monitoring of stimulation current of each channel is realized through combination of voltage sampling and a single-pole multi-throw analog switch, feedback information of a body position, myoelectricity, pressure and other multi-mode sensors is fused, a closed-loop control mechanism is constructed, and dynamic adjustment and individualized optimization of electrical stimulation parameters are realized. The system has the advantages of being more accurate in electrical stimulation positioning, more sensitive in response, more intelligent in control and the like, and is suitable for intelligent rehabilitation intervention in scenes of spinal cord injury, cerebral palsy, neurological dysfunction and the like.

The invention discloses a functional hydrogel microsphere and a preparation method and application thereof, and relates to the technical field of medicines.The preparation method comprises the steps that a hyaluronic acid methacrylic acid precursor solution and an IL-1beta shRNA adenovirus stock solution are mixed to obtain an Ad-atHAMA precursor solution; preparing the Ad (at) HAMA precursor solution through an oil-in-water micro-fluidic technology to obtain an Ad (at) HAMA microsphere; and sequentially adding the Ad (at) HAMA microspheres, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide into a 2-morpholinoethanesulfonic acid buffer solution, carrying out activating treatment, adding E selectin, and incubating to obtain the functionalized hydrogel microspheres. The functionalized hydrogel microspheres can inhibit a related mechanism of acute spinal cord injury pathological progress and promote neural function repair by targeting adsorption of neutrophil to regulate Nets-triggered innate immune inflammation cascade.

The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in the method of treating a disease, disorder, or medical condition in a patient, comprising modulating myosin II ATPase, such as treatment of substance abuse relapse disorder, or of renal disease, cancer and metastasis, benign prostate hyperplasia, hemostasis or thrombosis, nerve injury including retinal damage, lung fibrosis, liver fibrosis, arthrofibrosis, wound healing, spinal cord injury, periodontitis, glaucoma and immune-related diseases including multiple sclerosis; or wherein the disease, disorder, or medical condition comprises addiction including abuse of or addiction to anything classified as a Substance-Related or Addictive Disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM), such as, but not limited to, cocaine, opioids, amphetamines, ethanol, cannabis / marijuana, nicotine, and activities including gambling.Compounds are of general formulawith substituents as defined herein.

The invention relates to the technical field of biological medicine, in particular to application of halofuginone in medicine for treating spinal cord injury. The invention provides application of halofuginone in preparation of a medicine for treating spinal cord injury, application of halofuginone in preparation of a medicine for promoting spinal cord injury repair and application of halofuginone in preparation of a medicine for promoting exercise ability recovery after spinal cord injury. The therapeutic drug can promote functional recovery after spinal cord injury, inhibit activation of microglial cells after spinal cord injury and reduce inflammatory response. In addition, the treatment medicine can prevent neuronal reduction after spinal cord injury.

The invention discloses a fusion polypeptide TGNL and application of neural stem cells modified by the fusion polypeptide TGNL in spinal cord injury repair. The fusion polypeptide TGNL is composed of a TAT penetrating domain, a GSTP targeting domain, an NICDi inhibition domain, an MMP-2 activation domain and a flexible Linker connecting the three domains, and the full-length amino acid sequence is as shown in SEQ ID NO. 1. The invention also provides a preparation method of the polypeptide, a neural stem cell (hNSCs-TGNL) for expressing the polypeptide and a construction method of the neural stem cell (hNSCs-TGNL). Experiments show that the fusion polypeptide TGNL can efficiently penetrate nerve cells, specifically target glial scars, is selectively activated by MMP-2, and promotes neural stem cells to differentiate into neurons by inhibiting Notch signals; the hNSCs-TGNL has high survival rate and strong penetrability in an in-vitro glial scar model, and can significantly promote motor function recovery, reduce injury volume, increase axon density and reduce glial scars in a rat spinal cord contusion model. The invention provides a novel candidate drug and a cell treatment strategy for clinical treatment of spinal cord injury, and has remarkable clinical application value.

The invention discloses engineered small extracellular vesicle hydrogel as well as a preparation method and application thereof. The engineered small extracellular vesicle hydrogel comprises a hydrogel matrix, and GDNF-sEVs and a polyphenol compound which are loaded in the hydrogel matrix, wherein the hydrogel matrix comprises a polyacrylamide polymer, xanthan gum and carbomer, the polyacrylamide polymer comprises the following structural unit: [-CH2CH (-CONH-RX-CONH2)-], RX is C1-4 alkylene, and the polyacrylamide polymer comprises the following structural unit:-CH2CH (-CONH-RX-CONH2)-[-CH2CH (-CONH-RX-CONH2)-]. The GDNF-sEVs are small extracellular vesicles loaded with glial cell-derived neurotrophic factors (GDNF-sEVs). According to the engineered small extracellular vesicle hydrogel, through the synergistic effect of the small extracellular vesicles, the glial cell-derived neurotrophic factors and the hydrogel matrix, the injury microenvironment after spinal cord injury can be regulated and controlled, and repair of spinal cord injury is promoted.

The invention discloses an adjustable spinal cord impact vibration injury device and an injury method thereof, and belongs to the technical field of spinal cord injury experiment research. Two lifting sliding rods are fixedly installed at the rear end of the base, and lifting sliding blocks capable of vertically sliding are installed on the lifting sliding rods. An angle adjusting mechanism is installed on the lifting sliding block, the movable end of the angle adjusting mechanism is detachably connected with a supporting tool used for fixing the experimental animal, and the angle adjusting mechanism is used for adjusting the angle of the supporting tool so that different parts of the experimental animal can face the base; the base is further provided with an impact triggering mechanism. Through the mode, the experimental animal spinal cord impact oscillation injury model prepared by adopting the technical scheme can well simulate the injury process of a clinical spinal cord injury patient and the pathophysiological change after injury; and the spinal cord impact vibration injury models with different injury modes and different injury degrees are prepared by changing the free falling body height of the experimental animal, the vertical impact rods made of different materials and the impact point location of the experimental animal.

The invention belongs to the technical field of biological medicines, and particularly relates to an active peptide with a function of repairing neuroinflammation after spinal cord injury and a preparation method and application thereof. The invention firstly provides a recombinant active peptide. The structure of the recombinant active peptide at least comprises two groups of alpha spiral fragments; the amino acid sequence of the recombinant active peptide is as shown in SEQ ID NO. 2 or SEQ ID NO. 3. The bioactive peptide and the prepared nanofiber provided by the invention can effectively repair neuroinflammation after spinal cord injury, and have relatively high safety in a living body. And compared with the RK33A holoprotein, the RK33A holoprotein has a better effect.

The invention discloses a spinal cord electrical stimulation control method and system based on tremor detection. The method comprises the following steps: acquiring motion sensing data of a user; extracting tremor signal features of the user according to the motion sensing data and a preset feature extraction algorithm; determining an electrical stimulation parameter corresponding to the tremor signal feature according to a preset electrical stimulation parameter determination rule; according to the electrical stimulation parameters, generating an electrical stimulation control instruction corresponding to electrical stimulation equipment arranged in a spinal cord area of the user; the electrical stimulation control instruction is used for indicating current output of the electrical stimulation equipment. Therefore, accurate nerve intervention control in combination with tremor monitoring and spinal cord electrical stimulation can be realized, the physical therapy inhibition effect of electrical stimulation physical therapy measures on the tremor of the user is improved, and more efficient and accurate nerve regulation and control service is provided for the user.

The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and / or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and / or tissue hydration, myocardial ischemia, myocardial ischemia / reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.